- |||||||||| morphine sulphate / Generic mfg.
Morphine attenuates pain-induced hemorrhage following traumatic brain injury (TBI) (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_2461;
Pretreatment with morphine attenuated this effect. Ongoing work is examining the circumstances under which pain input fuels hemorrhage after TBI, how it affects behavioral function, and the neurobiological processes involved.; Grant Support: Mary Tucker Currie Professorship to JWG
- |||||||||| morphine sulphate / Generic mfg.
Translation regulation in development of hyperalgesia (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_1567;
In our experiments, we observed increase in BDNF level in brain stem samples of WT but not in KO mice treated with morphine. Lower level or delayed increase in morphine-induced BDNF expression in brain may explain lack of hyperalgesia after chronic morphine administration in KO mice.
- |||||||||| morphine sulphate / Generic mfg.
Behavioral sensitivity to acute and chronic opioid exposure in neuroligin-3 knockout mice (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_1435;
To characterize the effects of NL3 deletion on mesolimbic circuitry, we began by examining the psychomotor activating effects of morphine in constitutive NL3 KO animals...We are also examining form and function of synaptic input onto VTA dopamine neurons. Understanding the effects of NL3 depletion on synaptic architecture may provide insight into mechanisms of psychomotor sensitization as well as pathologic alterations that influence human vulnerability to substance use disorders.; Grant Support: NIH Grant F30 DA052109
- |||||||||| morphine sulphate / Generic mfg.
Cue-induced recall for cocaine or morphine self-administration increases ryanodine 2 (RyR2) phosphorylation in the prefrontal cortex (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_1410;
Taken together, these data indicate that the neuronal activation in the PFC during drug-seeking is not randomly distributed and is associated with greater RyR2 P expression for drug-seeking behaviors, rather than natural rewards. Consequently, overactivation of RyR2 P at serine 2808 may contribute to the ensemble activity of PFC neurons during relapse to drug-seeking.; Grant Support: NIH-NIDA RO1DA046476; Kempner Foundation Postdoctoral Fellowship
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Characterization and opioid sensitivity of nucleus accumbens interneurons expressing neuropeptide y (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_1374;
All electrophysiological experiments were done in both male and female mice of 6-12 weeks in age. These data indicate that while LTSIs only comprise about 1% of neurons in the NAc they have opioid sensitive synaptic transmission that can alter the overall function of NAc circuitry.; Grant Support: NIH Grant 1R01DA048946-01
- |||||||||| morphine sulphate / Generic mfg., naltrexone / Generic mfg.
Modulation of opioidergic function alters electroshock seizure responses in mice (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_1183;
Further, the greater proconvulsant effect of high dose naltrexone in D2 compared to B6 mice suggests that endogenous opioids may be involved in the robust difference in seizure susceptibility between these two classic inbred mouse strains, or that non-specific or off-target drug action is involved. We conclude that modulation of opioidergic function represents a viable means of ameliorating seizures and treating epilepsy.; Grant Support: NIH NS50554; CMSRU/Rowan
- |||||||||| morphine sulphate / Generic mfg.
Impact of neonatal opioid exposure and withdrawal on the adult innate immune response in female mice (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_1002;
We found that elevation of C1q is not maintained in adulthood, following chronic morphine exposure (PND 90-595), but we see a significant downregulation of expression in cortex following an exposure paradigm of escalating doses of morphine (20-100 mg/kg for 5 days; which induces dependence as evidenced by withdrawal symptoms in adults. These finding reveal disordered neuroimmune regulation in female mice exposed to NOWS, suggesting susceptibility to autoimmune disorders or reoccurring infections later in life, and aid in providing important targets for the development of rational treatment approaches for NOWS.; Grant Support: NIH Grant R25-GM07174514A1; NIH Grant 5R01DA047743-02
- |||||||||| morphine sulphate / Generic mfg.
Sex-specific effects of late adolescent morphine exposure on adult thermal nociception (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_846;
Together, these data suggest that modality-specific nociceptive circuit refinement is occurring in a sex-dependent manner in late adolescent rats. We are now determining whether morphine alters microglial signaling in the NAc to cause female-specific nociceptive responding in adulthood.
- |||||||||| morphine sulphate / Generic mfg.
Ensemble encoding of conditioned fear by prefrontal somatostatin interneurons (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_71;
Overall, our results point to an unappreciated capacity for functional specialization among SST-INs and suggest microcircuit mechanisms by which they orchestrate selective control over excitatory populations. In particular, these findings suggest that SST-INs coordinate the firing of memory-related projection neurons as part of a functional "subnetwork", which has important implications for stimulus processing by mPFC under normal and pathological conditions.; Grant Support: NIH Grant MH122228; NIH Grant MH114170; NIH Grant MH115688; NIH Grant MH116445
- |||||||||| ketamine / Generic mfg.
Clinical, Journal: Opioid Sparing Anesthesia and Enhanced Recovery After Surgery Protocol for Pancreaticoduodenectomy. (Pubmed Central) - Dec 20, 2021
Hospital length of stay decreased from 8.92 to 5.72 days, ICU days decreased from 1.52 to 0.42 days, and narcotics for the first five hospital days were significantly decreased from 130.13 to 71.2 morphine milligram equivalents...Likewise, there is limited data regarding opioid-sparing anesthesia techniques. Our protocol produced promising hospital length of stay and reduced opioid administration during the first five hospital days without increasing 30-day readmission rates.
- |||||||||| morphine sulphate / Generic mfg., epinephrine / Generic mfg.
COMPARISON OF MULTIPORT VERSUS SINGLE PORT VIDEO ASSISTED THORACOSCOPIC SURGERY FOR PEDIATRIC PNEUMOTHORAX. (Conductor's Room) - Dec 20, 2021 - Abstract #WSMRF2022WSMRF_487;
Morphine Milligram Equivalents (MME) were calculated for opioids using the opioid conversion guide by the Center for Disease Control...Intraoperative pain medications were delivered weight-based including intravenous acetaminophen and intradermal 0.25% bupivacaine hydrochloride and epinephrine...Conclusions In this small case series, outcomes were not significantly different for single port when compared with traditional multiport VATS for PSP. This provides a convincing basis to expand the usage for this technique and analyze with a larger group.
- |||||||||| Nucynta (tapentadol) / Collegium Pharma, Grunenthal
CHARACTERIZING OPIOID USER TYPES AND IDENTIFYING PRESCRIBING FACTORS CONTRIBUTING TO LONG TERM USE. (Babcock #6 (Sunset Center)) - Dec 20, 2021 - Abstract #WSMRF2022WSMRF_390;
Opioid user types were described by episode number, median total day supply, median total MME (morphine milligram equivalents) prescribed, first prescribing specialist and first opioid prescribed...First opioid prescribed across all user types was codeine (50%-70%), tramadol/tapentadol (19%), and hydromorphone (5%-15%)...Factors associated with longer episodes included initial prescription of oxycodone (HR 0.82) or hydromorphone (HR 0.85) relative to codeine; first prescriber speciality: psychiatry (HR 0.79) or diagnostic services (0.89) relative to general practice; and increasing age (HR 0.97 by 5-year increments). Conclusions This population-level datal provides a better understanding of the role of prescriber types/prescriptions and factors that contribute to increased likelihood of long-term use.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Journal, Patient reported outcomes: Longitudinal patient-reported outcomes and restrictive opioid prescribing after minimally invasive gynecologic surgery. (Pubmed Central) - Dec 18, 2021
We found that restrictive post-operative opioid prescribing was not associated with differences in longitudinal symptom burden among women undergoing minimally invasive gynecologic surgery. These results provide the most comprehensive picture to date of post-operative symptom recovery under different opioid prescribing approaches, lending additional support for existing recommendations to reduce opioid prescribing following gynecologic surgery.
- |||||||||| gabapentin / Generic mfg.
Preclinical, Journal: Mouse strain specificity of DAAO inhibitors-mediated antinociception. (Pubmed Central) - Dec 18, 2021
Furthermore, the specific GPx inhibitor D-penicillamine distinctly restored SUN antinociception in C57 mice. Our results reported that DAAO inhibitors produced antinociception in a strain-dependent manner in mice and the strain specificity might be associated with the difference in spinal GSH and GPx activity.
- |||||||||| midazolam hydrochloride / Generic mfg.
Clinical, Review, Journal: Palliative care and COVID-19 in the Australian context: a review of patients with COVID-19 referred to palliative care. (Pubmed Central) - Dec 18, 2021
There is limited research describing the Australian palliative care experience with the COVID-19 pandemic.What does this paper add?Patients with COVID-19 referred to a hospital-based palliative care consultancy service in Australia had similar demographic characteristics, symptoms, medication needs and outcomes to patients with COVID-19 referred to other palliative care services in the UK and the US. There were significant psychosocial issues affecting patients, families and staff in the context of the pandemic.What are the implications for practitioners?This study highlights the need for well-functioning working relationships between the palliative care consultancy service and other hospital teams that can be leveraged at a time of crisis, such as a pandemic, to provide optimal palliative care to patients.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Journal: Treatment of cancer pain in Mali: Experience of the mother-child medical oncology service of the CHU in Bamako (Pubmed Central) - Dec 18, 2021
A control of the pain was obtained in all the patients (100 %) with a dramatic improvement in quality of life. This study emphasizes the need for a pain control program at the Malian state level with a basic education of care givers, hospital-centric networks and access to morphine and opioids at the different levels involved in cancer management.
- |||||||||| Exparel (bupivacaine liposome injectable suspension) / Pacira
Journal: Liposomal Bupivacaine Injection in Nuss Procedure Allows Narcotic Avoidance and Improved Outcomes. (Pubmed Central) - Dec 18, 2021
There is a significant impact of liposomal Bupivacaine usage on epidural catheter avoidance and opioid administration correlating with a significantly decreased total cost and decreased LOS. While more study is necessary, liposomal Bupivacaine for Nuss procedure offers improvement of postoperative patient outcomes and drastic cost savings.
- |||||||||| Prialt (ziconotide) / Jazz
Journal: Combination Intrathecal Drug Therapy Strategies for Pain Management. (Pubmed Central) - Dec 18, 2021
The appropriate use of these strategies may be limited by increased or compounded risk of adverse effects, both of which are highly patient and scenario dependent. Therefore, practitioners should maintain a particularly low threshold of suspicion for adverse effects in patients with CIDT such that safety profiles associated with this therapy can be favorably maintained.
- |||||||||| morphine sulphate / Generic mfg.
Enrollment status, Trial completion date: Neuraxial Preservative Free Morphine for Normal Spontaneous Vaginal Delivery (clinicaltrials.gov) - Dec 17, 2021
P4, N=140, Enrolling by invitation,
We concluded that JMV2959 may be an effective candidate to treat drug addiction. Recruiting --> Enrolling by invitation | Trial completion date: Dec 2022 --> Mar 2023
- |||||||||| morphine sulphate / Generic mfg.
Journal: Evaluation of Opioid Prescription and Consumption Habits Following Endovascular Aortic Aneurysm Repair. (Pubmed Central) - Dec 17, 2021
These data identify key factors associated with receiving an opioid prescription at discharge and demonstrate that patients consume far fewer opioids than prescribed. These findings provide insight as to which patients may not require an outpatient prescription following EVAR, leading to potential practice-changing opioid reduction strategies.
- |||||||||| tramadol hydrochloride / Generic mfg.
Clinical, Review, Journal: Tapentadol Versus Tramadol: A Narrative and Comparative Review of Their Pharmacological, Efficacy and Safety Profiles in Adult Patients. (Pubmed Central) - Dec 17, 2021
The trials published to date show overall that tapentadol does not provide a clinically significant analgesic improvement compared to existing treatments, for which the safety profile is much better known. In conclusion, tapentadol is not a first-line opioid but represents an additional analgesic in the therapeutic choices, which some patients may benefit from after careful examination of their clinical situation, co-morbidities and co-medications.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Postoperative Prescriptions and Corresponding Opioid Consumption After Septoplasty or Rhinoplasty. (Pubmed Central) - Dec 16, 2021
The number of opioid tablets prescribed and the number consumed were converted to total morphine milligram equivalent (MME) for uniform comparison...Abuse of prescription opioids represents an important component of the nation's opioid crisis. Surgeons must be cognizant of the problem and adjust prescribing practices accordingly.
- |||||||||| dexketoprofen trometamol / Generic mfg.
FDA event, Journal: Prediction of novel inhibitors for Crotalus adamanteus l-amino acid oxidase by repurposing FDA-approved drugs: a virtual screening and molecular dynamics simulation investigation. (Pubmed Central) - Dec 16, 2021
Meanwhile, Arg88, Gln112, Lys345, Trp356 form consistent hydrogen bond interactions with Dexketoprofen, Flurbiprofen, Ketoprofen, Morphine, and Citric acid during simulation. According to the results, each of the four compounds can be an appropriate inhibitor of LAAO and since our study was based on drug repurposing could be evaluated in phase II clinical trials.
- |||||||||| loxicodegol (NKTR-181) / Nektar Therap
Preclinical, Journal: Preclinical Assessment of the Analgesic Pharmacology of NKTR-181 in Rodents. (Pubmed Central) - Dec 16, 2021
According to the results, each of the four compounds can be an appropriate inhibitor of LAAO and since our study was based on drug repurposing could be evaluated in phase II clinical trials. NKTR-181 had a slower onset, but similar efficacy, to morphine in the models studied supporting reduced abuse potential while maintaining analgesic effect in comparison with current opioids.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Preclinical, Journal: Synthesis and Characterization of Azido Aryl Analogs of IBNtxA for Radio-Photoaffinity Labeling Opioid Receptors in Cell Lines and in Mouse Brain. (Pubmed Central) - Dec 16, 2021
We demonstrate that both allyl and alkyne arylazido derivatives of IBNtxA efficiently radio-photolabeled mMOR-1 in cell lines and MOR-1 protein complexes expressed either exogenously or endogenously, as well as found in mouse brain. In future, design and application of such radio-photolabeling ligands with a conjugated handle will provide useful tools for further isolating or purifying MOR-1 to investigate site specific ligand-protein contacts and its signaling complexes.
- |||||||||| methadone / Generic mfg.
Review, Journal: Methadone in Pain Management: A Systematic Review. (Pubmed Central) - Dec 16, 2021
PERSPECTIVE: This article presents a systematic review, which includes a summary of published randomized controlled trials investigating the effectiveness of methadone in the management of pain. This is important for determining its analgesic utility and for identifying gaps in existing knowledge.
- |||||||||| morphine sulphate / Generic mfg.
Review, Journal: Relevance of Mu-Opioid Receptor Splice Variants and Plasticity of Their Signaling Sequelae to Opioid Analgesic Tolerance. (Pubmed Central) - Dec 16, 2021
The unique feature(s) of these variants that underlies their susceptibility to adapting to chronic morphine by altering the nature of their G protein coupling reveals the richness and pliability of MOR signaling that is enabled by generating a wide diversity of MOR variants. Furthermore, given differential anatomical expression patterns of MOR variants, MOR splice variant-dependent adaptations to chronic morphine could enable mechanistic underpinnings of tolerance and dependence that are CNS region- and cell-specific.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Treatment with 5-fluoro-2-oxindole Increases the Antinociceptive Effects of Morphine and Inhibits Neuropathic Pain. (Pubmed Central) - Dec 16, 2021
This treatment also potentiated the pain-relieving activities of morphine by normalizing the reduced MOR expression. This work demonstrates the antinociceptive, anxiolytic and antidepressant effects of 5-fluoro-2-oxindole, suggests a new strategy to enhance the antinociceptive actions of morphine and proposes a new mechanism of action of oxindoles during chronic neuropathic pain.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Journal: Postoperative Opioid Filling Patterns in Women Undergoing Midurethral Sling Placement. (Pubmed Central) - Dec 16, 2021
This work demonstrates the antinociceptive, anxiolytic and antidepressant effects of 5-fluoro-2-oxindole, suggests a new strategy to enhance the antinociceptive actions of morphine and proposes a new mechanism of action of oxindoles during chronic neuropathic pain. Patients undergoing isolated midurethral sling placement filled a median of 150 cumulative MMEs, and the proportion of patients filling perioperative opioid prescriptions increased over the study period.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Naloxone Facilitates Contextual Learning and Memory in a Receptor-Independent and Tet1-Dependent Manner. (Pubmed Central) - Dec 16, 2021
Opioids, like morphine and naloxone, regulate the proliferation and neuronal differentiation of neural stem cells (NSCs) in a receptor-independent and ten-eleven translocation methylcytosine dioxygenase (TET1)-dependent manner in vitro...In addition, these abilities of naloxone were not affected in Oprm1 mice. Therefore, naloxone facilitates contextual learning and memory in a receptor-independent and Tet1-dependent manner, which provides new understanding on the receptor-independent functions of opioids.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Review, Journal: CHRONIC OPIOID THERAPY: A SCOPING LITERATURE REVIEW ON EVOLVING CLINICAL AND SCIENTIFIC DEFINITIONS. (Pubmed Central) - Dec 16, 2021
Episode duration/dosage criteria was used in 90 studies, with 7.5% by Morphine Milligram Equivalents + days' supply and 32.2% by other "episode" combination definitions. COT definitions were applied in musculoskeletal CNCP (60.8%) most often, and typically in adults aged 18 to 64 (69.6%)...Perspective: This study summarized the most common, current definition criteria for chronic opioid therapy (COT) and recommends adoption of consistent definition criteria to be utilized in practice and research. The most recent literature trends toward shorter duration criteria overall, suggesting that COT definition criteria are increasingly stringent.
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