morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Clinical, Journal:  Opioid prescribing practices in chronic kidney disease: a population-based cohort study. (Pubmed Central) -  Dec 13, 2021   
    Opioid use was common in patients with CKD. While opioid prescriptions and potentially inappropriate prescribing have declined in recent years, interventions to improve pain management without the use of opioids and education on safer prescribing practices are needed.
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment open, Surgery:  SEQ Block for Perioperative Analgesia in Acetabular Surgery (clinicaltrials.gov) -  Dec 10, 2021   
    P3,  N=100, Recruiting, 
    Dexmedetomidine may be considered as a safe adjuvant medication that may have opiate-sparing effects for this patient population. Not yet recruiting --> Recruiting
  • ||||||||||  Korsuva IV (difelikefalin IV) / Cara Therap, Maruishi Pharma, Vifor, HSK21542 / Haisco
    Preclinical, Journal:  Antinociceptive and Antipruritic Effects of HSK21542, a Peripherally-Restricted Kappa Opioid Receptor Agonist, in Animal Models of Pain and Itch. (Pubmed Central) -  Dec 7, 2021   
    Although lacking morphine-like central nervous system (CNS) effects, KOR agonists do elicit sedation, dysphoria and diuresis which seriously impede their development...However, the only approved peripherally-restricted KOR agonist CR845 remains some frequent CNS adverse events...HSK21542 didn't affect the respiratory rate of mice. Therefore, HSK21542 might be a safe and effective KOR agonist and promising candidate for treating pain and pruritus.
  • ||||||||||  Olinvyk (oliceridine) / Trevena, Jiangsu NHWA Pharma
    Review, Journal:  A Dive Into Oliceridine and Its Novel Mechanism of Action. (Pubmed Central) -  Dec 7, 2021   
    These trials demonstrated a comparable efficacy to morphine with a decreased risk for serious adverse events. However, further studies need to be conducted to evaluate the true safety impact of oliceridine compared to conventional opioids.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Qualitative Needs Assessment for the Development of Chronic Pain Group Medical Visits. (Pubmed Central) -  Dec 7, 2021   
    Analysis generated two themes: (1) Participants expressed specific interest in GMVs with few barriers identified, and (2) Pain has a negative impact on mental health and most aspects daily life, creating a foundation for discussion in GMVs. Findings support significant patient interest in group medical visits for chronic pain, but careful planning is necessary to address patient needs, expectations, and barriers in order to ensure GMV sustainability.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Paravertebral anesthetic nerve block for pain control after peroral endoscopic myotomy. (Pubmed Central) -  Dec 7, 2021   
    In unadjusted analyses, there was no significant difference between patients who did and did not undergo PNB in peak pain score (7.8 vs. 8.7, p=0.14), cumulative pain score in the first 12 hours (area under curve 66.5 vs. 75.8, p=0.22), median total opioid use (38.9 mg morphine equivalent dosing vs. 42, p=1.00), and median length of hospitalization (26.5 hours vs. 24, p=0.35)...In this exploratory, observational study, paravertebral nerve block immediately before POEM did not result in a statistically significant reduction in pain-related outcomes or hospitalization. Additional observational studies may elucidate whether higher anesthetic doses or longer acting formulations would be of value.
  • ||||||||||  dexmedetomidine / Generic mfg.
    Enrollment change, Surgery, Bariatric surgery:  Dexmedetomidine to Treat Bariatric Surgery-associated Pain (clinicaltrials.gov) -  Dec 7, 2021   
    P3,  N=26, Completed, 
    Trial completion date: Dec 2022 --> Mar 2023 | Initiation date: Oct 2021 --> Jan 2022 | Trial primary completion date: Oct 2022 --> Jan 2023 N=10 --> 26
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Peripheral nerve blocks in advanced cancer pain: retrospective case series. (Pubmed Central) -  Dec 5, 2021   
    These results suggest the major impact of opioid stewardship programs for spine surgery may be on changing prescriber behavior. Peripheral nerve blocks seem safe and may provide considerable analgesia and decrease the need for opioids in patients with advanced cancer.
  • ||||||||||  morphine sulphate / Generic mfg.
    IT morphine (Twitter) -  Dec 5, 2021   
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Regional Anesthesia Use in Pediatric Burn Surgery: A Descriptive Retrospective Series. (Pubmed Central) -  Dec 3, 2021   
    In this cohort, 93% of patients scored a 0/10 on the Face, Legs, Activity, Cry and Consolability (FLACC) scale for pain by post-anesthesia care unit (PACU) discharge, with an average PACU stay of 70 minutes. Thirty-three percent of patients received no opioids, with the average opioid dose being 0.06mg/kg morphine equivalents. This case series serves to make clinicians aware of the feasibility of use and benefits of regional anesthesia in pediatric burn patients requiring operative repair.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Review, Journal:  The Effect of Cryotherapy Application on Post-operative Pain: A Systematic Review and Meta-analysis. (Pubmed Central) -  Dec 3, 2021   
    This case series serves to make clinicians aware of the feasibility of use and benefits of regional anesthesia in pediatric burn patients requiring operative repair. Cryotherapy is a pragmatic, noncostly intervention that reduces postoperative pain and opioid consumption with no effect on SSI rate or hospital LOS.
  • ||||||||||  Trial completion date, Trial primary completion date:  Post-Op Pain Control for Prophylactic Intramedullary Nailing. (clinicaltrials.gov) -  Dec 3, 2021   
    P3,  N=60, Recruiting, 
    Cryotherapy is a pragmatic, noncostly intervention that reduces postoperative pain and opioid consumption with no effect on SSI rate or hospital LOS. Trial completion date: Oct 2023 --> Oct 2024 | Trial primary completion date: Aug 2023 --> Aug 2024
  • ||||||||||  ketamine / Generic mfg.
    Journal:  Adsorption of Therapeutic and Recreational Drugs During Prolonged Storage of Plasma Samples in Gel Separator Tubes. (Pubmed Central) -  Dec 2, 2021   
    Central nervous system stimulants (e.g., methamphetamine and amphetamine) as well as naturally-occurring and semi-synthetic opioids (e.g., morphine, hydromorphone and oxycodone) were among the drugs least susceptible to adsorption and displayed only minimal relative decreases in concentration (if any) over the 3-month sample storage period. The potential for decreases in drug concentration due to adsorption of drugs to the gel material should be considered for toxicological interpretation based on the analysis of a sample collected in a gel separator tube.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Enhanced recovery after gynecological surgery: comparison between intrathecal and intravenous morphine multimodal analgesia. (Pubmed Central) -  Dec 2, 2021   
    The potential for decreases in drug concentration due to adsorption of drugs to the gel material should be considered for toxicological interpretation based on the analysis of a sample collected in a gel separator tube. Our present study showed that intrathecal morphine allows to achieve important management goals with minimal side effects and complications, in particular in case of laparoscopic hysterectomy.
  • ||||||||||  methadone / Generic mfg.
    Enrollment closed, Trial completion date, Trial primary completion date:  Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients (clinicaltrials.gov) -  Dec 2, 2021   
    P3,  N=44, Active, not recruiting, 
    Our present study showed that intrathecal morphine allows to achieve important management goals with minimal side effects and complications, in particular in case of laparoscopic hysterectomy. Recruiting --> Active, not recruiting | Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Dec 2021 --> Dec 2022
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Persistent Opioid Use After Open Aortic Surgery: Risk Factors, Costs and Consequences. (Pubmed Central) -  Dec 2, 2021   
    POU is a challenge after open aortic operations and can have longer-term impacts on health care payments and emergency department visits in the 6 months after surgery. Strategies to reduce outpatient opioid use after aortic surgery should be encouraged when feasible.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Neural basis of opioid-induced respiratory depression and its rescue. (Pubmed Central) -  Dec 2, 2021   
    PBL neuronal activity is tightly correlated with respiratory rate, and this correlation is abolished following morphine injection...We identified several excitatory G protein-coupled receptors expressed by PBL neurons and show that agonists for these receptors restore breathing rates in mice experiencing OIRD. Thus, PBL neurons are critical for OIRD pathogenesis, providing a promising therapeutic target for treating OIRD in patients.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Modulatory Potential of Cannabidiol on the Opioid-Induced Inflammatory Response. (Pubmed Central) -  Dec 2, 2021   
    The opioid, morphine, initiates a Toll-like receptor 4 (TLR4) signaling cascade that drives the activation of NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome proteins, resulting in cytokine production and effectively creating a positive feedback loop for continuous TLR4 activation...One potential source of insight into this mechanism is in how CBD regulates immune regulators such as cytokines and lipid signaling systems, including endocannabinoids and related immune-responsive lipids. In this review, we outline the immune response to chronic opioid use as well as CBD in the context of a lipopolysaccharide-induced immune response and speculate on the mechanism of CBD as a modulator of chronic opioid-induced immune system dysregulation.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Clinical, Journal:  Pain management in patients undergoing radiation therapy for head and neck cancer - a descriptive study. (Pubmed Central) -  Dec 2, 2021   
    A proactive stance, monitoring these patients closely and regularly, is probably crucial in order to achieve good treatment results. Further studies are needed to develop better pain treatment strategies for those patients who develop severe oral mucositis-related pain despite intensive opioid treatment.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  US national trends in prescription opioid use after burn injury, 2007 to 2017. (Pubmed Central) -  Dec 1, 2021   
    Efforts are needed to reduce high-dose use among Veterans with concurrent GI symptoms and diagnoses. While opioid prescribing after burn has declined in the past decade, significant variation remains among regions and age groups, suggesting a need to develop uniform guidelines to improve the quality of opioid prescribing and pain management protocols in burn patients.