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7 Diseases |  |
379 Trials |
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379 Trials |  |
12426 News |  |
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- | morphine sulphate / Generic mfg.
Journal: Opioid-induced pronociceptive signaling in the gastrointestinal tract is mediated by delta-opioid receptor signaling. (Pubmed Central) - Apr 23, 2022
Chronic in vivo administration of morphine by intraperitoneal injection in male C57BL/6 mice evoked tolerance and evidence of OIH in an assay of colonic afferent nerve mechanosensitivity; this was inhibited by the δ-opioid receptor (DOPr) antagonist naltrindole when intraperitoneally injected in previous morphine administration...Furthermore, the role of DOPr was dependent on OPr internalization and activation of a protein kinase C (PKC) signaling pathway. Thus, targeting DOPr or key components of the downstream signaling pathway could mitigate adverse side effects by opioids.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Postoperative Respiratory Events in Surgical Patients Exposed to Opioid Analgesic Shortages Compared to Fully Matched Patients Non-exposed to Shortages. (Pubmed Central) - Apr 23, 2022
Thus, targeting DOPr or key components of the downstream signaling pathway could mitigate adverse side effects by opioids. Given the shortage prevalence, reliance on opioid medications, and related risk of respiratory depression, harm prevention measures remain critical to prevent postoperative complications that may compromise patients' safety.
- | bepecin (BPC-157) / Pliva
Preclinical, Journal: The anti-nociceptive effect of BPC-157 on the incisional pain model in rats. (Pubmed Central) - Apr 23, 2022
A 1-cm longitudinal incision was made through the skin, fascia, and muscle of the plantar aspect of the hind paw in isoflurane-anesthetised rats...It was also effective during phase 1 but not during phase 2, as determined by the formalin test. BPC-157 might have a short antinociceptive effect, even though it has anti-inflammatory and wound healing effects.
- | morphine sulphate / Generic mfg.
Journal: Evaluation of Prescribing Patterns Following Surgical Procedures in Opioid Naïve Patients at a Veterans Affairs Teaching Hospital. (Pubmed Central) - Apr 23, 2022
The number of patients utilizing less than 50% of prescribed opioids, and few refills indicate that reductions in opioids prescribed would improve safety for both patients and the surrounding community without increasing the risk for the under-treatment of postoperative pain. Improved prescribing habits and patient safety will be targeted through provider education regarding risk review documentation in opioid naïve patients.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Opioid use after endoscopic skull base surgery: A descriptive, prospective, longitudinal cohort study. (Pubmed Central) - Apr 22, 2022
After ESBS, greater total opioid use was significantly associated with history of headaches and previous opioid use within 60 days. Overall, opioid use declined among all patients in the postoperative period, but several factors may contribute to longer duration of use.
- | fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal: A 13-Year National Monitoring Study to Assess Narcotic Prescriptions and Indications (2007-2019). (Pubmed Central) - Apr 22, 2022
Overall, opioid use declined among all patients in the postoperative period, but several factors may contribute to longer duration of use. This study demonstrates how narcotic opioids are prescribed, thanks to the active participation of health professionals, and confirms the striking increase in the prescription of oxycodone.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Association of clinical competence, specialty and physician country of origin with opioid prescribing for chronic pain: a cohort study. (Pubmed Central) - Apr 22, 2022
This study demonstrates how narcotic opioids are prescribed, thanks to the active participation of health professionals, and confirms the striking increase in the prescription of oxycodone. Clinical competence at entry into US graduate training, physician gender, specialty and country of origin play a role in opioid prescribing practices.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Impact of ultrasound-guided erector spinae plane block on outcomes after lumbar spinal fusion: a retrospective propensity score matched study of 242 patients. (Pubmed Central) - Apr 22, 2022
Erector spinae plane blocks were associated with clinically irrelevant reductions in 24-hour opioid consumption and no improvement in pain scores after lumbar fusion. The routine use of these blocks in the setting of a comprehensive care pathway for lumbar fusion may not be warranted.
- || morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
Clinical, Journal: Preoperative pericapsular nerve group (PENG) block for total hip arthroplasty: a randomized, placebo-controlled trial. (Pubmed Central) - Apr 22, 2022
P=N/A
The routine use of these blocks in the setting of a comprehensive care pathway for lumbar fusion may not be warranted. The addition of a preoperative PENG block to intra-articular injections of local anesthetic provides a limited benefit to postoperative analgesia in the recovery room with no discernible benefits thereafter.
- || morphine sulphate / Generic mfg.
Clinical data, Journal: Sex differences in prehospital analgesia in patients presenting with acute coronary syndromes and their association with clinical outcomes. (Pubmed Central) - Apr 22, 2022
Opioid administration was associated with impaired antegrade flow in the culprit artery in both sexes, but not short-term MACE. Trials evaluating nonopioid analgesics in ACS are needed.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Continuous peripheral nerve block for in-patients with lower limb ischemic pain. (Pubmed Central) - Apr 22, 2022
Trials evaluating nonopioid analgesics in ACS are needed. CPNB may be a good option for ischemic pain treatment in in-patients, as it provides effective pain control with fewer adverse effects.
- | morphine sulphate / Generic mfg.
Journal: Context evoked morphine conditioned effects can be equivalent to morphine induced drug effects in terms of behavioral response and ERK activation in reward associated subcortical brain structures. (Pubmed Central) - Apr 22, 2022
The MOR-UP group did not differ from the VEH group. We suggest that ERK activation evoked by acute morphine served as a Pavlovian unconditioned stimulus to enable the contextual cues to acquire morphine conditioned stimulus properties and increase the incentive value of the contextual cues.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Comparing liposomal bupivacaine plus bupivacaine to bupivacaine alone in interscalene blocks for rotator cuff repair surgery: a randomized clinical trial. (Pubmed Central) - Apr 22, 2022
P4
We suggest that ERK activation evoked by acute morphine served as a Pavlovian unconditioned stimulus to enable the contextual cues to acquire morphine conditioned stimulus properties and increase the incentive value of the contextual cues. LB added to bupivacaine interscalene blocks does not reduce opioid consumption within 72 hours following arthroscopic RCR.
- | morphine sulphate / Generic mfg.
Clinical protocol, Journal: Effects of pericapsular nerve group (PENG) block on postoperative recovery in elderly patients with hip fracture: study protocol for a randomised, parallel controlled, double-blind trial. (Pubmed Central) - Apr 22, 2022
The secondary outcomes will include measuring and comparing the strength of the quadriceps, the visual analogue scale at rest and on movement, the total morphine consumption, the rescue analgesic, the first time of postoperative out-of-bed mobilisation and complications...The results of this study will be published in peer-reviewed international journals. ChiCTR2100042341.
- ||| morphine sulphate / Generic mfg.
Journal, Adverse events: Examining Interventions and Adverse Events After Nonfatal Opioid Overdoses in Veterans. (Pubmed Central) - Apr 22, 2022
At the time of nonfatal opioid overdose, 29 (82.9%) had an active opioid prescription, and the mean morphine equivalent daily dose (MEDD) was 117 mg...This study may aid in the identification of potential areas for improvement in the prevention of opioid overdose and opioid-related mortality among veterans. Interventions designed to improve access to, engagement, and retention in effective care are pivotal for addressing the opioid epidemic as it evolves.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal: Opioid-Free Anesthesia in the Perioperative Setting-A Preliminary Retrospective Matched Cohort Study. (Pubmed Central) - Apr 21, 2022
Additional research is needed to explore if these findings can be extrapolated to a larger more heterogeneous population. Our preliminary work suggests that eliminating patient exposure to opioids in the intraoperative period does not have a deleterious effect on perioperative patient outcomes.
- | morphine sulphate / Generic mfg.
Journal: Examining current patterns of opioid prescribing and use after bariatric surgery. (Pubmed Central) - Apr 21, 2022
Patients who were least satisfied with their pain control reported knowledge gaps about pain control options that were more significant than patients who were more satisfied. Future initiatives should focus on the reduction of opioids prescribed to bariatric surgery patients post-operatively and on opioid education for patients.
- | Dsuvia (sufentanil sublingual) / AcelRx
Journal: The Newest Battlefield Opioid, Sublingual Sufentanil: A Proposal to Refine Opioid Usage in the U.S. Military. (Pubmed Central) - Apr 21, 2022
Accordingly, this commentary aims to (1) review the evolution of opioid use on the battlefield and discuss the medical benefits and limitations of SSTs in acute trauma settings, (2) highlight the importance of chronic pain management post-deployment through evidence-based non-opioid modalities, and (3) explore avenues of future research. Ultimately, we propose that SSTs are an important improvement from existing battlefield opioids and that refining, not abandoning, opioid usage will be key to effectively managing pain in the military.
- | morphine sulphate / Generic mfg.
Retrospective data, Journal, Real-world evidence: COMET - Effectiveness and tolerability of methocarbamol versus oral opioid-analgesics as add-on measure in patients with non-specific low back pain refractory to recommended 1 line treatments. A retrospective analysis of depersonalized propensity score matched open-label real-world 4-week data from the German Pain e-Registry. (Pubmed Central) - Apr 21, 2022
Mean ± SD (median) MET dose over the 4-week evaluation period was 2390.4 ± 1980 (3000) mg and 69.6 ± 25.9 (60) mg morphine equivalent for LAO...A significantly lower number of patients treated with MET vs. LAO reported DRAEs in response to study medication: 36 (9.6%) vs. 139 (37.2%; p < 0.001; NNT 4), and 9 patients treated with MET (2.4%) vs. 86 (23.0%) treated with LAO discontinued treatment in response to these DRAEs (p < 0.001; NNT: 5). 4-week add-on treatment with MET in patients with nsLBP who showed an inadequate response to recommended 1 line treatments is superior effective to LAO and significantly better tolerated.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Patient and in-hospital predictors of post-discharge opioid utilization: Individualizing prescribing after radical prostatectomy based on the ORIOLES initiative. (Pubmed Central) - Apr 21, 2022
Following RP, inpatient opioid use, patient-reported pain scores, prior opioid use, and BMI are correlated with post-discharge opioid utilization. These data can help guide individualized opioid prescribing to reduce risks of both overprescribing and underprescribing.
- || morphine sulphate / Generic mfg., paracetamol / Generic mfg.
Clinical, Journal: Harnessing choice architecture in urologic practice: Implementation of an opioid-sparing protocol grounded in cognitive behavioral theory. (Pubmed Central) - Apr 21, 2022
Adherence to an OSP is most effective when initiatives incorporate the entire team and are supported by nudge theory-based structural changes. Using these strategies, most patients following urologic MIS can dramatically reduce opioid use postoperatively.
- | morphine sulphate / Generic mfg.
Journal: CRISPR/Cas9 unveils the dynamics of the endogenous µ-opioid receptors on neuronal cells under continuous opioid stimulation. (Pubmed Central) - Apr 21, 2022
Our results indicate that even a few days of opioid administration could significantly reduce the MOP expression level. Our cell line could be a potential tool to investigate the molecular mechanisms underlying the problems caused by long-term opioid use.
- | morphine sulphate / Generic mfg.
Observational data, Journal, HEOR: Chronic postsurgical pain and quality of life after right minithoracotomy mitral valve operations. (Pubmed Central) - Apr 21, 2022
Right minithoracotomy approach is not burdened by a high incidence of CPSP: pain severity index was lower than 10 in more than 90% of patients. Then, in our experience, chronic pain seems not to be related to the type of perioperative analgesia adopted.
- ||| morphine sulphate / Generic mfg.
Reimbursement, Retrospective data, Journal, Adverse events, Medicare: Trajectories of prescription opioid dose and risk of opioid-related adverse events among older Medicare beneficiaries in the United States: A nested case-control study. (Pubmed Central) - Apr 21, 2022
An increased risk for ORAE was observed among older patients with a gradual increase in dose or among those with a consistent low-to-moderate dose of prescribed opioids when compared to patients with opioid dose discontinuation. Whether older patients are susceptible to low opioid doses warrants further investigations.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Acute morphine administration, morphine dependence, and naloxone-induced withdrawal syndrome affect the resting-state functional connectivity and local field potentials of the rat prefrontal cortex. (Pubmed Central) - Apr 21, 2022
In morphine-dependent rats, after each morphine administration, the LFP power in all frequency bands and the rsFC strength of the prefrontal cortex were increased, and these effects were further enhanced after naloxone precipitated withdrawal syndrome. The present study concludes that general correlation merely reflects the field activity of the local cortices imaged.
- | morphine sulphate / Generic mfg.
Journal: A cAMP-Related Gene Network in Microglia Is Inversely Regulated by Morphine Tolerance and Withdrawal. (Pubmed Central) - Apr 21, 2022
Direct activation of Gi/o-coupled DREADD receptors in CX3CR1-expressing cells exacerbated signs of opioid withdrawal rather than mimicking the effects of morphine. These results indicate that Gi-signaling and cAMP-associated gene networks are inversely engaged during opioid tolerance and early withdrawal, perhaps revealing a role of microglia in mitigating the consequences of opioids.
- | morphine sulphate / Generic mfg.
New P4 trial: Postoperative Analgesia in Patients Undergoing Elective Lumbar Fusion Operations Under General Anesthesia (clinicaltrials.gov) - Apr 21, 2022
P4, N=120, Not yet recruiting, Sponsor: Ain Shams University
- fentanyl citrate / Generic mfg.
Adenovirus Capsid Proteins-Based Anti-Fentanyl Vaccine Attenuates Fentanyl-Induced Behaviors in Mice (Room 206) - Apr 20, 2022 - Abstract #ASGCT2022ASGCT_1010;
On a hot plate sensitivity test, fentanyl-induced antinociception was blunted (>86% reduction) in dAd5-hapten 3 vaccinated mice compared to control (p<0.03). In summary, leveraging high immunogenicity of the adenovirus capsid proteins, we have developed potent anti-fentanyl vaccine that should be useful in preventing addiction reward and fentanyl overdose in addicts.
- morphine sulphate / Generic mfg.
EFFECTS OF THE CDC'S 2016 OPIOID GUIDELINES ON PEDIATRIC AND ADULT PATIENTS WITH SICKLE CELL DISEASE (live stream) - Apr 20, 2022 - Abstract #ASPHO2022ASPHO_175;
The CDC guideline release timing corresponded with decreases in opioid prescribing practices and unfavorable health outcomes among patients with SCD. The guideline may have an unintended negative impact on this population, with greater impact in adults compared to pediatric patients.*This study was funded by the American Association of Colleges of Pharmacy.
- |||||| Xtandi (enzalutamide capsule) / Pfizer, Astellas, Savaysa (edoxaban) / Daiichi Sankyo
New trial: MIND THE GAP: Determining the Clinical Relevance of the Interaction Between Enzalutamide and the Opioid Morphine and the DOAC Edoxaban (clinicaltrials.gov) - Apr 20, 2022
P=N/A, N=26, Not yet recruiting, Sponsor: Radboud University Medical Center
- | morphine sulphate / Generic mfg.
Journal: Associations of opioid prescription dose and discontinuation with risk of substance-related morbidity in long-term opioid therapy. (Pubmed Central) - Apr 20, 2022
Relative to initial treatment, risk was greater within individual during subsequent periods of >60 to 120 (adjusted odds ratio [OR], 1.29; 95% CI, 1.12 to 1.49) and >120 (OR, 1.48; 95% CI, 1.24-1.76) daily morphine milligram equivalents...Results were supported by a negative control pharmacotherapy analysis and additional sensitivity analyses. They suggest that LtOT recipients may experience increased substance-related morbidity risk during treatment subsequent to initial opioid prescription, particularly in periods involving higher doses.
- | pregabalin / Generic mfg.
Journal: Trajectories of pregabalin use and their association with longitudinal changes in opioid and benzodiazepine use. (Pubmed Central) - Apr 20, 2022
Among people using both pregabalin and benzodiazepines, the dose remained constant over time for people in all trajectories. Notwithstanding its reputation as opioid-sparing, in this outpatient setting we observed that people using opioids tended to use higher opioid daily doses after pregabalin initiation, especially those on high pregabalin doses.
- | morphine sulphate / Generic mfg.
Journal: Pain management, fluid therapy and thromboprophylaxis after pancreatoduodenectomy: a worldwide survey among surgeons. (Pubmed Central) - Apr 20, 2022
Although the majority of surgeons presume a relationship between pain management, fluid therapy and thromboprophylaxis and clinical outcomes, variations in practices were observed. Additional studies are needed to further optimize, standardize and implement ERAS protocols after pancreatic surgery.
- | morphine sulphate / Generic mfg.
Journal: Chronic paternal morphine exposure increases sensitivity to morphine-derived pain relief in male progeny. (Pubmed Central) - Apr 20, 2022
Using RNA sequencing across pain-relevant brain regions, we identify gene expression changes within the regulator of G protein signaling family of proteins that may underlie this multigenerational phenotype. Together, this rat pain scale revealed that paternal opioid exposure increases sensitivity to morphine's pain-relieving effects in male offspring.
- | morphine sulphate / Generic mfg.
Observational data, Retrospective data, Journal: Dose tapering, increases, and discontinuity among patients on long-term high-dose opioid therapy in the United States, 2017-2019. (Pubmed Central) - Apr 20, 2022
Dosage changes for patients on high-dose long-term opioid therapy may warrant special attention, particularly over shorter intervals, to understand how potentially sudden tapering and discontinuation can be reduced while emphasizing patient safety and shared decision-making. Rapid discontinuation of opioids can increase risk of adverse outcomes including opioid withdrawal.
- | dexamethasone / Generic mfg., morphine sulphate / Generic mfg.
Journal: Antinociceptive, anti-inflammatory and antioxidant activities of the crude ethanolic extract and alkaloid fraction of Waltheria viscosissima A. St. - Hil. (Malvaceae). (Pubmed Central) - Apr 20, 2022
These bioactive compounds showed promising and potential to replace standard medicines. This bioactive effect is statistically similar to morphine and dexamethasone, standard medicines on the market, but with the advantage of antioxidant activity.
- | morphine sulphate / Generic mfg.
Preclinical, Journal: Gnas Promoter Hypermethylation in the Basolateral Amygdala Regulates Reconsolidation of Morphine Reward Memory in Rats. (Pubmed Central) - Apr 20, 2022
Furthermore, Gnas promoter hypermethylation was confirmed to be inversely correlated with the downregulation of Gnas mRNA levels. The findings indicate that the specific transcription regulation mechanism in the BLA and NAc on reconsolidation of opiate-associated memories can be dissociable, and DNA hypermethylation of Gnas in the BLA is necessary for the reconsolidation of morphine reward memories.
- | dexmedetomidine / Generic mfg.
Trial completion date, Trial primary completion date, Surgery: Dexmedetomidine Supplemented Analgesia and Long-term Survival After Cancer Surgery (clinicaltrials.gov) - Apr 20, 2022
P=N/A, N=1500, Recruiting, Sponsor: Peking University First Hospital
The findings indicate that the specific transcription regulation mechanism in the BLA and NAc on reconsolidation of opiate-associated memories can be dissociable, and DNA hypermethylation of Gnas in the BLA is necessary for the reconsolidation of morphine reward memories. Trial completion date: Dec 2024 --> Apr 2024 | Trial primary completion date: Dec 2021 --> Apr 2022
- | morphine sulphate / Generic mfg.
Journal: A Practical Guide to Lower Extremity Nerve Blocks for the Sports Medicine Surgeon. (Pubmed Central) - Apr 20, 2022
Each block demonstrated a significant benefit (P > .05) in ≥1 of the following outcomes: intraoperative morphine, pain scores, nausea, and/or opioid consumption...When administered properly, PNBs were a safe and effective adjuvant method of pain control with a significant potential to limit postoperative narcotic use. While blockade choice varies by surgeon preference and procedure, all PNBs should be administered with ultrasound guidance, and vigilant protocols for the risk of postoperative falls should be exercised in patients who receive them.
- |||| morphine sulphate / Generic mfg.
Clinical: Euthanized the elderly. You proud of Sweden? "Many elderly people were administered morphine instead of oxygen despite available supplies, effectively ending their lives." 22 March 2022 Evaluation of science advice during the COVID-19 pandemic in Sweden https://t.co/un1fePcqrf (Twitter) - Apr 20, 2022
- || morphine sulphate / Generic mfg.
Did Sweden beat the pandemic by refusing to lock down? No, its record is disastrous March 31, 2022 “Many elderly people were administered morphine instead of oxygen despite available supplies, effectively ending their lives....” https://t.co/Aq3OuN9aW0 (Twitter) - Apr 20, 2022
- || ketorolac / Generic mfg.
Clinical, Journal: Safety and Efficacy of Single-Dose Ketorolac for Postoperative Pain Management After Primary Palatoplasty: A Prospective Cohort Study With Historical Controls. (Pubmed Central) - Apr 19, 2022
All patients received intraoperative acetaminophen, dexmedetomidine, and opioids while the study group received an additional single dose of ketorolac (0.5 mg/kg) at the conclusion of PP...The mean dose of opioid rescue medication measured as morphine milligram equivalents did not differ between groups (P = .56)...Although lack of standardization between study and historical control groups may have precluded observation of an analgesic benefit, analysis demonstrated a single dose of ketorolac after PP is safe. Further investigations with more patients and different postoperative regimens may clarify the role of ketorolac in improving pain after PP.
- | morphine sulphate / Generic mfg.
Journal: Mechanism of Dopaminergic Nerve Transmission in Different Doses of Morphine Addiction and Stress-Induced Depression. (Pubmed Central) - Apr 19, 2022
The average NIV of PEN before injection was 11.92 ± 2.90 Hz, and the average latency was 0.16 ± 0.03 s. The results indicate that CUMS may reduce the conditioned learning and memory ability by damaging the learning loop, rather than affecting the reward loop to weaken the establishment of morphine-dependent CPP.
- | Nucynta (tapentadol) / Collegium Pharma, Grunenthal
Journal: Pharmaceutical opioid poisonings in Victoria, Australia: rates and characteristics of a decade of Emergency Department presentations across nine pharmaceutical opioids. (Pubmed Central) - Apr 19, 2022
The results indicate that CUMS may reduce the conditioned learning and memory ability by damaging the learning loop, rather than affecting the reward loop to weaken the establishment of morphine-dependent CPP. In Victoria, Australia, rates and characteristics of emergency department presentations for pharmaceutical opioids show distinct variations by opioid type.
- || morphine sulphate / Generic mfg., baclofen / Generic mfg.
Clinical, Journal: Severe altered mentation due to cervicothoracic intrathecal pump after correction of cervical stenosis: a case report. (Pubmed Central) - Apr 19, 2022
This case presents clinical evidence that severe spinal stenosis may impede the rostral CSF distribution of intrathecal medications. Intrathecal medications previously tolerated by patients prior to decompression may need to be significantly reduced in the postoperative period.
- || morphine sulphate / Generic mfg.
Clinical, Journal: A prospective cohort study evaluating the impact of upscheduling codeine in Australia among frequent users of codeine. (Pubmed Central) - Apr 19, 2022
Intrathecal medications previously tolerated by patients prior to decompression may need to be significantly reduced in the postoperative period. Rescheduling codeine in Australia has been accompanied by significant reductions in codeine use and prevalence rates of opioid use disorder in a cohort of individuals who regularly use the medication, without apparent adverse impacts on pain or measures of anxiety and depression.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Trajectories of opioid consumption from day of surgery to 28 days postoperatively: a prospective cohort study in patients undergoing abdominal, joint, or spine surgery. (Pubmed Central) - Apr 19, 2022
We observed distinct opioid use trajectories following abdominal and joint or spine surgery that were associated with different patterns of pain and duration of opioid use postoperatively. Prediction of postoperative opioid use trajectory groups may be clinically important for identifying risk of prolonged opioid use.
- || morphine sulphate / Generic mfg.
Clinical, Journal: Comparison of Pericapsular nerve group (PENG) block with fascia iliaca compartment block (FICB) for pain control in hip fractures: A double-blind prospective randomized controlled clinical trial. (Pubmed Central) - Apr 19, 2022
PENG block is a good method in hip fractures analgesia and provides better analgesia than FICB. However, further studies with larger sample sizes are required to validate the efficacy and superiority of the PENG blocks over conventional techniques.
- | morphine sulphate / Generic mfg.
Reimbursement, Journal: Association of opioid fills with centers for disease control and prevention opioid guidelines and payer coverage policies: physician, insurance and geographic factors. (Pubmed Central) - Apr 19, 2022
Aim We evaluated differences in the rate of first-time opioid fills at doses ≥ 50 morphine milligram equivalents (MME)/day and first-time opioid fills with benzodiazepine fill overlap following the CDC guidelines and following a PCC between provider types, geographic locations, and insurance types...Conclusion Responses to the CDC opioid guidelines and a PCC differed between PCPs and SPs, urban and rural PCSAs, and when prescribing to MA and CIPs. Understanding these differences is important to help inform future guidelines.
- | morphine sulphate / Generic mfg.
Journal: Progress update: Palliative care development between 2017 and 2020 in five African countries. (Pubmed Central) - Apr 19, 2022
Understanding these differences is important to help inform future guidelines. The experiences in these countries suggest that mixing advocacy, communications, and technical assistance can lead to substantial progress for patient access although full inclusion in universal health coverage remained uncertain in all but Rwanda.