hydrocortisone / Generic mfg. 
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 337 Diseases   131 Trials   131 Trials   6489 News 


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  • ||||||||||  Enbrel (etanercept) / Pfizer, Amgen
    SEVERE POLYAUTOIMMUNITY AFTER ALLOGENIC HEMATOPOIETIC STEM CELL TRANSPLANTATION: POTENTIAL ROLE OF THE GENETIC BACKGROUND AND CHIMERISM LOSS (ePoster area) -  Feb 14, 2024 - Abstract #EBMT2024EBMT_2537;    
    Moreover, although genetic testing is currently ongoing, it highlights the need for searching for underlying causes responsible both for the early development of malignancies and immune dysregulation in this category of patients, as the knowledge in the field of inborn errors of immunity with immune dysregulation is rapidly expanding. Finally, the chimerism reduction observed in this patient opens interesting physiopathological and clinical perspectives.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal, IO biomarker:  Hydrocortisone cardioprotection in ischaemia/reperfusion injury involves antioxidant mechanisms. (Pubmed Central) -  Jan 31, 2024   
    There is no apparent advantage to recover HPA axis function in converting to multiple dosing hydrocortisone. Our results provide the first evidence that acute HC treatment during early reperfusion induces cardioprotection against AMI, associated with a non-genomic HC-triggered NHE1 inhibition by AKT and antioxidant action that might involves mitochondrial dynamics improvement.
  • ||||||||||  methimazole / Generic mfg., hydrocortisone / Generic mfg., propranolol / Generic mfg.
    AN UNSUAL ACUTE ST SEGMENT MYOCARDIAL INFARCTION AS FIRST MANIFESTATION OF SEVERE HYPERTHYROIDISM (Hall B4-5) -  Jan 26, 2024 - Abstract #ACC2024ACC_6777;    
    Hyperthyroidism, a potentially life-threatening condition, underscores the importance of routine thyroid function testing even in patients without risk factors who experience chest pain. A delay in diagnosis is linked to unfavorable outcomes and increased risk of cardiovascular complications.
  • ||||||||||  APPROACH TO THE USE OF BETA-ADRENOCEPTOR BLOCKERS IN HEART FAILURE DUE TO HYPERTHYROIDISM (Hall B4-5) -  Jan 26, 2024 - Abstract #ACC2024ACC_4912;    
    Where the cardiac failure is truly congestive, due to intravascular expansion and subsequent decompensation, the negative ionotropic BBs are best avoided. If required, a Low dose of propranolol such as 0.5 mg should be given first, or ultra short-acting esmolol should be tried first.
  • ||||||||||  methimazole / Generic mfg., hydrocortisone / Generic mfg.
    FLAIL MITRAL VALVE IN THYROTOXICOSIS - A RARE PRESENTATION OF GRAVES DISEASE (Hall B4-5) -  Jan 26, 2024 - Abstract #ACC2024ACC_2207;    
    Our patient with untreated hyperthyroidism presented with thyrotoxicosis complicated by chordae tendineae rupture, which resulted in heart failure and cardiogenic shock. We stress the importance of early treatment of Grave's disease, and suggest early screening to visualize mitral valve abnormalities, which can avoid life-threatening long-term sequelae.
  • ||||||||||  hydrocortisone / Generic mfg.
    A CASE OF PROFOUND SINUS BRADYCARDIA AS AN UNUSUAL PRESENTATION OF ADRENAL INSUFFICIENCY (Hall B4-5) -  Jan 26, 2024 - Abstract #ACC2024ACC_330;    
    We stress the importance of early treatment of Grave's disease, and suggest early screening to visualize mitral valve abnormalities, which can avoid life-threatening long-term sequelae. Sinus bradycardia is a rare manifestation of AI, but timely recognition and management are essential to prevent potentially life-threatening complications associated with adrenal crisis.
  • ||||||||||  hydrocortisone / Generic mfg.
    Retrospective data, Review, Journal:  Therapeutic Role of HAT Therapy in Sepsis: A Systematic Review and Meta-Analysis. (Pubmed Central) -  Jan 24, 2024   
    Supplementation of septic and septic shock patients with HAT therapy has significant beneficial effects on SOFA score over 72 hours, duration of exogenous vasopressor infusion and procalcitonin clearance. Considering the results of cohort studies, supplementation with HAT is efficacious in reducing ICU mortality.
  • ||||||||||  hydrocortisone / Generic mfg., epinephrine / Generic mfg.
    Trial completion date, Trial primary completion date:  Arterial Pressure and Stress-Dose Steroids in Cardiac Arrest. (clinicaltrials.gov) -  Jan 17, 2024   
    P=N/A,  N=191, Not yet recruiting, 
    Trial completion date: Jun 2024 --> Jul 2025 Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Dec 2026
  • ||||||||||  hydrocortisone / Generic mfg.
    Association Between Weiss-Kruszka Syndrome (WSKA) and Obesity (MTCC - Exhibit Halls DE) -  Jan 10, 2024 - Abstract #ACMG2024ACMG_753;    
    To delve deeper into this association and elucidate the relationship between WSKA and failure to thrive, larger case series are warranted. Previous data suggests that failure to thrive in WSKA is primarily secondary to feeding difficulties rather than an intrinsic concern.
  • ||||||||||  hydrocortisone / Generic mfg.
    Expansion of TAOK1 Related Developmental Delay Phenotype (MTCC - Exhibit Halls DE) -  Jan 10, 2024 - Abstract #ACMG2024ACMG_526;    
    P
    To our knowledge, heart defects, endocrinopathies and/or mitochondrial dysfunction have not been previously reported and may represent an expansion of the phenotype. Mitochondrial and neuronal abnormalities have been reported in the axons of knockdown flies, including disturbed mitochondrial distribution and significantly decreased mitochondrial size.
  • ||||||||||  opevesostat (ODM-208) / Orion Corp, Merck (MSD)
    Enrollment open, Trial completion date, Metastases:  Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003) (clinicaltrials.gov) -  Jan 9, 2024   
    P3,  N=1200, Recruiting, 
    Mitochondrial and neuronal abnormalities have been reported in the axons of knockdown flies, including disturbed mitochondrial distribution and significantly decreased mitochondrial size. Not yet recruiting --> Recruiting | Trial completion date: Jun 2029 --> Aug 2028
  • ||||||||||  Phase classification, Enrollment change, Trial completion date, Trial primary completion date:  RECOVERY: Randomised Evaluation of COVID-19 Therapy (clinicaltrials.gov) -  Jan 5, 2024   
    P3,  N=70000, Recruiting, 
    Not yet recruiting --> Recruiting | Trial completion date: Jun 2029 --> Aug 2028 Phase classification: P2/3 --> P3 | N=50000 --> 70000 | Trial completion date: Nov 2032 --> Jun 2036 | Trial primary completion date: Nov 2023 --> Jun 2026
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Potentials of Gynura procumbens to modulate chronic stress and immunological responses in Oreochromis niloticus. (Pubmed Central) -  Dec 31, 2023   
    Hydrocortisone (0.01% of body weight) was incorporated with the feed to induce the stress response in stress, prevention and treatment groups...The result is substantiated by significant decrease in blood glucose level in prevention (29.5 mg/dL; p = 0.002) and treatment (31.5 mg/dL; p = 0.006) groups, compared to stress group (47.33 mg/dL) at the end of the experiment. Considering the current finding, we can conclude the GPE has potential to be used as therapeutic option for stress regulation however there is a room for further detailed study to understand the in-depth mechanism.
  • ||||||||||  simvastatin / Generic mfg., hydrocortisone / Generic mfg.
    Journal:  Bioinformatics and system biology analysis revealed the crosstalk between COVID-19 and osteoarthritis. (Pubmed Central) -  Dec 29, 2023   
    Considering the current finding, we can conclude the GPE has potential to be used as therapeutic option for stress regulation however there is a room for further detailed study to understand the in-depth mechanism. Four hub genes, disease-related miRNAs, TFs, drugs, and immune infiltration help to understand the pathogenesis and perform further studies, providing a potential therapy target for COVID-19 and OA.
  • ||||||||||  Dipentum (olsalazine sodium) / Viatris, UCB
    VISUALIZING HETEROGENEOUS TRAJECTORIES OF SUBJECTS WITH SURGICAL RELAPSE IN INFLAMMATORY BOWEL DISEASE FROM UK BIOBANK GENERAL PRACTICE DATA (Bellagio Ballroom - Bellagio Las Vegas) -  Dec 24, 2023 - Abstract #CCCongress2024CCCongress_323;    
    Poor response to dexamethasone was associated with antenatal and postnatal inflammation, low birth weight and early pulmonary hypertension. Additionally, data for the 9 most used IBD prescription medications: budesonide, sulfasalazine, methotrexate, hydrocortisone, balsalazide, olsalazine, prednisolone, azathioprine, and mesalamine was analyzed as well...The majority of patients fell within the states labeled
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Shifting the Focus from Dissolution to Permeation: Introducing the Meso-fluidic Chip for Permeability Assessment (MCPA). (Pubmed Central) -  Dec 18, 2023   
    The results were highly reproducible and clearly displayed the method's potential for evaluating the performance of enabling formulations, and possibly even predicting in vivo performance. We believe that, upon further development, the MCPA will serve as a useful in vitro tool that could push sustainability into pharmaceutics by refining, reducing and replacing animal testing in early-stage drug development.
  • ||||||||||  hydrocortisone / Generic mfg.
    A case of nodular cystic fat necrosis after Whipple procedure (Carmel Women's Club) -  Dec 13, 2023 - Abstract #WRMC2024WRMC_388;    
    She was on pancreatic enzyme supplementation and hydrocortisone...Two factors could have contributed to its pathophysiology. One being vascular compromise from the Whipple procedure, and the other being her systemic corticosteroid use resulting in diabetes mellitus and Cushing