- |||||||||| morphine sulphate / Generic mfg.
Oral administration of nitrous oxide reduces vaso-occlusive pain in mice with sickle cell disease (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1125;
N2O via HBI-201 shows promise and potential for home use to reduce hospitalization and opioid utilization in sickle patients experiencing a painful VOC. Studies are ongoing, including assessing if oral N2O reduces spontaneous and persisting pain during VOC, and if oral N2O produces side effects including reward and motor dysfunction.
- |||||||||| morphine sulphate / Generic mfg.
Sustained opioid exposure exacerbates chronic osteoarthritis-like pain via regionally-specific alter (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1097;
MEA recordings revealed regional specific change in spinal network activity, indicating a locus in the intermediate and deep dorsal horn. Complementary anatomical (immunohistochemistry & super-resolution microscopy) approaches are being employed to investigate the cellular mechanisms.
- |||||||||| How Can We Make Pain Relief Accessible and Equitable for Children with Cancer Across the World? (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1059;
Nevertheless, the use of acetaminophen and ibuprofen in the context of pediatric pain related to cancer may be limited by concerns of masking fever or bleeding risks, respectively, and the efficacy of tramadol may be limited by its weak opioid effect. Difficulties with obtaining pediatric formulations have been identified and education of pharmacists in local preparation of morphine solution may improve availability.
- |||||||||| tetracycline / Generic mfg.
Tetracycline transactivator expression in keratinocytes triggers chronic, TRPV1-dependent itch (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1019;
As gabapentin, but not morphine, relieved the scratching, we consider this phenotype to result from chronic neuropathic itch, not pain... These temporal properties suggest that the neuropathic itch condition arises not only from localized keratinocyte activation of peripheral nerves but also from a persistent, gabapentin-sensitive state of central sensitization.
- |||||||||| morphine sulphate / Generic mfg.
Peripheral Nerve Stimulation for Refractory Low Back Pain (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_955;
We suggest PNS may provide clinically significant long-term reductions in chronic axial low back pain. Given the minimally invasive nature of PNS, it may be used safely and earlier in treatment algorithms unresponsive to other conservative treatments [3].
- |||||||||| Preassessment Pathway to Optimise Patients on High Dose Opioids & Gabapentinoids Before Surgery (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_947;
This is a challenging and complex patient cohort and a multidisciplinary approach to their chronic conditions and planned surgery is essential with input from surgical specialties, preassessment, chronic pain, anaesthetic and primary care colleagues working together to make their perioperative journey safer with minimal perioperative complications. The preassessment team plays a key role in identifying this high-risk cohorts and coordinating a safer perioperative journey for the patients.
- |||||||||| morphine sulphate / Generic mfg.
Use and adverse effects of opioids after neurotrauma in the transition from acute to chronic pain (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_944;
The average MEDD remained relatively stable during the transition period from acute to chronic pain and within the recognized safe zone for avoiding intoxication in TBI and SCI patients. However, many participants reported drowsiness and constipation, AEs that could be explained by the neurotrauma itself, but could also be exacerbated by opioid use and thus compromise the ability to engage in rehabilitation activities.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
An RCT of pre-anesthetic Subjective Effects of Morphine, Oxycodone, and Fentanyl (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_870;
Contrary to the general assumption that opioids enhance well-being but replicating our earlier results, we show a decrease in 'feeling good' after opioids. Patients also reported reduced anxiety.
- |||||||||| morphine sulphate / Generic mfg.
Uncovering genetic predictors for extreme morphine responses in infants and children (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_860;
Background & Aims: Morphine and fentanyl are commonly prescribed for relief of major pain in infants and children; however, responses range from inadequate pain relief (requiring higher doses/other analgesics) to adverse effects (e.g., respiratory depression, hypotension, allergic reaction), and the long-term consequences of opioid use on the developing brain remain unclear [1,2]. Knowledge of genetic variants that contribute to extreme opioid responses will facilitate development of predictive pharmacogenetic tests so that the safest and most effective pain management strategies are used.
- |||||||||| morphine sulphate / Generic mfg.
Medical opioids in chronic pain: analyzing sleep and stress via wearables and biomarkers (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_856;
In cases of high-dose strong opioid use, there is an observed increase in the severity and depressive nature of pain, which may adversely affect sleep quality. Moreover, the association of high-dose strong opioid use with elevated salivary amylase levels upon waking (rather than before sleeping) suggests that these opioids are more likely impacting sleep quality rather than amplifying subjective stress experienced during the day.
- |||||||||| morphine sulphate / Generic mfg.
Peripheral TREK1 channels contribute to nociceptors excitability and heat sensitivity (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_846;
Background & Aims: The TREK1 potassium channel plays a crucial role in polymodal pain and morphine-induced analgesia... Our findings highlight the involvement of TREK1 in heat sensitivity, implicating a reduction of nociceptors excitability at the periphery together with a contribution of central TREK1 channels that remains to be explored.
- |||||||||| morphine sulphate / Generic mfg.
Spiritual health of drivers with chronic low back pain. (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_824;
Through this study, it became obvious that individuals exhibited spiritual needs in dealing with pain. Handing over to God the power to make major medical decision does not mean giving up free will.
- |||||||||| morphine sulphate / Generic mfg.
Systemic Morphine Administration in the Postnatal Period Alters Adult Spinal Pain Processing (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_818;
We have studied the impact of the administration of morphine, the prototypical opioid analgesic, in pre-adolescent rats. Our data indicate that morphine exposure during this critical preadolescent period alters normal maturation of pain and anxiety responses in a sex-dependent manner.
- |||||||||| Characterization of the Rat MIA Model of Osteoarthritis in Support of the NIH PSPP Program (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_795;
Our data indicate that morphine exposure during this critical preadolescent period alters normal maturation of pain and anxiety responses in a sex-dependent manner. Pharmacology was examined by evaluating dose-dependent effects of the reference analgesics morphine sulfate (0.3
- |||||||||| morphine sulphate / Generic mfg.
First-in-Human Results of a Non-Opioid Implantable Anesthetic in Spine Fixation Surgery (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_726;
A substantial reduction in pain and opioid use was found as compared to a recent observational cohort in the same hospitals. A large randomized controlled trial is planned to substantiate the impact of BR-003 on pain, opioid use, and enhanced recovery after spine fixation surgery.
- |||||||||| fentanyl citrate / Generic mfg., dexamethasone / Generic mfg., morphine sulphate / Generic mfg.
Neurolysis of Superior Hypogastric Plexus in Patient with Penile Cancer Pain and HIV: a Case Report (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_720;
Despite this, superior and inferior hypogastric plexus and ganglion impar block are choices for pelvic pain and genito-urinaria. Bilateral neurolysis of the superior hypogastric plexus was chosen to control pain relating to penile cancer pain at a level that can be acceptable to the patient.
- |||||||||| morphine sulphate / Generic mfg., ketamine / Generic mfg., methadone / Generic mfg.
The Impact of Opioid Prescribing on Nursing Workload (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_659;
This also has a large cost implication.The time taken to sign out CDs could be a barrier to all patients on a ward receiving their drugs in a safe and timely fashion. It may also impact on prioritisation of other nursing tasks.
- |||||||||| fentanyl citrate / Generic mfg.
A Correlation Of Fentanyl Patches Prescribing With Raised Opioid Awareness Over 10 Years in England (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_625;
The maximum dose of OME to 120mg/day would imply all fentanyl patches greater than a 25 microgram patch would exceed this target and therefore should be reviewed and titrated down. The encouraging results can be seen that NuTH and the surrounding primary care setting are working collaboratively to ensure the prescribing trends are in the correct direction.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal: A (Pubmed Central) - Jul 17, 2024
The NAM alters orthosteric ligand kinetics in therapeutically desirable ways and works cooperatively with low doses of naloxone to effectively inhibit various morphine-induced and fentanyl-induced behavioural effects in vivo while minimizing withdrawal behaviours. Our results provide detailed structural insights into the mechanism of negative allosteric modulation of the
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Review: Opioid analgesic use among patients with kidney disease: a systematic review. (Pubmed Central) - Jul 17, 2024
Greater caution and consideration of potential risks and benefits should be applied when using other opioids. Further high-quality studies examining clinical outcomes associated with the use of different opioids and opioid doses in renal disease are warranted.
- |||||||||| methadone / Generic mfg.
Retrospective data, Journal: Post-operative pain control in patients on buprenorphine or methadone for opioid use disorder. (Pubmed Central) - Jul 17, 2024
This study reinforces existing evidence supporting the continuation of medications for opioid use disorder, specifically buprenorphine and methadone, during the perioperative period. Dissemination of guideline recommendations is essential to ensure optimal post-operative pain management for this patient population.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Journal: "What helps your back pain?" A qualitative analysis of pain management strategies in opioid-treated adults with chronic low back pain. (Pubmed Central) - Jul 17, 2024
Over time, the reports of medication and active pain management strategies, eg, physical activity, remained stable, while the reports of some passive pain management strategies, eg, position and thermal, declined over time. Increased use of psychological strategies implies that study interventions were incorporated as useful pain self-management strategies.
- |||||||||| morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg., methadone / Generic mfg.
Review, Journal: Challenges in the treatment of opioid dependence (Pubmed Central) - Jul 15, 2024
The first-line treatment for opioid addiction is opioid-assisted substitution treatment, including diamorphine and heroin-assisted treatment. Long-acting depot medications and implants still play a
- |||||||||| morphine sulphate / Generic mfg.
Journal: Antinociceptive and anti-inflammatory actions of curcumin and nano curcumin: a comparative study. (Pubmed Central) - Jul 15, 2024
Rats were randomly allocated into ten groups of six for formalin and tail-flick tests including the control group, curcumin and nano curcumin groups (20, 50, 100 mg/kg), morphine group (10 mg/kg), naloxone + 100 mg/kg curcumin group, and naloxone + 100 mg/kg nano curcumin group...Myeloperoxidase activity and lipid peroxidation decreased at doses of 50 and 100 mg/kg of curcumin but at three doses of nano curcumin (20, 50, and 100 mg/kg). In conclusion, our results suggest that the nanoemulsion formulation of curcumin can be efficient in reducing pain and especially inflammation in lower doses compared to the native form of curcumin.
- |||||||||| morphine sulphate / Generic mfg.
Preclinical, Journal: Spectrotemporal profiling of ultrasonic vocalizations during neonatal opioid withdrawal reveals a kappa opioid receptor component in female mice. (Pubmed Central) - Jul 15, 2024
To effectively model NOWS traits in mice, we used a third trimester-approximate opioid exposure paradigm, where neonatal inbred FVB/NJ and outbred Carworth Farms White(CFW) pups were injected twice-daily with morphine(10-15mg/kg, s.c.) or saline(0.9%, 20 ul/g, s.c.) from postnatal day(P) one to P14...Furthermore, treatment with the KOR agonist, U50,488h(0.625 mg/kg, s.c.), was sufficient to increase USV emission on P10(both sexes) and on P14(females only) in FVB/NJ mice. Together, these results indicate a female-specific recruitment of the dynorphin/KOR system in neonatal opioid withdrawal symptom severity.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Nucleus accumbens sub-regions experience distinct dopamine release responses following acute and chronic morphine exposure. (Pubmed Central) - Jul 15, 2024
This study uses fiber photometry to examine dopamine changes that occur in response to repeated morphine, and morphine withdrawal, at multiple stages of a longitudinal opioid-dependence paradigm. We reveal key differences in how dopamine levels respond to opioid administration in distinct sub-regions of the ventral striatum and lay a foundation for future opioid research that appreciates our contemporary understanding of the dopamine system.
- |||||||||| morphine sulphate / Generic mfg.
Journal, Surgery: Opioid consumption before discharge predicts outpatient opioid use in adolescents undergoing surgery. (Pubmed Central) - Jul 14, 2024
For adolescents undergoing surgery, patient-reported pain at discharge and oral morphine equivalents administered 24 hours before discharge are associated with cumulative outpatient opioid use. Tailoring outpatient prescriptions to total oral morphine equivalent consumption 24 hours before discharge could reduce excess opioid prescribing.
- |||||||||| morphine sulphate / Generic mfg., alprazolam / Generic mfg., methadone / Generic mfg.
Journal: "Tranq-dope": The first fatal intoxication due to xylazine-adulterated heroin in Italy. (Pubmed Central) - Jul 13, 2024
The combination of central nervous system depressants, i.e., opioids, benzodiazepines, and xylazine, was the principal cause of death by cardiorespiratory failure. The case was promptly reported to the UE Early Warning System on drugs.
- |||||||||| cenicriviroc (TBR-652) / Takeda, AbbVie
Preclinical, Journal: A New Application for Cenicriviroc, a Dual CCR2/CCR5 Antagonist, in the Treatment of Painful Diabetic Neuropathy in a Mouse Model. (Pubmed Central) - Jul 13, 2024
Moreover, repeated coadministration of cenicriviroc with morphine delays the development of opioid tolerance, while the best and longest-lasting analgesic effect is achieved by repeated administration of cenicriviroc alone, which reduces pain hypersensitivity in STZ-exposed mice, and unlike morphine, no tolerance to the analgesic effects of CVC is observed until Day 15 of treatment. Based on these results, we suggest that targeting CCR2 and CCR5 with CVC is a potent therapeutic option for novel pain treatments in diabetic neuropathy patients.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Synthesis and Biological Evaluation of Novel Biased Mu-Opioid Receptor Agonists. (Pubmed Central) - Jul 13, 2024
Molecular docking studies underscore the pivotal role of the D147 amino acid residue in the analgesic mechanism of 6a. Consequently, 6a is a compelling candidate for the development of safer opioid analgesics and warrants further attention.
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