morphine sulphate / Generic mfg. 
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  • ||||||||||  morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
    Journal:  Should INCB Consumption Data Be Utilized to Guide Opioids Policy? (Pubmed Central) -  Apr 19, 2022   
    INCB data should not be utilized to benchmark the adequacy of pain management among different countries without taking into consideration variations in disease burden and the use of tramadol and other pain drugs.
  • ||||||||||  morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
    Journal:  Comparison of the analgesic effects of morphine and tramadol after tumor surgery in dogs. (Pubmed Central) -  Apr 19, 2022   
    Intravenous fentanyl citrate was used for intraoperative analgesia after stabilization of the anesthesia...Pain scores were lower in the morphine group than in the tramadol group during all postoperative processes. As a result, it was determined that tramadol has immediate analgesic effects than morphine; however, morphine provides better analgesia than tramadol.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Retrospective data, Review, Journal:  Effect of Intravenous Dexamethasone on Postoperative Pain in Patients Undergoing Total Knee Arthroplasty: A Systematic Review and Meta-Analysis. (Pubmed Central) -  Apr 19, 2022   
    Our results supported the addition of perioperative intravenous dexamethasone to multimodal analgesia in total knee arthroplasty to reduce postoperative pain, opioids consumption, and length of hospital stay. Current evidence did not support the superiority of repeated-dose dexamethasone over single-dose dexamethasone; thus, we recommended perioperative 8-10 mg intravenous dexamethasone to be used based on adequate basic analgesia; however, the results may have been affected by small sample sizes and heterogeneity.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Quality Improvement Project to Reduce Opioid Use in Patients Undergoing Cesarean Birth. (Pubmed Central) -  Apr 19, 2022   
    Results showed a reduction use of morphine milligram equivalents of opioids, a slight decrease in length of hospital stay, and no change in the inpatient costs. The team recognized that implementation of an ERAS protocol is a best practice to reduce opioid use in patients undergoing a cesarean birth and decided to permanently include it in patient care processes.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Immuno-epidemiological co-affection model of HIV infection and opioid addiction. (Pubmed Central) -  Apr 19, 2022   
    CD4 cells and viral load data obtained from morphine addicted SIV-infected monkeys are used to validate the within-host model...Elasticity analysis suggests that the most sensitive number is the invasion number of opioid epidemic with respect to the parameter of enhancement of HIV infection of opioid-affected individual. We conclude that the most effective control strategy is to prevent opioid addicted individuals from getting HIV, and to treat the opioid addiction directly and independently from HIV.
  • ||||||||||  morphine sulphate / Generic mfg.
    Retrospective data, Journal:  Evaluation of U.S. state opioid prescribing restrictions using patient opioid consumption patterns from a single, urban, academic institution. (Pubmed Central) -  Apr 19, 2022   
    In many states, overlapping duration and daily dose limits yield maximum prescription limits of 150-350 morphine milligram equivalents (MMEs)...Real consumption data should be used to guide these restrictions and inform future interventions so the risk of worsened pain control (and its troublesome effects on opioid misuse) is minimized. Procedure-specific prescribing limits may be one approach to prevent misuse, while also optimizing post-operative pain control.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  A Novel Morphine Drinking Model of Opioid Dependence in Rats. (Pubmed Central) -  Apr 19, 2022   
    Voluntary morphine consumption was also shown to generate brain oxidative stress and neuroinflammation, signs associated with opioid dependence development. We present a robust two-bottle choice animal model of oral morphine self-administration for the evaluation of therapeutic interventions for the treatment of morphine dependence.
  • ||||||||||  Review, Journal:  The Influence of Analgesic Modalities on Postoperative Cancer Recurrence. (Pubmed Central) -  Apr 19, 2022   
    Fentanyl administration significantly diminishes NK-cells and CD8+ cytotoxic T-cells...COX inhibitors have also shown promise in persevering cancer immune function, as in literature involving ketorolac and celecoxib. In summary, inhaled anesthesia and opioids may contribute to a pro-tumor metastasis environment also known as cancer propagation; whereas propofol and COX inhibitors may provide a better alternative to reduce cancer recurrence and propagation.
  • ||||||||||  GSK3036656 / GSK
    Journal:  Agonists Specific for κ-Opioid Receptor Induces Apoptosis of HCC Cells Through Enhanced Endoplasmic Reticulum Stress. (Pubmed Central) -  Apr 19, 2022   
    Taken together, our results revealed that activation of KOR by U50488h inhibited malignant phenotypes of HCC both in vitro and in vivo, while activation of MOR by morphine did not have such effect. Because of their dual roles in the relief of pain and in the suppression of malignant phenotypes, opioids such as U50488h that act on KOR should be considered as the first choice for HCC management.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Opioid prescribing practices for pediatric tonsillectomy before and after policy interventions. (Pubmed Central) -  Apr 19, 2022   
    Data collected included demographics, procedure performed, indication, complications, medical comorbidities, opioid prescribing practices (medication, dose, morphine milliequivalents, and postdischarge opioid prescriptions), and postoperative telephone calls and emergency department (ED) visits...Implementation of statewide policy interventions can have a substantial impact on opioid prescribing practices in the pediatric tonsillectomy population without an increase in office phone calls, postdischarge opioid prescriptions, and ED visits. 4.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  The Effect of an Electronic Prescribing Policy for Opioids on Physician Prescribing Patterns Following Common Upper Extremity Procedures. (Pubmed Central) -  Apr 19, 2022   
    Specifically, we aimed to answer the following: (1) is there a change in the number of opioids prescribed after the institution of ePrescribing for carpal tunnel release (CTR), ganglion excision, distal radius fracture (DRF) open reduction internal fixation (ORIF), and carpometacarpal (CMC) arthroplasty and (2) what factors are associated with an increased number of tablets or total morphine milligram equivalents (MMEs) prescribed...These findings support the value of ePrescribing as a potential tool to further decrease excess opioid prescriptions. Therapeutic III.
  • ||||||||||  AGEP induced by codeine confirmed by patch testing, without crossreactivity to other opioids () -  Apr 19, 2022 - Abstract #BSACI2022BSACI_186;    
    She also had negative oral challenges to tramadol, diazepam, ibuprofen and morphine...Complete avoidance of codeine phosphate is recommended, whereas other opioids can be given. Conclusions We describe the first reported case to our knowledge of AGEP induced by codeine confirmed by patch testing, without cross-reactivity to other opioids.
  • ||||||||||  methadone / Generic mfg.
    Retrospective data, Journal:  Comparison between Preoperative Methadone and Buprenorphine Use on Postoperative Opioid Requirement: A Retrospective Cohort Study. (Pubmed Central) -  Apr 15, 2022   
    Preoperative buprenorphine use was associated with more than a 50% reduction in postoperative opioid dose requirement and a statistically significant, though clinically unimportant, reduction in acute pain burden in comparison to methadone. The study is limited by several important factors such as the exclusion of patients requiring intravenous patient controlled analgesia, small number of patients were on higher dose of buprenorphine, and a large percentage of methadone patients were not on stable dose of methadone yet.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Aquaporin-4 deletion attenuates opioid-induced addictive behaviours associated with dopamine levels in nucleus accumbens. (Pubmed Central) -  Apr 15, 2022   
    Our previous work demonstrated that AQP4 deficiency in mice attenuated morphine-induced physiological dependence...The present findings suggest that deficiency of AQP4 decreases opiate-induced drug seeking and taking behaviours, and AQP4 may be involved in the treatment of addiction. Therefore, the development of a pharmacological antagonist to AQP4 may be valuable to investigate as opioid addiction therapy.
  • ||||||||||  Observational data, Retrospective data, Journal:  Opioid prescribing in out-of-hours primary care in Flanders and the Netherlands: A retrospective cross-sectional study. (Pubmed Central) -  Apr 15, 2022   
    We observed large differences in strong opioid prescribing at OOH-PCSs between Flanders and the Netherlands that are likely to be caused by differences in accessibility of secondary care, and possibly existing opioid prescribing habits. Measures to ensure judicious and evidence-based opioid prescribing need to be tailored to the organisation of the healthcare system.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Full agonist opioid prescribing by primary care clinicians after buprenorphine training. (Pubmed Central) -  Apr 14, 2022   
    Using prescriber data generated by an electronic medical record system, opioid prescribing and morphine milligram equivalents (MME) per day per patient were calculated...As expected, buprenorphine prescribing by X-waivered, trained clinicians increased significantly post-training. X-waivers plus Project ECHO support for the treatment of OUD using buprenorphine had no effect on full agonist opioid prescribing by primary care clinicians.
  • ||||||||||  morphine sulphate / Generic mfg.
    Clinical, Journal:  Presurgical and Postsurgical Opioid Rates in Patients Undergoing Total Shoulder Replacement Surgery. (Pubmed Central) -  Apr 14, 2022   
    These include creating strategies to decrease attrition, offering the program throughout the care continuum to higher risk patients, and evaluating the impacts of reduced opioid use. Although presurgical non-opioid patients were more likely to receive a postsurgical opioid prescription, based on dosage, most patients were at low risk for an opioid-related overdose or death according to CDC guidelines.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Evaluation of Chronic, Noncancer Pain Management Initiative in a Multidisciplinary Pain Clinic. (Pubmed Central) -  Apr 14, 2022   
    Findings support the use of non-pharmacologic and non-opioid therapy for chronic pain management which can result in reduced patient-reported pain. Further research is warranted to examine both pharmacologic (non-opioid) and non-pharmacologic strategies that promote pain management while tapering opioids.
  • ||||||||||  morphine sulphate / Generic mfg., gabapentin / Generic mfg.
    Clinical, Clinical guideline, Journal:  Clinical Practice Guideline: Chronic Cough. (Pubmed Central) -  Apr 14, 2022   
    Chronic cough should be evaluated according to an established diagnostic algorithm in collaboration with specialists. Treatments such as inhaled corticosteroids should be tested exhaustively in accordance with the guidelines, and the possibility of multiple causes as well as the role of patient compliance should be kept in mind before a diagnosis of unexplained or intractable cough is assigned.
  • ||||||||||  morphine sulphate / Generic mfg.
    Preclinical, Journal:  HPA Axis Dysfunction during Morphine Withdrawal in Offspring of Female Rats Exposed to Opioids Preconception. (Pubmed Central) -  Apr 14, 2022   
    While there were no differences in somatic withdrawal signs, gene expression data revealed a sex-specific and time-dependent effect on Crh as well as increased Ucn3 and corticosterone in females at 48hrs withdrawal. Overall, these data point to differences in withdrawal and stress reactivity in Mor-F1 animals that may contribute to observed differences in addiction-like behaviors.
  • ||||||||||  morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
    Retrospective data, Journal:  An evaluation of emergency pain management practices in fragility fractures of the pelvis. (Pubmed Central) -  Apr 14, 2022   
    One in three older adults presenting to the ED with nonoperative fragility pelvic fractures receive no analgesia during the course of their prehospital and ED care. Barriers to quality care must be identified and processes implemented to ensure adequate pain management for this population.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Experience with opioids does not modify the brain network involved in expectations of placebo analgesia. (Pubmed Central) -  Apr 14, 2022   
    We addressed this question by recruiting two groups of individuals holding comparable verbally-induced expectations regarding morphine analgesia but either (i) with or (ii) without prior experience with opioids...We then tested our hypothesis on the recruitment of different PA-associated brain networks in individuals with vs without prior experience with opioids and found no evidence for a topographic N2 and P2 ERP components difference between the two groups. Our results thus suggest that in the presence of verbally-induced expectations, modifications in the PA-associated brain activity by conditioning is either absent or very small.
  • ||||||||||  remifentanil / Generic mfg., morphine sulphate / Generic mfg., ketamine / Generic mfg.
    Retrospective data, Journal, Video:  Non-intubated video-assisted thoracoscopic surgery under combination of erector spinae plane block and thoracic paravertebral block. (Pubmed Central) -  Apr 14, 2022   
    In conclusion, combined ESPB and TPVB with added intravenous sedo-analgesia in the presence of good cooperation between the surgical team and the anesthesiologist in the perioperative period can provide optimal surgical conditions including the prevention of cough in NIVATS. It is not sufficient to state that this combination is superior to alone ESPB or alone TPVB, as it is a preliminary study with a limited number of cases.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Morphine-induced microglial immunosuppression via activation of insufficient mitophagy regulated by NLRX1. (Pubmed Central) -  Apr 14, 2022   
    It is not sufficient to state that this combination is superior to alone ESPB or alone TPVB, as it is a preliminary study with a limited number of cases. Morphine activated insufficient mitophagy in microglia which was regulated by NLRX1, ultimately leading to host immunosuppression and susceptible conditions in the brain.