morphine sulphate / Generic mfg. 
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 7 Diseases   379 Trials   379 Trials   12426 News 


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  • ||||||||||  Nexavar (sorafenib) / Bayer, Amgen
    PK/PD data, Preclinical, Journal:  Pharmacokinetic Drug Interaction Study of Sorafenib and Morphine in Rats. (Pubmed Central) -  Dec 29, 2021   
    Observed changes in sorafenib and morphine may be of clinical significance. The increased exposure to both drugs may improve the response to therapy in cancer patients, but on the other hand, increase the risk of adverse effects.
  • ||||||||||  rifampicin / Generic mfg.
    Clinical, Clinical data, Review, Journal:  Clinical outcomes of concomitant rifamycin and opioid therapy: a systematic review. (Pubmed Central) -  Dec 29, 2021   
    Available literature suggests that a decrease in opioid clinical effects are appreciated with concomitant rifamycin therapy. Further research is needed to focus on specific mitigation strategies beyond opioid agent selection, such as dosing adjustment recommendations.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery, Tumor cell:  POACC-1: Influence of Opioid Analgesia on Circulating Tumor Cells in Open Colorectal Cancer Surgery (clinicaltrials.gov) -  Dec 29, 2021   
    P4,  N=120, Recruiting, 
    Further research is needed to focus on specific mitigation strategies beyond opioid agent selection, such as dosing adjustment recommendations. Trial completion date: Jan 2021 --> Jan 2023 | Trial primary completion date: Jan 2021 --> Jan 2023
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery, Tumor cell:  POACC-2: Influence of Opioid Analgesia on Circulating Tumor Cells in Laparoscopic Colorectal Cancer Surgery (clinicaltrials.gov) -  Dec 29, 2021   
    P4,  N=200, Recruiting, 
    Trial completion date: Jan 2021 --> Jan 2023 | Trial primary completion date: Jan 2021 --> Jan 2023 Trial completion date: Jan 2021 --> Jan 2023 | Trial primary completion date: Jan 2021 --> Jan 2023
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Immune modulation mediated by extracellular vesicles of intestinal organoids is disrupted by opioids. (Pubmed Central) -  Dec 29, 2021   
    EVs derived from morphine-treated organoids failed to suppress the immune response in both these models. Our study suggests that EVs derived from intestinal crypt cells play crucial roles in maintaining host homeostasis and opioid use is a risk factor for exacerbating inflammation in patients with inflammatory diseases such as sepsis and colitis.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Rapid response team activation after major hip surgery: A case series. (Pubmed Central) -  Dec 28, 2021   
    Mortality after RRT activation is associated with non-modifiable patients factors rather than surgical or anesthesia factors. Our findings provide opportunities for the implementation of strategies aimed at improving postoperative outcomes.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion date, Trial primary completion date:  Morphine Consumption in Thoracotomy (clinicaltrials.gov) -  Dec 28, 2021   
    P=N/A,  N=44, Recruiting, 
    Further pediatric studies are needed to evaluate the clinical impact of delirium, benzodiazepine-limited sedation and early mobilization protocols on patients' long-term functional outcomes and on hospital finances. Trial completion date: Sep 2021 --> Jan 2022 | Trial primary completion date: Sep 2021 --> Jan 2022
  • ||||||||||  morphine sulphate / Generic mfg., alprazolam / Generic mfg.
    Trial initiation date:  MAP: Opioid/Benzodiazepine Polydrug Abuse: Aim 3 (clinicaltrials.gov) -  Dec 28, 2021   
    P2,  N=24, Not yet recruiting, 
    Trial completion date: Sep 2021 --> Jan 2022 | Trial primary completion date: Sep 2021 --> Jan 2022 Initiation date: Oct 2021 --> Feb 2022
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Zebrafish (Danio rerio) larvae show behavioral and embryonic development defects when exposed to opioids at embryo stage. (Pubmed Central) -  Dec 28, 2021   
    The aim of this work was to evaluate the effect of early embryonic codeine or morphine exposure in zebrafish (Danio rerio), examining gastrulation progression (epiboly), teratogenic effects, mortality and locomotor behavior response to light/dark cycles...Animals exposed to high levels and higher exposure times of opioids were hypoactive, relative to controls, in the dark period. Future studies will be needed to understand the neural defects producing behavior changes.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Prevalence and Distribution of High-Risk Prescription Opioid Use in the United States, 2011-2016. (Pubmed Central) -  Dec 28, 2021   
    Well-designed RCTs with an evidence-based approach are imperative for determining the most appropriate opioid for cesarean sections. Despite clinically significant declines in high-risk opioid use, in 2016 nearly 1 in 10 adult retail pharmacy users remained at high-risk for opioid overdose in the U.S. Future clinical and policy interventions should consider targeting older adults with Medicare Part-D, including those using a single pharmacy to fill their opioid prescriptions.
  • ||||||||||  ropivacaine / Generic mfg.
    Clinical, Journal:  Liposomal Bupivacaine vs Ropivacaine for Adductor Canal Blocks in Total Knee Arthroplasty: A Prospective Randomized Trial. (Pubmed Central) -  Dec 28, 2021   
    Despite clinically significant declines in high-risk opioid use, in 2016 nearly 1 in 10 adult retail pharmacy users remained at high-risk for opioid overdose in the U.S. Future clinical and policy interventions should consider targeting older adults with Medicare Part-D, including those using a single pharmacy to fill their opioid prescriptions. We did not find any supporting evidence that liposomal bupivacaine yields increased pain relief following total knee arthroplasty compared to the control drug, ropivacaine.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  A Comparison of EIS and QCM NanoMIP-Based Sensors for Morphine. (Pubmed Central) -  Dec 27, 2021   
    In addition, whereas the QCM enables visualization of the binding events between the target molecule and the sensor in real-time, the EIS method does not allow such a feature and measurements are taken post-binding. The work also highlighted the advantages of using QCM as an automated, rapid and multiplex sensor compared to the much simpler EIS platform used in this work, though, the QCM method will require sample preparation, especially when a sensitive (ng·mL) detection of a small analyte is needed.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Influence of Escherichia coli on Expression of Selected Human Drug Addiction Genes. (Pubmed Central) -  Dec 27, 2021   
    Human genome-wide experiments on RNA transcripts expressed in response to three selected Escherichia coli strains allowed for significant alteration (p > 0.05) of the linear regression model between HT-29 RNA transcripts associated with the KEGG pathway:hsa05030:Cocaine addiction after 3 h stimulation with intracellular pathogenic E. coli strain UM146 versus non-pathogenic E. coli Nissle 1917. Among the features influenced by the UM146 bacterial strain were visual learning, response to the presence of morphine, response to hypoxia, behavioral fear response and cognitive functions.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  The Learning Curve of Reaching the Planned Limb Alignment in Robotic-Arm-Assisted Total Knee Arthroplasty. (Pubmed Central) -  Dec 27, 2021   
    Length of stay, discharge disposition, complications, reoperation/readmission (90 days), and total morphine equivalents (TMEs) prescribed were compared between phases...A surgeon can reach the planned limb alignment with increased accuracy over time (110-cases). Progressive robotic learning and associated operative time efficiency can lead to significantly lower opioid consumption in patients undergoing TKA.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Epigenetic controller:  Epigenetic control of ion channel expression and cell-specific splicing in nociceptors: Chronic pain mechanisms and potential therapeutic targets. (Pubmed Central) -  Dec 25, 2021   
    An estimated 30% of disease-causing mutations are associated with altered alternative splicing, and mis-splicing is a feature of numerous highly prevalent diseases including neurodegenerative, cancer, and chronic pain. Here we discuss the important role of epigenetic regulation of gene expression and cell-specific alternative splicing of calcium ion channels in nociceptors, with emphasis on how these processes are disrupted in chronic pain, the potential therapeutic benefit of correcting or compensating for aberrant ion channel splicing in chronic pain.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Implementation of a nonopioid protocol following robot-assisted radical cystectomy with intracorporeal urinary diversion. (Pubmed Central) -  Dec 25, 2021   
    Here we discuss the important role of epigenetic regulation of gene expression and cell-specific alternative splicing of calcium ion channels in nociceptors, with emphasis on how these processes are disrupted in chronic pain, the potential therapeutic benefit of correcting or compensating for aberrant ion channel splicing in chronic pain. The implementation of a NOP protocol for patients undergoing RARC with ICUD allows for both decreased postoperative narcotic use and reduced need for narcotic prescriptions at discharge with acceptable complication and readmission rates.
  • ||||||||||  Nucynta (tapentadol) / Collegium Pharma, Grunenthal
    Journal:  Nitric oxide modulates tapentadol antinociceptive tolerance and physical dependence. (Pubmed Central) -  Dec 25, 2021   
    In conclusion, our data suggest that the NOS system plays an important role in the attenuation of tapentadol-induced tolerance and withdrawal. Thus, inhibition of NOS activity can serve as a promising treatment option for long-term tapentadol use by extending its effectiveness and improving the side-effects profile.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Persistent exposure to Δ- tetrahydrocannabinol during adolescence does not affect nociceptive responding in adult mice. (Pubmed Central) -  Dec 25, 2021   
    We also investigated, using the tail immersion test, the antinociceptive effects of morphine and the development of tolerance to such effects...This raises the possibility that regular use of Δ-THC-containing cannabis during adolescence might cause changes in nociception that persist into adulthood. We found that frequent early-life exposure to a moderate dose of Δ-THC does not permanently alter nociceptive function in male or female mice.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Spatiotemporal Analysis of the Association between Pain Management Clinic Laws and Opioid Prescribing and Overdose Deaths. (Pubmed Central) -  Dec 25, 2021   
    We analyzed county-level opioid overdose deaths (National Vital Statistics System) and patients filling long-duration (≥30 day) or high-dose (≥90 morphine milligram equivalents per day) opioid prescriptions (IQVIA, Inc.) in the United States in 2010-2018...Conversely, PMC laws were associated with increased relative rates of synthetic opioid and heroin overdose deaths, especially criminal penalties (adjusted RR: 1.83, 95% CrI: 1.59, 2.11; and 2.59, and 2.22, 3.02, respectively). Findings suggest laws with criminal penalties were associated with intended reductions in high-risk opioid prescribing and some opioid overdoses, but raise concerns regarding unintended consequences on heroin/synthetic overdoses.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Diminished Peripheral CD29hi Cytotoxic CD4+ T Cells Are Associated With Deleterious Effects During SIV Infection. (Pubmed Central) -  Dec 25, 2021   
    However, little is known about their contribution towards HIV persistence, how they are affected following exposure to immune modulators like morphine, and what factors maintain their frequencies and function...Lastly, increased functionality of CD29hi CD4+ T cells as depicted by elevated levels of either IL-21 or granzyme B hi T Bet+ gag specific responses were linked to limiting the size of the replication-competent reservoir during cART treatment. Collectively, our data suggest that CD4+ CTLs are crucial in limiting SIV pathogenesis and persistence.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Opioid Reduction Through Postoperative Pain Management in Pediatric Orthopedic Surgery. (Pubmed Central) -  Dec 25, 2021   
    Collectively, our data suggest that CD4+ CTLs are crucial in limiting SIV pathogenesis and persistence. The creation of these guidelines has led to a significant reduction in the number of opioids prescribed while maintaining effective postoperative pain management.