- |||||||||| morphine sulphate / Generic mfg.
Journal: Risk Factors for Postoperative Ileus in Patients Undergoing Spine Surgery. (Pubmed Central) - Feb 8, 2022
This retrospective cohort study demonstrates that greater postoperative MME is an independent risk factor for POI after thoracolumbar spine fusion when accounting for demographic, medical, and surgical variables with multiple logistic regression. Prospective studies are warranted to evaluate clinical measures to decrease the risk of POI among patients undergoing instrumented thoracolumbar spinal fusions.
- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal: Morphine promotes migration and lung metastasis of mouse melanoma cells. (Pubmed Central) - Feb 6, 2022
Epidural instillation of bupivacaine and morphine is safe and enables better pain relief in the initial 48 hours which helps in early mobilisation, and enhanced functional recovery. Morphine increases the migration and metastasis of mouse melanoma cells by activating TLR4.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Overdoses due to fentanyl and its analogues (F/FAs) push naloxone to the limit. (Pubmed Central) - Feb 5, 2022
This study suggests that prophylactic gabapentin at 600 mg TID is not effective in improving treatment-related pain in a select group of patients. As a competitive antagonist at μ-opioid receptors, naloxone is often a life-saving agent in cases of overdose caused by conventional opioids, but it may not be versatile or powerful enough to combat the rising tide of overdoses due to fentanyl and its illicit analogues, or in cases of overdose involving combinations of opioids and non-opioids.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Circuit and neuropeptide mechanisms of the paraventricular thalamus across stages of alcohol and drug use. (Pubmed Central) - Feb 5, 2022
In this review, we present the current status of preclinical research regarding PVT circuits and neuropeptide modulation of the PVT in three aspects of the addiction cycle: reward/acquisition, withdrawal, and relapse, with a focus on alcohol, opioids (particularly morphine), and psychostimulants (particularly cocaine). Given the PVT's unique position within the broader neural landscape, we further discuss the potential ways in which neuropeptides may regulate these behaviors through their actions upon PVT circuits.
- |||||||||| morphine sulphate / Generic mfg.
Biomarker, Review, Journal: Pharmacogenomics and Morphine. (Pubmed Central) - Feb 4, 2022
The genes coding for the proteins impacting either the pharmacokinetics or pharmacodynamics of morphine may bear genetic variations, also known as polymorphisms, which may alter the function of the proteins in such a manner that an individual may have disparate treatment outcomes. The purpose of this review is to highlight some of the genes coding for proteins that impact morphine pharmacokinetics and pharmacodynamics and present some treatment considerations.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Workers' compensation prescription medication patterns and associated outcomes. (Pubmed Central) - Feb 4, 2022
The association between increasing opioid doses and deaths for low-severity diagnoses was disturbing given the lack of demonstrated efficacy of opioids for treatment of minor injuries. A focus on provider education, increased utilization of non-opioids, and early intervention for minor soft-tissue injuries could reduce claims costs, disability, and future deaths.
- |||||||||| Chirocaine (levobupivacaine) / Purdue, AbbVie
Journal: Utility of Pecs Block for Perioperative Opioid-Sparing Analgesia in Cancer-Related Breast Surgery: A Randomized Controlled Trial. (Pubmed Central) - Feb 4, 2022
The primary aim is to find the risks and benefits of the block in providing analgesia for intraoperative and immediate postoperative cancer-related breast surgery and total morphine consumption...A total of 60 patients were recruited, randomizing them into two groups: group 1 (n = 30): ultrasound-guided PECS I (0.2 ml/kg) and PECS II (0.4 ml/kg) block, post-induction with 0.25% levobupivacaine, maximum dose of 2 mg/kg; group 2 (n = 30): no block, only general anesthesia...The two-level PECS block is safe, effective, reliable, and easy to perform. Clinical Trial Registration Number: CTRI/2017/11/010630.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Predictors of Opiate Utilization in the Treatment of Headache and Impact on Three-Month Outcomes Following Subarachnoid Hemorrhage. (Pubmed Central) - Feb 4, 2022
We found that of 138 patients, the majority (90%) were prescribed opiates during their hospitalization, and the mean daily morphine equivalent dosage was 18.74 mg...However, patients continued to suffer from headaches at three months follow-up. This high opiate consumption is associated with increased hospital length of stay. Studies are needed to identify opiate sparing analgesics that target the pathogenesis of headaches in this patient population.
- |||||||||| morphine sulphate / Generic mfg.
Trial completion, Trial completion date, Surgery: MONDAY: Multimodal Versus Opioid aNalgesia in carDiAc Surgery (clinicaltrials.gov) - Feb 4, 2022
P4, N=95, Completed,
Also, this method had fewer adverse reactions in circulation and respiration compared to the CTEB. Recruiting --> Completed | Trial completion date: Jun 2022 --> Dec 2021
- |||||||||| morphine sulphate / Generic mfg.
Journal: Behavioral, histopathological, and biochemical evaluations on the effects of cinnamaldehyde, naloxone, and their combination in morphine-induced cerebellar toxicity. (Pubmed Central) - Feb 3, 2022
Cinnamaldehyde, naloxone, and their combination treatments improved all the above-mentioned alterations induced by morphine. We concluded that cinnamaldehyde produced a neuroprotective effect through anti-oxidant, anti-inflammatory, apoptotic, and probably naloxone-sensitive opioid receptor interaction mechanisms.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Projection from the basolateral amygdala to the anterior cingulate cortex facilitates the consolidation of long-term withdrawal memory. (Pubmed Central) - Feb 3, 2022
We found that (1) the inhibition of the BLA-ACC projection during conditioning had no effects on the formation of early withdrawal memory; (2) the inhibition of the BLA-ACC projection had no effects on the retrieval of either early or long-term withdrawal memory; and (3) the persistent inhibition of the BLA-ACC projection after early withdrawal memory formation could inhibit the formation of long-term withdrawal memory and decrease Arc protein expression in the ACC. These results suggested that the persistent activation of the BLA-ACC projection after the formation of early withdrawal memory facilitates the formation of long-term withdrawal memory by increasing the plasticity of ACC neurons.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Journal: A randomised, double-blind study investigating the relationship between early childhood trauma and the rewarding effects of morphine. (Pubmed Central) - Feb 3, 2022
Childhood trauma may therefore sensitise individuals to the pleasurable and motivational effects of opioids and reduce sensitivity to the negative effects, providing compelling evidence for individual differences in opioid reward sensitivity. This may explain the link between childhood trauma and vulnerability to OUD, with consequent implications on interventions for OUD, the prescribing of opioids, and reducing stigmas surrounding OUD.
- |||||||||| morphine sulphate / Generic mfg.
Journal: The in situ near-total pancreatectomy (LIVOCADO procedure) for end-staged chronic pancreatitis. (Pubmed Central) - Feb 3, 2022
The Livocado procedure was safe and carried out successfully in patients with chronic pancreatitis with vascular involvement where other procedures would be contraindicated. Perioperative outcomes, post-operative pain scores, and employment rehabilitation were comparable with other procedures carried out in patients without vascular involvement.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Journal: Bupivacaine Use After Posterior Colporrhaphy to Reduce Postoperative Pain: A Multicenter, Double-Blinded, Placebo-Controlled, Randomized Clinical Trial. (Pubmed Central) - Feb 3, 2022
Perioperative outcomes, post-operative pain scores, and employment rehabilitation were comparable with other procedures carried out in patients without vascular involvement. Use of bupivacaine for muscle block after posterior colporrhaphy does not reduce postoperative pain, opiate use, and time to first bowel movement, or increase void trial success.
- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal: Activation of the spinal EGFR signaling pathway in a rat model of cancer-induced bone pain with morphine tolerance. (Pubmed Central) - Feb 3, 2022
Inhibition of EGFR by a small molecule inhibitor markedly attenuated the degree of morphine tolerance and decreased the number of microglia, and the protein levels of EGFR, p-EGFR, ERK1/2, and p-ERK1/2 were also reduced. In summary, our results suggest that the activation of the EGFR signaling pathway in spinal microglia plays an important modulatory role in the development of morphine tolerance and that inhibition of EGFR may provide a new therapeutic option for cancer-induced bone pain.
- |||||||||| temozolomide / Generic mfg., methamphetamine / Generic mfg.
Preclinical, Journal: Hippocampal neurogenesis interferes with extinction and reinstatement of methamphetamine-associated reward memory in mice. (Pubmed Central) - Feb 3, 2022
Drugs of abuse, including morphine and cocaine, can reduce hippocampal neurogenesis (HN)...To promote/inhibit HN levels, 7,8-dihydroxyflavone (DHF), a small tyrosine kinase receptor B (TrkB) agonist and temozolomide (TMZ), an alkylating agent, were administered intraperitoneally (i.p.), respectively...The present study indicated that METH administration could induce a temporal inhibitory effect on HN. More importantly, promotion of HN after the acquisition of METH-associated reward memory, but not inhibition of HN or promotion of HN before the acquisition of reward memory, could facilitate METH extinction and inhibit METH reinstatement, indicating the beneficial effect of HN on METH addiction by erasing the according reward memory.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Variation in opioid prescribing patterns after abdominal transplant surgery. (Pubmed Central) - Feb 3, 2022
More importantly, promotion of HN after the acquisition of METH-associated reward memory, but not inhibition of HN or promotion of HN before the acquisition of reward memory, could facilitate METH extinction and inhibit METH reinstatement, indicating the beneficial effect of HN on METH addiction by erasing the according reward memory. The wide variation in opioid prescribing patterns has implications for transplant practice innovation, guideline development, and further study.
- |||||||||| morphine sulphate / Generic mfg., methadone / Generic mfg.
Preclinical, Journal: Buprenorphine Increases HIV-1 Infection In Vitro but Does Not Reactivate HIV-1 from Latency. (Pubmed Central) - Feb 3, 2022
our results suggest that buprenorphine, in contrast to morphine or methadone, increases the in vitro susceptibility of leukocytes to HIV-1 infection but has no effect on in vitro HIV reactivation. These findings contribute to our understanding how opioids, including those used for MAT, affect HIV infection and reactivation, and can help to inform the choice of MAT for people living with HIV or who are at risk of HIV infection.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Retrospective data, Journal: Effect of Enhanced Recovery Protocol on Opioid Use in Pelvic Organ Prolapse Surgery. (Pubmed Central) - Feb 3, 2022
Our results were primarily driven by patients on lower buprenorphine dose as only 22% of patients were on daily doses of 24▒mg or above. Women undergoing apical pelvic organ prolapse surgery at an academic medical center received significantly fewer opioids after implementation of an ERP without a change in postoperative pain scores.
- |||||||||| morphine sulphate / Generic mfg.
Retrospective data, Journal: An Interprofessional Approach to Chronic Pain Management and Education. (Pubmed Central) - Feb 3, 2022
Women undergoing apical pelvic organ prolapse surgery at an academic medical center received significantly fewer opioids after implementation of an ERP without a change in postoperative pain scores. Our study illustrates the effectiveness of an interprofessional committee in lowering prescribed opioid doses and enhancing chronic pain education in a community-based residency setting.
- |||||||||| morphine sulphate / Generic mfg., ketamine / Generic mfg.
Preclinical, Journal: Stimulatory and inhibitory effects of morphine on pentylenetetrazol-induced epileptic activity in rat. (Pubmed Central) - Feb 2, 2022
Moreover, being pretreatment with naloxone at a dose of 1 mg/kg, the morphine group showed significantly increased in the spike count (p < 0.05). Morphine has biphasic effects on PTZ-induced epileptiform activities that way at a low dose has an inhibitory effect, but if the dose is increased, it will intensify the desired event and that the stimulatory effects of morphine appear not to be via opioid receptors.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Observational data, Journal: Safety of ibogaine administration in detoxification of opioid dependent individuals: a descriptive open-label observational study. (Pubmed Central) - Feb 2, 2022
Morphine has biphasic effects on PTZ-induced epileptiform activities that way at a low dose has an inhibitory effect, but if the dose is increased, it will intensify the desired event and that the stimulatory effects of morphine appear not to be via opioid receptors. An open-label observation study found that ibogaine treatment of patients with opioid use disorder can induce a clinically relevant but reversible QTc prolongation, bradycardia, and severe ataxia.
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