morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    A Translational Investigation of Morphine-Induced Neuroimmune Signaling: Implications for Opioid Use Disorder (Exhibit Hall C) -  Nov 28, 2021 - Abstract #ACNP2021ACNP_109;    
    Second, the magnitude of neuroimmune response in the caudate was linearly related to the magnitude of morphine-induced ‘high’ and accounted for 57% of the variance. Given the well-established role of the caudate in mesolimbic reward circuitry, our data suggest the neuroimmune signaling may modulate opioid-induced euphoria.
  • ||||||||||  midazolam hydrochloride / Generic mfg.
    Journal:  Continuous subcutaneous infusion: is community anticipatory prescribing and administration safe? (Pubmed Central) -  Nov 25, 2021   
    The results of this study can be used to stratify the average opioid requirement of pediatric patients undergoing primary bone sarcoma resection. The practice of anticipatory CSCI prescribing and administration can be safe in the community non-specialist setting when supported by clinical guidelines, specialist advice and ongoing multiprofessional education.
  • ||||||||||  remifentanil / Generic mfg., morphine sulphate / Generic mfg., rocuronium / Generic mfg.
    Anaesthetic management in Moyamoya disease: a case report. ([VIRTUAL]) -  Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_1229;    
    In the operating room balanced general anesthesia is performed by induction of intravenous drugs: propofol 1 mg/kg, lidocaine 1 mg/kg, rocuronium 0.6 mg/kg and continuous infusion of remifentanil 0.05 mcg/ kg/min...We control pain in the immediate postoperative period with intravenous morphine prior to delivery...Learning points: The objective in MMD is to maintain the balance between the supply and demand of oxygen at the brain, ensuring an adequate CBF by avoiding hypotension, perform a correct anxiolysis and pain management and maintaining a state of hypervolemia to avoid episodes of ischemia. At the respiratory level, the goal is normocapnia.
  • ||||||||||  morphine sulphate / Generic mfg., sevoflurane / Generic mfg.
    iPACK combined with adductor canal block as a safe adjunct to perioperative pain management in patients with severe hemophilia A undergoing total knee arthroplasty: a case report ([VIRTUAL]) -  Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_1174;    
    In the recovery room he was supplemented with 2,5mg of morphine hourly (total 7mg) for moderate knee pain in the recovery room...Perioperative management of hemophilic patients requires FVIII assays, blood products as well as a multidisciplinary team effort.1 The regional analgesia acts as an adjunct to pain management as it can avoid excessive opioid consumption, leading to keen recovery and shorter hospital stay.2 Learning points: A multidisciplinary team is necessary to manage the perioperative course of hemophiliac patients due to the high risk of hemorrhagic complications. The use of nerve blocks could be an adjunct to better manage perioperative pain, provide early ambulation, leading to better patient outcomes.
  • ||||||||||  ketamine / Generic mfg., dexketoprofen trometamol / Generic mfg.
    The opioid-sparing effect of bilateral superficial cervical plexus block (BSCPB) in thyroid surgery Patients ([VIRTUAL]) -  Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_1116;    
    Ketamine 25 mg IV was used for induction anaesthesia in both groups... Combine Methods GA with BSCPB have some benefits vs mono GA such as intraoperative opioid-sparing effect, better post-op pain control, avoiding post-op opioid using and better PONVcontrol level.
  • ||||||||||  ketamine / Generic mfg.
    Emergent tracheostomy in a critical airway – which anesthesia to use? ([VIRTUAL]) -  Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_1072;    
    Additionally, 20mg ketamine was administrated...Analgesia was achieved with 4mg of morphine and 1g of paracetamol...Our case offers a possible anesthetic approach for patients in which intubation or use of supraglottic devices are extremely difficult and maintaining a spontaneous ventilation is imperative until the definitive airway is established. Use of CPAP helps maintain airway patency during the procedure.Learning points: Sedoanalgesia may be a useful approach in a patient presenting with severe UAO undergoing emergent tracheostomy
  • ||||||||||  morphine sulphate / Generic mfg.
    The importance of systematic verification on drug preparation and administration: the swiss cheese Mode ([VIRTUAL]) -  Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_1071;    
    Background: Intrathecal morphine is used for postoperative analgesia in major abdominal surgeries...Learning points: The systematic verification of every step in the performance of a subarachnoid approach, from drug preparation to the procedure itself, is of utmost importance. Applying systematic strategies of human error mitigation is essential to prevent these errors.
  • ||||||||||  pethidine / Samaritan
    Intrathecal opioids plus abdominal wall nerve blocks for paracaval paraganglioma resection: a case report ([VIRTUAL]) -  Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_1004;    
    Before general anaesthesia (GA), a subarachnoid puncture was performed and 300 μg morphine, 20 μg fentany and 30 μg clonidine were given...He was given 50 mg pethidine IM and 1 gr paracetamol IV at 18h postoperative...When given without local anaesthetics, better haemodynamic stability can be reached. Moreover, nerve blocks of the anterior abdominal wall can further reduce postoperative pain.Learning points: Multimodal analgesia have to be tailored to every case Individually.
  • ||||||||||  morphine sulphate / Generic mfg.
    Management of accidental high-dose epidural morphine administration in a deaf-mute patient ([VIRTUAL]) -  Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_956;    
    Drug concentrations should be standardized to avoid medication errors. Alternative Methods of communication such written communication, gestures or facial expressions and objective assessment of pain or discomfort are key to a successful outcome in deaf-mute Patients.
  • ||||||||||  Bridion (sugammadex) / Merck (MSD)
    Journal:  Postoperative respiratory depression after hysterectomy. (Pubmed Central) -  Nov 25, 2021   
    Respiratory depression was not associated with increased hospital stay, postoperative complications, or mortality. Postoperative respiratory depression risk in women increased with age, lower weight, and higher intraoperative opioids and decreased with sugammadex use; however, it was not associated with postoperative pulmonary complications.
  • ||||||||||  remifentanil / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Postoperative Thoracic Pain Treatment: Serratus Anterior or Erector Spinae Plane Block? (Pubmed Central) -  Nov 25, 2021   
    Postoperative respiratory depression risk in women increased with age, lower weight, and higher intraoperative opioids and decreased with sugammadex use; however, it was not associated with postoperative pulmonary complications.  ESPB was more effective compared with SAPB in postoperative thoracic pain management.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Celiac plexus block for chronic flank pain: a case series. (Pubmed Central) -  Nov 25, 2021   
    Subjective improvement in pain occurred in 11 individuals (79%), and 5 (50%) were able to reduce their daily morphine equivalent dose (MED). Celiac plexus blockade is a viable option for symptomatic relief in urologic patients with non-obstructive chronic flank pain.
  • ||||||||||  SCH-23390 / Boehringer Ingelheim
    Journal:  Dopamine receptors in the anterior cingulate cortex implicate in nicotine enhanced morphine analgesia. (Pubmed Central) -  Nov 25, 2021   
    These characteristics of MG may provide further support for use as a novel pharmacotherapeutic intervention for managing opioid use disorder. The findings suggest that the ACC has an important role in acute thermal pain perception and modulates the analgesia induced by nicotine plus morphine via dopaminergic receptors.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Evaluation of Kratom Opioid Derivatives as Potential Treatment Option for Alcohol Use Disorder. (Pubmed Central) -  Nov 24, 2021   
    Paynantheine did not produce robust antinociception but did block morphine-induced antinociception and hyperlocomotion...7-hydroxyspeciogynine has a maximally tolerated dose of at least 10 mg∙kg (s.c.) at which it did not produce significant CPP neither alter general locomotion nor induce noticeable seizures. Conclusion and Implications: Derivatizing kratom alkaloids with the goal of enhancing δOR potency and reducing off-target effects could provide a pathway to develop novel lead compounds to treat alcohol use disorder with an improved therapeutic window.
  • ||||||||||  Movantik (naloxegol) / AstraZeneca, RedHill, Kyowa Kirin
    Journal:  Acute opioid withdrawal syndrome from naloxone/naloxegol interaction. (Pubmed Central) -  Nov 24, 2021   
    He was switched back to the previous oxycodone dose without naloxone, with naloxegol being maintained. In the light of this case we suggest to avoid the use of naloxone and naloxegol in combination, or at least, to use it with extreme caution and monitorisation of tolerance.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  The Role of Hydrogen Sulfide in the Development of Tolerance and Dependence to Morphine in Mice. (Pubmed Central) -  Nov 24, 2021   
    Taken together, our findings will extend the association between dysbiosis of the gut microbiome and the opioid-induced rewarding or reinforcing behaviors. It has been concluded that hydrogen sulfide synthase inhibitors may have utility in preventing morphine tolerance.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Effect of cryotherapy on pain and analgesic consumption after wrist or thumb surgery. (Pubmed Central) -  Nov 24, 2021   
    During the hospital stay, morphine consumption was significantly lower in the cryotherapy group (p = 0.04)...The VAS score was not significantly different between the two groups. In our study, we demonstrated the benefits of cryotherapy on consumption of analgesics and NSAIDs after bone surgery of the wrist or the base of the thumb.
  • ||||||||||  morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Review, Journal:  Morphine or hydromorphone: which should be preferred? A systematic review. (Pubmed Central) -  Nov 24, 2021   
    Current literature does not permit a rational choice between Mo and Hm. A ratio of 5:1 seems adequate for intravenous administration and leads to a similar rate of adverse effects.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Assessing the impact of a restrictive opioid prescribing law in West Virginia. (Pubmed Central) -  Nov 24, 2021   
    There was, however, no association of the legislation on first-time opioid prescriptions or days' supply of opioid medication, and all variables were trending downward prior to implementation of SB 273. The control demonstrated no relationship to the law.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Persistent Opioid Use After Ophthalmic Surgery in Opioid-Naive Patients and Associated Risk Factors. (Pubmed Central) -  Nov 24, 2021   
    This suggests that this exposure to opioids is an independent risk factor for persistent use in patients undergoing incisional ophthalmic surgery. Surgeons should be aware of those risks to identify at-risk patients in the current national opioid crisis and minimize prescribing opioids when possible.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  GPER in the rostral ventromedial medulla is essential for mobilizing descending inhibition of itch. (Pubmed Central) -  Nov 24, 2021   
    Our data have provided novel insights into the cellular organization and molecular mechanisms of descending regulation of itch in normal and pathological conditions: GPER neurons (largely GABAergic) in the RVM are anti-pruritic neurons under tonic opioidergic inhibition; activation of GPER promotes phosphorylation of MOR and dis-inhibition of the anti-pruritic GPER neurons from inhibitory opioidergic inputs; failure to mobilize GPER neurons may result in exacerbation of itch. Our data also illuminate on some of the outstanding questions in the field, such as the mechanisms underlying sex bias in itch, pain and opioid analgesia and the paradoxical effects of morphine on pain and itch.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Release of endogenous dynorphin opioids in the prefrontal cortex disrupts cognition. (Pubmed Central) -  Nov 24, 2021   
    Naloxone-precipitated withdrawal in morphine-dependent mice or optical stimulation of pdyn neurons using Channelrhodopsin-2 disrupted delayed alternation performance, and the dynorphin-induced effect was blocked by local norBNI. Our findings describe a mechanism for control of cortical function during opioid dependence and suggest that KOR antagonism could promote abstinence.