morphine sulphate / Generic mfg. 
Welcome,         Profile    Billing    Logout  
 7 Diseases   379 Trials   379 Trials   12426 News 


«12...121122123124125126127128129130131...217218»
  • ||||||||||  cisplatin / Generic mfg.
    Review, Journal:  Interactions of Analgesics with Cisplatin: Modulation of Anticancer Efficacy and Potential Organ Toxicity. (Pubmed Central) -  Jan 26, 2022   
    Different types of analgesics, such as acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDS), and narcotic analgesics, could be used according to the severity of pain...Concerning safety, some analgesics share the same adverse effects on normal tissues as CDDP, augmenting its potentially hazardous effects on organ impairment. This article offers an overview of the reported literature on the interactions between analgesics and CDDP, paying special attention to possible mechanisms that modulate CDDP's cytotoxic efficacy and potential adverse reactions.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Morphine Perinatal Exposure Induces Long-Lasting Negative Emotional States in Adult Offspring Rodents. (Pubmed Central) -  Jan 26, 2022   
    Morphine-exposed mice presented alterations in the nociceptive responses on the writhing test. This study showed that sex difference plays a role in pain threshold and that deleterious effects of morphine during pre/perinatal periods are nonrepairable in adulthood, which highlights the long-lasting clinical consequences related to anxiety, depression, and nociceptive disorders in adulthood followed by intrauterine and lactation morphine exposure.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Effects of Morphine on Gp120-induced Neuroinflammation Under Immunocompetent Vs. Immunodeficient Conditions. (Pubmed Central) -  Jan 26, 2022   
    Further, expression of TNFα and IFNγ were enhanced by morphine regardless of host immune status. Altogether, our results suggest that the effects of morphine are complex and dependent on the immune status of the host, and host immune status-specific, targeted anti-neuroinflammatory strategies are required for effective treatment of HAND.
  • ||||||||||  Review, Journal:  Opioids in COVID-19: Two Sides of a Coin. (Pubmed Central) -  Jan 26, 2022   
    Out of the 5,273,598 opioid units used in this period all over the country, morphine, fentanyl, and remifentanil, accounted for, respectively, 559,270 (10.6%), 4,624,328 (87.6%), and 90,000 (1.8%) units...In the COVID-19 pandemic scenario, positive points related to opioids were mainly the occurrence of analgesia, to facilitate intubation and their use as coadjutants in the management of acute intensification of pain, whereas the negative points were indiscriminate use, the presence of human immunosuppressor response and increased adverse effects due to higher doses of the drug. The importance of rational and individualized use of analgesic hypnotics and sedative anesthetics should be considered at all times, especially in situations of high demand such as the COVID-19 pandemic.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Transdermal Buprenorphine for Pain Management Following a Neck of Femur Fracture. (Pubmed Central) -  Jan 26, 2022   
    38 patients (32%) required more than 20 mg of oral morphine sulphate solution in the first week post-admission. This series suggests that transdermal buprenorphine is safe and effective in the management of pain following a neck of femur fragility fracture.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Evaluating the Efficacy of Two Regional Pain Management Modalities in Autologous Breast Reconstruction. (Pubmed Central) -  Jan 26, 2022   
    Neither length of stay (P = 0.953), nor oral morphine equivalents consumption (P = 0.883) differed by type of regional analgesia. Compared with control patients, both approaches to regional transversalis abdominis plane block analgesia as part of an opiate-sparing enhanced recovery pain management strategy were successful, but neither superior to the other.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion:  Morphine Consumption in Thoracotomy (clinicaltrials.gov) -  Jan 26, 2022   
    P=N/A,  N=44, Completed, 
    No change in total activity counts between groups was confirmed. Recruiting --> Completed
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion date, Trial primary completion date:  Low Dose Morphine to Relieve Dyspnea in Acute Respiratory Failure (OPIDYS) (clinicaltrials.gov) -  Jan 25, 2022   
    P2,  N=22, Recruiting, 
    Recruiting --> Completed Trial completion date: Dec 2021 --> Jun 2022 | Trial primary completion date: Dec 2021 --> Jun 2022
  • ||||||||||  morphine sulphate / Generic mfg., ropivacaine / Generic mfg., epinephrine / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  Peri-Incisional Drug Injection in Lumbar Spine Surgery (clinicaltrials.gov) -  Jan 24, 2022   
    P3,  N=200, Recruiting, 
    Trial completion date: Dec 2021 --> Jun 2022 | Trial primary completion date: Dec 2021 --> Jun 2022 Trial completion date: Sep 2021 --> Sep 2022 | Trial primary completion date: Mar 2021 --> Mar 2022
  • ||||||||||  morphine sulphate / Generic mfg.
    Reimbursement, Journal, Medicaid:  Evaluation of a Medicaid performance improvement project to reduce high-dose opioid prescriptions. (Pubmed Central) -  Jan 23, 2022   
    Although Oregon's high-dose opioid performance improvement project was associated with declines in high-dose opioid prescriptions, rates of opioid overdose did not decrease. Policy efforts to reduce opioid prescribing risks may not be sufficient to address the growing opioid crisis.
  • ||||||||||  Olinvyk (oliceridine) / Trevena
    New P1/2 trial:  Oliceridine effects on CNS and Pain (EUDRACT) -  Jan 22, 2022   
    P1/2,  N=20, Ongoing, 
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Review, Journal:  Alternative Pre-mRNA Splicing of the Mu Opioid Receptor Gene, OPRM1: Insight into Complex Mu Opioid Actions. (Pubmed Central) -  Jan 21, 2022   
    More importantly, the OPRM1 variants can be targeted for development of novel opioid analgesics that are potent against multiple types of pain, but devoid of many side-effects associated with traditional opiates. In this review, we provide an overview of OPRM1 alternative splicing and its functional relevance in opioid pharmacology.
  • ||||||||||  cimetidine / Generic mfg.
    Journal:  Photoaged polystyrene microplastics serve as photosensitizers that enhance cimetidine photolysis in an aqueous environment. (Pubmed Central) -  Jan 21, 2022   
    This work also demonstrated that other compounds that are susceptible to indirect photolysis, such as codeine and morphine, are likewise significantly degraded under irradiation in the presence of aged PS-MPs. Although previous studies have reported how MPs can increase the persistence of contaminants, this study demonstrates that MPs can serve as photosensitizers and alter the fate of coexisting pharmaceuticals in aquatic environments.
  • ||||||||||  methionine enkephalin (STAT-401) / Immune Therap, Statera BioPharma
    Review, Journal:  Review of Kyotorphin Research: A Mysterious Opioid Analgesic Dipeptide and Its Molecular, Physiological, and Pharmacological Characteristics. (Pubmed Central) -  Jan 21, 2022   
    These studies would include not only the brain-permeable kyotorphin derivatives but also hybrid kyotorphin derivatives conjugated with small compounds that have additional pharmacological actions. Further, since there are reports of kyotorphin being involved in either the etiology or treatment of Alzheimer's disease, epilepsy, inflammation, and chronic pain, studies on the beneficial effects of kyotorphin derivatives should also be expected in the future.
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment open:  Intrathecal Morphine for Cesarean Delivery (clinicaltrials.gov) -  Jan 20, 2022   
    P4,  N=72, Recruiting, 
    In contrast, a single dose of 10 mg kg tramadol has no such effects. Not yet recruiting --> Recruiting
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Dorsal raphe nucleus serotoninergic neurons mediate morphine rewarding effect and conditioned place preference. (Pubmed Central) -  Jan 20, 2022   
    Accordingly, optogenetic inhibition of DRN 5-HT neurons following morphine injection reversed conditioned place preference (CPP) during chronic morphine treatment. These findings aid our understanding of the new functions of the DRN 5-HT neurons for morphine rewarding effect and provide a potential approach for the treatment of morphine addiction.
  • ||||||||||  morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
    Trial completion date:  PEF-Block & Ribs Fractures (clinicaltrials.gov) -  Jan 19, 2022   
    P=N/A,  N=90, Recruiting, 
    This finding suggested that MKPs may serve as a new target for alleviating morphine tolerance. Trial completion date: Dec 2020 --> Dec 2022
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  The role of HINT1 protein in morphine addiction: An animal model-based study. (Pubmed Central) -  Jan 19, 2022   
    We found that HINT1 has varying degrees of involvement in different stages of multiple addictive animal models. The absence of HINT1 can attenuate morphine-mediated addictive behavior to a certain extent and can alleviate the withdrawal symptoms of morphine.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Effects of Opioid-Limiting Legislation on Postoperative Opioid Use in Shoulder Arthroplasty in an Epidemic Epicenter. (Pubmed Central) -  Jan 19, 2022   
    Opioid prescription-limiting legislation for acute pain in the state of Ohio is associated with a notable reduction in opioid MME dosing in the 90-day postoperative period after shoulder arthroplasty, particularly in opioid-naive patients in the first 30 days postoperatively. Preoperative opioid tolerance is correlated with significantly higher MME dosing postoperatively after shoulder arthroplasty.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Anesthesia and World War II: When the Battlefield Becomes a Research Field-A Bibliometric Analysis of the Influence of World War II on the Development of Anesthesiology. (Pubmed Central) -  Jan 19, 2022   
    After reviewing the literature, we selected 12 keywords representing important advances in anesthesiology since 1920: "anesthesia," "balanced anesthesia," "barbiturates," "d-tubocurarine," "endotracheal intubation," "ether," "lidocaine," "morphine," "spinal anesthesia," "thiopental," "transfusion," and "trichloroethylene." Titles of original articles from all selected journals editions between 1920 and 1965 were screened for the occurrence of 1 of the 12 keywords...It also offers an objective record of the chronology of the major advances in anesthesiology before and after the conflict. While the war arguably helped to enhance anesthesiology as a specialty, in return anesthesiology helped to heal the wounds of war.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Review, Journal:  Opioids for Treatment of Pre-hospital Acute Pain: A Systematic Review. (Pubmed Central) -  Jan 19, 2022   
    Intravenous administration of synthetic, fast-acting opioids may be as effective and safe as intravenous administration of morphine. More controlled studies are needed on alternative routes for opioid administration and pre-hospital pain management for potentially more frail patient subgroups.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, HEOR:  Comparative Cost Analysis of Robotic-Assisted and Jig-Based Manual Primary Total Knee Arthroplasty. (Pubmed Central) -  Jan 18, 2022   
    Length of stay (LOS) was reduced 25% (1.2 vs. 1.6 days, respectively, p < 0.0001) and prescribed opioids were reduced 57% (984.2 versus 2240.4 morphine milligram equivalents, respectively, p < 0.0001) comparing raTKA with mTKA...Cost savings with raTKA were primarily driven by reduced instrument pan reprocessing fees, shorter LOS, and reduced prescribed opioids compared with mTKA technique. raTKA demonstrated improved value compared with mTKA based on significantly lower average 90-day EOC costs and superior quality exemplified by reduced LOS, less postoperative opioid requirements, and reduced postdischarge resource utilization.
  • ||||||||||  morphine sulphate / Generic mfg., methadone / Generic mfg.
    Review, Journal:  Opioid use during pregnancy can impair maternal behavior and the Maternal Brain Network: A literature review. (Pubmed Central) -  Jan 18, 2022   
    A standard form of pharmacological treatment for OUD is Opioid Maintenance Therapy (OMT) and buprenorphine has emerged as the preferred treatment for pregnant women with OUD relative to methadone...This review describes the Maternal Brain Network as a framework for understanding how pharmacological differences in exogenous opioid exposure can disrupt the onset and maintenance of the maternal brain and summarizes opioid and OMT (in particular buprenorphine) use in the context of pregnancy and maternal behavior. This review also highlights future directions for evaluating exogenous opioid effects on the Maternal Brain Network in the hopes of raising awareness for the impact of the opioid crisis not only on exposed infants, but also on mothers and subsequent mother-infant bonds.
  • ||||||||||  morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
    Preclinical, Journal:  Synergistic analgesic effect of morphine and tramadol in non‑sensitized and morphine‑sensitized mice: an isobolographic study. (Pubmed Central) -  Jan 18, 2022   
    An isobolographic analysis of data was performed, indicating a synergistic interaction between morphine and tramadol in non‑sensitized and morphine‑sensitized mice. Our data indicated that both morphine and tramadol elicit more anti‑nociceptive response in morphine sensitized mice; there is a synergistic effect between morphine and tramadol upon induction of analgesic effect in non‑sensitized and morphine‑sensitized mice.