morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  A narcotic free pathway for postoperative pain following urethroplasty. (Pubmed Central) -  Apr 9, 2022   
    The narcotic free pathway resulted in a dramatic reduction in narcotic prescriptions without a significant difference in postoperative pain scores. Opioid use can be minimized following urethral and perineal surgery.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Review, Journal:  Efficacy of regional blocks or local anaesthetic infiltration for analgesia after caesarean delivery: a network meta-analysis of randomised controlled trials. (Pubmed Central) -  Apr 9, 2022   
    The primary outcome was dose of parenteral morphine equivalents in the first 24 postoperative hours...The ordered mean (95% credible interval) reduction in dynamic pain scores (0-10 scale) at 24 h compared with placebo were as follows: wound infusion 1.2 (0.2-2.1); erector spinae 1.3 (-0.5 to 3.1); quadratus lumborum 1.0 (0.1-1.8); ilio-inguinal-iliohypogastric 0.6 (-0.5 to 1.8); transverse abdominis 0.6 (-0.1 to 1.2); wound infiltration 0.5 (-0.3 to 1.3); transversalis fascia -0.8 (-3.4 to 1.9); ilio-inguinal -0.9 (-3.6 to 1.7); and no intervention -0.8 (-1.8 to 0.2). We categorised our confidence in effect sizes as low or very low.
  • ||||||||||  morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
    Journal:  Pain after Arteriovenous Access Creation. (Pubmed Central) -  Apr 9, 2022   
    Morbidity and mortality related to opiate use continues to be a public health issue in the United States. This study demonstrates that regional anesthetic techniques in comparison to general anesthesia can result in a significant decrease in postoperative opiate consumption.
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  A systematic review of opioid prevalence in Australian residential aged care facilities. (Pubmed Central) -  Apr 9, 2022   
    Up to half of the residents were dispensed opioids over 12 months. The prevalence of opioid prescribing, dispensing and administration was highly variable, suggesting the potential value of opioid quality indicators and analgesic stewardship interventions to ensure opioid appropriateness.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  Maternal morphine intake during pregnancy and lactation affects the circadian clock of rat pups. (Pubmed Central) -  Apr 8, 2022   
    Our data reveal that the circadian system responds to early-life morphine administration with significant changes in clock gene expression profiles both in the SCN and in the liver. The observed differences between the groups suggest that the dose, timing and accompanying stress events such as cross-fostering may play a role in the final magnitude of the physiological challenge that opioids bring to the developing circadian clock.
  • ||||||||||  morphine sulphate / Generic mfg., gabapentin / Generic mfg.
    Preclinical, Journal:  Characterization of pain-related behaviors, changes in bone microarchitecture and sensory innervation induced by chronic cadmium exposure in adult mice. (Pubmed Central) -  Apr 8, 2022   
    We also observed a significant reduction in the density of both CGRP and PGP 9.5 nerve fibers in the femoral neck, but not in the hindpaw glabrous skin, suggesting tissue-dependent neurotoxicity. This model may help in developing a mechanism-based understanding of the factors that generate and maintain musculoskeletal pain and bone loss caused by chronic cadmium exposure and in translating these findings into new therapies for treating cadmium-induced bone toxicity.
  • ||||||||||  morphine sulphate / Generic mfg., methadone / Generic mfg.
    Journal:  Morphine to methadone, and beyond. (Pubmed Central) -  Apr 8, 2022   
    AMPK-autophagy activation suppresses neuroinflammation and improves morphine tolerance via the upregulation of SOCS3 by inhibiting miRNA-30a-5p. No abstract available
  • ||||||||||  morphine sulphate / Generic mfg.
    Review, Journal:  Interactive role of acid sensing ion channels and glutamatergic system in opioid dependence. (Pubmed Central) -  Apr 8, 2022   
    Dysregulation in glutamatergic receptors and transporters has been found to mediate drugs of abuse, including morphine...This review discussed the role of nitric oxide in the modulation of ASIC function and potentially opioid dependence. We also discussed the role of ASICs in the modulation of the function of both glutamatergic receptors in post-synaptic neurons and glutamatergic transporters in astrocytes in animals exposed to drugs of abuse.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., alprazolam / Generic mfg.
    The New and Dynamic Nature of the Opioid Epidemic (Great Hall Foyer, Third Floor) -  Apr 8, 2022 - Abstract #ASAM2022ASAM_323;    
    Despite the large settlements recently reported widely in the media with drug manufacturers and distributors, the surge in overdoses is driven by illicitly obtained fentanyl and its powerful analogs. This represents a departure from the longstanding story of pharmaceutical companies “dumping” pills into communities.
  • ||||||||||  Impact of a Pharmacist-Initiated Naloxone Dispensing Program in Community Pharmacies (Great Hall Foyer, Third Floor) -  Apr 8, 2022 - Abstract #ASAM2022ASAM_262;    
    More than two-thirds of eligible patients in the program accepted naloxone, suggesting that patients are willing to be counseled about overdose prevention by pharmacists and that standing orders can increase naloxone access for patients at risk of overdose. As the program was structured to offer naloxone to eligible patients once, it is not surprising that the highest percentage of eligible patients received naloxone in program’s initial phase.
  • ||||||||||  morphine sulphate / Generic mfg., alprazolam / Generic mfg., paracetamol / Generic mfg.
    2 Methyl-AP-237 Overdose: A Case Report (Great Hall Foyer, Third Floor) -  Apr 8, 2022 - Abstract #ASAM2022ASAM_221;    
    2 Methyl-AP-237 and Bucinnazine, are synthetic opioids that are currently not scheduled in the United States, can be easily procured and undetected by urine drug screening. When combined with benzodiazepine, 2 Methyl-AP-237 may cause life-threatening acute opioid overdose with apnea which can be reversed using extended duration IV naloxone infusion.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., methadone / Generic mfg.
    How to Implement Low-Dose Buprenorphine Initiation in Your Practice: A Case-Based Workshop (Regency Ballroom, Second Floor) -  Apr 8, 2022 - Abstract #ASAM2022ASAM_113;    
    At the end of the sessions, prescribers should have a better understanding of the current evidence for low dose buprenorphine initiation and know how to approach it with patients. Learning Objectives: Learners will be able to: Describe low-dose buprenorphine initiation and clinical indications for its use Engage in shared decision-making with patients about the risks and benefits of low-dose buprenorphine initiation Understand how to initiate low-dose buprenorphine in different clinical situations in both the inpatient and outpatient setting
  • ||||||||||  gabapentin / Generic mfg.
    Clinical, Journal:  Impact of a Multimodal Analgesia Protocol on Inpatient and Outpatient Opioid Use in Acute Trauma. (Pubmed Central) -  Apr 7, 2022   
    Implementation of an updated multimodal analgesia protocol decreased total MME, daily MME, hydromorphone, and oxycodone consumed while increasing gabapentin use. This suggests that while reducing opioid usage in-hospital is critical to reducing outpatient usage, multimodal pain protocols may lead to an increase in gabapentin prescriptions and utilization after discharge.
  • ||||||||||  morphine sulphate / Generic mfg., paroxetine / Generic mfg.
    Preclinical, Journal:  Paroxetine effects on morphine analgesic tolerance in rats. (Pubmed Central) -  Apr 7, 2022   
    This suggests that while reducing opioid usage in-hospital is critical to reducing outpatient usage, multimodal pain protocols may lead to an increase in gabapentin prescriptions and utilization after discharge. We conclude that paroxetine could decrease tolerance to morphine when used after the occurrence of morphine tolerance, while it was not able to prevent morphine tolerance when administered preemptively.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Clinical, Journal:  Pre-Hospital Administration of Opioids in Trauma Patients: Is Dose Associated With Outcomes? (Pubmed Central) -  Apr 7, 2022   
    Pre-hospital administration of high dose opioids is associated with increased odds of adverse outcomes. Collaborative efforts to standardize and control the overuse of opioids should target the pre-hospital setting to limit opioid associated adverse effects.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  The use of fly artifacts in a crime scene: Is there any application for forensic toxicology? (Pubmed Central) -  Apr 7, 2022   
    The ratios of cocaine/benzoylecgonine, codeine/morphine, and 6-monoacetylmorphine/morphine recovered in FA from cotton-textile materials and from non-absorptive surfaces were consistent with data resulted from original post-mortem blood. The preliminary study herein reported demonstrated that FA are extremely informative in case of cocaine and heroin users and merit further research in order to be applied in real caseworks.
  • ||||||||||  morphine sulphate / Generic mfg., paracetamol / Generic mfg.
    Clinical, Journal:  Efficacy of erector spinae plane block on postoperative pain in patients undergoing lumbar spine surgery. (Pubmed Central) -  Apr 7, 2022   
    The preliminary study herein reported demonstrated that FA are extremely informative in case of cocaine and heroin users and merit further research in order to be applied in real caseworks. ESPB is adequate for postoperative analgesia in patients undergoing lumbar spine surgery and can reduce opioid consumption compared with standard analgesia.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Evaluating Age as a Predictor of Postoperative Opioid Use and Prescribing Habits in Older Adults With Cancer. (Pubmed Central) -  Apr 7, 2022   
    Older patients with cancer reported lower pain scores, consumed less narcotics, were discharged with significantly less narcotics, and called for refills less often compared with younger patients after surgery. These data suggest this population may require less opioids for satisfactory pain control, and development of a guideline targeting postoperative multimodal analgesia in older adults is warranted.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Risk factors and trajectories of opioid use following total knee replacement. (Pubmed Central) -  Apr 7, 2022   
    Novel analysis revealed five distinct opioid use trajectories and identified key characteristics to help guide clinicians when determining perioperative opioid use. Results demonstrate that interventional studies attempting to reduce opioids after TKA are needed if reductions in long-term use are to be realized in this high-risk patient population.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal, Real-world evidence:  Real World Opioid Prescription To Patients With Serious, Non-Malignant, Respiratory Illnesses And Chronic Breathlessness. (Pubmed Central) -  Apr 7, 2022   
    Results demonstrate that interventional studies attempting to reduce opioids after TKA are needed if reductions in long-term use are to be realized in this high-risk patient population. Within this integrated respiratory and palliative care service, patients with severe, non-malignant respiratory diseases safely used long-term, low-dose opioids for breathlessness with subjective benefits reported and no serious adverse events.
  • ||||||||||  morphine sulphate / Generic mfg.
    Enrollment open, Head-to-Head:  PENG Block vs Intrathecal Morphine in Total Hip Arthroplasty (clinicaltrials.gov) -  Apr 7, 2022   
    P4,  N=60, Recruiting, 
    Older patients benefit from CAM, and adverse effects do not limit the (chronic) use and prescription of CAM in the elderly. Not yet recruiting --> Recruiting
  • ||||||||||  Tenex (guanfacine immediate release tablet) / Dr. Reddy's, Intuniv (guanfacine XR) / Shionogi, Takeda
    Trial completion date, Trial primary completion date:  Effect of Guanfacine on Opioid-induced Hyperalgesia (OIH) and Tolerance (clinicaltrials.gov) -  Apr 6, 2022   
    P4,  N=200, Active, not recruiting, 
    Not yet recruiting --> Recruiting Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Dec 2021 --> Dec 2022
  • ||||||||||  paracetamol / Generic mfg.
    Clinical, Review, Journal:  The efficacy and safety of acetaminophen use following liver resection: a systematic review. (Pubmed Central) -  Apr 6, 2022   
    All studies analysed support that toxicity is not reached; and that acetaminophen provides a morphine sparing effect without adverse effects. Acetaminophen dose reduction should be considered in patients where extra risk factors for hepatotoxicity are present.