morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Chemokine receptor antagonists enhance morphine's antinociceptive effect but not respiratory depression. (Pubmed Central) -  Nov 17, 2021   
    These results support the conclusion that combinations of CRAs can increase the potency of sub-analgesic doses of morphine analgesia without increasing respiratory depression. The results support an "opioid sparing" strategy for alleviation of pain using reduced doses of opioids in combination with CRAs to achieve maximal analgesia.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  A comparison of preincisional and postincisional ultrasound guided transversus abdominis plane block. (Pubmed Central) -  Nov 16, 2021   
    The total morphine requirement was significantly less in the preincisional TAP group (P-value 0.001)...Post operative nausea and vomiting was significantly higher and so the dose of the antiemetic used was also observed to be more in the postincisional TAP block group. Preincisional TAP blocks are more effective than postincisional ones with better analgesia and lesser side effects, for total abdominal hysterectomies.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Epitope specificity of two anti-morphine monoclonal antibodies: In vitro and in silico studies. (Pubmed Central) -  Nov 16, 2021   
    According to our modeling and docking results, the very different modes of morphine binding to mAbs 3K11 and 6G1 are qualitatively similar to those previously reported for cocaine and two anti-cocaine antibodies. Thus, the obtained structural information brings more insight into the hapten recognition diversity.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Clinical, Journal:  Concomitant inpatient prescribing of strong opioids with sedatives: Associations with comorbid conditions. (Pubmed Central) -  Nov 16, 2021   
    Patients with comorbidities resulting in increased risk of respiratory depression/OIVI were more likely to have sedative co-prescription. Clinicians should be aware of the effects of high-risk medications and ensure that systems and monitoring are in place that help mitigate adverse outcomes.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Recent Chemical and Pharmacological Developments on 14-Oxygenated-N-methylmorphinan-6-ones. (Pubmed Central) -  Nov 16, 2021   
    Morphine and structurally related derivatives (e.g., oxycodone, oxymorphone, buprenorphine) are highly effective opioid analgesics, mediating their effects via the activation of opioid receptors, with the mu-opioid receptor subtype as the primary molecular target...We focus on drug design strategies and structure-activity relationships on specific modifications in positions 5, 6, 14 and 17 on the morphinan skeleton, with the goal of aiding the discovery of opioid analgesics with more favorable pharmacological properties, potent analgesia and fewer undesirable effects. Targeted molecular modifications on the morphinan scaffold can afford novel opioids as bi- or multifunctional ligands targeting multiple opioid receptors, as attractive alternatives to mu-opioid receptor selective analgesics.
  • ||||||||||  morphine sulphate / Generic mfg., sevoflurane / Generic mfg.
    Preclinical, Journal:  The effect of cannabidiol on sevoflurane minimum alveolar concentration reduction produced by morphine in rats. (Pubmed Central) -  Nov 12, 2021   
    ESP block was associated with reduced perioperative opioid consumption, intraoperative adjuvant analgesic use and incidence of pharmacological interventions to treat cardiovascular complications in dogs undergoing hemilaminectomy. MAC in rat was unaltered by the action of CBD alone, the reduction in MAC produced by morphine was not enhanced by the addition of CBD at the doses studied.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Inequity in Discharge Pain Management for Trauma Patients with Limited English Proficiency. (Pubmed Central) -  Nov 12, 2021   
    LEP patients with traumatic injuries were less likely to receive any opioid prescription and were prescribed lower quantities of opiates, which could contribute to suboptimal pain management and recovery. Addressing these disparities is an important focus for future quality improvement efforts.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Comparison between femoral block and PENG block in femoral neck fractures: A cohort study. (Pubmed Central) -  Nov 12, 2021   
    In the management of hip fractures, PENG block is not associated in our study with a significant change in postoperative morphine consumption, compared to femoral block. However, it does significantly improve the immediate mobility of the operated limb, making it appropriate for inclusion in enhanced recovery programs after surgery.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Association of 3 CDC opioid prescription guidelines for chronic pain and 2 payer pharmacy coverage changes on opioid initiation practices. (Pubmed Central) -  Nov 12, 2021   
    The study used multiple treatment period segmented regression analysis to evaluate the association, across different provider specialties, between the CDC guideline release and the payer pharmacy coverage changes with immediate change in level and overall change in the rate of first-time extended-release opioid prescriptions, firsttime opioid prescriptions at doses of at least 50 MME (morphine milligram equivalent) per day, and first-time opioid prescriptions with overlapping benzodiazepine prescription...Karaca-Mandic reports grants from the American Cancer Society and Sempre Health, along with fees from Tactile Medical and Precision Health Economics, unrelated to this study. The other authors have nothing to disclose.
  • ||||||||||  morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Enrollment closed, Trial completion date, Trial primary completion date:  NCI-2018-01139: Levorphanol as a Second Line Opioid in Reducing Pain in Patients With Cancer (clinicaltrials.gov) -  Nov 11, 2021   
    P1,  N=86, Active, not recruiting, 
    The other authors have nothing to disclose. Recruiting --> Active, not recruiting | Trial completion date: Jan 2021 --> Dec 2022 | Trial primary completion date: Jan 2021 --> Dec 2022
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Fecal microbiota transplantation and antibiotic treatment attenuate naloxone-precipitated opioid withdrawal in morphine-dependent mice. (Pubmed Central) -  Nov 11, 2021   
    ML-7, a pharmacological inhibitor of gut permeability, reduced the morphine-induced increase in gut permeability in vivo but did not reliably alter somatic signs of naloxone-precipitated opioid withdrawal. Our results suggest that the gut microbiome impacts the development of physical dependence induced by chronic morphine administration, and that therapeutic manipulations of the gut microbiome may reduce opioid withdrawal.
  • ||||||||||  paracetamol / Generic mfg.
    Clinical, Review, Journal:  Paracetamol as an adjuvant to opioids for cancer pain management (Pubmed Central) -  Nov 10, 2021   
    However, this technical report also describes that there is uncertainty about the impact of paracetamol as an adjuvant in patients with cancer pain who are already receiving strong opioids. This review aims to describe the current state of the art regarding the role of paracetamol as a coadjuvant in cancer pain patients.
  • ||||||||||  midazolam hydrochloride / Generic mfg.
    Clinical, Journal:  Sedation and analgesia requirements during venovenous extracorporeal membrane oxygenation in acute respiratory distress syndrome patients. (Pubmed Central) -  Nov 10, 2021   
    Midazolam, sufentanil, and remifentanil were main sedatives and analgesics used in the patient population...Multiple linear regression analysis revealed a linear correlation between midazolam equivalents and morphine equivalents (p < 0.001)...The sedation and analgesia requirements of ARDS patients receiving VV-ECMO often increase simultaneously. More large-scale studies are needed to confirm the risk factors for increased sedation and analgesia needs in patients supported on VV-ECMO.
  • ||||||||||  celecoxib oral / Generic mfg.
    Clinical, Journal:  Postoperative outcomes of total knee arthroplasty across varying levels of multimodal pain management protocol adherence. (Pubmed Central) -  Nov 10, 2021   
    Five groups were compared based on the combination of multimodal analgesics ranging from no MMPM to full MMPM with acetaminophen, gabapentinoids, and celecoxib...MMPM protocols are effective at reducing LOS and postoperative narcotic requirements post-TKA. Patients appear to derive similar benefit from receiving all three medications, as well as various combinations of these drugs.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Differential Effects of Saikosaponins A, B2, B4, C and D on Alcohol and Chocolate Self-Administration in Rats. (Pubmed Central) -  Nov 10, 2021   
    The wide spectrum of efficacy of saikosaponins in reducing alcohol and chocolate self-administration suggests that even relatively small structural differences are sufficient to produce remarkable changes in their in vivo pharmacological profile. Together, these results confirm that roots of B. falcatum may be an interesting source of compounds with anti-addictive potential.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Enhanced recovery for obese patients undergoing gynecologic cancer surgery. (Pubmed Central) -  Nov 10, 2021   
    Neither post-operative length of stay nor the rate of serious complications differed significantly despite longer surgeries, greater blood loss, and more opioid use among obese patients. An ERAS program was safe, effective, and feasible for obese patients with suspected gynecologic cancer.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Impact of a Nurse-Driven Opioid Titration Protocol on Quality of Orders at End of Life. (Pubmed Central) -  Nov 10, 2021   
    In addition, prescribers were more likely to order additional medications to manage nausea/vomiting, constipation, anxiety, or pain using a nonopioid (P < .05 for all). In this study, implementation of a standardized opioid titration protocol and symptom management order set led to an improvement in the quality of morphine infusion orders for pain management at the end of life and increased the use of medications to manage nonpain symptoms in dying patients.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Clinical, Journal:  Analgesic efficacy of sufentanil in dressings after surgical treatment of burn wounds. (Pubmed Central) -  Nov 10, 2021   
    Effective pain assessment, management and advocacy are assisted by evidence-based assessment practices. Sufentanil in dressings after burn wound surgery provides effective and safe analgesia and the sufentanil concentration in dressings should be ≥0.10 μg/mL in a solution of octenidine and phenoxyethanol.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Variations in Postoperative Opioid Prescription Practices and Impact on Refill Prescriptions Following Lumbar Spine Surgery. (Pubmed Central) -  Nov 10, 2021   
    Compared to PIA alone, a combination of LFCNB and IHINB along with PIA can improve early pain relief, reduce morphine consumption, and accelerate functional recovery, without increasing complications after THA via the DAA. In analysis of filled opioid prescriptions, we observed significant proportion of prescriptions>200 MMEs and wide regional variation in post-discharge opioid prescribing patterns following elective lumbar spine surgery.