- |||||||||| morphine sulphate / Generic mfg., methadone / Generic mfg.
Review, Journal: Neonatal opioid withdrawal syndrome: a review of the science and a look toward the use of buprenorphine for affected infants. (Pubmed Central) - Apr 30, 2022
Although morphine and methadone are the most commonly used pharmacotherapies for NOWS, buprenorphine has emerged as a treatment option based on its pharmacologic profile and results from initial single site clinical trials. The objective of this report is to provide an overview of NOWS including a summary of ongoing work in the field and to review the state of the science, knowledge gaps, and practical considerations specific to the use of buprenorphine for the treatment of NOWS as discussed by a panel of experts during a virtual workshop hosted by the National Institutes of Health.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Palliative care in Uganda: quantitative descriptive study of key palliative care indicators 2018-2020. (Pubmed Central) - Apr 30, 2022
The existing services, both private and public, are limited by the amount of pain-relieving morphine, financial and transport resources. More quality data collected on key palliative care indicators is needed into geographical accessibility of palliative care services, morphine availability trends, and patient diagnoses in order to improve the provision of palliative care in Uganda.
- |||||||||| morphine sulphate / Generic mfg., lorazepam / Generic mfg.
Journal: Adult Medical Cannabinoid Use and Changes in Prescription Controlled Substance Use. (Pubmed Central) - Apr 30, 2022
Unadjusted analyses did not find significant changes in either morphine equivalents (p=0.81) or lorazepam equivalents (p=0.980), and patients similarly received relatively low doses of THC (2.32 mg/day) and CBD (2.24 mg/day). Findings demonstrated minimal to no change in either opioids or sedative hypnotics over the 6 months of medical cannabis use but may be limited by low retention rates, external generalizability, and an inability to account for nonprescribed substance use.
- |||||||||| morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
Clinical, Journal: Ultrasound-guided erector spinae plane block for open inguinal hernia repair: a randomized controlled trial. (Pubmed Central) - Apr 29, 2022
RLB was a more effective analgesic method than ESPB in the treatment of MRF. At the doses used in this study, the ESP block was an ineffective technique for providing postoperative analgesia in unilateral open inguinal hernioplasty and was associated with higher consumption of rescue opioids when compared to spinal anesthesia with or without opioid.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Journal: Pilot study of the effect of therapeutic photobiomodulation on postoperative pain in knee arthroplasty. (Pubmed Central) - Apr 29, 2022
Nine participants undergoing primary TKA submitted to spinal anesthesia, sedation, ultrasound-guided obturator and Femoral nerve Block analgesia, and photobiomodulation Therapy (FBMT) were evaluated regarding postoperative pain and morphine consumption...At IPO, mean pain score was 4.8±3.2 and 5.6±3.5, at rest and on movement, respectively. Photo biomodulation therapy can be considered an option for mitigating pain for patients undergoing TKA.
- |||||||||| morphine sulphate / Generic mfg.
Journal: The placenta as a target of opioid drugs. (Pubmed Central) - Apr 29, 2022
These drugs might affect placental hormones associated with maternal recognition of pregnancy, including placental lactogens and human chorionic gonadotropin (hCG) in rodents and humans, respectively. A further understanding of how such drugs affect the placenta may open up new avenues for early diagnosis and remediation approaches.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Involvement of Hippocampal Astrocytic Connexin-43 in Morphine dependence. (Pubmed Central) - Apr 29, 2022
Our findings suggest that hippocampal Cx43 may be involved in morphine-induced behavioral responses. Therefore, gliotransmitter release by astrocytes seems to be a mechanism which is engaged in addictive-like behaviors.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Clinical Efficacy of Pulsed Radiofrequency Combined with Intravenous Lidocaine Infusion in the Treatment of Subacute Herpes Zoster Neuralgia. (Pubmed Central) - Apr 29, 2022
Patients with poor pain control during the treatment were given 10 mg morphine tablets for pain relief to reach visual analog scale (VAS) ≤4 points...Among them, the erythrocyte sedimentation rate, CRP level, CGRP level, and interleukin-6 level of group B were significantly lower than those of group A. The incidence of postherpetic neuralgia (PHN) in group B patients (6.25%) was also lower than that in group A patients (25%). DSA-guided nerve pulse radiofrequency surgery combined with intravenous lidocaine infusion can effectively relieve pain in patients diagnosed with herpes zoster nerves at the subacute stage, reduce the number of analgesic drugs used in patients, reduce postherpetic neuralgia incidence rate, and improve sleep and quality of life.
- |||||||||| morphine sulphate / Generic mfg., epinephrine / Generic mfg.
Journal: The mechanism for ligand activation of the GPCR-G protein complex. (Pubmed Central) - Apr 29, 2022
Most surprising is that the GP binds first to the GPCR to form a precoupled complex that remains at rest until the drug binds to induce the signaling. Most important, it is the precoupled GPCR-GP structure that provides the basis for the design of therapeutics to maximize activity and selectivity.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Embryonic opioid exposure impairs inhibitory transmission of striatum in day-old chicks. (Pubmed Central) - Apr 29, 2022
Furthermore, GABA injection in the chick embryo following morphine administration mitigated damage to GABA transmission and recovered the behavioral response to acute morphine injection in chicks. Collectively, our findings suggest that abnormal GABA release in the early embryonic period induced by opioid exposure is attributable to functional and structural developments of the GABA synapse, and that the dysfunction of striatal GABA transmission may be linked to enhanced psychomotor response during initial drug exposure in postnatal life.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Pilot survey of prescription opioid use patterns and engagement with harm-reduction strategies in emergency department patients. (Pubmed Central) - Apr 29, 2022
Reported daily POM consumption was converted to milligram morphine equivalents (MME)...The majority of patients (66%) were not aware of take-home naloxone programs to treat opioid overdose. In this pilot survey of ED patients with a pain-related chief complaint, many respondents reported risk factors for opioid misuse, and the majority of participants were unaware of the existence of important harm-reduction strategies, such as take-home naloxone programs, even among those with the highest daily POM use.
- |||||||||| morphine sulphate / Generic mfg., buprenorphine/naloxone sublingual film / Generic mfg., buprenorphine sublingual tablets / Generic mfg.
Retrospective data, Journal: Continuation Versus Discontinuation of Buprenorphine in the Perioperative Setting: A Retrospective Study. (Pubmed Central) - Apr 29, 2022
Buprenorphine was restarted postoperatively for 143 (52%) patients and held for 132 (48%) postoperatively. Conclusions The use of buprenorphine perioperatively was associated with significantly reduced oral morphine equivalent (OME) requirements postoperatively. Further research is needed to give definitive recommendations for whether to continue or discontinue buprenorphine prior to surgery.
- |||||||||| morphine sulphate / Generic mfg., dexmedetomidine / Generic mfg.
Enrollment open, Trial primary completion date, Surgery: The Effect of Intraoperative Dexmedetomidine on Postoperative Morphine Requirements After Breast Cancer Surgery (clinicaltrials.gov) - Apr 29, 2022
P=N/A, N=60, Recruiting,
Conclusions The use of buprenorphine perioperatively was associated with significantly reduced oral morphine equivalent (OME) requirements postoperatively. Further research is needed to give definitive recommendations for whether to continue or discontinue buprenorphine prior to surgery. Not yet recruiting --> Recruiting | Trial primary completion date: Jul 2023 --> Jul 2024
- |||||||||| morphine sulphate / Generic mfg., paracetamol / Generic mfg.
Journal: A Comparison of Acute Pain Management Strategies After Cesarean Delivery. (Pubmed Central) - Apr 28, 2022
Transition to a multimodal pain management regimen for women undergoing cesarean delivery resulted in decreased opioid use while adequately controlling postoperative pain. A multimodal regimen was associated with early successful exclusive breastfeeding.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Opioid-Prescribing Trends in San Diego County, 2008-2019. (Pubmed Central) - Apr 28, 2022
Opioid-prescribing trends in San Diego County from 2008 to 2019 are defined by 2 distinct periods. These trends may serve as an example of how local, state, and national efforts focusing on prescriber outreach, patient education, and regulatory oversight can address the impact of prescription opioids on the ongoing opioid epidemic.
- |||||||||| morphine sulphate / Generic mfg.
Clinical, Journal: Comparison between ultrasound-guided suprainguinal fascia iliaca block and anterior quadratus lumborum block for total hip arthroplasty: a prospective, double-blind, randomized controlled trial. (Pubmed Central) - Apr 28, 2022
These trends may serve as an example of how local, state, and national efforts focusing on prescriber outreach, patient education, and regulatory oversight can address the impact of prescription opioids on the ongoing opioid epidemic. Under the circumstances of this study, when combined with periarticular infiltration analgesia, the SFIB provided similar pain relief compared with AQLB in patients undergoing THA, but was associated with muscle weakness within 6 hours after surgery.
- |||||||||| morphine sulphate / Generic mfg.
Retrospective data, Journal: Percutaneous CT-Guided Microwave Ablation Combined with Vertebral Augmentation for Treatment of Painful Spinal Metastases. (Pubmed Central) - Apr 28, 2022
Under the circumstances of this study, when combined with periarticular infiltration analgesia, the SFIB provided similar pain relief compared with AQLB in patients undergoing THA, but was associated with muscle weakness within 6 hours after surgery. This study demonstrates that percutaneous CT-guided microwave ablation combined with vertebral augmentation is a safe and effective minimally invasive intervention for the treatment of painful spinal metastases.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Predictors and predictive effects of acute pain trajectories after gastrointestinal surgery. (Pubmed Central) - Apr 28, 2022
Body mass index, morphine milligram equivalent (MME) consumption, preoperative chronic pain and anxiety were predictors of the APSP trajectory intercept...In addition, pain trajectory was associated with CPSP. Clinicians need to stay alert for these predictors and pay close attention to pain resolution.
- |||||||||| morphine sulphate / Generic mfg.
Association of opioid use with response to immune checkpoint inhibitors. () - Apr 28, 2022 - Abstract #ASCO2022ASCO_6022;
On the other hand, there was no statistical association between opioid therapy and median PFS. These data highlight a potential drug interaction in oncology care, and further analysis looking at duration of opioid use and ECOG PS is planned.*:Not enough progression was observed in the group to estimate upper confidence limit.
- |||||||||| morphine sulphate / Generic mfg.
Persistent high-risk opioid use in lymphoma survivors following treatment. (Available On Demand; 367) - Apr 28, 2022 - Abstract #ASCO2022ASCO_4759;
The absolute incidence of high-risk opioid use decreased over time and may be due to increased awareness of the opioid epidemic. Close clinical follow-up in the post-treatment period may be warranted for patients at high risk of adverse outcomes.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., ropivacaine / Generic mfg.
New strategies for multimodal analgesia in patients with high-risk geriatric cancer in perioperative period. (Available On Demand; 292) - Apr 28, 2022 - Abstract #ASCO2022ASCO_854;
Group 1 (n = 52): patient-controlled analgesia with morphine and nonsteroidal anti-inflammatory drugs (NSAIDs); group 2 (n = 63): ultrasound-guided bilateral transversus abdominis plane (TAP) block with ropivacaine. The strategy of multimodal analgesia based on a combination of intraoperative TAP block and infusions of lidocaine and microdoses of fentanyl can significantly improve the quality of analgesia in perioperative period.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Chronic opioid use is associated with obstructive and spastic disorders in the esophagus. (Pubmed Central) - Apr 27, 2022
The strategy of multimodal analgesia based on a combination of intraoperative TAP block and infusions of lidocaine and microdoses of fentanyl can significantly improve the quality of analgesia in perioperative period. Opioid use is associated with multiple abnormalities on esophageal motility and these effects may be dose-dependent.
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