morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Dihydroartemisinin alleviates morphine-induced neuroinflammation in BV-2 cells. (Pubmed Central) -  Feb 19, 2022   
    In conclusion, DHA remarkably suppressed microglial activation and neuroinflammation through regulating miR-16-mediated TLR4/NF-κB signaling. This study may provide a new solution to improve clinical analgesic efficacy of morphine.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Retrospective data, Journal:  Risk predictive tools of perioperative drug hypersensitivity reaction: A case-control study. (Pubmed Central) -  Feb 19, 2022   
    Our predictive tool for perioperative DHR provided a modest predictive ability. History of drug allergies, rhinitis, morphine use and endotracheal intubation were significant risk factors of DHR after adjusting for age and type of surgery.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  A Case Study of Pain Management at End-of-Life for a Patient on High-Dose Buprenorphine. (Pubmed Central) -  Feb 19, 2022   
    We include potential management options and the rationale for our decision to rotate John from high-dose sublingual buprenorphine to subcutaneous oxycodone. We conclude with practice implications and suggestions for improved patient care and clinician experience, including increased collaboration between palliative medicine, acute pain, and addiction medicine services, increased education and training for palliative care specialists about high-dose buprenorphine, and ultimately the development of consensus high-dose buprenorphine to oral morphine equivalence guidelines.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Multimodal Pain Management With Adductor Canal Block Decreases Opioid Consumption Following Total Knee Arthroplasty. (Pubmed Central) -  Feb 19, 2022   
    The mean (SD) IV morphine equivalent dose (MED) requirement was 178.2 (98.0) for the control and 12.0 (24.6) for the protocol group (P < .001)...The described analgesic protocol resulted in significant decreases in IV and total opioid requirement, and lower rates of opioid prescriptions at the first postoperative visit. These findings demonstrate a decrease in opioid utilization with modern perioperative analgesia protocols and reinforce multiple recommendations to decrease opioid exposure and access.
  • ||||||||||  Nontraumatic Subdural Hematoma: A Cautionary Tale of Anticoagulation with Parenteral Prostacyclin Therapy (Area K, Hall F (North Building, Exhibition Level), Moscone Center) -  Feb 19, 2022 - Abstract #ATS2022ATS_4758;    
    Head imaging should be obtained in the setting of headache when prostacyclin therapy and anticoagulation are being used in combination, especially at low doses. Until further studies support anticoagulation use, caution should be given when using empiric anticoagulation in the management of PAH.
  • ||||||||||  morphine sulphate / Generic mfg.
    Careful Long-Term Opioid Prescription May Safely Relieve Chronic Breathlessness (Area F, Hall F (North Building, Exhibition Level), Moscone Center) -  Feb 19, 2022 - Abstract #ATS2022ATS_2733;    
    This study reflected the real-world practice of opioid prescription for chronic breathlessness to a particularly vulnerable patient group who were at high risk for opioid-associated adverse effects. With careful prescribing and long-term holistic patient-centered care, these patients safely used long-term, low-dose oral opioids for breathlessness with relatively good effect and compliance, with no serious adverse events.
  • ||||||||||  Nucala (mepolizumab) / GSK
    Successful Use of Mepolizumab for Steroid-Dependent Chronic Eosinophilic Pneumonia (Area B, Hall F (North Building, Exhibition Level), Moscone Center) -  Feb 19, 2022 - Abstract #ATS2022ATS_2682;    
    Medications included pregabalin, quetiapine, olanzapine, duloxetine, oxycodone, and morphine...She was prescribed prednisone 50 mg/day, and tapered to 30 mg/d with improvement in pulmonary symptoms...Methotrexate and OCS were rapidly weaned off and eosinophil levels were suppressed...Chest computed tomography demonstrating bilateral ground glass opacities (B) and peripheral consolidation (C). Evolution in blood eosinophil counts and therapy (D).
  • ||||||||||  morphine sulphate / Generic mfg.
    Cerebrovascular CO2 Responsiveness in Opioid Associated Sleep Disordered Breathing (Area A, Hall F (North Building, Exhibition Level), Moscone Center) -  Feb 19, 2022 - Abstract #ATS2022ATS_1709;    
    Our preliminary results demonstrate similar HCVD between opioid associated SDB and control patients. In future studies, we expect to elucidate the effects of opioid use and variable opioid doses on HCVD.Research funded by VA CSRD Grant number: 1I01CX001938-02A0
  • ||||||||||  morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date:  Programmed Intermittent Bolus Infusion of Thoracic Paravertebral Block for Hepatectomy (clinicaltrials.gov) -  Feb 18, 2022   
    P=N/A,  N=76, Completed, 
    In future studies, we expect to elucidate the effects of opioid use and variable opioid doses on HCVD.Research funded by VA CSRD Grant number: 1I01CX001938-02A0 Recruiting --> Completed | Trial completion date: Jul 2020 --> Dec 2021 | Trial primary completion date: Apr 2020 --> Jun 2021
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date:  Optimal Morphine Dosing Schedule for Neonatal Abstinence Syndrome (clinicaltrials.gov) -  Feb 18, 2022   
    P4,  N=17, Completed, 
    Recruiting --> Completed | Trial completion date: Jul 2020 --> Dec 2021 | Trial primary completion date: Apr 2020 --> Jun 2021 Recruiting --> Completed | Trial completion date: Mar 2022 --> Oct 2021 | Trial primary completion date: Dec 2021 --> Oct 2021
  • ||||||||||  morphine sulphate / Generic mfg.
    Ok. Never morphine. (Twitter) -  Feb 18, 2022   
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., paracetamol / Generic mfg.
    Journal:  Pain management for necrotizing enterocolitis: getting the balance right. (Pubmed Central) -  Feb 17, 2022   
    These findings highlight the need for improvement of neonatal pain management in NEC patients, including better pain monitoring and guidelines for individualized analgesic therapy. Improved pain management guidelines may help to prevent short-term and long-term consequences of neonatal exposure to pain, as well as excessive exposure to opioids.
  • ||||||||||  amphetamine / Generic mfg.
    Journal:  Evaluation of Latent Fingerprints for Drug-Screening In A Social Care Setting. (Pubmed Central) -  Feb 16, 2022   
    The study is a step change in the routine drug screening procedures in a social care setting: especially useful for on-site cocaine detection in clients whose drug use was being monitored. Additionally, testing was easily accepted by clients and social care workers.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Experience with an Enhanced Recovery After Spine Surgery protocol at an academic community hospital. (Pubmed Central) -  Feb 16, 2022   
    The authors found that the development and implementation of a comprehensive ERASS protocol led to a modest reduction in postoperative opiate consumption and hospital length of stay in patients undergoing elective cervical or lumbar procedures. As suggested by these results and those of other groups, the implementation of ERASS protocols may reduce care costs and improve patient outcomes after spine surgery.
  • ||||||||||  morphine sulphate / Generic mfg., mirtazapine / Generic mfg.
    Clinical, Journal:  Heroin Fatality in a Feline: A Case Report with Postmortem Liver Concentrations. (Pubmed Central) -  Feb 16, 2022   
    Subsequent quantitation of mirtazapine, heroin, morphine, 6-acetylmorphine, 6-acetylcodeine was performed by gas chromatography tandem quadrupole mass spectrometry (GC-MS/MS). Although companion animal fatalities arising from toxicities are a likely consequence of drug abuse in a home, this is the first reported case of a malicious feline fatality resulting from heroin with quantitation of heroin metabolites.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Observational data, Journal, Adverse events, IO biomarker:  Influence of genetic variants of opioid-related genes on opioid-induced adverse effects in patients with lung cancer: A STROBE-compliant observational study. (Pubmed Central) -  Feb 16, 2022   
    Incidence rates for 6 adverse effects of opioid therapy (somnolence, nausea, constipation, delirium, urinary retention, and pruritus) were determined and the influence of single nucleotide polymorphisms in coding regions of the opioid μ receptor 1 (OPRM1) (rs1799971), opioid δ receptor 1 (rs2234918), opioid κ receptor 1 (rs1051660), catechol-O-methyltransferase (COMT) (rs4680), dopamine receptor D2 (rs6275), adenosine triphosphate binding cassette B1 (rs1045642), G-protein regulated inward rectifier potassium channel 2 (rs2070995), and fatty acid amide hydrolase (rs324420) genes on those adverse effects were analyzed.Analysis of OPRM1 gene variant status (Asn133Asp A > G) showed that G/G homozygotes were at significantly lower risk of somnolence compared with A allele carriers (0% vs 28.4%; Fisher exact test, P = .005; OR, 0; 95% CI, 0-0.6), and analysis of COMT gene variant status (Val158Met, G > A) showed that G/G homozygotes were at significantly higher risk of somnolence compared with A allele carriers (35.0% vs 10.4%; Fisher exact test, P = .008; OR, 4.5; 95% CI, 1.4-18.1). No relationship between variant status and adverse effects was found for the other genes.These findings demonstrate that OPRM1 and COMT gene variants influence the risk of somnolence as an adverse effect of opioid analgesic therapy.
  • ||||||||||  morphine sulphate / Generic mfg., clonidine / Generic mfg., methadone / Generic mfg.
    Clinical, Review, Journal:  Clinical Pharmacology and Dosing Regimen Optimization of Neonatal Opioid Withdrawal Syndrome Treatments. (Pubmed Central) -  Feb 15, 2022   
    As population pharmacokinetics of pharmacologic agents in NOWS become more well-defined and knowledge of patient-specific factors affecting treatment outcomes continues to accumulate, pharmacokinetic/pharmacodynamic modeling and simulation will be powerful tools to aid the design of optimal dosing regimens at the patient level. Though there is an increasing number of clinical trials on the comparative efficacy of treatment agents in NOWS, here we also draw attention to the importance of optimizing the dosing regimen, which can be arguably equally important as identifying the optimal treatment agent.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Interactive effects of (±)-trans-U50488 and its stereoisomers with cannabinoids. (Pubmed Central) -  Feb 15, 2022   
    When three cannabinoids and morphine were tested in the (±)-U-50488 discrimination procedure to determine the similarity of these drugs' discriminative stimulus effects to those for (±)-U-50488, the rank order similarity was (-)-CP 55,940 > (-)-trans-THC > (+)-WIN 55,212-2 ≥ morphine...Further, the diuretic effect of (-)-CP 55,940 was enhanced by a dose of (+)-U50488, which itself did not alter urine output. These data together indicate that a combination of cannabinoid and kappa opioid agonists can enhance diuresis, but may have limited potential for serving as opioid-sparing pharmacotherapeutics for treatment of pain.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Loss of SUR1 subtype K channels alters antinociception and locomotor activity after opioid administration. (Pubmed Central) -  Feb 15, 2022   
    Hyperlocomotion after administration of morphine and buprenorphine was potentiated in SUR1 KO mice, but was not seen after administration of fentanyl or DAMGO. These results suggest SUR1-subtype K channels mediate the antinociceptive response of several classes of opioids (alkaloid and synthetic/semi-synthetic), but may not contribute to the "drug-seeking" behaviors of all classes of opioids.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Differential expression of H19, BC1, MIAT1, and MALAT1 long non-coding RNAs within key brain reward regions after repeated morphine treatment. (Pubmed Central) -  Feb 15, 2022   
    The MIAT1 and MALAT1 expression site-specifically altered in the midbrain, hypothalamus, and striatum; however, no significant changes were detected in their expression in the PFC and hippocampus after repeated morphine treatment. We conclude that alterations in the expression of these lncRNAs in the brain reward regions especially in the midbrain, striatum and hypothalamus may have critical roles in the development of morphine dependence and tolerance, which need to be considered in future researches.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Hypocretin/orexin interactions with norepinephrine contribute to the opiate withdrawal syndrome. (Pubmed Central) -  Feb 15, 2022   
    We previously found that human heroin addicts and mice chronically exposed to morphine exhibit a significant increase in the number of detected hypocretin/orexin (Hcrt)-producing neurons...This increase is correlated with a massive increase in tyrosine hydroxylase expression in locus coeruleus. Elimination of hypocretin neurons prevents tyrosine hydroxylase increase and dampens the somatic and affective components of opioid withdrawal.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Temporal Trends and Predictors of Opioid Use Among Older Patients With Cancer. (Pubmed Central) -  Feb 15, 2022   
    Temporal trends in opioid use in cancer patients depend on patient, demographic, and tumor characteristics. Overall, understanding these correlations may help physicians better identify patient-specific risks of opioid use and could help better inform future evidence-based, cancer-specific opioid prescription guidelines.
  • ||||||||||  morphine sulphate / Generic mfg., clonidine / Generic mfg., methadone / Generic mfg.
    Journal:  Emerging therapies for the treatment of neonatal abstinence syndrome. (Pubmed Central) -  Feb 11, 2022   
    These emerging therapies may be as effective as morphine or methadone for NAS, in combination with nonpharmacologic strategies. Long-term follow-up is needed.