morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg., rocuronium / Generic mfg.
    Journal:  Reliability of early and late testing for suspected perioperative hypersensitivity. (Pubmed Central) -  Apr 13, 2022   
    TAP blocks provide the same analgesic quality with optimal pain control than epidural technique, with less adverse effects. Our data confirm that evaluation of drug allergy for suspected POH can be performed before 6 weeks after the event, and there is no maximal upper time limit disclosing ex vivo and in vitro testing.
  • ||||||||||  Clinical, Journal:  Opioid misuse in community pharmacy patients with chronic non-cancer pain. (Pubmed Central) -  Apr 13, 2022   
    Our data confirm that evaluation of drug allergy for suspected POH can be performed before 6 weeks after the event, and there is no maximal upper time limit disclosing ex vivo and in vitro testing. The high proportion of patients with high POMI scores underlines the interest of prescription opioid misuse screening in community pharmacies, in order to help these patients and refer them to pain specialists, if needed.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Does size matter? Opioid use after laparoscopy for apical pelvic organ prolapse using an 8mm versus 10-12mm accessory port. (Pubmed Central) -  Apr 13, 2022   
    The high proportion of patients with high POMI scores underlines the interest of prescription opioid misuse screening in community pharmacies, in order to help these patients and refer them to pain specialists, if needed. Compared with a 10-12 mm port, the use of an 8 mm LAP during laparoscopic native tissue apical POP surgery is associated with decreased opioid use in the first 24 hours after surgery.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Clinical, Journal:  Effect of erector spinae plane block on postoperative analgesia after pediatric hip surgery: Randomized controlled study. (Pubmed Central) -  Apr 13, 2022   
    Compared with a 10-12 mm port, the use of an 8 mm LAP during laparoscopic native tissue apical POP surgery is associated with decreased opioid use in the first 24 hours after surgery. The use of ESPB in pediatric patients undergoing hip surgery prolonged the time for the first call of analgesia, decreased the intraoperative and postoperative opioid consumption, and decreased the postoperative pain.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Erector Spinae Plane Block For Postoperative Analgesia After Kidney Transplant. (Pubmed Central) -  Apr 13, 2022   
    NCT04528563, Pre-results. Continuous erector spinae plane block in combination with nonopioid analgesics provided adequate pain control and significantly reduced postoperative opioid requirements after kidney transplant.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  A Minimal Opioid Postoperative Management Protocol in Congenital Cardiac Surgery: Safe and Effective. (Pubmed Central) -  Apr 12, 2022   
    The median cumulative opioid exposure was 0.25 morphine milligram equivalents per kg (interquartile range, 0.10-0.75)...A minimal opioid postoperative management protocol can be safe and effective in children undergoing cardiac surgery. Future prospective studies are needed to determine optimal practice and patient selection.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Association of Inpatient Postpartum Opioid Use with Bedside Nurse. (Pubmed Central) -  Apr 12, 2022   
    Patients with higher BMI, history of headaches, or preoperative opioid use may require additional prescriptions. There is significant variation in postpartum women's opioid use based on the nurse that is not explained by patient, birth, or prescriber factors.
  • ||||||||||  Journal:  Pharmacological Management of Heroin Withdrawal Syndrome: A Century of Expert Opinions in Cecil Textbook of Medicine. (Pubmed Central) -  Apr 12, 2022   
    The pharmacological management of heroin withdrawal syndrome in the past century has progressed from the introduction of methadone to the utilization of clonidine and buprenorphine. More recent advances in treating opioid use disorder have changed the goals of opioid withdrawal management to achievement of abstinence from all opioids to facilitation of long-term treatment with medications for opioid use disorder.
  • ||||||||||  methionine enkephalin (STAT-401) / Immune Therap, Statera BioPharma
    Journal:  Agonist specific regulation of G protein-coupled receptors after chronic opioid treatment. (Pubmed Central) -  Apr 12, 2022   
    Profound tolerance develops after chronic treatment with fentanyl without affecting kinase regulation. The homeostatic change in the kinase regulation of non-opioid GPCRs could account for the systems level in vivo development of tolerance that is seen with opioid agonist such as morphine and oxycodone that develop more rapidly than the tolerance induced by efficacious agonist such as fentanyl and etorphine.
  • ||||||||||  morphine sulphate / Generic mfg., metronidazole oral / Generic mfg.
    Review, Journal:  Practical aspects of palliative care & palliative radiotherapy in incurable cervical cancer. (Pubmed Central) -  Apr 12, 2022   
    Palliative radiotherapy is a cost-effective intervention to reduce vaginal discharge, bleeding, pressure effects and nociceptive or neuropathic pain caused by pelvic and para-aortic disease. The role of palliative radiotherapy in patients with malignant fistulae is discussed and the literature on hypo-fractionated pelvic radiotherapy is briefly reviewed.
  • ||||||||||  5-fluorouracil / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Chemotherapy-induced cachexia and model-informed dosing to preserve lean mass in cancer treatment. (Pubmed Central) -  Apr 12, 2022   
    Area-under-the-curve metrics are proposed to quantify the treatment's effects on lean mass and tumour control. Model simulations are used to explore alternate dosing schedules, aging effects, and morphine use in chemotherapy treatment with the aim of better protecting lean mass while actively targeting the tumour, ultimately leading to improved personalization of treatment planning and improved patient quality of life.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Opioid Use at End-Of-Life Among Nova Scotia Patients With Cancer. (Pubmed Central) -  Apr 12, 2022   
    Although the annual average parenteral morphine equivalents (MEQ) did not change during the study period, the number of opioid prescriptions per patient per year increased from 5.9 in 2006 to 7.0 in 2009 (p < 0.0001)...This information can be used to increase awareness among general practitioners, and to inform recommendations from professional regulatory bodies, to aid in managing pain for cancer patients at end-of-life. Future work could address how opioid prescribing has changed over time, and whether efforts to reduce opioid prescribing in response to the opioid crisis have affected patients with cancer at end-of-life in Nova Scotia.
  • ||||||||||  Journal:  Pain management on a trauma service: a crisis reveals opportunities. (Pubmed Central) -  Apr 12, 2022   
    All pain medications were recorded daily; doses were converted to oral morphine equivalents (OMEs)...81% of patients received opioids at DC, of whom 69% were prescribed an opioid/acetaminophen combination drug; and only 13% were prescribed non-steroidal anti-inflammatory drugs, 19% acetaminophen, and 31% gabapentin...These findings highlight opportunities for improvement and further study. IV.
  • ||||||||||  ketorolac / Generic mfg., morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Enrollment open:  PATIENCE: Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid (clinicaltrials.gov) -  Apr 11, 2022   
    P2,  N=50, Recruiting, 
    Trial completion date: Oct 2021 --> Oct 2022 | Trial primary completion date: Aug 2021 --> Aug 2022 Not yet recruiting --> Recruiting
  • ||||||||||  morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
    Erector spinae plane blocks for analgesia after percutaneous nephrolithotomy: a pathway to reduce opiates (Room 252) -  Apr 10, 2022 - Abstract #AUA2022AUA_2981;    
    Patients received either a single injection or a disposable ambulatory pump delivering intermittent boluses of ropivacaine 0.2% (15mL automatic bolus every 2 hours with 5 ml patient-controlled bolus available every 30 minutes)...The primary outcomes were opiate use measured in morphine equivalent dose (MED) and patient reported pain scores during the first 24 hours of hospitalization, as assessed by nursing staff at regular intervals...Continuous ESP blocks may offer superior duration of pain control, decreasing the need for opiates and possibly enhancing the recovery process via a pump that can be taken home. This approach can help facilitate same day surgical discharges as well as opiate sparing surgical pathways.
  • ||||||||||  morphine sulphate / Generic mfg.
    Redefining Opioid Use After Prostatectomy: Results from the Implementation of a Statewide Opioid-Free Pain Optimization Pathway (Room 245) -  Apr 10, 2022 - Abstract #AUA2022AUA_2907;    
    Opioids were converted to total morphine milligram equivalents (MME) for standardization...An estimated 16,000 fewer tablets of 5 mg oxycodone were prescribed due to MPOP implementation. Conclusions : Implementation of a statewide opioid-free pain optimization pathway after RP led to decreased opioid prescriptions at discharge, reduced opioid consumption, and similar overall pain control reported by patients.
  • ||||||||||  morphine sulphate / Generic mfg.
    Favorable Outcomes of Contemporary Percutaneous Nephrolithotomy versus Retrograde Intrarenal Surgery for Treatment of Renal Stones in Adult Patients: A Cochrane Review (Room 228) -  Apr 10, 2022 - Abstract #AUA2022AUA_2583;    
    PCNL probably results in little to no difference in narcotic use measured in morphine equivalents (MD 5.23 higher, 95%CI 2.87 higher to 7.59 higher, participants=91, studies=2, I2=0%, moderate certainty of evidence)...Conclusions : Findings of this review that include a large number of recent studies using an access size <24 Fr, suggest more favorable outcomes for PCNL versus RIRS when the access size is =24, there are multiple stones and stone(s) are in a non-lower pole location. Our confidence in these findings is reduced due to study limitations, inconsistency, and concerns over publication bias as well the large proportion of across-, rather within study subgroup comparisons.
  • ||||||||||  morphine sulphate / Generic mfg.
    Evaluating the Long-Term Impact of Implementing Standardized Postoperative Opioid Prescribing Guidelines Following Pelvic Organ Prolapse Surgery (Room 243) -  Apr 10, 2022 - Abstract #AUA2022AUA_2538;    
    Prescribing patterns including the quantity of opioids prescribed (in oral morphine equivalents [OMEs]) and refill rates were compared for opioid naïve patients undergoing prolapse surgery before (November 2015 through November 2017, N=238) and after (December 2017-December 2019, N=361) guideline implementation...Conclusions : With two years of postimplementation follow up, the use of procedure-specific, tiered opioid prescribing guidelines at our institution was associated with a significant reduction in opioids prescribed without adversely impacting refill rates. This study further supports the use of evidence-based guidelines for opioid prescribing.
  • ||||||||||  morphine sulphate / Generic mfg.
    Pudendal Block Analgesia with Vaginal Surgery: A Randomized; Double-blind; Placebo Controlled Trial (Room 243) -  Apr 10, 2022 - Abstract #AUA2022AUA_2537;    
    Opioid administration was standardized as morphine milligram equivalents (MME), and VAS scores were compared with Wilcoxon-Mann-Whitney analysis...Conclusions : Pudendal nerve block resulted in decreased pain reported in the immediate postoperative period and less opioid use, though not statistically significant. Pudendal block may be an additional tool for non-narcotic perioperative analgesia with vaginal PRS.
  • ||||||||||  morphine sulphate / Generic mfg.
    Robotic Single-Port versus Laparoscopic Donor Nephrectomy: An Institutional Analysis (Room 228) -  Apr 10, 2022 - Abstract #AUA2022AUA_2334;    
    Outcomes included pain scores (scale of 1-10), inpatient opioid use (converted to oral morphine milligram equivalent [MME]), renal function, and Clavien-Dindo complications...Conclusions : SP RDN is a safe alternative to LDN, offering similar donor postoperative clinical outcomes and recipient renal function up to 6 months. Further studies are needed to assess the long-term outcomes, postoperative opioid usage, and potential for improved cosmesis of SP RDN compared to other kidney donor surgical modalities.
  • ||||||||||  morphine sulphate / Generic mfg.
    Single Port Robotic versus Open Kidney Transplantation: A Comparison of Outcomes (Room 228) -  Apr 10, 2022 - Abstract #AUA2022AUA_2321;    
    The morphine milligram equivalents (MME) score during admission was 44.91 (40.15) in SP and 149.16 (119.70) in open groups (P = 0.0091)...Conclusions : Single port robotic kidney transplantation offers a minimally invasive approach with similar safety and allograft function compared to open kidney transplantation with the added benefit of less postoperative narcotics requirement. Larger series are required in this setting.
  • ||||||||||  morphine sulphate / Generic mfg.
    Passive Opioid Stewardship Initiatives Associated with Significant Change in Opioid Prescribing Following Urologic Surgery (Room 228) -  Apr 10, 2022 - Abstract #AUA2022AUA_2165;    
    We captured filled opioid prescriptions within 14 days of discharge and identified dose (median morphine milligram equivalents, MME) and duration (median days) for the initial prescription...Despite the decrease, prescribing remains above recommended levels. Active interventions focused on direct urologist engagement may lead to further improvement in opioid stewardship.
  • ||||||||||  morphine sulphate / Generic mfg.
    Statewide Opioid Stewardship Policies Associated with Minimal Changes in Opioid Prescribing Following Urologic Surgery (Room 228) -  Apr 10, 2022 - Abstract #AUA2022AUA_2049;    
    We captured filled opioid prescriptions within 7 days of a discharge and identified dose (median morphine milligram equivalents (MME)) and duration (median days) for the initial prescription...Modest changes in the dose prescribed occurred but prescribing remained in excess of guideline recommendations. Direct surgeon engagement and surgeon-led local initiatives may be better positioned to achieve continued improvements in opioid stewardship.
  • ||||||||||  morphine sulphate / Generic mfg., paracetamol / Generic mfg.
    Opioid and Multimodal Analgesia Use Following Urological Trauma (Room 225) -  Apr 10, 2022 - Abstract #AUA2022AUA_1773;    
    Conclusions : Multimodal analgesia is severely underutilized following urological trauma. Combined with the development of opioid tolerance over long hospital stays, this creates an avenue for opioid misuse following discharge and opportunities for improvement.