- |||||||||| hydrocortisone / Generic mfg.
Journal: Thermosensitive In Situ Gelling Poloxamers/Hyaluronic Acid Gels for Hydrocortisone Ocular Delivery. (Pubmed Central) - Mar 27, 2024
Also, in vitro drug release studies demonstrated significant hydrocortisone release within 8 h, governed by an anomalous transport mechanism, prompting further investigation for optimized release kinetics. The produced platforms offer promising prospects for efficacious ocular drug delivery, addressing pivotal challenges in ocular therapeutics and heralding future advancements in the domain.
- |||||||||| thyroxine / Generic mfg., hydrocortisone / Generic mfg.
Navigating Diagnosis and Management of a Rare Cause of Hyponatremia () - Mar 23, 2024 - Abstract #NKFSCM2024NKF_SCM_640;
This case underscores a rare presentation of SIADH secondary to endocrine abnormalities associated with a pituitary adenoma. Management involves addressing the underlying adenoma and appropriate hormone supplementation.
- |||||||||| Polivy (polatuzumab vedotin-piiq) / Roche, Rituxan (rituximab) / Roche
Trial completion date, Trial primary completion date, Combination therapy: Polatuzumab Vedotin and Combination Chemotherapy for the Treatment of Previously Untreated Lymphoma (clinicaltrials.gov) - Mar 21, 2024
P2, N=49, Recruiting,
Management involves addressing the underlying adenoma and appropriate hormone supplementation. Trial completion date: Nov 2023 --> Nov 2026 | Trial primary completion date: Nov 2023 --> Nov 2025
- |||||||||| hydrocortisone / Generic mfg., epinephrine / Generic mfg.
Preclinical, Journal: In vitro generation of epidermal keratinocytes from human CD34-positive hematopoietic stem cells. (Pubmed Central) - Mar 19, 2024
The results revealed the expression of K5 and K14 genes in D6 cells (early keratinocytes), K10 and K1 genes in D11-D18 cells (mature keratinocytes) with active telomerase enzyme, and FLG, IVL, and TGM1 in D18-D24 cells (terminal keratinocytes), and by D30, the KCs were completely enucleated similar to cornified matrix. This method of differentiation of HSCs to KCs explains the cellular order exists in the normal epidermis and opens the possibility of exploring the use of human HSCs in the epidermal differentiation.
- |||||||||| hydrocortisone / Generic mfg.
Review, Journal: Opioid-induced adrenal insufficiency: diagnostic and management considerations. (Pubmed Central) - Mar 17, 2024
Once a diagnosis of adrenal insufficiency has been made, glucocorticoid replacement in the form of hydrocortisone is likely the mainstay of treatment, and effort should be made to taper down opioids where possible...In this review, we provide context for diagnostic challenges in OAI, suggest diagnostic tools for this population based on available data, and offer recommendations for the management of this disorder. There is a paucity of literature in this field; given the widespread use of opioids in the general population, more investigation into the effects of opioids on the HPA axis is sorely needed.
- |||||||||| dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
THE PUZZLE OF HYPOKALEMIA IN ADRENAL INSUFFICIENCY: A CASE OF AUTOIMMUNE POLYGLANDULAR SYNDROME TYPE 2 () - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_834;
Severe anorexia, resulting in a prolonged malnourished state causing body depletion of potassium stores, is believed to have played a significant role, likely compounded by gastrointestinal potassium losses due to vomiting. In patients with primary AI, negative feedback causes the release of high levels of corticotropin releasing hormone (CRH), which then causes increased production of a prohormone proopiomelanocortin (POMC).
- |||||||||| hydrocortisone / Generic mfg.
AGRESSIVE BILATERAL ADRENAL LYMPHOMAS : ABOUT THREE CASE REPORTS (Station 01) - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_762;
This case emphasizes the importance of genetic testing in diagnosing rare genetic disorders and highlights a novel mutation in the NR5A1 gene. The prognosis of PAL is usually poor,it grows progressively throughout the adrenal glands.Thus early diagnosis and treatment is the key to saving patients.
- |||||||||| NEUROSARCOIDOSIS PRESENTING WITH HYPOTHALAMIC-PITUITARY DYSFUNCTION () - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_731;
Hormonal changes secondary to hypothalamic-pituitary involvement of sarcoidosis are often irreversible especially with delayed presentation. Although data on hormonal reversibility are minimal, early diagonsis and prompt treatment will increase the chance of recovery.
- |||||||||| AN INTERESTING CASE OF MULTIPLE PITUITARY HORMONE DEFICIENCY WITH STALK INTERRUPTION () - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_726;
Early identification of hormonal deficiencies and hormonal replacement influences both the prognosis and the quality of life in patients with hypopituitarism. If PSIS patients are identified before the fusion of epiphyses, they have an excellent opportunity to reach their normal height, prevent short stature and optimize quality of life.
- |||||||||| A RARE CASE OF PITUITARY METASTASIS FROM COLONIC ADENOCARCINOMA () - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_704;
Biochemistry confirmed anterior hypopituitarism with disconnection hyperprolactinemia but no evidence of diabetes insipidus (DI); commenced on hydrocortisone, levothyroxine...Post-operatively, he developed DI and commenced on desmopressin, but no improvement in vision...He received adjuvant radiotherapy to the brain with high dose dexamethasone, developed steroid induced diabetes mellitus and myopathy... Pituitary gland should not be overlooked as a site of metastasis and sellar symptoms could be the first presentation of neoplastic disease.
- |||||||||| hydrocortisone / Generic mfg.
PITUITARY STALK INTERRUPTION SYNDROME, CASE SERIES WITH VARIABLE PRESENTATION. () - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_700;
To conclude this syndrome have variable presentation could present as isolated growth hormone deficiency or multiple pituitary hormone deficiency. It also have progressive course which indicate the need for long-term follow up.
- |||||||||| WHEN HEAD TRAUMA UNCOVERS A COLLISION PITUITARY SELLA LESION! () - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_696;
Collision sella tumours are an exceptionally rare phenomenon and histological studies are essential to confirm the diagnosis. Future research advances in molecular genetics will hopefully clarify how they develop.
- |||||||||| MODERATE TO SEVERE GRAVE'S ORBITOPATHY IN THE FIRST TRIMESTER () - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_620;
Given low blood pressure and fatigue, random cortisol was checked and it was 72nmol/l (110-460nmol/l) and ACTH was 6ng/l (0-50ng/l), this necessitated starting Hydrocortisone replacement...The pregnancy test was positive and the patient was commenced on propylthiouracil and propranolol...Given GO grade, a discussion with the obstetrics team concluded commencing Azathioprine as a safe immunosuppression option during pregnancy to halt GO progression... GO poses vision threats, this necessitates high vigilance, prompt diagnosis, severity assessment, and swift treatment initiation to prevent progression.
- |||||||||| hydrocortisone / Generic mfg.
PREMILOC Hydrocortisone Use and Risk of Late Onset Sepsis (Convention Center Exhibit Hall) - Mar 16, 2024 - Abstract #PAS2024PAS_5039;
Infants will be stratified according to whether or not they completed a course of hydrocortisone. Statistical analysis will be completed to detect whether significant differences exist in the incidence of late onset sepsis between the groups.
- |||||||||| hydrocortisone / Generic mfg.
Effect of Hydrocortisone (HC) on Cardiac Mass in Preterm Intubated Infants < 30 weeks Gestational Age (Convention Center Exhibit Hall) - Mar 16, 2024 - Abstract #PAS2024PAS_4336;
This sample will be expanded for analysis prior to April 2024 by further data collection from a pool of 996 subjects. Background: Dexamethasone use in preterm infants has been associated with adverse effects including hypertension, and an increase in the left ventricular mass index (LVMI), a surrogate for left ventricular hypertrophy...None of the infants in the HC group were receiving sildenafil or bosentan at 36 weeks
- |||||||||| dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
Corticosteroids enhance endothelial restitution through alterations in TGF-b signaling (Convention Center Exhibit Hall) - Mar 16, 2024 - Abstract #PAS2024PAS_3325;
No significant differences were seen in those treated after TNF injury (n=9, Figure 1B, 2B). Flow cytometry demonstrated steroid treatment following inflammation significantly increases the ALK1:ALK5 ratio as compared to control (n=8, Table 1).
- |||||||||| hydrocortisone / Generic mfg.
Early hydrocortisone for BPD prevention: meta-analysis and effect size modifiers (Convention Center Exhibit Hall) - Mar 16, 2024 - Abstract #PAS2024PAS_2694;
Hydrocortisone treatment did not reduce BPD (RR: 0.84 (95%CI: 0.64-1.04)) although heterogeneity was evident (I2=51.6%). The effect size for BPD is greatest for 10-12 days duration of treatment (?= 0.032 (0.01); p=0.007) and tended to be greater in patients with chorioamnionitis (?= -1.5 (0.841); p=0.07).
- |||||||||| Zilretta (triamcinolone acetonide ER) / Pacira, Bydureon (exenatide XR once-weekly) / AstraZeneca
Mapping the drug-loading design space of long-acting cross-linked microparticles (In-person; Galerie 6 (New Orleans Marriott)) - Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_11653;
Therefore, we should bear in mind the possibility of hypoadrenocorticism when we stop steroid therapy in patients who are treated with steroids after ICI administration. Polymeric microparticles (MPs) are clinically well-established formulations (e.g., Lupron Depot
- |||||||||| hydrocortisone / Generic mfg.
Switchable DNA photocatalysts for radical polymerization controlled by chemical stimuli | Poster Board #M54 (In-person; Poster Board #M54; Studio 3 - 10 (New Orleans Marriott)) - Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_7833;
We show these photocatalysts can initiate free-radical polymerization to form bulk hydrogels in response to complementary DNA, a metal ion (Zn 2+ ), or small molecules (glucose and hydrocortisone)...These results demonstrate that DNA conformational changes triggered by chemically diverse stimuli can regulate the activity of radical polymerization photocatalysts. This platform offers new capabilities in spatially and temporally controlled polymer synthesis, with potential applications in diagnostics, sensing, and environmentally responsive materials.
- |||||||||| hydrocortisone / Generic mfg.
Journal: A One-Stone-Two-Birds Strategy of Targeting Microbubbles with "Dual" Anti-Inflammatory and Blood-Brain Barrier "Switch" Function for Ischemic Stroke Treatment. (Pubmed Central) - Mar 12, 2024
In this study, we constructed hydrocortisone-phosphatidylserine microbubbles and combined them with ultrasound (US)-targeted microbubble destruction technology to successfully open the BBB to achieve targeted drug delivery...A confocal microendoscope was used to directly observe the polarization of microglial cells in living animal models for dynamic microscopic visualization detection showing the advantage of being closer to clinical work. Taken together, this study constructed a multifunctional targeted US contrast agent with the function of "one-stone-two-birds", which can not only "on-off" the BBB but also have "two" anti-inflammatory functions, providing a new strategy of integrated anti-inflammatory targeted delivery and imaging monitoring for ischemic stroke treatment.
- |||||||||| Kineret (anakinra) / SOBI, Tecvayli (teclistamab-cqyv) / Genmab, J&J
Managing Neurotoxicity in B-cell Maturation Antigen (BCMA)-directed Therapy: A Case-series Study (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_3506;
Despite employing a range of interventions, disease progression was observed, ultimately resulting in the death of both patients. It's vital to highlight that, in both of these patients, despite experiencing severe ICANS, imaging did not reveal any abnormalities.
- |||||||||| methotrexate / Generic mfg.
Cough-headache as a Novel Presentation of Methotrexate Neurotoxicity (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_3488;
Patients receiving high-dose or intrathecal MTX are also at high risk of spontaneous intracerebral hemorrhage which should first be ruled out. Following initial imaging, MTX neurotoxicity should be considered in the differential with appropriate imaging ordered to evaluate for its presence.
- |||||||||| hydrocortisone / Generic mfg.
Journal: Photo-crosslinkable polyester microneedles as sustained drug release systems toward hypertrophic scar treatment. (Pubmed Central) - Mar 5, 2024
Hydrocortisone was chosen as model drug...The drug release profile of the arrays was evaluated, suggesting that the developed PCL arrays can offer efficient drug delivery for up to two days, while the AUP-PCL arrays can provide a release up to three weeks. Finally, the insertion of MN arrays into skin samples was performed, followed by histological analysis demonstrating the AUP-PCL MNs outperforming the PCL arrays upon providing pyramidical-shaped perforations through the epidermal layer of the skin.
- |||||||||| hydrocortisone / Generic mfg.
Journal: Epidermoid Cyst of the Brainstem in 3-Year-Old Child: A Rare Case Report. (Pubmed Central) - Mar 5, 2024
After completing the surgery, the cavity was irrigated using a solution containing hydrocortisone and Ringer lactate to prevent the occurrence of aseptic meningitis. In the postoperative, the patient recovered without any complications, as all symptoms showed immediate improvement, and the lower cranial nerves returned to normal functioning.
- |||||||||| Iclusig (ponatinib) / Takeda, Otsuka, Incyte
Enrollment closed, Trial completion date: A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (clinicaltrials.gov) - Mar 3, 2024
P1/2, N=68, Active, not recruiting,
This suggests that utilizing hydrocortisone as an irrigating solution, compared to povidone-iodine, has been proven to be a significantly effective option in reducing postoperative pain, edema, and trismus resulting from the surgical removal of impacted teeth. Trial completion date: Aug 2027 --> Jan 2027 | Recruiting --> Active, not recruiting
- |||||||||| Venclexta (venetoclax) / Roche, AbbVie, navitoclax (ABT 263) / AbbVie
Trial primary completion date: Trial Treating Relapsed Acute Lymphoblastic Leukemia With Venetoclax and Navitoclax (clinicaltrials.gov) - Mar 2, 2024
P1/2, N=90, Recruiting,
The study protocol was approved by the Beth Israel Deaconess Medical Center Committee on Clinical Investigation (CCI) (protocol 2021 P-000803). Trial primary completion date: Aug 2024 --> Aug 2025
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