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- | morphine sulphate / Generic mfg.
Journal: Opioid Prescribing after Implementation of Single Click Access to a State Prescription Drug Monitoring Program Database in a Health System's Electronic Health Record. (Pubmed Central) - Feb 11, 2022
Integration of the PDMP into the EHR markedly increased the number of searches but was associated with modest decreases in opioids prescribed and patients receiving a prescription. Single click EHR integration of the PDMP, if implemented broadly, may be a way for states to significantly increase PDMP utilization.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Comparison of intraoperative and short-term postoperative outcomes between robot-assisted laparoscopic multi-port pyeloplasty using the da Vinci Si system and single-port pyeloplasty using the da Vinci SP system in children. (Pubmed Central) - Feb 11, 2022
This study confirmed that pyeloplasty using the da Vinci® SP system can be started by robotic surgeons who can overcome the learning curve. Robot-assisted laparoscopic single-port pyeloplasty is feasible in noninfant pediatric patients.
- | pethidine / Samaritan
Journal: Analgesic effects of ultrasound-guided fourquadrant transversus abdominis plane in patients with cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: a prospective, randomized, controlled study. (Pubmed Central) - Feb 11, 2022
Robot-assisted laparoscopic single-port pyeloplasty is feasible in noninfant pediatric patients. The 4Q-TAP block enhanced multimodal analgesia and decreased opioid requirements in patients with CRS with HIPEC, but did not change postoperative recovery outcomes.
- || morphine sulphate / Generic mfg.
Retrospective data, Review, Journal: Intravenous lidocaine in spine surgery: A meta-analysis of randomized controlled trials. (Pubmed Central) - Feb 11, 2022
Cumulative morphine consumption at 48 h was not statistically significant between lidocaine and control groups...Our results indicated that current literature does not support the use of intravenous lidocaine as an adjunctive measure of pain management after spine surgery. Given the relatively few numbers of studies in this field, further randomized controlled trials are needed to make a definitive conclusion on the effectiveness of lidocaine in spine surgery patients.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Bilateral Radioscopically-Guided Erector Spinae Plane Block for Postoperative Analgesia in Spine Surgery: A Randomized Clinical Trial. (Pubmed Central) - Feb 11, 2022
The ESP block is a safe procedure which seems to outperform the infiltration wound technique for postoperative pain management in patients undergoing open spinal surgery. Future studies are needed to verify its effectiveness for arthrodesis/fixation and minimally-invasive procedures, and for chronic spine pain relief.
- || morphine sulphate / Generic mfg.
Clinical, Journal, Combination therapy: Comparison of Femoral Triangle Block in Combination with IPACK to Local Periarticular Injection in Total Knee Arthroplasty. (Pubmed Central) - Feb 11, 2022
Future studies are needed to verify its effectiveness for arthrodesis/fixation and minimally-invasive procedures, and for chronic spine pain relief. Combining FTB and IPACK significantly increased the quadriceps muscle in patients, together with relieving early pain and reducing the amount of anesthetic consumption at different postoperative intervals.
- | morphine sulphate / Generic mfg.
New P3 trial: Subcutaneous Versus Intravenous Morphine When Switching From Oral to Parenteral Route in Palliative Cancer Patients (clinicaltrials.gov) - Feb 10, 2022
P3, N=60, Not yet recruiting, Sponsor: University Hospital, Akershus
- || tramadol hydrochloride / Generic mfg.
Clinical, Journal, Real-world evidence: Real-World Data on Nonmedical Use of Tramadol from Patients Evaluated for Substance Abuse Treatment in the NAVIPPRO Addiction Severity Index-Multimedia Version (ASI-MV) Network. (Pubmed Central) - Feb 10, 2022
Tramadol had a significantly lower rate of NMU than comparator opioids and was less likely to be diverted or used via higher-risk non-oral routes. These findings support previous evaluations by WHO and the United States Drug Enforcement Agency that concluded that tramadol has a low potential for abuse.
- | morphine sulphate / Generic mfg.
Journal: Prescribing Trends in Post-Operative Pain Management After Urologic Surgery: A Quality Care Investigation for Healthcare Providers. (Pubmed Central) - Feb 10, 2022
Approximately 1 in 7 postoperative urology patients receive a postoperative narcotics refill; however, nearly two-thirds receive refills exclusively from non-urologic providers. Attempts to avoid overprescribing of post-operative narcotics need to account for both surgeon and non-surgeon sources of opioid refills.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Contrasting effects of the α7 nicotinic receptor antagonist methyllycaconitine in different rat models of heroin reinstatement. (Pubmed Central) - Feb 10, 2022
We showed previously that the α7 nicotinic acetylcholine receptor antagonist, methyllycaconitine, specifically attenuated morphine-primed reinstatement of conditioned place preference in rodents and this effect was mediated in the ventral hippocampus...The α7 nicotinic acetylcholine receptor antagonist, methyllycaconitine, prevented reinstatement of the opioid conditioned place preference, consistent with a role for α7 nicotinic acetylcholine receptors in the retrieval of associative memories of drug liking. The lack of effect of methyllycaconitine in heroin-dependent rats in two intravenous self-administration models suggests that α7 nicotinic acetylcholine receptors do not play a role in later stages of heroin abuse.
- || Procoralan (ivabradine) / Amgen, Servier, Ono Pharma
Review, Journal: Regulatory Role of Endogenous and Exogenous Fibroblast Growth Factor 1 in the Cardiovascular System and Related Disease. (Pubmed Central) - Feb 10, 2022
Finally, we highlight therapeutic considerations of FGF1 for CVD in the future. Thus, this article may be as a reference to provide some ideas for the follow-up research.
- | morphine sulphate / Generic mfg.
Journal: The role of circTmeff-1 in incubation of context-induced morphine craving. (Pubmed Central) - Feb 10, 2022
These findings suggested that circTmeff-1, a novel circRNA, promotes incubation of context-induced morphine craving by sponging miR-541/miR-6934 in the NAc core. Thus, circTmeff-1 represents a potential therapeutic target for context-induced opioid craving, following prolonged abstinence.
- || morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Clinical, Journal: Hydromorphone and codeine concentrations in oral fluid specimens from patients receiving substitution therapy with Substitol™ (morphine sulphate). (Pubmed Central) - Feb 10, 2022
Clinical administration of morphine can lead to detectable concentrations of both hydromorphone and codeine in oral fluids. This should be taken into consideration when using drug testing in oral fluid samples for compliance assessment in this patient group.
- || metformin / Generic mfg.
Clinical, PK/PD data, Journal: Oral and intravenous pharmacokinetics of metformin with and without oral codeine intake in healthy subjects - a cross-over study. (Pubmed Central) - Feb 10, 2022
These small pharmacokinetic changes may well contribute to an increased risk of early discontinuation of metformin. Hence, a clinically relevant drug-drug interaction between metformin and codeine seems plausible.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Myelopeptides Reduce Morphine Tolerance in C57BL/6j Mice. (Pubmed Central) - Feb 10, 2022
In the hot plate test, only three myelopeptides (MP2, MP5, and MP6) were found to reduce the formation of morphine tolerance. MP1 significantly reduced the analgesic effect of morphine on days 1-3 of administration, but contributed to the preservation of the analgesic effect during the period of tolerance development.
- | morphine sulphate / Generic mfg.
Journal: Perceptions on the use of opioids in COVID-19 : A survey of members of the German Association for Palliative Medicine (Pubmed Central) - Feb 10, 2022
DGP members perceived substantial uncertainty in the handling of M/O for medical fields outside PC. Uniform interdisciplinary guidelines for symptom control, more education, and involvement of a PC consultation team should be increasingly considered in the future.
- | morphine sulphate / Generic mfg.
Journal: Alternative Splicing Mechanisms Underlying Opioid-Induced Hyperalgesia. (Pubmed Central) - Feb 10, 2022
Insights into the nociceptive and antinociceptive modulatory action of Hnrnpk were gained. The results from our study highlight the impact of alternative splicing and transcriptional regulators on OIH and expose the need for isoform-level research to advance the understanding of morphine-associated hyperalgesia.
- | morphine sulphate / Generic mfg.
Biomarker, Journal: Blockade of CC Chemokine Receptor Type 3 Diminishes Pain and Enhances Opioid Analgesic Potency in a Model of Neuropathic Pain. (Pubmed Central) - Feb 10, 2022
Moreover, we have shown for the first time that an inhibitor of myeloperoxidase-4-aminobenzoic hydrazide may relieve pain and simultaneously enhance morphine and buprenorphine efficacy. The obtained results indicate the important role of CCR3 and its modulation in neuropathic pain treatment and suggest that it represents an interesting target for future investigations.
- || morphine sulphate / Generic mfg.
Review, Journal: Plant Secondary Metabolites Produced in Response to Abiotic Stresses Has Potential Application in Pharmaceutical Product Development. (Pubmed Central) - Feb 10, 2022
Plants either synthesize new chemicals or increase the concentration (in most instances) of existing chemicals, including the prominent bioactive lead compounds morphine, camptothecin, catharanthine, epicatechin-3-gallate (EGCG), quercetin, resveratrol, and kaempferol...This review provides an overview of variation in bioactive phytochemical production in plants under various abiotic stress and their potential in the biodiscovery of therapeutic drugs. We excluded studies on the effects of biotic stress on PSMs.
- ||||||| SHR0410 / Jiangsu Hengrui Medicine
Trial completion, Trial completion date, Surgery: A Trial of SHR0410 Injection for the Treatment of Pain After Endoscopic Surgery of the Lower Abdominal (clinicaltrials.gov) - Feb 10, 2022
P3, N=228, Completed, Sponsor: Jiangsu HengRui Medicine Co., Ltd.
We excluded studies on the effects of biotic stress on PSMs. Not yet recruiting --> Completed | Trial completion date: Dec 2021 --> Jul 2021
- | morphine sulphate / Generic mfg., methamphetamine / Generic mfg.
Journal: Endocannabinoids and addiction memory: Relevance to Methamphetamine/Morphine Abuse. (Pubmed Central) - Feb 10, 2022
Also, the amygdala, hippocampus, and prefrontal cortex are three important brain regions that participate in both drug addiction and memory task processes, and endocannabinoid neurotransmission have been investigated. This review aims to summarize the role of ECS in the modulation of METH/morphine-induced memory impairments.
- | morphine sulphate / Generic mfg.
Enrollment change, Trial termination: pRESTO: Slow-Release Oral Morphine for the Treatment of Opioid Use Disorder (clinicaltrials.gov) - Feb 10, 2022
P3, N=27, Terminated, Sponsor: M. Eugenia Socias
This review aims to summarize the role of ECS in the modulation of METH/morphine-induced memory impairments. N=198 --> 27 | Suspended --> Terminated; Study unable to proceed per protocol due to COVID-19 precautions
- | morphine sulphate / Generic mfg.
Journal: Enriched environment and social isolation differentially modulate addiction-related behaviors in male offspring of morphine-addicted dams: the possible role of μ-opioid receptors and ΔFosB in the brain reward pathway. (Pubmed Central) - Feb 9, 2022
However, rearing in the EE declined ΔFosB protein expression. Together, these findings help to elucidate long lasting impacts of early life morphine exposure and rearing environment on the behavioral and molecular profile of addicted individuals.
- || morphine sulphate / Generic mfg.
Review, Journal: Endogenous Opiates and Behavior: 2019. (Pubmed Central) - Feb 9, 2022
This paper is the forty-second consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2019 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides and receptors as well as effects of opioid/opiate agonists and antagonists. The review is subdivided into the following specific topics: molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors (1), the roles of these opioid peptides and receptors in pain and analgesia in animals (2) and humans (3), opioid-sensitive and opioid-insensitive effects of nonopioid analgesics (4), opioid peptide and receptor involvement in tolerance and dependence (5), stress and social status (6), learning and memory (7), eating and drinking (8), drug abuse and alcohol (9), sexual activity and hormones, pregnancy, development and endocrinology (10), mental illness and mood (11), seizures and neurologic disorders (12), electrical-related activity and neurophysiology (13), general activity and locomotion (14), gastrointestinal, renal and hepatic functions (15), cardiovascular responses (16), respiration and thermoregulation (17), and immunological responses (18).
- | morphine sulphate / Generic mfg., disulfiram / Generic mfg.
Preclinical, Journal: Treatment with dopamine β-hydroxylase (DBH) inhibitors prevents morphine use and relapse-like behavior in rats. (Pubmed Central) - Feb 9, 2022
The review is subdivided into the following specific topics: molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors (1), the roles of these opioid peptides and receptors in pain and analgesia in animals (2) and humans (3), opioid-sensitive and opioid-insensitive effects of nonopioid analgesics (4), opioid peptide and receptor involvement in tolerance and dependence (5), stress and social status (6), learning and memory (7), eating and drinking (8), drug abuse and alcohol (9), sexual activity and hormones, pregnancy, development and endocrinology (10), mental illness and mood (11), seizures and neurologic disorders (12), electrical-related activity and neurophysiology (13), general activity and locomotion (14), gastrointestinal, renal and hepatic functions (15), cardiovascular responses (16), respiration and thermoregulation (17), and immunological responses (18). These results seem to point to the significance of DBH inhibition as a potential pharmacotherapy against morphine use disorders.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Effects of the selective dopamine D receptor antagonist PG01037 on morphine-induced hyperactivity and antinociception in mice. (Pubmed Central) - Feb 9, 2022
These results suggest that attenuation of acute opioid-induced hyperactivity may be a behavioral effect shared among DR-selective antagonists, thus supporting continued investigations into their use as potential treatments for opioid use disorder. However, PG01037 is unlike newer, highly-selective DR antagonists in its capacity to reduce opioid-induced antinociception, indicating that modulation of opioid analgesia may vary across different DR antagonists.
- || Exparel (bupivacaine liposome injectable suspension) / Pacira
Clinical, Retrospective data, Journal: Next day discharge after the Nuss procedure using intercostal nerve cryoablation, intercostal nerve blocks, and a perioperative ERAS pain protocol. (Pubmed Central) - Feb 9, 2022
However, PG01037 is unlike newer, highly-selective DR antagonists in its capacity to reduce opioid-induced antinociception, indicating that modulation of opioid analgesia may vary across different DR antagonists. INC combined with bupivacaine intercostal nerve blocks and a pre- and post-hospital analgesia protocol facilitated discharge one day after the Nuss procedure, achieved excellent pain control, and eliminated the need for intravenous opioids.
- | morphine sulphate / Generic mfg.
Journal: Inhibition of Geranylgeranylacetone on cholecystokinin-B receptor, BDNF and dopamine D1 receptor induced by morphine. (Pubmed Central) - Feb 9, 2022
Then, our results showed that morphine increased the expressions of dopamine D1 receptor, tyrosine hydroxylase (TH), CCKB receptor and BDNF in the VTA and NAc in mice, which was inhibited by GGA. These results suggest that CCK and BDNF in dopaminergic systems are associated with the role of GGA blocking morphine-CPP.
- | morphine sulphate / Generic mfg.
Journal: Ultrasound-guided erector spinae plane block versus thoracic epidural analgesia: Postoperative pain management after Nuss repair for pectus excavatum. (Pubmed Central) - Feb 9, 2022
These results suggest that CCK and BDNF in dopaminergic systems are associated with the role of GGA blocking morphine-CPP. Ultrasound-guided ESPB is thus a feasible, safe, and effective alternative to TEA in postoperative pain management after Nuss repair and results in decreased hospital stay.
- | morphine sulphate / Generic mfg.
Preclinical, Journal, IO biomarker: Effects of different intensities of treadmill exercise on cued fear extinction failure, hippocampal BDNF decline, and Bax/Bcl-2 ratio alteration in chronic - morphine treated male rats. (Pubmed Central) - Feb 9, 2022
Light and moderate, but not high-intensity treadmill exercise enhanced the up-regulation of Bcl-2 and down-regulation of the Bax proteins in both saline- and morphine-treated rats, which shifted the balance between pro-apoptotic and anti-apoptotic factors in favor of cell survival. These findings highlight the impact of exercise up to moderate intensity in the recovery of cued extinction failure, more likely via BDNF in addicted individuals.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Amniotic membrane dressing versus nitrofurazone-impregnated dressing in the treatment of second-degree burn wounds: a randomized clinical trial. (Pubmed Central) - Feb 9, 2022
This study indicated that the use of amniotic membrane dressing improved factors key to healing in second-degree burn wounds compared with nitrofurazone-impregnated dressing. Further research with a larger sample is warranted.
- | morphine sulphate / Generic mfg.
Trial completion date, Trial primary completion date: Individualized Analgesia for Pediatric Adenotonsillectomy (clinicaltrials.gov) - Feb 9, 2022
P4, N=128, Not yet recruiting, Sponsor: Children's Hospital of Fudan University
Further research with a larger sample is warranted. Trial completion date: Sep 2022 --> Dec 2023 | Trial primary completion date: Jun 2022 --> Jun 2023
- | Lucemyra (lofexidine) / US WorldMeds, Stada
Trial completion date, Trial initiation date, Trial primary completion date: Assessing a Clinically-meaningful Opioid Withdrawal Phenotype (clinicaltrials.gov) - Feb 9, 2022
P2, N=60, Recruiting, Sponsor: Johns Hopkins University
Trial completion date: Sep 2022 --> Dec 2023 | Trial primary completion date: Jun 2022 --> Jun 2023 Trial completion date: Jul 2026 --> Jan 2026 | Initiation date: Oct 2021 --> Feb 2022 | Trial primary completion date: Jul 2026 --> Nov 2025
- || morphine sulphate / Generic mfg.
Clinical, Journal: Preadmission Cannabis Use Is Positively Correlated With Inpatient Opioid Dose Exposure in Hospitalized Patients With Inflammatory Bowel Diseases. (Pubmed Central) - Feb 8, 2022
Cannabis use is positively correlated with inpatient opioid exposure after controlling for confounders. A personalized pain management approach should be considered to limit inpatient and possibly future opioid exposure among hospitalized patients with IBD who use cannabis.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Early life maternal deprivation attenuates morphine-induced inhibition in lateral paragigantocellularis neurons in adult rats. (Pubmed Central) - Feb 8, 2022
These findings suggest that early life MD induces long-term alterations in LPGi neuronal activity in response to acute administration of morphine. Therefore, the MD may alter the vulnerability to develop opiate abuse in adulthood.
- | morphine sulphate / Generic mfg., ketamine / Generic mfg.
Preclinical, Journal: Sub-chronic Exposure to Morphine Alters General Anesthetic Potency by Differentially Regulating the Expression of Neurotransmitter Receptor Subunits in Mice. (Pubmed Central) - Feb 8, 2022
Therefore, the MD may alter the vulnerability to develop opiate abuse in adulthood. Sub-chronic exposure to morphine can differentially modulate the expressions of NR1 and GABARβ3 in mice, which may contribute to the changes in ED of ketamine and propofol in vivo.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., methadone / Generic mfg.
Journal: The effects of morphine, methadone, and fentanyl on mitochondria: a live cell imaging study. (Pubmed Central) - Feb 8, 2022
Both methadone and fentanyl altered mitochondrial morphology with no effects seen from morphine treatment. These data suggest that methadone and fentanyl impact mitochondrial morphology negatively, which may be associated with neuronal cell death.
- | morphine sulphate / Generic mfg., cisplatin / Generic mfg.
Preclinical, Journal: Morphine Deteriorates Cisplatin-Induced Cardiotoxicity in Rats and Induces Dose-Dependent Cisplatin Chemoresistance in MCF-7 Human Breast Cancer Cells. (Pubmed Central) - Feb 8, 2022
In MCF-7 breast cancer cells, administration of MOR in concentrations of 0.1, 1, 10 or 30 μM concomitantly with 1 or 10 μM CP caused dose-dependent reduction in CP-induced cytotoxicity in vitro. In conclusion, MOR administration might deteriorate CP-induced cardiotoxicity during cancer chemotherapy through oxidant, pro-inflammatory and apoptotic mechanisms, and might reduce CP chemotherapeutic efficacy.
- | morphine sulphate / Generic mfg.
Journal: Benefits of the enhanced recovery after surgery pathway for orthognathic surgery. (Pubmed Central) - Feb 8, 2022
The patient charts were analyzed for postoperative opioid consumption (measured in morphine milligram equivalents, MME) and PONV...The ERAS group also had a lower incidence of PONV, with 1.2 episodes of PONV compared to 2.4 episodes in the non-ERAS group (P= 0.008). This study demonstrates that the ERAS protocol is effective in decreasing postoperative opioid consumption and PONV.
- || morphine sulphate / Generic mfg.
Review, Journal: Molecular Mechanism of Neuroprotective Effect of Melatonin on Morphine Addiction and Analgesic Tolerance: an Update. (Pubmed Central) - Feb 8, 2022
In this review, we attempt to summarize the recent findings about the beneficial effect and molecular mechanism of melatonin on mitochondrial dysfunction, uncontrolled autophagy, and neuroinflammation in morphine addiction and morphine analgesic tolerance. We propose that melatonin might be a useful supplement in the treatment opiate abuse.
- | amphetamine / Generic mfg.
Journal: Combined Cardiopulmonary Assessments Using Impedance and Digital Implants in Conscious Freely Moving Cynomolgus Monkeys, Beagle Dogs, and Göttingen Minipigs: Pharmacological Characterization and Social Housing Effects. (Pubmed Central) - Feb 8, 2022
Concomitant monitoring of cardiovascular and respiratory parameters from the same animals may help reduce the number of animals (3 Rs) needed to fulfill the S7A guidelines and allows for identification of organ system functional correlations. Globally, the data support the use of social housing in non-rodents for safety pharmacology multi-organ system (heart and lungs) monitoring investigations.
- | morphine sulphate / Generic mfg.
Journal: Association Between Local Anesthetic Dosing, Postoperative Opioid Requirement, and Pain Scores After Lumpectomy and Sentinel Lymph Node Biopsy with Multimodal Analgesia. (Pubmed Central) - Feb 8, 2022
Higher amounts of local anesthetics reduce acute postoperative pain and opioid requirement after lumpectomy and SLNB. Maximizing dosing within weight-based limits is a low-risk, cost-effective pain control strategy that can be used in diverse practice settings.
- | morphine sulphate / Generic mfg., gabapentin / Generic mfg.
Journal, Combination therapy: Gabapentin and intrathecal morphine combination therapy results in decreased oral narcotic use and more consistent pain scores after posterior spinal fusion for adolescent idiopathic scoliosis. (Pubmed Central) - Feb 8, 2022
Addition of gabapentin resulted in reduced oral opioid consumption and more consistent postoperative pain scores after PSF for AIS. The patients who received intrathecal morphine and gabapentin also experienced a lower rate of nausea/vomiting and pruritus.
- || morphine sulphate / Generic mfg.
Clinical, Retrospective data, Journal: Unstable minimally displaced lateral compression type 1 (LC1) pelvic ring injuries have a similar hospital course as intertrochanteric femur fractures. (Pubmed Central) - Feb 8, 2022
Patients with minimally displaced unstable LC1 injuries had worse hospital courses than stable LC1 injuries and similar hospital courses as intertrochanteric femur fractures. These findings emphasize the associated morbidity of unstable LC1 injuries.
- || midazolam hydrochloride / Generic mfg., clonidine / Generic mfg.
Clinical, Retrospective data, Journal: Use of continuous infusion of clonidine for sedation in critically ill infants and children. (Pubmed Central) - Feb 8, 2022
Continuous infusion of clonidine in critically ill children is safe and effective. Clonidine is a sedative-sparing agent and this can help reduce complications associated with prolonged use of opioids and benzodiazepines.
- | morphine sulphate / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Morphine (clinicaltrials.gov) - Feb 8, 2022
P1/2, N=30, Completed, Sponsor: University of Texas Southwestern Medical Center
Clonidine is a sedative-sparing agent and this can help reduce complications associated with prolonged use of opioids and benzodiazepines. Recruiting --> Completed | Trial completion date: May 2022 --> Jan 2022 | Trial primary completion date: May 2022 --> Jan 2022
- || pethidine / Samaritan
Clinical, Journal: Comparison between continuous rate infusion and target-controlled infusion of propofol in dogs: a randomized clinical trial. (Pubmed Central) - Feb 8, 2022
Both techniques provided a smooth induction of anaesthesia but caused a high incidence of side effects. Titration of anaesthesia with TCI caused fewer fluctuations in Cp and lower risk of hypotension compared with CRI.
- || ketamine / Generic mfg.
Review, Journal: Motor Cortex Stimulation for Pain: A Narrative Review of Indications, Techniques, and Outcomes. (Pubmed Central) - Feb 8, 2022
Scientific evidence supports the use of MCS for treatment of refractory neuropathic pain syndromes. Further studies are warranted to elucidate the specific indications and stimulation protocols that are most amenable to the different types of MCS.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Experimental Study on the Central Mechanism of Penehyclidine Hydrochloride against Relapse Behavior in Morphine-Dependent Rats. (Pubmed Central) - Feb 8, 2022
Each group was randomly divided into 5 subgroups (n = 10): 4 h after administration, 7 h after administration, 13 h after administration, 25 h after administration (K48, LP48, MP48, and HP48), and 37 h after administration, and then, Morris water maze experiment and immunohistochemical detection of the rat brain hippocampus were carried out. 4 and 7 hours after administration, compared with group 1, the TchE activity increased and Ach level decreased in groups 2, 3, and 4 and the difference was significant (P < 0.05), so the principle of penehyclidine hydrochloride against morphine-dependent rats is that penehyclidine hydrochloride causes cognitive impairment in the brain of mice, thereby achieving antimorphine effects.
- | morphine sulphate / Generic mfg.
Journal: Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia. (Pubmed Central) - Feb 8, 2022
Reduced clinical analgesic efficacy of morphine was recapitulated in a model of high anxiety and OA-like pain, in which endogenous opioid tone was altered, and MOR function attenuated, in the absence of previous exogenous opioid ligand exposure. These findings shed new light on the mechanisms underlying the increased opioid analgesic use in high anxiety patients with chronic pain.