morphine sulphate / Generic mfg. 
Welcome,         Profile    Billing    Logout  
 7 Diseases   379 Trials   379 Trials   12426 News 


«12...107108109110111112113114115116117...217218»
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion date, Trial primary completion date:  Intrathecal Morphine for Robotic-assisted Laparoscopic Hysterectomy. (clinicaltrials.gov) -  Apr 6, 2022   
    P=N/A,  N=80, Recruiting, 
    Thus, it appears that the advantages of minimally invasive surgery are seen in minimally invasive TLIFs. Trial completion date: Mar 2022 --> Jun 2022 | Trial primary completion date: Dec 2021 --> Jun 2022
  • ||||||||||  morphine sulphate / Generic mfg.
    PK/PD data, Preclinical, Journal:  A pharmacokinetic study of morphine-6-O-sulfate in rat plasma and brain. (Pubmed Central) -  Apr 5, 2022   
    The low oral bioavailability of M6S may be due to poor permeation of the intestinal epithelial membrane. After i.p.-administration, M6S appears to reach brain tissues in low, but significant, concentrations.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Review, Journal:  Opioid dependency and myocardial infarction: A systematic review and meta-analysis. (Pubmed Central) -  Apr 5, 2022   
    The increasing prevalence of opioid abuse in developing countries may be a reason for the growing incidence of MI in younger ages and individuals with no risk factors. Besides, physicians should consider the presence of impurities in morphine-based opioids and its possible effects on health.
  • ||||||||||  ibuprofen / Generic mfg.
    Clinical, Journal:  Incidence of Neck Pain in Patients With Concussion in a Pediatric Emergency Department. (Pubmed Central) -  Apr 5, 2022   
    Although patients with neck pain were more likely to receive a referral and follow-up with neurosurgery, they were not more likely to have concussion-related follow-up visits. Indeed, most patients had no follow-up visits related to their concussion, which supports the notion that concussion is a self-limiting condition.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Involvement of P2X7 receptors in chronic pain disorders. (Pubmed Central) -  Apr 5, 2022   
    In the present review, we invite you to a journey through inflammatory and neuropathic pain, primary headache, and regulation of morphine analgesic tolerance, in the pathophysiology of which P2X7Rs are centrally involved. P2X7R bearing microglia and astrocyte-like cells playing eminent roles in chronic pain will be also discussed.
  • ||||||||||  morphine sulphate / Generic mfg., paracetamol / Generic mfg.
    Journal:  Opiate Use After Endoscopic Endonasal Transsphenoidal Surgery. (Pubmed Central) -  Apr 5, 2022   
    Patients undergoing EETS have higher opiate needs compared to those undergoing endoscopic sinus surgery, although the overall requirements are still considered low. Independent risk factors associated with higher opiate use in the immediate postoperative period included current smokers and grade 3 intraoperative cerebrospinal fluid leaks.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Nanoarchitectonics for Abused-Drug Biosensors. (Pubmed Central) -  Apr 5, 2022   
    Modern sensors that utilize next-generation technologies, e.g., nanobiotechnology and nanoarchitectonics, have triggered revolutionary progress in the field as they allow accurate detection and tracking of trace levels of major classes of drugs. This paper reviews advances in the field of biosensors for the detection of commonly abused drugs, both prescribed such as codeine and morphine, and illegal narcotics like cocaine.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Impact of Music on Postoperative Pain, Anxiety, and Narcotic Use After Robotic Prostatectomy: A Randomized Controlled Trial. (Pubmed Central) -  Apr 5, 2022   
    Inpatient narcotic use (morphine milligram equivalent, or MME) and outpatient narcotic use were measured, and the State-Trait Anxiety Inventory (STAI) survey was completed on POD 1 and POD 7 by an inpatient advanced practitioner (AP)...After adjusting for age, blood loss, and inpatient MME use, patients assigned to the music intervention had a 26% reduction in post-hospitalization use. Our prospective randomized study suggests that music can be an AP-driven adjunct to facilitate postoperative patient comfort and reduce narcotic use upon discharge in prostate cancer patients.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Activity-Based Checks (ABCs) of Pain: A Functional Pain Scale Used by Surgical Patients. (Pubmed Central) -  Apr 5, 2022   
    Secondary outcomes included assessing the impact of patient factors and prescribing patterns on opioid consumption, in milligrams of morphine equivalents (MME), after discharge...Individual functions, such as, "Out of Bed to Chair", may be of particular importance. Clinicians must be aware that the strongest predictor of MMEs taken by patients was MMEs prescribed, highlighting the importance of better pain assessments and opioid stewardship.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Impact of a Multimodal Analgesia Protocol in an Intensive Care Unit: A Pre-post Cohort Study. (Pubmed Central) -  Apr 5, 2022   
    There was an increasing trend in the use of adjuvant analgesics and morphine in preemptive and therapeutic analgesia. Conclusion The implementation of a multimodal pain control protocol significantly reduced morbidity and mortality and the use of opioids in the ICU.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Effectiveness of Transdermal Buprenorphine for Pain Control in the ICU After Major Surgical Procedures. (Pubmed Central) -  Apr 5, 2022   
    rTMS is expected to be a new effective adjuvant therapy for cancer pain in advanced NSCLC patients. In patients who are admitted to the ICU after major GI or GU procedures, the use of TBUP in the ICU was not associated with improved pain control or opioid consumption compared with those who did not receive TBUP.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., methadone / Generic mfg.
    Journal:  New Synthetic Opioids Use among Patients in Treatment for an Opioid Use Disorder in Barcelona. (Pubmed Central) -  Apr 5, 2022   
    The reasons for using these substances and also the well-being differed between the genders. There is therefore both voluntary and involuntary NSO consumption in our country which highlights the importance of approaching this potential public health problem.
  • ||||||||||  gabapentin / Generic mfg.
    Preclinical, Journal:  Postinjury stimulation triggers a transition to nociplastic pain in mice. (Pubmed Central) -  Apr 2, 2022   
    Specifically, ongoing afferent activity at the previously capsaicin-injected area was critical in females, whereas activated spinal microglia were crucial in males. These results demonstrate that postinjury stimulation of the injured area can trigger the transition from transient pain to nociplastic pain more readily in females, and sex-dependent mechanisms maintain the nociplastic pain state.
  • ||||||||||  PLX5622 / Daiichi Sankyo
    Preclinical, Journal:  Microglial ablation does not affect opioid-induced hyperalgesia in rodents. (Pubmed Central) -  Apr 2, 2022   
    We confirmed this conclusion with a behavioral test of mechanical and thermal hyperalgesia, in male and female mice, and with different species (mouse and rat). These findings raise caution about the widely assumed contribution of microglia to the development of opioid-induced hyperalgesia.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Topical Opioid Use in Dermatologic Disease: A Systematic Review. (Pubmed Central) -  Apr 2, 2022   
    Topical opioids included in this review were topical morphine and diamorphine...Topical opioids were generally well tolerated. Insufficient data exist to adequately evaluate the efficacy and safety of topical opioid use in the context of non-pressure ulcers, burns, oral lichen planus, photodynamic therapy, and split-thickness skin grafts.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Development of a sterile morphine hydrogel for the local treatment of painful skin ulcers. (Pubmed Central) -  Apr 2, 2022   
    With the described formulation, packaging, sterilisation and stability data, together with the previously reported biopharmaceutical dissolution profile, we present a complete solution for a morphine containing poloxamer 407 hydrogel that can be compounded in any pharmacy with a steam or hot water steriliser at their disposal. This might improve the availability of a sterile morphine hydrogel for the treatment of painful skin ulcers.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Medical Cannabis Used as an Alternative Treatment for Chronic Pain Demonstrates Reduction in Chronic Opioid Use - A Prospective Study. (Pubmed Central) -  Apr 2, 2022   
    Presenting medical cannabis to chronic pain patients on COT should be done in the context of a patient choice between medical cannabis WITH decrement of COT or continued current dose of COT in order to maximize effectiveness in opioid reduction as well as to limit polypharmacy concerns regarding medical cannabis. Allowing for a temporary short-term period where patients may trial medical cannabis, while concomitantly gradually weaning their COT, is also essential in determining medical cannabis' individual effectiveness for that patient's specific type of chronic pain, which should serve to maximize long-term opioid reduction results and hence decrease opioid-related overdose deaths.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Epidural anesthesia in dogs undergoing hindlimb orthopedic surgery: effects of two injection sites. (Pubmed Central) -  Apr 2, 2022   
    Fentanyl (1 µg/kg) was the intraoperative rescue analgesia (iRA) administered if mean arterial pressure increased by 30% above pre-stimulation value...The L5-L6 EA decreased significantly iRA but delays the proprioceptive recovery time. Further studies are needed to determine whether a lower bupivacaine dose reduces the duration of the residual block retaining the same incidence of iRA.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Serratus anterior plane block and erector spinae plane block in postoperative analgesia in thoracotomy: A randomised controlled study. (Pubmed Central) -  Apr 2, 2022   
    Postoperative morphine consumption was significantly lower in ESBP and SAPB groups than control group [ESPB (8.52 ± 4.29 mg) < SAPB (19.57 ± 7.63 mg) < control (36.37 ± 8.27 mg)] (P < 0.001)...Postoperative forced vital capacity and forced expiratory volume in the first second after 24 h were the best in ESPB group and better in SAPB group compared to the control group. Both ESPB and SAPB reduced intraoperative and postoperative opioid consumptions and postoperative dynamic pain scores with improved postoperative pulmonary functions in thoracic surgery with the ESPB being superior.