- |||||||||| morphine sulphate / Generic mfg.
Mismatched opioid prescription in patients discharged after surgery (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_2182;
In sharp contrast to the decreased rate of opioid over-prescription in recent years, the rate of opioid under-prescription has increased during the same period. Importantly, opioid under-prescription, not over-prescription, is an independent factor associated with increased risks of opioid refill 1-30 and 31-90 days after discharge.
- |||||||||| morphine sulphate / Generic mfg.
Reducing Opioid Reliance: Retrospective Audit Evaluating an Opt-In Education & Skills Building Group (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_2176;
The program was successfully completed by all but three participants, with favourable results.Whilst there are guidelines available on opioid weaning/tapering these are targeted at primary care and do not take into account the complexities of patients that have previously failed opioid reduction or patient requiring tertiary care. The broader project is currently underway and aims to inform further development of the ROR program.
- |||||||||| morphine sulphate / Generic mfg.
Effects of information about efficacy of post-operative analgesics on pain and opioids consumption (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_2159;
The current study results provide direct ecological evidence for the additive value of positive information about opioids efficacy during post-operative recovery. Adding couple of positive sentences about the treatment efficacy could substantially increase the analgesic effect and could reduce the number of morphine dosages.
- |||||||||| morphine sulphate / Generic mfg.
Exploring the Roles of Rostral Ventromedial Medulla Neuronal Subtypes in Descending Pain Modulation (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_2090;
We also found that pain induces dramatic cFos activation in the RVM. Our upcoming results will quantify the fraction of pain-activated cells among each RVM subpopulation and directly examine the overlap between pain-activated and MOR+ neurons.The findings that MOR KO on RVM cell bodies increases Hargreaves latency, but presynaptic and GABAergic MOR KO decrease thermal pain thresholds, further support our hypothesis that different RVM cell types have divergent effects on descending pain modulation.
- |||||||||| dipraglurant (ADX-48621) / Addex
Characterization of Rat Models of Headache in Support of the NIH PSPP Program (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_2036;
Clinically effective treatments for headache and migraine, including 5-HT1B/1D receptor agonists and CGRP receptor antagonists, can prevent the development of facial allodynia in preclinical models of headache and trigeminal sensitization in male and female rats. Treatments that are less effective clinically (e.g.
- |||||||||| morphine sulphate / Generic mfg.
Examining the Effect of Perioperative Transdermal Nicotine Patch on Postoperative Pain: A Systematic (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1902;
The perioperative transdermal nicotine patch effectively reduced postoperative pain in smokers, contrasting with non-smokers who exhibited no significant differences from the placebo group. These results underscore the need for extensive randomized trials to solidify the observed analgesic benefits in smokers and ascertain the broader applications of nicotine patches in managing postoperative pain across diverse patient populations.
- |||||||||| morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
Continuous Epidural Analgesia & Peripheral Nerve Block in Unilateral Lower Limb Orthopaedic Surgery (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1892;
These results underscore the need for extensive randomized trials to solidify the observed analgesic benefits in smokers and ascertain the broader applications of nicotine patches in managing postoperative pain across diverse patient populations. Ultrasound guided peripheral nerve block and catheter (SOLO-DEX Fascile
- |||||||||| Chirocaine (levobupivacaine) / Purdue, AbbVie
Postoperative Analgesic Efficacy of Erector Spinae Plane Block in Modified Radical Mastectomy (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1890;
ESP block with levobupivacaine 0.125% administered in automated intermittent boluses and patient-controlled dose supplementation provided safe and effective pain management with minimal opioid requirements after modified radical mastectomy. Further investigation involving randomized controlled trials is indicated to determine the optimal dosing strategies for the ESP block and other clinical benefit of ESP block for MRM and other thoracic surgeries.
- |||||||||| morphine sulphate / Generic mfg., hydroxyurea / Generic mfg.
Effect of a web-app based music intervention on vaso-occlusive crisis pain in sickle cell disease (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1883;
Further investigation involving randomized controlled trials is indicated to determine the optimal dosing strategies for the ESP block and other clinical benefit of ESP block for MRM and other thoracic surgeries. Our study revealed a non-significant decrease in the daily intravenous morphine intake in the music intervention group vs. control group (mean
- |||||||||| morphine sulphate / Generic mfg.
Baseline Patient Characteristics Associated with Long-Term Opioid Therapy in Specialized Pain Care (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1880;
This study provides information on opioid use, how it is associated with a large number of bio-psycho-social factors, and whether these associations are dose-dependent in a sample with a relatively high proportion of opioid users (6, 7). The study has some limitations, especially its cross-sectional design, which impedes us from drawing any conclusions on causal relationships between different factors and opioid use.
- |||||||||| morphine sulphate / Generic mfg.
Nalbuphine as a first-line parenteral opioid: A retrospective review (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1876;
Utilizing nalbuphine in opioid-tolerant patients provided less optimal pain control compared to nalbuphine use in opioid-naive patients. Nalbuphine may represent an under-appreciated first-line parenteral opioid when strong analgesia is required in the acute care setting.
- |||||||||| morphine sulphate / Generic mfg.
Transitional Clinic for Complex Pain: Sub-acute Opioid Weaning and Functional Recovery (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1871;
Median [IQR] oral morphine equivalent daily doses (oMEDD) were reduced from baseline to clinic discharge (45mg [15-80] to 30mg [0-60], p<0.01), and further reduced at follow up (20mg [4-45], p<0.01)... An interdisciplinary Transition Clinic can effectively support patients with complex pain during the sub-acute period after a hospital admission, and mitigate risks of post-operative opioid use.Meaningful reductions in opioid doses from baseline are achievable and likely to continue even after clinic discharge.Although many patients with complex pain at baseline continue to experience some pain, education and support during this time of change can facilitate the adoption of new management strategies, resulting in improvement in symptoms and function as they recover.The public health burdens of persistent pain and opioid use warrant development of transitional pain services to improve patient outcomes.Future work in the clinic aims to integrate functional assessments for all patients at baseline and follow-up, and conduct a prospective controlled study to measure clinic impact.
- |||||||||| morphine sulphate / Generic mfg., methadone / Generic mfg.
Epidemiology of Continuous Opioid Use in California Over Past Decade (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1824;
This methodology will allow us to:1. To evaluate the strength of prescription-related factors associated with chronic continuous use of opioids.2.
- |||||||||| morphine sulphate / Generic mfg., diclofenac sodium suppository / Generic mfg.
TAP Block Vs Local Anaesthetic Wound Infiltration for Postoperative Analgesia Post-Hysterectomy (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1810;
As a component of multimodal analgesia, TAP block is superior to LWI for postoperative TAH pain management. Specifically, TAP block compared to LWI was associated with: reduced pain scores, reduced opioid consumption; earlier mobilization and improved patient satisfaction.This study, supported the following recommendations:
- |||||||||| morphine sulphate / Generic mfg.
Effects of PICK1 Inhibition on Acute Nociception (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1761;
Repeated, daily administration of PICK1 inhibitors did not evoke problems with spatial memory. Behavioral experiments in larger animals, with brains more like humans will be needed to make informed conclusions about potential side effects in humans, but the results of these experiments are optimistic.
- |||||||||| Fibrous Dysplasia Bone Pain (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1733;
Grid hanging and burrowing could be reversed when analgesics were administered, demonstrating that the behavioral deficits were due, in part, to nociceptive changes. Within FD lesions, sensory and sympathetic nerve fibers and blood vessels were present, which may contribute to nociception.
- |||||||||| morphine sulphate / Generic mfg., ibuprofen / Generic mfg.
Paediatric Pain Management Practices in Northern Ghana, an Observational Study (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1695;
This could be attributed to lack of policies such as formalising pain assessment and guidelines for pain management. Additionally, nurses exhibited inadequate knowledge on the topic.
- |||||||||| SUCCESSFUL MANAGEMENT OF TOTAL PAIN FOR A LADY WITH ASTROCYTOMA. (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1670;
She tolerates her anti-epileptic therapy which also covers now the behavioural and vegetative aspects. The frontal headaches most likely represented her total pain represented initially by the raised intracranial pressure and poor prognosis.
- |||||||||| LY2828360 / Eli Lilly
Cannabinoid receptor 1 and 2 are involved in HIV-related neuropathic pain model (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1641;
Current preliminary data suggest that both CB1/2 agonists produced analgesia, but chronic ACEA for induced antinociceptive tolerance in HIV-related neuropathic pain model. We will continue to study the molecular mechanisms of HIV-related pain.No Conflict(s) of Interest in the research.
- |||||||||| morphine sulphate / Generic mfg.
Serratus plane block in the treatment of postoperative pain after thoracic surgery (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1617;
The total dose of morphine required to relieve pain after thoracic surgery is bile and bile are significantly lower in patients receiving SAP block than in patients receiving primary standard pain control therapy. SAPB block was not associated with any complications in this study.
- |||||||||| morphine sulphate / Generic mfg.
Comparing outcomes with multifidus neurostimulation for chronic low back pain to published evidence. (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1591;
Patients with chronic low back pain (> 6 months) who have not responded to physiotherapy, medicines, or pain management, with MRI scan and physical assessment showing Multifidus atrophy and dysfunction, respectively, and not having any contraindications (previous spinal surgery or radiofrequency denervation of dorsal primary ramus of medial branches, BMI <35, Opioids< 120mgs equivalent daily oral morphine), are discussed in a multidisciplinary team meeting, to decide if the treatment is appropriate and can be offered to the patient... Outcome data for comparison and conclusion will be available at the time of poster presentation.
- |||||||||| morphine sulphate / Generic mfg., pregabalin / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Parsonage (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1583;
Presented spontaneous recovery 3 months after first symptom arousal and electrophysiological signs of reinnervation in supraspinatus and infraspinatus muscles without any intervention or surgical management. Patient continued with medical treatment and occupational therapy sessions.
- |||||||||| morphine sulphate / Generic mfg.
ENDOGENOUS OPIOID SYSTEM FUNCTION PREDICTS RESPONSES TO ORAL OXYCODONE (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1570;
Given the common clinical use of oxycodone for postsurgical pain management, the current study has relevance to understanding factors driving postoperative pain management responses. Individuals with low natural pain inhibitory capacity obtain significantly greater pain relief with oxycodone.
- |||||||||| MoxDuo IR (morphine + oxycodone) / QRxPharma, AbbVie
Restrictive Domains in Healthcare Opioid Legislation in Low- and Middle-Income Countries (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1524;
Recruitment to the pilot study (traditional approach):[3] busy clinicians While analyses of associations of restrictive domains and HDI and QDI are ongoing and results are pending, this scoping review preliminarily calls attention to the specific restrictive domains of the legislative language that may negatively influence access to quality pain management.Individual models of success in facilitating access to opioids and developing palliative care programs were identified in Nepal, Mongolia, and Uganda.
- |||||||||| morphine sulphate / Generic mfg., aspirin / Generic mfg.
Menthol: An exploration from antiquity to modernity (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1483;
In modernity, when referring to menthol, usually the L-(-)menthol isomer is implied as this has become a prominent ingredient in a variety of products (6). With the advent of modern science, our understanding of menthol's mode of action has deepened, revealing specific receptors, including TRPM8, as pharmacological targets responsible for the cooling analgesic effects (5,8-10).
- |||||||||| morphine sulphate / Generic mfg.
Development of a Mouse Model of Opioid Tapering (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1429;
With the advent of modern science, our understanding of menthol's mode of action has deepened, revealing specific receptors, including TRPM8, as pharmacological targets responsible for the cooling analgesic effects (5,8-10). Future experiments will investigate whether there are opioid tapering paradigms that reduce withdrawal symptoms in distinct sub-populations, with particular attention to sex-specific or incentive salience-specific outcomes.
- |||||||||| morphine sulphate / Generic mfg.
Negative affective states and susceptibility to opioid abuse in a mouse model of neuropathic pain (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1425;
Lower oxycodone consumption in the SNIt group could indicate that pain relief is becoming less rewarding and more aversive overall. Further studies are necessary to document the effects of traumatic neuropathic nerve injury in female mice and susceptibility to opioid addiction.
- |||||||||| morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
Cocktail of Ropivacaine, Morphine and Diprospan prolong analgesic effects after knee arthroplasty (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1421;
Although the small statistical benefit may not result in MCID, the LIA cocktail still reduces opioid consumption, results in better sleeping quality and faster rehabilitation and does not increase adverse events. Therefore, cocktails of ropivacaine, morphine and Diprospan have good application value for pain control in TKA.
- |||||||||| Remitch (nalfurafine) / Toray, Mitsubishi Tanabe, resatorvid (TAK-242) / Takeda, Akaza Bioscience
NIH HEAL Initiative Preclinical Screening Platform for Pain Program and Data Sharing (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1412;
Therefore, cocktails of ropivacaine, morphine and Diprospan have good application value for pain control in TKA. (PGI), carbamazepine (3-300 mg/kg, PO), celecoxib (3-100 mg/kg, PO), diazepam (1-30 mg/kg, PO), diclofenac sodium (1-100 mg/kg, PO), duloxetine hydrochloride (3-100 mg/kg, PO), gabapentin (10-300 mg/kg, PO), ketoprofen (0.3-10 mg/kg, PO), morphine sulfate (0.3-10 mg/kg, SC), naproxen sodium (1-100 mg/kg, PO), nalfurafine hydrochloride (1-3,000
- |||||||||| morphine sulphate / Generic mfg.
Ozone therapy for pain management in patients with thermal burns (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1405;
Current scientific evidence suggests that the use of ozone therapy as an adjuvant in patient contributes to reducing costs, infections and complications, as well as speeding up the healing process and healing process and improving the quality of life of these victims. However, the literature lacks robust studies that can evaluate the effectiveness of ozone in reducing pain in burn patients.
- |||||||||| morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
Take Home Opioid Prescribing After Surgery in the United Kingdom (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1356;
Prolonged duration of surgery that involves dissection and removal of a significant portion of liver, limits the metabolism of opioids and also leads to metabolic and lactic acidosis. Dihydrocodeine was the sole opioid dispensed for caesarean section, while tramadol was the preferred choice after colorectal resection.Opioid prescribing was more diverse after the orthopaedic procedures with little conformity and more dispensing of stronger opioids
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Pain Management in Cancer Patients (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1351;
72 patients (86%) benefited of major opioids administration (Morphine, Fentanyl, Oxycodone), and for 51 patients co-analgesics were administered. Although in Romania palliative care at home is still not sufficiently well developed, it can represent a viable solution for controlling the pain of cancer patients at their home, and for improving their quality of life.
- |||||||||| remifentanil / Generic mfg., morphine sulphate / Generic mfg.
Effects of Postoperative Transcranial Direct Current Stimulation on Chronic Post-Thoracotomy Pain (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1282;
The difference between patients who had CPTP in a-tDCS vs control was a lack of an affective component of pain and less presence of a neuropathic component of pain. However, more studies are needed to evaluate the effects of tDCS on acute and chronic postoperative pain.
- |||||||||| morphine sulphate / Generic mfg.
Cacao Extract vs Oral Morphine as An Analgesic: Study in Mice (Mus musculus) (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1273;
This is demonstrated by the efficacy of ethanol extract-raw cacao administered as an adjuvant & as a single dose to mice given acute discomfort with 1% v/v acetic acid. When ethanol extract-raw cacao was combined with morphine, which is a definitive therapy for individuals with severe pain, the efficacy was enhanced.
- |||||||||| Chirocaine (levobupivacaine) / Purdue, AbbVie
Case Report: Hip Radiofrecuency Ablation in a 12 years Old Cancer Pain Girl (Rhabdomyosarcoma) (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1270;
Using the hip denervation technique described, the sciatic innervation remains and reduces the possibility of a Charcot joint. Regardless, hip denervation in a pediatric patient should be considered a last resort in the treatment of hip pain.Hip denervation is a potentially useful pain intervention when conservative or surgical options fail.
- |||||||||| morphine sulphate / Generic mfg.
Adductor Block Plus Morphine/Betamethasone Boosts Knee Arthroplasty Pain Relief (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1267;
Although the small statistical benefit may not result in minimal clinically important difference, Adductor canal block combined with Local infiltration analgesia also reduce opioid requirements, improve sleeping quality, and do not increase the complication rate. Therefore, Adductor canal block combined with Local infiltration analgesia still have good application prospects as an effective pain management for total knee arthroplasty.
- |||||||||| Zelnorm (tegaserod) / Novartis
Gut Dysbiosis and Alterations of Gastrointestinal Motility as Drivers of Opioid-Induced Hyperalgesia (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1252;
Therefore, Adductor canal block combined with Local infiltration analgesia still have good application prospects as an effective pain management for total knee arthroplasty. Male and female C57Bl6J mice were treated with escalating doses of morphine (10-40 mg/kg, i.p.) for 4 days...To assess the role of gut motility, drug-na
|
