 |
7 Diseases |  |
379 Trials |
|
379 Trials |  |
12426 News |  |
| «12...130131132133134135136137138139140...217218» |
- || morphine sulphate / Generic mfg.
Clinical, Journal: Opioid dosing among patients with 3 or more years of continuous prescription opioid use before and after the CDC opioid prescribing guideline. (Pubmed Central) - Dec 16, 2021
Among patients on multiyear opioid therapy, the CDC guideline was associated with a modest change in dosing, except for patients on very high doses. The guideline was not associated with decreasing MME among lower-dose, long-term users.
- | glibenclamide / Generic mfg., nifedipine immediate release / Generic mfg.
Journal: Antinociceptive Effect of The Hydroethanolic Leaf Extract of Calotropis procera (Ait) R. Br. (Apocynaceae): possible involvement of glutamatergic, cytokines, opioidergic and adenosinergic pathways. (Pubmed Central) - Dec 16, 2021
The guideline was not associated with decreasing MME among lower-dose, long-term users. Overall, the hydroethanolic leaf extract of Calotropis procera possesses analgesic properties that is mediated possibly through the glutaminergic, opioidergic, and adenosinergic pathways.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Evaluation of an Enhanced Recovery After Surgery Protocol Including Parasternal Intercostal Nerve Block in Cardiac Surgery Requiring Sternotomy. (Pubmed Central) - Dec 16, 2021
Overall, the hydroethanolic leaf extract of Calotropis procera possesses analgesic properties that is mediated possibly through the glutaminergic, opioidergic, and adenosinergic pathways. The ERAS multimodal pain management protocol utilizing intraoperative parasternal blocks appears to reduce pain and decrease opioid use after CABG.
- | morphine sulphate / Generic mfg.
Journal: Computed tomography-guided cyanoacrylate injection for localization of multiple ipsilateral lung nodules. (Pubmed Central) - Dec 16, 2021
• CT-guided cyanoacrylate localization for multiple ipsilateral SPNs allowed a flexible surgical schedule. • Position change was the only independent risk factor for pneumothorax during the multiple ipsilateral SPN localization.
- | morphine sulphate / Generic mfg.
Journal: Structure-activity relationship study of dihydroartemisinin C-10 hemiacetal derivatives as Toll-like receptor 4 antagonists. (Pubmed Central) - Dec 16, 2021
Further, 2k was active in vivo; it significantly increased and prolonged morphine analgesia. Collectively, this study provides a structural guidance to reposition DHA derivatives as TLR4 antagonists.
- | morphine sulphate / Generic mfg.
Journal: Combined local treatments for vertebral metastases with limited epidural extension. (Pubmed Central) - Dec 16, 2021
CLT was safe and effective for pain palliation and long-term prevention of skeletal-related events for treatment of patients with VMLEE. The effectiveness of this combined treatment on tumor control and epidural involvement on the long term needs further investigation.
- | fentanyl citrate / Generic mfg.
Preclinical, Journal: Fentanyl-related substances elicit antinociception and hyperlocomotion in mice via opioid receptors. (Pubmed Central) - Dec 16, 2021
Naltrexone (1 mg/kg) increased ED values several fold with decreasing magnitudes of para-methylfentanyl (63.1×) > para-methoxyfentanyl (22.5×) > beta'-phenylfentanyl (21.0×) > 3-furanylfentanyl (20.6×) > beta-methylfentanyl (19.2×) > phenylfentanyl (5.23×) > fentanyl (3.95×) > fentanyl carbamate (2.21×) > morphine (1.48×). These findings expand upon in vivo results from previous studies and establish that the effects of these fentanyl related-related substances are at least in part mediated by the MOR.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Comparison of Oral Loading Dose to Intravenous Acetaminophen in Children for Analgesia After Tonsillectomy and Adenoidectomy: A Randomized Clinical Trial. (Pubmed Central) - Dec 16, 2021
Opioid-sparing effects did not differ following an oral or standard IV acetaminophen loading dose with no identified acetaminophen toxicity in pediatric patients undergoing tonsillectomy and adenoidectomy who received standardized multimodal postoperative analgesia. An oral loading dose may provide more consistent serum acetaminophen levels at lower cost compared to a standard IV dose.
- | morphine sulphate / Generic mfg.
Journal: Involvement of the ventral tegmental area but not periaqueductal gray matter in the paradoxical rewarding and aversive effects of morphine. (Pubmed Central) - Dec 16, 2021
Thus, the VTA, but not the PAG, appears to contribute to the paradoxical effect reward in CPP and aversion in CTA induced by morphine. The VTA's involvement in morphine-induced CTA aversion and CPP reward supports the paradoxical effect hypothesis of abused drugs.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Does Engaging Patients With Relevant Education About Long-Term Opioid Use Before Spine Surgery Affect Long-term Opioid Use? A Randomized Controlled Trial. (Pubmed Central) - Dec 16, 2021
Prior opioid use was a strong predictor of future opioid use in this cohort. Strategies to improve education engagement, understanding, and decision- making continue to be of high importance for mitigating risk of long-term opioid use after spine surgery.Level of Evidence: 1.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Analgesic Drug Therapy in Kidney Patients (Pubmed Central) - Dec 16, 2021
When treating kidney patients with morphine, the accumulation kinetics of the M6 glucuronide must be observed. Otherwise, the risk increases for respiratory depression.
- || carotuximab ophthalmic (DE-122) / Tracon Pharma, Santen
Clinical, Journal: Reduction of Opioid Overprescribing and Use Following Standardized Educational Intervention: A Survey of Patient Experiences Following Anorectal Procedures. (Pubmed Central) - Dec 16, 2021
Educational interventions emphasizing evidence-based recommended opioid prescription quantities and regimented multimodal pain regimens are effective in decreasing excessive opioid prescribing and use without compromising satisfactory pain control in patients undergoing ambulatory anorectal procedures. See Video Abstract at http://links.lww.com/DCR/B529.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., midazolam hydrochloride / Generic mfg.
Preclinical, Journal: Sequestration of Midazolam, Fentanyl, and Morphine by an Ex Vivo Cardiopulmonary Bypass Circuit. (Pubmed Central) - Dec 16, 2021
Less midazolam was present after 180 minutes when given with morphine compared to midazolam given alone in the absence of an oxygenator (1264.9 +/- 425.6 vs. 2124 +/- 254 ng/ml, P = 0.037). We successfully characterized the adsorption of various combinations of midazolam, fentanyl, and morphine to our CPB circuit, showing that fentanyl and midazolam behave differently based on other medications present.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Preconception paternal morphine exposure leads to an impulsive phenotype in male rat progeny. (Pubmed Central) - Dec 16, 2021
Paternal opiate exposure during adolescence was found to primarily impair inhibitory control in male progeny. These results further our understanding of the long-term costs and risk of opioid abuse, extending across generations.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Pain-induced impulsivity is sexually dimorphic and mu-opioid receptor sensitive in rats. (Pubmed Central) - Dec 16, 2021
These findings demonstrate unique sex differences in CFA-induced impulsivity, response to morphine, and the impact of mu-opioid receptors. A better understanding of cognitive deficits and their mechanisms can provide insight into the development of substance abuse and psychiatric comorbidities that occur in people with chronic pain.
- | ketamine / Generic mfg.
Journal: A chemiluminescence sensor array for discrimination seven toxicants. (Pubmed Central) - Dec 16, 2021
The CL response pattern or "fingerprints" were obtained for a given compound on the sensor array and then discriminated through principal component analysis (PCA). Also, the established sensor array has been applied to real-life samples and the results showed that it possesses excellent discrimination.
- ||| morphine sulphate / Generic mfg.
Clinical, Journal, Adverse events: A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects. (Pubmed Central) - Dec 16, 2021
6 (SC13) showed MOR-dependent analgesia with potency similar to morphine without respiratory depression, hyperlocomotion, constipation, or place conditioning in mice. These results suggest the possibility of activating MOR minimally (G-protein E ≈ 10%) in cell lines while yet attaining maximal antinociception in vivo with reduced opioid liabilities.
- | fentanyl citrate / Generic mfg.
Journal: Buprenorphine/naloxone associated with a reduced odds of fentanyl exposure among a cohort of people who use drugs in Vancouver, Canada. (Pubmed Central) - Dec 16, 2021
In this cohort of people who use opioids in Vancouver, only use of BUP/NX was associated with lower odds of fentanyl-positive UDT. Our findings highlight high rates of ongoing fentanyl use despite the use of OAT and support the expansion of BUP/NX for the treatment of people who use fentanyl.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Effect of ultrasound-guided selective sensory nerve blockade of the knee on pain management compared with periarticular injection for patients undergoing total knee arthroplasty: A prospective randomized controlled trial. (Pubmed Central) - Dec 16, 2021
The SSNB did not provide superior postoperative analgesia, or improvement in immediate functional performance. However, it may result in lower opioid consumption postoperatively when compared with the intraoperative PAI.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Tiered Guidelines in a Pediatric Orthopaedic Practice Reduce Opioids Prescribed at Discharge. (Pubmed Central) - Dec 16, 2021
Furthermore, we noted excellent adherence and no overall increase in the rates of narcotic refills. Such guidelines may improve pediatric orthopaedists' ability to responsibly treat postoperative pain while limiting the distribution of unneeded opioids.
- || methadone / Generic mfg.
Review, Journal: Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies. (Pubmed Central) - Dec 16, 2021
Further, persons with OUD on OAT may remain vulnerable to opioid-induced abuse potential and respiratory depression. Together, these finding have clinical, methodological, and mechanistic implications for the treatment of acute pain in the context of OAT.
- | fentanyl citrate / Generic mfg.
Journal: The use of diverted pharmaceutical opioids is associated with reduced risk of fentanyl exposure among people using unregulated drugs in Vancouver, Canada. (Pubmed Central) - Dec 16, 2021
This reduced likelihood was primarily observed among PWUD with morphine positive UDT, which could partially be explained by longer duration of action and lower street cost of slow-release oral morphine relative to other POs and fentanyl. Findings suggest that access to a regulated supply of pharmaceutical-grade opioids may serve to reduce fentanyl-related harms.
- || fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
PK/PD data, Preclinical, Journal: Pharmacokinetics and pharmacodynamics of cyclopropylfentanyl in male rats. (Pubmed Central) - Dec 16, 2021
Our study shows that cyclopropylfentanyl produces typical opioid-like effects in male rats. Cyclopropylfentanyl displays much greater analgesic potency when compared to morphine, suggesting that cyclopropylfentanyl poses increased overdose risk for unsuspecting users.
- || morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
Clinical, Journal: Preoperative Paravertebral Block and Chronic Pain after Breast Cancer Surgery: A Double-blind Randomized Trial. (Pubmed Central) - Dec 16, 2021
Paravertebral block did not reduce the incidence of chronic pain after breast surgery. Paravertebral block did result in less immediate postoperative pain, but there were no other significant differences in postoperative outcomes.
- | isoflurane / Generic mfg., dexmedetomidine / Generic mfg.
Journal: Effect of administering dexmedetomidine with or without atropine on cardiac troponin I level in isoflurane-anesthetized dogs. (Pubmed Central) - Dec 16, 2021
The cTnI level returned to normal within 72 hr after premedication in all groups. The administration of atropine in combination with 10 µg/kg dexmedetomidine increased the cTnI level, indicating subclinical myocardial damage.
- ||| morphine sulphate / Generic mfg., aspirin / Generic mfg.
Retrospective data, Journal, Adverse events, Checkpoint inhibition: Baseline co-medications may alter the anti-tumoural effect of checkpoint inhibitors as well as the risk of immune-related adverse events. (Pubmed Central) - Dec 16, 2021
The administration of atropine in combination with 10 µg/kg dexmedetomidine increased the cTnI level, indicating subclinical myocardial damage. Co-medications must be carefully assessed at the time of ICI initiation and clinicians aware of their possible deleterious effect, notably for PPIs, glucocorticoids, antibiotics and psychotropic drugs.
- || pregabalin / Generic mfg., celecoxib oral / Generic mfg.
Clinical, Retrospective data, Journal: Factors Impacting Postoperative Opioid Use Among Patients Undergoing Implantation of Inflatable Penile Prosthesis. (Pubmed Central) - Dec 16, 2021
Factors Impacting Postoperative Opioid Use Among Patients Undergoing Implantation of Inflatable Penile Prosthesis. J Sex Med 2021;XX:XXX-XXX.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Long-term opioid therapy tapering: Trends from 2014 to 2018 in a Midwestern State. (Pubmed Central) - Dec 16, 2021
J Sex Med 2021;XX:XXX-XXX. The Guideline may be a useful tool in altering opioid prescribing practices, particularly for patients on shorter durations of LTOT.
- || dexmedetomidine / Generic mfg.
Clinical, Journal: Effects of Intravenous Dexmedetomidine Versus Lidocaine on Postoperative Pain, Analgesic Consumption and Functional Recovery After Abdominal Gynecological Surgery: A Randomized Placebo-controlled Double Blind Study. (Pubmed Central) - Dec 16, 2021
Lidocaine significantly reduced postoperative opioid consumption, while dexmedetomidine prevented early postoperative nausea. However, hypotension and the need for vasopressors was common with both agents, especially with dexmedetomidine.
- || fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Retrospective data, Review, Journal: Opioids for the Prevention of Post-dural Puncture Headache in Obstetrics: A Systematic Review and Meta-analysis of Efficacy and Safety. (Pubmed Central) - Dec 16, 2021
However, hypotension and the need for vasopressors was common with both agents, especially with dexmedetomidine. Exposure to opioids for any reason after the diagnosis of unintentional dural puncture is not associated with a reduced risk of PDPH and does not decrease the need for therapeutic EBP.
- | morphine sulphate / Generic mfg.
Journal: Comparison of Thermal and Mechanical Noxious Stimuli for Testing Analgesics in White's Tree Frogs (Litoria caerulea) and Northern Leopard Frogs (Lithobates pipiens). (Pubmed Central) - Dec 16, 2021
These resultsindicate that morphine is not antinociceptive in WTF, supporting previously reported results, and demonstrate the importanceof using an appropriate experimental antinociceptive test in amphibians. Our data suggest that nociception in amphibianspecies may be best evaluated by using mechanical nociceptive models, although species differences must also be considered.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Preoperative Opioid Utilization Patterns and Postoperative Opioid Utilization: A Retrospective Cohort Study. (Pubmed Central) - Dec 16, 2021
Our data suggest that nociception in amphibianspecies may be best evaluated by using mechanical nociceptive models, although species differences must also be considered. Changes in preoperative opioid utilization were not associated with clinically significant differences for several postoperative outcomes including postoperative opioid utilization.
- || ketorolac / Generic mfg., ibuprofen / Generic mfg., celecoxib oral / Generic mfg.
Clinical, Review, Journal: Perioperative systemic nonsteroidal anti-inflammatory drugs (NSAIDs) in women undergoing breast surgery. (Pubmed Central) - Dec 16, 2021
However, there was very little evidence to indicate whether NSAIDs affect the rate of breast hematoma or bleeding from any location within 90 days of breast surgery, the need for blood transfusion and incidence of other side effects compared to placebo or other analgesics. High-quality large-scale RCTs are required before definitive conclusions can be made.
- || morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
Clinical, Journal: Analgesic Efficacy of Tramadol and Morphine in White's Tree Frogs (Litoria caerulea). (Pubmed Central) - Dec 16, 2021
No significant difference in withdrawal latency was detectedbetween the control and either tramadol or morphine. These negative results were surprising, suggesting that the thermalnociceptive model may not be biologically relevant in amphibian species.
- || morphine sulphate / Generic mfg.
Clinical, Clinical protocol, Journal, Head-to-Head: Single-centre, double-blind, randomised, parallel-group, superiority study to evaluate the effectiveness of general anaesthesia and ultrasound-guided transversus thoracis muscle plane block combination in adult cardiac surgery for reducing the surgical stress response: clinical trial protocol. (Pubmed Central) - Dec 16, 2021
P=N/A
The secondary outcomes are the difference between the two groups in the means of total 24-hour postoperative morphine consumption and time of first postoperative patient-controlled analgesia (PCA) dose...The result will be released to the medical community through presentation and publication in peer-reviewed journals. NCT04544254.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Factors Associated with Pain Treatment Satisfaction Among Patients with Chronic Non-Cancer Pain and Substance Use. (Pubmed Central) - Dec 16, 2021
The relationship between PTSD and tobacco use with lower satisfaction should be explored to augment pain outcomes. Higher satisfaction among individuals with HIV and prescription cannabis use presents potential research areas to guide CNCP management and reduce reliance on opioid therapies.
- | morphine sulphate / Generic mfg.
Journal: Palliative Care - more than just Morphines (Pubmed Central) - Dec 16, 2021
Higher satisfaction among individuals with HIV and prescription cannabis use presents potential research areas to guide CNCP management and reduce reliance on opioid therapies. No abstract available
- || morphine sulphate / Generic mfg.
Clinical, Clinical protocol, Journal: Optimal peripheral nerve block after minimally invasive colon surgery - a study protocol for a randomised trial. (Pubmed Central) - Dec 16, 2021
P4
The primary outcome is morphine dose equivalents administered during the first 24 hours after surgery...Funding A and JC Tvergaards Fond, Helen Rudes Fond, Fru Olga Bryde Nielsens Fond, Aage og Johanne Louis-Hansen Fond, Medicine and Treatment Research Fund of the Danish Regions and a Research Grant from Copenhagen University Hospital - North Zealand Hospital. Trial registration ClinicalTrials.gov: NCT04311099.
- || morphine sulphate / Generic mfg.
Clinical, Retrospective data, Journal: Preoperative and Postoperative Opioid Prescription Rates in the Total Hip Replacement Surgical Patient. (Pubmed Central) - Dec 16, 2021
The purpose of this study was to (1) compare presurgical and postsurgical opioid rates, (2) compare presurgical and postsurgical morphine milligram equivalents (MME), and (3) determine whether having a presurgical opioid prescription predicts the receipt of postsurgical opioid prescriptions among patients undergoing THR surgery...The median average MME/day/person was 26.5 (range = 0.3-180.0) for patients with an opioid prescribed during the presurgery period and 40.4 (range = 1.5-270.0) during the postsurgery period. Opioid use, regardless of strength, in the presurgical period as well as having one or more comorbidities predicted opioid use in the postsurgical period.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Factors associated with postoperative nausea or vomiting in parturients undergoing caesarean delivery under spinal anaesthesia with intrathecal morphine: A prospective cohort study. (Pubmed Central) - Dec 16, 2021
Opioid use, regardless of strength, in the presurgical period as well as having one or more comorbidities predicted opioid use in the postsurgical period. No abstract available
- naloxone injection / Generic mfg., morphine sulphate / Generic mfg.
The reduction of opioid withdrawal symptoms and modulation of behavioral response in mice following treatment with Teneurin C terminal associated peptide () - Dec 15, 2021 - Abstract #CNSSUMMIT2021CNS_SUMMIT_98;
TCAP was administered subcutaneously prior to study initiation or just before the naloxone injection... TCAP demonstrated prophylactic potential in a mice model, suggesting its potential utility in addiction responses in humans.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Oral morphine versus transmucosal diamorphine for breakthrough pain in children: methods and outcomes: UK (DIPPER study) consensus. (Pubmed Central) - Dec 15, 2021
TCAP demonstrated prophylactic potential in a mice model, suggesting its potential utility in addiction responses in humans. The nominal group technique allowed consensus to be reached for a small-scale, prospective, cohort study and provided information to inform the design of a randomised controlled trial.
- | Enbrel (etanercept) / Pfizer, Amgen
Journal: Inhibition of Different Pain Pathways Attenuates Oxidative Stress in Glial Cells: A Mechanistic View on Neuroprotective Effects of Different Types of Analgesics. (Pubmed Central) - Dec 15, 2021
Furthermore, the oxidative damage markers were significantly decreased by morphine and etanercept in all investigated days. Since arachidonic acid metabolites and TNF-α are produced during neuropathic pain and inflammation, it can be concluded that the inhibition of the substances production or inhibition of the ligands binding with their receptors would help to decrease the destructive effects of neuropathic pain in the glial cells of rat brain.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: PMSF Attenuates Morphine Antinociceptive Tolerance and Dependence in Mice: Its Association with the Oxidative Stress Suppression. (Pubmed Central) - Dec 15, 2021
In conclusion, it seems that PMSF can suppress morphine tolerance and dependence. However, more studies are needed to clarify its mechanism.
- || Instanyl (fentanyl) / Takeda
Clinical, Review, Journal: The effectiveness and safety of paediatric prehospital pain management: a systematic review. (Pubmed Central) - Dec 14, 2021
Intranasal fentanyl and inhalational methoxyflurane seem to be the preferred drugs for children in pre-hospital settings due to their ease of administration, similar effect and safety profile when compared to other analgesic drugs. However, the level of evidence (LOE) in the included studies was only three or four, and further studies are therefore necessary.
- || morphine sulphate / Generic mfg.
Intrathecal morphine (Twitter) - Dec 14, 2021
- || morphine sulphate / Generic mfg.
Clinical, Journal: Efficacy of Perioperative Continuous Intravenous Lidocaine Infusion for 72 Hours on Postoperative Pain and Recovery in Patients Undergoing Hepatectomy: Study Protocol for a Prospective Randomized Controlled Trial. (Pubmed Central) - Dec 13, 2021
This is the first prospective trial to shed light on the efficacy of intraoperative period and 72 postoperative hours intravenous lidocaine on postoperative pain and recovery after hepatectomy. The findings will provide a new strategy of perioperative pain management for hepatectomy.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Association of Preoperative Opioid Use With Complication Rates and Resource Use in Patients Undergoing Hip Arthroscopy for Femoroacetabular Impingement. (Pubmed Central) - Dec 13, 2021
Opioid prescriptions filled in the 6 months preceding surgery were queried, and the average daily oral morphine equivalents (OMEs) in this period were computed for each patient...Perioperative adjusted costs were increased for all preoperative opioid users and were highest for the >5 OMEs per day cohort ($6255; 95% CI, $5143-$7368). A large number of patients with FAI are prescribed opioids before undergoing hip arthroscopy, and use of these pain medications is associated with increased health care utilization, increased costs, prolonged opioid use, and early revision surgery.
- | morphine sulphate / Generic mfg.
Journal: Training on adequate use of opioid analgesics in West and Central Africa: a neglected step on the way to access to essential medicines? (Pubmed Central) - Dec 13, 2021
Hence, it is urgent to fill the existing gaps in training and educational activities to improve access to essential opioid analgesics in West and Central Africa, involving different stakeholders at the national and regional level. Furthermore, such experiences should be published and made publicly available to allow for mutual learning and further upscale.
- | morphine sulphate / Generic mfg.
Journal: Implementation science for the adductor canal block: A new and adaptable methodology process. (Pubmed Central) - Dec 13, 2021
Physician education, technical support, and performance monitoring were deemed key facilitators of our program's success. Expanded patient populations and additional orthopedic procedures are recommended for future study.