morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Review, Journal, Adverse events, Serious adverse event:  Serious Adverse Events after a Single Shot of Intrathecal Morphine: A Case Series and Systematic Review. (Pubmed Central) -  Mar 30, 2022   
    No prolonged sequalae occurred. This study reveals that respiratory depression and somnolence are the predominant serious adverse events after intrathecal morphine in a perioperative setting and demonstrated a large variation in the presentation of symptoms.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Erector Spinae Plane Block: A Novel Anesthetic Approach for Pleuroscopy. (Pubmed Central) -  Mar 30, 2022   
    This study reveals that respiratory depression and somnolence are the predominant serious adverse events after intrathecal morphine in a perioperative setting and demonstrated a large variation in the presentation of symptoms. This case series demonstrates the feasibility of utilizing single shot ESPB in combination with MAC as the primary anesthetic for thoracoscopic procedures.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion, Enrollment change:  Epidural Morphine Versus Epidural Fentanyl Infusion Following Cesarean Section (clinicaltrials.gov) -  Mar 29, 2022   
    P=N/A,  N=381, Completed, 
    This case series demonstrates the feasibility of utilizing single shot ESPB in combination with MAC as the primary anesthetic for thoracoscopic procedures. Recruiting --> Completed | N=200 --> 381
  • ||||||||||  morphine sulphate / Generic mfg., methamphetamine / Generic mfg.
    Journal:  The effect of mitragynine on extracellular activity of brain dopamine and its metabolites. (Pubmed Central) -  Mar 29, 2022   
    MIT led to a significant increase of DOPAC and/or HVA in these brain regions while MOR and METH had only moderate effects. These findings suggest a strong and prolonged effect of MIT on DA synthesis/metabolism, but not on extracellular DA activity, which may limit the addiction risk of MIT, in contrast to MOR and METH.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Effects of codon optimization, N-terminal truncation and gene dose on the heterologous expression of berberine bridge enzyme. (Pubmed Central) -  Mar 29, 2022   
    Morphine, sanguinarine and chelerythrine are benzylisoquinoline alkaloids (BIAs), and these compounds possess strong biological activities...In conclusion, our work achieved high-efficiency expression of McBBE in S. cerevisiae, explored the influence of N-terminal truncation on the yield of (S)-scoulerine, and obtained a genetically stable S. cerevisiae strain with high McBBE expression. This study provides a reference for further complex metabolic engineering optimization and lays a foundation for the efficient biosynthesis of BIAs.
  • ||||||||||  morphine sulphate / Generic mfg.
    Observational data, Journal:  Ambulance service use by patients with lower back pain: an observational study. (Pubmed Central) -  Mar 29, 2022   
    Of the patients, 49% received analgesia, including Entonox (24%) and morphine (13%)...Current guidance on back pain focuses on primary care and specialist settings. Future updates may need to consider emergency care as a distinct setting with a potentially different patient population.
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial suspension:  2 Dose Neuraxial Morphine for Prevention of PDPH (clinicaltrials.gov) -  Mar 29, 2022   
    P4,  N=400, Suspended, 
    Future updates may need to consider emergency care as a distinct setting with a potentially different patient population. Recruiting --> Suspended
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  NOWSHINE: CHF6563 in Babies With Neonatal Opioid Withdrawal Syndrome (clinicaltrials.gov) -  Mar 28, 2022   
    P2,  N=16, Terminated, 
    Recruiting --> Suspended N=99 --> 16 | Trial completion date: Jan 2024 --> Dec 2021 | Recruiting --> Terminated | Trial primary completion date: Sep 2023 --> Dec 2021; Low recruitment rate
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Morphine exposure alters Fos expression in a sex-, age-, and brain region-specific manner during adolescence. (Pubmed Central) -  Mar 26, 2022   
    These data suggest that heterogeneity in the consequences of adolescent opioid exposure may be due to age- and sex-specific developmental profiles in individual reward processing regions. In future studies, it will be important to add age within adolescence as an independent variable for a holistic view of healthy or abnormal reward-related neural development.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  High-risk Opioid Analgesic Dispensing to Adolescents 12-18 Years Old in South Carolina: 2010-2017. (Pubmed Central) -  Mar 26, 2022   
    Among persons 12-18 dispensed an opioid analgesic, receipt of ≥ 90 daily MME declined during the years 2010-2017, as did the percentage of adolescent opioid days that overlapped with benzodiazepines. More than half of the individuals who received extended-release opioid analgesics were identified as opioid naïve and, counter to guidelines, received products intended for opioid-tolerant individuals.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Prolonged cessation of chronic opioid analgesic therapy: a multidisciplinary intervention. (Pubmed Central) -  Mar 26, 2022   
    More than half of the individuals who received extended-release opioid analgesics were identified as opioid naïve and, counter to guidelines, received products intended for opioid-tolerant individuals. This pilot study contributes to the literature by documenting a successful and potentially generalizable strategy to promote COAT cessation, and by providing unusually lengthy follow-up for postintervention COAT cessation monitoring.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Association of opioid utilization management with prescribing and overdose. (Pubmed Central) -  Mar 26, 2022   
    Opioid utilization management among these beneficiaries was associated with mixed effects on opioid prescribing, and prior authorization was associated with a decreased likelihood of subsequent overdose. Further work exploring the impact of utilization management and insurer policies is needed.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Phloem-specific localization of benzylisoquinoline alkaloid metabolism in opium poppy. (Pubmed Central) -  Mar 26, 2022   
    Opium poppy is the only commercial source of the narcotic analgesics morphine and codeine, and semi-synthetic derivatives of the natural opiate precursor thebaine, including oxycodone and the opioid antagonist naloxone...In spite of the extensive elucidation of BIA biosynthetic enzymes in opium poppy, additional transporters and other auxiliary proteins are clearly necessary to support the complex spatial organization and dynamics involved in product formation and sequestration. In this review, we provide an update of BIA metabolism in opium poppy with a focus on the role of phloem in the biosynthesis of the major alkaloids.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Molecular Mechanisms Underlying the Retrieval and Extinction of Morphine Withdrawal-Associated Memories in the Basolateral Amygdala and Dentate Gyrus. (Pubmed Central) -  Mar 26, 2022   
    Finally, our results support the coordinated activity of some of these neuroplastic proteins for the extinction of morphine withdrawal memories in a regional-dependent manner. Present data provide evidence of differential expression and activity of synaptic molecules during the retrieval and extinction of aversive memories of opiate withdrawal in the amygdalar and hippocampal regions that will likely permit the development of therapeutic strategies able to minimize relapses induced by morphine withdrawal-associated aversive memories.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Fascia Iliaca Blocks Performed in the Emergency Department Decrease Opioid Consumption and Length of Stay in Hip Fracture Patients. (Pubmed Central) -  Mar 25, 2022   
    Present data provide evidence of differential expression and activity of synaptic molecules during the retrieval and extinction of aversive memories of opiate withdrawal in the amygdalar and hippocampal regions that will likely permit the development of therapeutic strategies able to minimize relapses induced by morphine withdrawal-associated aversive memories. Undergoing FI block in the emergency department was associated with decreased opioid consumption, decreased length of stay, and decreased hospital readmission within 30 days of hip fracture.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Fluoroscopy-Guided High-Intensity Focused Ultrasound Neurotomy of the Lumbar Zygapophyseal Joints: A Clinical Pilot Study. (Pubmed Central) -  Mar 25, 2022   
    Comanagement programs are essential to improving and standardizing hip fracture care for older adults. The first clinical pilot study using a noninvasive, fluoroscopy-guided, high-intensity focused ultrasound lumbar zygapophyseal neurotomy resulted in no significant device- or procedure-related adverse events and achieved clinical success comparable with routine radiofrequency ablation.
  • ||||||||||  hydromorphone hydrochloride / Generic mfg., ropivacaine / Generic mfg.
    Journal:  Analgesic Effect of Ropivacaine Combined with Hydromorphone following Surgery for Mixed Hemorrhoids: A Pilot Study. (Pubmed Central) -  Mar 25, 2022   
    There were no significant differences between groups in vomiting incidence or LoS. In patients with mixed hemorrhoids, spinal anesthesia with ropivacaine/hydromorphone has a comparable analgesic effect and a lower incidence of pruritus during the first 24 hours after surgery than spinal anesthesia with ropivacaine/morphine.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  The Effect of Upper Extremity Tourniquet Time on Postoperative Pain and Opiate Consumption. (Pubmed Central) -  Mar 25, 2022   
    Postoperative pain, morphine equivalent dose (MED) usage, and demographic variables were collected...Tourniquet usage under current guidelines does not appear to have an effect on postoperative pain and narcotic usage. Preoperative narcotic usage, BMI, and surgery complexity are significant factors for postoperative opiate consumption.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Post-operative vomiting and enhanced recovery after congenital cardiac surgery. (Pubmed Central) -  Mar 25, 2022   
    Greater cumulative intraoperative opioids are associated with severe post-operative vomiting after congenital cardiac surgery. Multimodal pain strategies targeting the reduction of intraoperative opioids should be considered during congenital cardiac surgery to enhance recovery after surgery.
  • ||||||||||  morphine sulphate / Generic mfg.
    COMBINED CANNABINOID RECEPTOR 1 AND MU-OPIOID RECEPTOR AGONISTS SYNERGISTICALLY INHIBIT VISCERAL PAIN IN VIVO WITHOUT ADVERSE SIDE EFFECTS OR TOLERANCE ([VIRTUAL]) -  Mar 25, 2022 - Abstract #CDDW2022CDDW_239;    
    Mice were injected intraperitoneally with vehicle, arachidonyl-2’-chloroethylamide (ACEA), a selective CB1R agonist (0.3, 1, 3 mg/kg), HU-308, a selective CB2R agonist (0.3, 1, 3mg/kg), morphine, a MOR agonist (0.3, 3 mg/kg), or a combination, 30-minutes prior to distention...Conclusions A combination of sub-analgesic doses of CB1R and MOR agonists significantly inhibits visceral pain in vivo, without development of sides effects or tolerance with chronic use. Thus, combining low doses of CB1R and MOR agonists may be an effective visceral pain management strategy.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Opioid-free versus opioid-based anesthesia in pancreatic surgery. (Pubmed Central) -  Mar 24, 2022   
    OFA included a combination of continuous infusions of dexmedetomidine, lidocaine, and esketamine...All patients received intraoperative propofol, sevoflurane, dexamethasone, diclofenac, neuromuscular blockade...In this series, OFA during pancreatic resection is feasible and independently associated with a better outcome, in particular pain outcomes. The lower rate of postoperative complications may justify future randomized trials to test the hypothesis that OFA may improve outcomes and shorten length of stay.