morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Cardiorespiratory anomalies and increased brainstem microglia in a rat model of neonatal opioid withdrawal syndrome. (Pubmed Central) -  Mar 3, 2022   
    Chronic morphine exposure is associated with increased midbrain microglial expression...Microglial cell counts were increased in the nucleus tractus solitarius (nTS), dorsal motor nucleus of the vagus (DMNV) and nucleus ambiguous (NAamb), but not the retrapezoid nucleus (RTN) or the non-cardiorespriatory region, the cuneate nucleus (CN). These data suggest that the cardiorespiratory features and autonomic dysregulation in NOWS infants may be associated with altered microglial function in specific brainstem cardiorespiratory control regions.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Paternal preconception exposure to chronic morphine alters respiratory pattern in response to morphine in male offspring. (Pubmed Central) -  Mar 3, 2022   
    Our results indicated that sires who introduce chronic morphine during adolescence leads to increase irregularity of respiratory pattern and asynchronization between inter-breath interval (IBI) and respiratory volume (RV) time series in male offspring. These findings provide evidence that chronic morphine use by parents even before pregnancy can affect respiratory pattern and response to morphine in the offspring.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  m-CF-substituted diphenyl diselenide attenuates all phases of morphine-induced behavioral locomotor sensitization in mice. (Pubmed Central) -  Mar 3, 2022   
    For patients susceptible to the adverse effects of NSAIDs, a low concentration of SNB and dexamethasone is an effective adjunctive technique for early postoperative pain control (especially on movement) following TKAs, without an increase in motor weakness. (m-CF-PhSe) was effective against the behavioral and molecular alterations caused by morphine at all phases of locomotor sensitization.
  • ||||||||||  Chantix (varenicline) / Pfizer
    Journal:  Specificity of varenicline in blocking mesolimbic circuit activation to natural and drug rewards. (Pubmed Central) -  Mar 3, 2022   
    Furthermore, varenicline has no effect on DA release in response to naturally rewarding behavior such as food intake or exercise. These results demonstrate the exquisite specificity with which varenicline blocks nicotine reward and highlight the complexity with which different rewards activate the mesolimbic DA system.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Insights into opium poppy (Papaver spp.) genetic diversity from genotyping-by-sequencing analysis. (Pubmed Central) -  Mar 3, 2022   
    Phylogenetic analysis identified genetic groups that were largely consistent with the subpopulations detected and that could be differentiated broadly based on traits such as number of branches and seed weight. These accessions and the associated genotypic data are valuable resources for further genetic diversity analysis, which could include definition of poppy core sets to facilitate genebank management and use of the diversity for genetic improvement of this valuable crop.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  RNA-seq analysis of peripheral blood dendritic cells maturated by dezocine in patients with lung cancer. (Pubmed Central) -  Mar 3, 2022   
    However, conventional analgesics such as morphine and its derivatives have been reported to have immunosuppressive side effects...The results of transcriptomic analysis as well as in vitro validation showed that the upregulation of CXCL10, CD3G, and GRB2 were significantly associated with dezocine-induced DCs maturation. Overall, our data showed that dezocine might exhibit unique properties by acting as an immunostimulant, which provides new evidence for its application in postoperative pain management of patients with lung cancer.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Medical Cannabis Use Reduces Opioid Prescriptions in Patients With Osteoarthritis. (Pubmed Central) -  Mar 3, 2022   
    Average morphine milligram equivalents (MME) per day of opioid prescriptions filled within the six months prior to MC certification was compared to that of the six months after...VAS scores decreased significantly at three and six months, and Global Physical Health score increased significantly by three months. Conclusions MC reduces opioid prescription for patients with chronic OA pain and improves pain and quality of life.
  • ||||||||||  morphine sulphate / Generic mfg., metronidazole oral / Generic mfg.
    Review, Journal:  Practical aspects of palliative care & palliative radiotherapy in incurable cervical cancer. (Pubmed Central) -  Mar 3, 2022   
    Palliative radiotherapy is a cost-effective intervention to reduce vaginal discharge, bleeding, pressure effects and nociceptive or neuropathic pain caused by pelvic and para-aortic disease. The role of palliative radiotherapy in patients with malignant fistulae is discussed and the literature on hypo-fractionated pelvic radiotherapy is briefly reviewed.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion, Enrollment change, Surgery:  SEQ Block for Perioperative Analgesia in Acetabular Surgery (clinicaltrials.gov) -  Mar 3, 2022   
    P3,  N=52, Completed, 
    The role of palliative radiotherapy in patients with malignant fistulae is discussed and the literature on hypo-fractionated pelvic radiotherapy is briefly reviewed. Recruiting --> Completed | N=100 --> 52
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Opioid specific effects on central processing of sensation and pain: a randomized, cross-over, placebo-controlled study. (Pubmed Central) -  Mar 1, 2022   
    Twenty healthy male volunteers were included and 3 sets of assessments were done at each of the 2 visits: 1) baseline, 2) during continuous morphine or placebo intravenous infusion and 3) during simultaneous morphine + naloxone or placebo infusion...Perspective: This exploratory study presents evidence of opioid specific effects on the pain system at peripheral and central levels. The findings give insights into which measures are the most sensitive for assessing opioid-specific effects.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  The impact of aging on symptom prevalence and management in terminally ill patients with cancer. (Pubmed Central) -  Mar 1, 2022   
    The ALCP-II Index is useful for assessing and comparing palliative care development across countries. We found age to be inversely related to symptom prevalence and medical interventions among terminally ill patients with cancer, contributing to the understanding of the experience of older patients with cancer.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Spotlight on Nociceptin/Orphanin FQ Receptor in the Treatment of Pain. (Pubmed Central) -  Mar 1, 2022   
    In addition to these harmful effects, the uprising opioid epidemic is responsible for becoming one of the most disastrous public health issues in the US. In this article, the contributing molecular and cellular structure in controlling the cellular trafficking of NOP receptor and studies that support the role of NOP receptor and its ligands in pain management are reviewed.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Medical Cannabis Use Reduces Opioid Prescriptions in Patients With Chronic Back Pain. (Pubmed Central) -  Mar 1, 2022   
    The average morphine milligram equivalent (MME)/day of opioid prescriptions filled within the six months prior to MC certification was compared to that of six months after...Pain and disability scores were improved at follow-up as well. Conclusion MC use reduces opioid prescription for patients with chronic back pain and improves pain and disability scores.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Gestational Age Alters Assessment of Neonatal Abstinence Syndrome. (Pubmed Central) -  Mar 1, 2022   
    Preterm infants were less likely to require first-line pharmacotherapy with morphine (52% versus 75%) and to experience GI symptoms during their hospitalization. Newer NAS assessment modalities, such as eat, sleep, console (ESC), may overcome the existing challenges of traditional scoring systems, but will require validation in preterm infants.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  An Unusual Case of Right Lower Quadrant Pain: A Case Report. (Pubmed Central) -  Mar 1, 2022   
    Newer NAS assessment modalities, such as eat, sleep, console (ESC), may overcome the existing challenges of traditional scoring systems, but will require validation in preterm infants. This case further underlines that even in the era of sensitive imaging tools, the diagnostic value of a targeted physical exam with clinical re-evaluation can never be overestimated.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Trends in the Prescription of Strong Opioids for Chronic Non-Cancer Pain in Primary Care in Catalonia: Opicat-Padris-Project. (Pubmed Central) -  Feb 27, 2022   
    There was a predominance of transdermal fentanyl in the defined daily dose (DDD) per thousand inhabitants/day, with the greatest increase for tapentadol (312% increase)...The mean daily oral morphine equivalent dose/day dispensed for all drugs was 83.09 mg...In conclusion, there was a sustained increase in the prescription of SO for CNCP, at high doses, and in mainly elderly patients, predominantly low-income women. The new SO are displacing other drugs.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Etazene induces developmental toxicity in vivo Danio rerio and in silico studies of new synthetic opioid derivative. (Pubmed Central) -  Feb 26, 2022   
    The results of our study proved severe dose-dependent developmental toxicity of etazene (applied concentrations 10-300 µM), including an increase in mortality, developmental malformations, and serious cardiotoxic effects, as compared with well-known and used opioid-morphine (applied concentrations 1-50 mM)...Furthermore, phase I metabolite of etazene resulting from N-dealkylation reaction was identified, and therefore it should be considered as a target for toxicological screening. Nonetheless, the exact mechanism of observed effects in response to etazene should be further examined.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Guideline-based Care for patients with malignant lesions : The new S3 guideline for patients with incurable cancer (Pubmed Central) -  Feb 26, 2022   
    The pain recommendations focus on a preventive atraumatic dressing change, positioning, systemic pain medication (anticipated, rescue and baseline) and local application of morphine or local anesthetics...The recommendations on prevention and management of bleeding (antifibrinolytica, haemostyptica) are vital for patients and caregivers. This guideline is one of the first evidence-based and consented guideline on malignant wound care and has the potential to improve the palliation of patients who suffer from there malignant wounds.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Mitragyna Species as Pharmacological Agents: From Abuse to Promising Pharmaceutical Products. (Pubmed Central) -  Feb 26, 2022   
    Mitragynine and 7-hydroxymitragynine have agonist morphine-like effects on opioid receptors...A literature search was performed and information collected using electronic databases including Scopus, ScienceDirect, PubMed, directory open access journal (DOAJ), and Google Scholar in early 2020 to mid-2021. This narrative review highlights some aspects of this genus, including historical background and botanical origins, habitat, cultivation, its use in traditional medicine, phytochemistry, pharmacology and toxicity, abuse and addiction, legal issues, and the potential of Mitragyna species as pharmaceutical products.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Discharge Opioid Prescription Patterns after Kidney Cancer Surgery. (Pubmed Central) -  Feb 25, 2022   
    Prior opioid exposure conveys a higher risk of medical resource utilization. More judicious opioid prescribing may limit medical resource utilization and help combat the opioid epidemic.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Epidural analgesia for reduction of postoperative systemic opioid use following selective dorsal rhizotomy in children. (Pubmed Central) -  Feb 25, 2022   
    Patients who received postoperative epidural analgesia required less systemic opioid use and had at least equivalent reported pain scores on PODs 1-4, and they required less respiratory support on POD 1, although they remained in the hospital longer when compared to patients who received systemic analgesia only. A larger prospective study is needed to confirm whether epidural analgesia lowers systemic opioid use in children, contributes to a safer postoperative hospital stay, and results in better pain control following SDR.
  • ||||||||||  morphine sulphate / Generic mfg., methamphetamine / Generic mfg.
    Journal:  Reverse Takotsubo Cardiomyopathy Precipitated by Chronic Cocaine and Cannabis Use. (Pubmed Central) -  Feb 25, 2022   
    In this case, multiple insults including severe headache, cannabis hyperemesis and cocaine and methamphetamine-induced serotonin toxicity culminated in a drug-induced seizure which led to catecholamine cardiotoxicity resulting in rTC. Clinicians should be cognizant of stress cardiomyopathy as a differential diagnosis in patients with substance use disorders.