morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Breaking the Pain Cycle: The Impact of Enhanced Recovery Protocols Following Mastectomy on Long-term Opioid and Sedative Use (Zoom Meeting) -  Feb 25, 2022 - Abstract #SSO2022SSO_15;    
    ERAS protocols for mastectomy patients with or without IBR are associated with decreases in chronic opioid use, without concomitant increases in chronic sedative use. Learning Objectives: Understand how to calculate oral morphine equivalents and understand the definition of opioid naïve Describe the relationship between breast enhanced recovery protocols and the prevalence of chronic opioid use following mastectomy with or without implant-based breast reconstruction Delineate the relationship between breast enhanced recovery protocols and the prevalence of chronic sedative use following mastectomy with or without implant-based breast reconstruction
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Clinical Update on Patient-Controlled Analgesia for Acute Postoperative Pain. (Pubmed Central) -  Feb 25, 2022   
    The most commonly observed complications are nausea and vomiting, pruritus, respiratory depression, sedation, confusion and urinary retention. However, human factors such as pharmacy preparation and device programming can also be involved in the occurrence of these complications, while device failure is much less of an issue.
  • ||||||||||  Journal:  Determination of Prenatal Substance Exposure Using Meconium and Orbitrap Mass Spectrometry. (Pubmed Central) -  Feb 25, 2022   
    The application allows the detection of 88 substances, including 47 pharmaceuticals and 15 pharmaceutical metabolites, cocaine and its metabolites, THC and its metabolites, and natural (morphine, codeine) and synthetic (methadone, buprenorphine, tramadol, norfentanyl) opioids. This method is now used routinely for toxicological screening in high-risk pregnancies.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Comparative analysis of the effects of opioids in angiogenesis. (Pubmed Central) -  Feb 24, 2022   
    Preoperative IV acetaminophen for women undergoing oocyte retrieval did not reduce postoperative pain scores or shorten the time to discharge when compared with PO acetaminophen or placebo and, thus, cannot currently be recommended routinely in this patient population. Our work demonstrates the differential effects and mechanisms of opioids on angiogenesis.
  • ||||||||||  Remitch (nalfurafine) / Toray, Mitsubishi Tanabe
    Journal:  Morphinan derivatives with an oxabicyclo[3.2.1]octane structure as dual agonists toward δ and κ opioid receptors. (Pubmed Central) -  Feb 24, 2022   
    To seek a novel KOR agonist we designed 6-amide derivatives with an oxabicyclo[3.2.1]octane structure based on a proposed active conformation of a selective KOR agonist nalfurafine...On the other hand, 6S-phenylacetamide 8b was potent full DOR agonist with less efficacious agonist activity for the μ receptor and KOR. 6-Amide derivatives with an oxabicyclo[3.2.1]octane structure were expected to be a promising fundamental skeleton for the dual DOR/KOR agonists and/or selective DOR agonists.
  • ||||||||||  gabapentin / Generic mfg., celecoxib oral / Generic mfg.
    Clinical, Review, Journal:  Spinal cord stimulation in the approach to chronic pelvic pain: A case report and literature review. (Pubmed Central) -  Feb 24, 2022   
    Additionally, both EuroQOL-5D and visual analogue scale scores improved after the intervention. Through the combination of spinal cord stimulation Spectra Wavewriter and 3D programming technology, both lumbar and leg pain and CPP were successfully relieved, along with an improvement in the quality of life of the patient.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Association Between Prescription Opioid Therapy for Noncancer Pain and Hepatitis C Virus Seroconversion. (Pubmed Central) -  Feb 24, 2022   
    In secondary analyses, long-term exposure was stratified by intensity of use (chronic vs. episodic) and by average daily dose in morphine equivalents (MEQ)...These results suggest injection drug use initiation risk is higher among people dispensed long-term therapy and may be useful for informing approaches to identify and prevent HCV infection. These findings should not be used to justify abrupt discontinuation of long-term therapy, which could increase risk of harms.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date, Surgery:  Effects of Anaesthesia on Inflammatory Markers (clinicaltrials.gov) -  Feb 24, 2022   
    P=N/A,  N=81, Completed, 
    These findings should not be used to justify abrupt discontinuation of long-term therapy, which could increase risk of harms. Recruiting --> Completed | Trial completion date: Dec 2020 --> Oct 2021 | Trial primary completion date: Dec 2020 --> Oct 2021
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion, Head-to-Head:  TAP Block With Intrathecal Fentanyl vs. Intrathecal Morphine in Cesarean Delivery (clinicaltrials.gov) -  Feb 24, 2022   
    P=N/A,  N=80, Completed, 
    Recruiting --> Completed | Trial completion date: Dec 2020 --> Oct 2021 | Trial primary completion date: Dec 2020 --> Oct 2021 Recruiting --> Completed
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Pharmacometric dose optimization of Buprenorphine in Neonatal Opioid Withdrawal Syndrome. (Pubmed Central) -  Feb 23, 2022   
    Results from Blinded Buprenorphine OR Neonatal morphine solution (BBORN), a previous phase III trial in infants with neonatal opioid withdrawal syndrome (NOWS), demonstrated that sublingual buprenorphine resulted in a shorter duration of treatment and shorter length of hospital stay than the comparator, oral morphine...Simulations indicated that further benefits can be gained by increasing starting doses of buprenorphine and increasing wean rates. Use of a model-based analysis to provide focused guidelines for care can be used with goals of reducing treatment time and hospital stays in infants with NOWS.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Evaluation of Liposomal Bupivacaine at Split Thickness Skin Graft Donor Sites Through a Randomized, Controlled Trial. (Pubmed Central) -  Feb 23, 2022   
    Donor site pain scores and opioid consumption in morphine equivalents (MEE) were evaluated...No adverse events occurred in either group. There is no statistical benefit to the use of liposomal bupivacaine for infiltration at STSG donor sites compared to standard of care with respect to pain control, opioid use, or length of stay when evaluated in a randomized, controlled fashion.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Impact of Opioid-Minimizing Pain Protocols after Burn Injury. (Pubmed Central) -  Feb 23, 2022   
    The primary outcome was total morphine milligram equivalents (MMEs)...The Post group had significantly lower total MME (Post 110 MME [32, 325] versus Pre 230 [60, 840], p<0.001), MME/day (Post 33 MME/day [15, 54] versus Pre 52 [27, 80], p<0.001), and domain-specific total MME. No difference in average normalized pain scores was seen.Implementation of opioid-minimizing protocols for acute burn pain was associated with a significant reduction in inpatient opioid exposure without an increase in pain scores.
  • ||||||||||  midazolam hydrochloride / Generic mfg., dexmedetomidine / Generic mfg.
    Journal:  Reducing Benzodiazepine Exposure by Instituting a Guideline for Dexmedetomidine Usage in the NICU. (Pubmed Central) -  Feb 23, 2022   
    Ketamine or dexmedetomidine CRIs, at the studied rates, did not reduce propofol TIVA requirements in dogs undergoing orthopaedic surgery with epidural anaesthesia. Implementation of a quality improvement initiative was successful in reducing the percentage of patients receiving midazolam infusions and increased midazolam-free days per sedation episode, revealing an overall reduction in benzodiazepine exposure while maintaining adequate sedation.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Analgesic Opioid Ligand Discovery Based on Nonmorphinan Scaffolds Derived from Natural Sources. (Pubmed Central) -  Feb 23, 2022   
    Strong opioid analgesics, including morphine, are the mainstays for treating moderate to severe acute pain and alleviating chronic cancer pain...In this Perspective, medicinal chemistry strategies are addressed, where structurally diverse nonmorphinan-based opioid ligands derived from natural sources were deployed as lead molecules. The current state of play, clinical or experimental status, and novel opioid ligand discovery approaches are elaborated in the context of retaining analgesia with improved safety and reduced adverse effects, especially addiction liability.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Impact of In-Station Medication Automated Dispensing Systems On Prehospital Pain Medication Administration. (Pubmed Central) -  Feb 23, 2022   
    Time at hospital for all calls decreased by more than 11 minutes for all transports, from a median of 34 minutes (IQR; 23.7, 45.5) to 22.7 minutes (IQR:18.5, 27.6) in P3, p < 0.001 and by 27.9 minutes for calls in which a controlled substance was given: P1 = 50.6 minutes (IQR: 34.6, 63.2), P3 = 22.7 minutes (IQR: 18.3, 27.4), p < 0.001. In this system, medication ADS implementation was associated with an increase in the rates of controlled substance administration and a decrease in the time units were at hospitals.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, PK/PD data, Journal:  Quantifying the pharmacodynamics of morphine in the treatment of postoperative pain in preverbal children. (Pubmed Central) -  Feb 22, 2022   
    These findings support a dosing regimen previously suggested by Krekels et al., which would put more than 95% of patients within this morphine target concentration range at steady-state. Our modelling approach provides a promising platform for pharmacodynamic research of analgesics and sedatives in children.
  • ||||||||||  ampicillin / Generic mfg., midazolam hydrochloride / Generic mfg.
    Journal:  Medication Use in the Neonatal Intensive Care Unit and Changes from 2010-2018. (Pubmed Central) -  Feb 22, 2022   
    Trends of medication use in the NICU change substantially over time. It is imperative to identify changes in medication usage in the NICU to better inform further prospective studies.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Mapping of Brain Activity in the Analgesia Induced by Phα1β and Morphine. (Pubmed Central) -  Feb 22, 2022   
    Morphine treatment leads to small and selective inhibition at the bilateral amygdala striatum and accumbens. Our results indicate that the analgesic effect of Phα1β and Morphine possesses a differential profile of central processing in the pain state.
  • ||||||||||  ketamine / Generic mfg.
    Retrospective data, Review, Journal:  Multicenter Retrospective Review of Ketamine Use in the ICU. (Pubmed Central) -  Feb 22, 2022   
    Hemodynamic instability was the most common adverse effect. In the 48 hours after ketamine initiation compared with the 24 hours prior, proportion of time spent in goal pain/sedation score range increased and exposure to other analgesics/sedatives decreased.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Clinical, Journal:  Optimization of the medication-use process for fentanyl patches at a small community hospital. (Pubmed Central) -  Feb 19, 2022   
    However, potential overdose could occur for some tea samples when scaled up to the starter quantity of seed suggested for new users. Evaluation of the fentanyl patch medication-use process and pharmacy-driven interventions resulted in an increase in appropriate utilization of fentanyl patches and a decrease in accessible MME of this potent dosage form.