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- || morphine sulphate / Generic mfg.
Clinical, Journal: Open-Label Placebo Treatment for Acute Postoperative Pain (OLP-POP Study): Study Protocol of a Randomized Controlled Trial. (Pubmed Central) - Nov 24, 2021
P=N/A
The treatment as usual group consists of participants receiving a patient-controlled morphine pump...Results of the analysis will be submitted for publication in a peer-reviewed journal. Clinical Trial Registration: The study is registered at ClinicalTrials.gov (NCT04339023) and is listed in the Swiss national registry at kofam.ch (SNCTP000003720).
- || morphine sulphate / Generic mfg.
Clinical, Journal: Implementation and Knowledge of the Clinical Practice Guide for Palliative Care in the Ecuadorian Primary Care Level. (Pubmed Central) - Nov 24, 2021
Only 25% treat the agony symptoms and 30%, delirium; 4.4% acknowledge the use of morphine in dyspnea, and 13.3% identify the subcutaneous route as the first choice for hydration at the end-of-life phase. Strategies to implement the GPCCP guide and to improve the health personnel's knowledge must be implemented in Zone 7 centers.
- || morphine sulphate / Generic mfg.
Clinical, Retrospective data, Journal: The use of bilateral transversus abdominis plane blocks with liposomal bupivacaine on postoperative cesarean delivery patients during COVID-19 pandemic is associated with reduced narcotics use and reduced length of stay. (Pubmed Central) - Nov 24, 2021
Post cesarean delivery, patients who received both bilateral transversus abdominis plane blocks with liposomal bupivacaine and neuraxial morphine was associated with a significant decrease in the number of patients using post operative opioids, 54%-60% decreased to 18% (p < 0.001), and a decreased length of stay; 3.1 days was reduced to 2.39 (p < 0.001). Neuraxial opioids combined with liposomal bupivacaine transversus abdominis plane blocks provided significant pain relief for patients post cesarean delivery, required less post operative opioids, and facilitated earlier discharge that may aid in reducing patient exposure and hospital burden secondary to COVID-19.
- | morphine sulphate / Generic mfg.
Journal: Overexpression of RAPGEF3 enhances the therapeutic effect of dezocine in treatment of neuropathic pain. (Pubmed Central) - Nov 23, 2021
In addition, dezocine has an analgesic effect similar to that of morphine, alleviating moderate to severe pain...Through western blotting, we further found that pro-inflammatory proteins were decreased, and these effects might be mediated by inhibition of the Ras/p-38 MAPK signaling pathway. Taken together, we speculated that RAPGEF3overexpression enhances the therapeutic effect of dezocine on neuropathic pain by inhibiting the inflammatory response through inhibition of the Ras/p-38 MAPK signaling pathway.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Does the Transversus Abdominis Plane Block Reduce Morbidity Following Iliac Crest Bone Harvest in Pediatric Patients With Alveolar Clefts? (Pubmed Central) - Nov 22, 2021
Taken together, we speculated that RAPGEF3overexpression enhances the therapeutic effect of dezocine on neuropathic pain by inhibiting the inflammatory response through inhibition of the Ras/p-38 MAPK signaling pathway. The results of our study suggest there may be no role for a TAP block in reducing pain and improving opioid stewardship.
- | morphine sulphate / Generic mfg.
Journal: Duhaldea pterocaula (Franch.) Anderb. Attenuates Nociception and Inflammation via GABA Receptors. (Pubmed Central) - Nov 21, 2021
Furthermore, IPEA improved the tolerance of mice to morphine...I. pterocaula may be useful as a complementary or alternative therapeutic agent for the treatment of pain and inflammation.
- | morphine sulphate / Generic mfg.
Clinical, Journal: Opioid Prescriptions for Female Pelvic Reconstructive Surgery Patients Before and After Implementation of Tennessee State Legislation. (Pubmed Central) - Nov 21, 2021
State legislation was associated with a significant decrease in prescribed OMEs at the time of discharge in patients undergoing female pelvic reconstructive surgery. These results support ongoing legislative efforts to address the current opioid crisis.
- || morphine sulphate / Generic mfg.
Clinical, Journal: The development of a nomogram to determine the frequency of elevated risk for non-medical opioid use in cancer patients. (Pubmed Central) - Nov 21, 2021
We established a practical nomogram to assess the +risk. The application of a nomogram based on routinely collected clinical data can help clinicians establish patients with +risk and positively impact care planning.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Ghrelin receptor agonist hexarelin attenuates antinociceptive tolerance to morphine in rats. (Pubmed Central) - Nov 21, 2021
Besides, co-administration of hexarelin and morphine increases the analgesic effect. In conclusion, these data indicate that administration of GHS-R agonist hexarelin with morphine enhances the antinociception and attenuates morphine tolerance.
- || morphine sulphate / Generic mfg., paracetamol / Generic mfg.
Clinical, Journal: Patient Satisfaction and Refill Rates After Decreasing Opioids Prescribed for Urogynecologic Surgery. (Pubmed Central) - Nov 21, 2021
In conclusion, these data indicate that administration of GHS-R agonist hexarelin with morphine enhances the antinociception and attenuates morphine tolerance. A multimodal analgesia regimen limiting postoperative opioids decreased postoperative opioid prescribing and consumption while maintaining similar patient satisfaction and refill rates.
- || morphine sulphate / Generic mfg., paracetamol / Generic mfg.
Clinical, Journal: Analysis of Narcotic Use in Isolated Facial Fractures: Potential Targets for a Narcotic Reduction Protocol. (Pubmed Central) - Nov 21, 2021
Interestingly, non-narcotic analgesic use including acetaminophen and lidocaine-epinephrine resulted in significantly lower narcotic usage in the postoperative setting. These findings suggest a role for narcotic-reducing enhanced recovery after surgery protocols in the setting of isolated facial trauma.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Predictors of Opioid Prescription After Orthognathic Surgery in Opioid Naive Adults From a Large Database. (Pubmed Central) - Nov 21, 2021
Prescription opioids are relatively uncommon after jaw surgery, although 17.9% of patients continue to use opioids beyond 3 months after surgery. Predictors of persistent opioid use in this population include the number of days hospitalized, increasing age, and increasing amount of opioid prescribed postoperatively.
- | pregabalin / Generic mfg.
Journal: MCRT, a Multifunctional Ligand of Opioid and Neuropeptide FF Receptors, Attenuates Neuropathic Pain in Spared Nerve Injury Model. (Pubmed Central) - Nov 21, 2021
administration. Notably, the local efficacy of MCRT in SNI mice was about one thousand-fold higher than morphine and ten thousand-fold higher than pregabalin, indicating a great promise in the future treatment of neuropathic pain.
- | morphine sulphate / Generic mfg.
Journal: Opium Effect in Pregnancy on the Dynamics of Maternal Behavior: Testing a Neurochemical Model. (Pubmed Central) - Nov 21, 2021
There is no effect of opium exposure on self-grooming behavior. This pattern supports the FET hypothesis about the role of 5-HT and BDNF in endurance, differential regulation of endurance, integrative and emotionality aspects of behavior, and differential association of the MOR system with endurance aspects, in comparison with kappa- and delta opioid receptors.
- | morphine sulphate / Generic mfg.
Journal: Exploring the Chemistry of Alkaloids from Malaysian Mitragyna speciosa (Kratom) and the Role of Oxindoles on Human Opioid Receptors. (Pubmed Central) - Nov 21, 2021
Further, corynoxine (1) was 1.8-fold more potent than morphine in rats subjected to a nociceptive hot plate assay. These findings have important implications for evaluating the combined effects of the minor oxindole alkaloids in the overall therapeutic activity of M. speciosa.
- | morphine sulphate / Generic mfg.
Journal: Opioid Prescribing Patterns After Head and Neck Surgery. (Pubmed Central) - Nov 21, 2021
Female sex, younger age, smokers, and high inpatient opioid dose requirements are associated with inadequately controlled pain. These patients may benefit from additional education, earlier postoperative visits, and a more comprehensive nonopioid regimen.
- || morphine sulphate / Generic mfg.
Clinical, Journal: The safety and efficacy of intrathecal morphine in pediatric spinal deformity surgery: a 25-year single-center experience. (Pubmed Central) - Nov 21, 2021
Pre-incision IM is a safe adjunct for pain management in select children in all diagnostic groups undergoing spinal deformity surgery. There were no serious complications.
- || morphine sulphate / Generic mfg.
Retrospective data, Review, Journal: Local Infiltration Analgesia Versus Femoral Nerve Block for Pain Control in Anterior Cruciate Ligament Reconstruction: A Systematic Review With Meta-analysis. (Pubmed Central) - Nov 21, 2021
Compared with FNB, LIA was not as effective at 2 hours, comparable within 12 hours, and significantly more effective at 24 hours postoperatively for reducing pain after ACLR. Total morphine-equivalent consumption showed no significant differences between the 2 techniques.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Inhibition of the phosphoinositide 3-kinase-AKT-cyclic GMP-c-Jun N-terminal kinase signaling pathway attenuates the development of morphine tolerance in a mouse model of neuropathic pain. (Pubmed Central) - Nov 21, 2021
Overall, the PI3K/AKT intracellular signaling pathway is a potential target for reducing the development of morphine tolerance in the peripheral nervous system. Continued research into this pathway will contribute to the development of new analgesic drug therapies.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Effect of Daily Dosage of Morphine Milligram Equivalents on Free Flap Complications: A Single-Institution Retrospective Study. (Pubmed Central) - Nov 21, 2021
Chronic preoperative opioid use is common for free flap surgery, and according to our single-center experience, higher daily doses are a risk factor for flap complications and surgical site infections. These findings add to the growing body of evidence that opioid use is a modifiable risk factor that may increase surgical morbidity.
- | morphine sulphate / Generic mfg.
Journal: Perioperative Recovery and Narcotic Use in Laparoscopic Versus Robotic Surgery for Endometrial Cancer. (Pubmed Central) - Nov 21, 2021
Recovery time was longer for robotic surgery but this was not significant in multivariate analysis. Same day discharges are less frequent with robotics, which may be more related to physician choice rather than procedure.
- || fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Review, Journal: Recent Advances in Peripheral Opioid Receptor Therapeutics. (Pubmed Central) - Nov 21, 2021
Recent innovations in peripheral opioid receptor therapeutics of pH-sensitive opioid ligands and limiting opioid permeability across the blood-brain barrier have had promising results in animal models. While this is grounds for optimism that some of these therapeutics will be efficacious in human subjects at a future date, each drug must undergo individualized testing for specific chronic pain syndromes to establish not only the nuances of each drug's therapeutic effect but also a comprehensive safety profile.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Bioactive peptide release and the absorption tracking of casein in the gastrointestinal digestion of rats. (Pubmed Central) - Nov 21, 2021
After intestinal digestion for 2 h, peptides with weights less than 5 kDa were enriched and identified using LC-MS-MS, and they were found to be mainly derived from β-casein, containing potential angiotensin-I-converting enzyme inhibitory, antioxidant, dipeptidyl peptidase IV inhibitory, and morphine-like peptides. The peptides from casein hydrolysate were tracked entering the blood through the intestinal epithelial barrier in the form of complete fragments, and they might exert potential physiological activity in vivo.
- | morphine sulphate / Generic mfg.
Journal: Postoperative pain control after arthroscopic rotator cuff repair: Arthroscopy-guided continuous suprascapular nerve block versus ultrasound-guided continuous inter-scalene block. (Pubmed Central) - Nov 21, 2021
The peptides from casein hydrolysate were tracked entering the blood through the intestinal epithelial barrier in the form of complete fragments, and they might exert potential physiological activity in vivo. Our findings show that AS-SSNB is not inferior to US-ISB for postoperative pain control following ARCR while showing fewer temporary neurologic complications.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Patient-reported opioid use for tissue expander-based breast reconstruction. (Pubmed Central) - Nov 21, 2021
For patients discharging home after a one-night stay for immediate TE breast reconstruction, we recommend a prescription for 10 oxycodone 5 mg tablets, or 15 tablets if they are less than age 49 or have had high inpatient opioid use. Patients should also be counseled that the expected duration of outpatient opioid use is 7-11 days, and that 20 % of patients did not use any opioids following hospital discharge, making nonnarcotic pain regimens a real possibility.
- | morphine sulphate / Generic mfg., methamphetamine / Generic mfg., piracetam / Generic mfg.
Journal, Epigenetic controller: Psychostimulants and opioids differentially influence the epigenetic modification of histone acetyltransferase and histone deacetylase in astrocytes. (Pubmed Central) - Nov 21, 2021
Majorly psychostimulants such as cocaine, methamphetamine (METH) and opioids such as morphine are known to induce epigenetic changes of histone modifications and chromatin remodeling which are mediated by histone acetyltransferase (HAT) and histone deacetylase (HDAC)...In addition, we have explored the neuroprotective "nootropic" drug piracetam were exposed with or without psychostimulants and opioid in the human primary astrocytes...Psychostimulants and opioid exposure upregulated global acetylation levels of all H3Ks, except H3K14. These results suggest that psychostimulants and opioids differentially influence HATs and HDACs.
- || ketorolac / Generic mfg., ibuprofen / Generic mfg.
Clinical, Journal: Thoracic paravertebral nerve catheter reduces postoperative opioid use for vertebral body tethering patients. (Pubmed Central) - Nov 21, 2021
These results suggest that psychostimulants and opioids differentially influence HATs and HDACs. In this series compared to controls, patients treated with a TPVB had reduced postoperative requirement of opioids and decreased length of hospital stay.
- | morphine sulphate / Generic mfg.
Journal: Predictors of severe postoperative pain after orthopedic surgery in the immediate postoperative period. (Pubmed Central) - Nov 21, 2021
In this series compared to controls, patients treated with a TPVB had reduced postoperative requirement of opioids and decreased length of hospital stay. Preoperative predictors of severe postoperative pain should be considered when assessing and treating orthopedic patients postoperatively to assure adequate pain relief.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Association between opioid-related deaths and prescribed opioid dose and psychotropic medicines in England: a case-crossover study. (Pubmed Central) - Nov 21, 2021
Daily OMEQ dose greater than 120 mg and the concomitant use of psychotropic medicines were related to ORDs in the UK. Prescribers should cautiously avoid prescribing opioids with a daily OMEQ dose greater than 120 mg day and the combination of opioids and gabapentinoids, even with low opioid doses.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Morphine-induced kinase activation and localization in the periaqueductal gray of male and female mice. (Pubmed Central) - Nov 21, 2021
Taken together, this study demonstrates increased activation of ERK 1/2, PKC, and PKA in response to repeated morphine treatment. The study opens avenues to explore the impact of chronic morphine treatment on G-protein signaling and kinase nuclear transport.
- | morphine sulphate / Generic mfg.
Journal: Unconditioned and learned morphine tolerance influence hippocampal-dependent short-term memory and the subjacent expression of GABA-A receptor alpha subunits. (Pubmed Central) - Nov 21, 2021
The study opens avenues to explore the impact of chronic morphine treatment on G-protein signaling and kinase nuclear transport. Our data supports the hypothesis that unconditioned and learned morphine tolerance influences short-term memory and the expression of GABArα 1, α2, α5 mRNAs and GABArα protein level differently, and adds to our understanding of the behavioral and molecular aspects of the learned tolerance to morphine effects.
- | morphine sulphate / Generic mfg.
Journal: Continuous Deep Sedation until Death in Neonates and Infants in Flanders: A Post-Mortem Survey. (Pubmed Central) - Nov 21, 2021
CDS precedes about 2 in 5 neonatal and infant deaths. Guidelines for CDS in this age group are non-existent and it is unclear whether the same recommendations as in the adult population apply and can be considered a good practice.
- | morphine sulphate / Generic mfg.
Journal: Morphine promotes microglial activation by upregulating the EGFR/ERK signaling pathway. (Pubmed Central) - Nov 21, 2021
The activation, migration, and production of proinflammatory cytokines in BV-2 cells were inhibited by blocking the EGFR signaling pathway with AG1478. The present study demonstrated that the EGFR/ERK signaling pathway may represent a novel pharmacological strategy to suppress morphine tolerance through attenuation of microglial activation.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Periarticular Liposomal Bupivacaine Mixture Injection versus Single Shot Interscalene Block for Post-operative Pain in Arthroscopic Rotator Cuff Repair: A Prospective Randomized Controlled Trial. (Pubmed Central) - Nov 21, 2021
The charge per patient for PAI is approximately $300 less than ISB. Thus, PAI may offer surgeons and patients an effective postoperative analgesic modality as an alternative to ISB.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Positive Toxicology Results Are Not Associated with Emergency Physicians' Opioid Prescribing Behavior. (Pubmed Central) - Nov 21, 2021
Notably, none of the 103 patients who had toxicology screens were prescribed naloxone upon discharge. More research on the associations between illicit drug use, opioids, and naloxone prescriptions is necessary to help establish guidelines for high-risk patients.
- | morphine sulphate / Generic mfg.
Journal: HIV Increases the Inhibitory Impact of Morphine and Antiretrovirals on Autophagy in Primary Human Macrophages: Contributions to Neuropathogenesis. (Pubmed Central) - Nov 21, 2021
These results indicate that inhibition of autophagy, both in bulk and selective, in CNS macrophages may mediate neurocognitive dysfunction in PWH using opioids. Increasing autophagic activity in the context of HIV may represent a novel therapeutic strategy for reducing HAND in these individuals.
- || morphine sulphate / Generic mfg.
Self-administration effect of morphine was equivalent to cocaine in non-human primates. Shows the strong reinforcing effects of #opioid. (Twitter) - Nov 21, 2021
- || morphine sulphate / Generic mfg., buprenorphine/naloxone sublingual film / Generic mfg.
Also, #DoseMakesThePoison Suboxone, for example has a very narrow therapeutic 🪟, regardless of tolerance (natural bodily adaptation to substance), but if ⬆️ slowly, morphine has no known ceiling dose. Alternatively, give a person ⬆️⬆️ dose w/o slow ⬆️ they'll OD. #dosematters (Twitter) - Nov 20, 2021
- |||| morphine sulphate / Generic mfg., aspirin / Generic mfg., paracetamol / Generic mfg.
Clinical: 93% participants also got heparin. It's like giving paracetamol to someone on morphine. Meanwhile another study found people already on long term low dose aspirin prior to infection had signific reduction in mortality. I'm not a doctor and it's obvious to me. (Twitter) - Nov 19, 2021
- dexamethasone / Generic mfg.
Regional Analgesia After Cystectomy with Urinary Diversion: Erector Spinae Plane Block vs. Transversus Abdominus Plane Block () - Nov 19, 2021 - Abstract #SUO2021SUO_246;
Increased adoption of ESP could have major impacts on both clinical outcomes and patient satisfaction in patients undergoing cystectomy. Prospective study is needed to better characterize the differences between these two modalities.
- morphine sulphate / Generic mfg., hydrocodone/paracetamol / Generic mfg.
STATEWIDE OPIOID STEWARDSHIP PROGRAMS NOT ASSOCIATED WITH CHANGES IN OPIOID PRESCRIBING FOLLOWING UROLOGIC CANCER SURGERY () - Nov 19, 2021 - Abstract #SUO2021SUO_236;
The median dose prescribed is equivalent to 30 tablets of acetaminophen 300mg/hydrocodone 5mg, a number substantially higher than reported patient use. Prescribers appear to have made the minimum necessary changes to achieve compliance with the policies instead of implementing meaningful changes in opioid prescribing following surgery.
- morphine sulphate / Generic mfg.
PROLONGED OPIOID USE FOLLOWING TURBT: INSURANCE CLAIMS REVIEW OF HIGH-RISK PRESCRIBING TO OPIOID-NAÏVE PATIENTS () - Nov 19, 2021 - Abstract #SUO2021SUO_215;
These results suggest that prescribing initial post-TURBT opioids increases the likelihood of continued use at 3-6 months. Those who go on to radical treatment are refilling opioids at a higher rate than others at one month.
- | ketamine / Generic mfg.
Trial completion date, Trial primary completion date: Comparison of Low-dose Ketamine to Opioids in the Management of Acute Pain in Patients Presenting to the Emergency Department With Long Bone Fractures (clinicaltrials.gov) - Nov 18, 2021
P2, N=30, Not yet recruiting, Sponsor: The University of Texas Health Science Center, Houston
Those who go on to radical treatment are refilling opioids at a higher rate than others at one month. Trial completion date: Jun 2022 --> Dec 2022 | Trial primary completion date: Dec 2021 --> Dec 2022
- | morphine sulphate / Generic mfg.
Enrollment open, Surgery: Ultrasound Guided ESP Block Versus Intrathecal Morphine for Postoperative Analgesia in Major HPB Surgery. (clinicaltrials.gov) - Nov 18, 2021
P=N/A, N=40, Recruiting, Sponsor: Assiut University
Trial completion date: Jun 2022 --> Dec 2022 | Trial primary completion date: Dec 2021 --> Dec 2022 Not yet recruiting --> Recruiting
- || fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Clinical, Journal: Effect of Ultrasound-Guided Thoracolumbar Interfascial Plane Block on the Analgesic Requirements in Patients Undergoing Lumbar Spine Surgery Under General Anesthesia: A Randomized Controlled Trial. (Pubmed Central) - Nov 17, 2021
The intraoperative fentanyl consumption was lower in the TLIP group (15±35.11 mcgs) versus the control group (105±62.08 mcgs)...Patients in the TLIP group had lower perioperative hemodynamic responses to surgical stimulation in comparison to the control group. Combined TLIP block with general anesthesia in patients undergoing spinal surgery reduced both postoperative and intraoperative analgesic needs, reduced intra-operative hemodynamic response to surgery, and achieved good postoperative pain control.
- || morphine sulphate / Generic mfg.
Clinical, Review, Journal: Enteral feeding and the microbiome in critically ill children: a narrative review. (Pubmed Central) - Nov 17, 2021
Factors within the PICU that are often associated with dysbiosis include the use of broad-spectrum antibiotics, proton-pump inhibitors (PPIs), intravenous morphine, and fasting...Further microbiome research is needed to provide mechanistic insights into the impact of the ever changing gut microbiome. In the future, new microbiota targeted therapies could potentially be the treatment of challenging PICU conditions and restore homeostasis in these children.
- | morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
Retrospective data, Journal: Ultrasound-Guided Continuous Bilateral Erector Spinae Plane Blocks Are Associated with Reduced Opioid Consumption and Length of Stay for Open Cardiac Surgery: A Retrospective Cohort Study. (Pubmed Central) - Nov 17, 2021
Patients who received blocks had shorter times to extubation (126 ± 87 vs. 257 ± 188 min) and lengths of stay in the intensive care unit (35 ± 17 vs. 58 ± 42 h) and hospital (5.6 ± 1.6 vs. 7.7 ± 4.6 days). Continuous erector spinae plane blocks placed prior to open cardiac surgical procedures reduced opioid consumption, time to extubation, and length of stay compared to a standard perioperative pathway.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Bedside Evaluation of Early VAS/NRS Based Protocols for Intravenous Morphine in the Emergency Department: Reasons for Poor Follow-Up and Targeted Practices. (Pubmed Central) - Nov 17, 2021
In conclusion, IV morphine prescription is rarely based on first pain scores. Triage assessment is used for screening by bedside physicians, who prefer targeted practices to automatic protocols.
- || morphine sulphate / Generic mfg.
Review, Journal, IO biomarker: Interaction of Opioids with TLR4-Mechanisms and Ramifications. (Pubmed Central) - Nov 17, 2021
In addition to a direct interaction at the receptor, opioids affect NF-κB activation downstream of both TLR4 and opioid receptors and modulate TLR4 expression, leading to a range of in vivo outcomes. Here, we review the literature reporting the activity of opioids at TLR4, its proposed mechanism(s), and the complex functional consequences of this interaction.
- || morphine sulphate / Generic mfg.
Clinical, Review, Journal: Do Lipid-based Nanoparticles Hold Promise for Advancing the Clinical Translation of Anticancer Alkaloids? (Pubmed Central) - Nov 17, 2021
Since the commercialization of morphine in 1826, numerous alkaloids have been isolated and exploited effectively for the betterment of mankind, including cancer treatment...The review then discusses several limitations of the studies analyzed, particularly the discrepancies in reporting the pharmacokinetics, biodistribution and toxicity data. Finally, we conclude with examples of clinically successful encapsulated alkaloids that have received regulatory approval and are undergoing clinical evaluation.