hydrocortisone / Generic mfg. 
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 337 Diseases   132 Trials   132 Trials   6523 News 


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  • ||||||||||  dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
    Review, Journal:  Systemic corticosteroid regimens for prevention of bronchopulmonary dysplasia in preterm infants. (Pubmed Central) -  Mar 14, 2023   
    Despite the fact that the studies investigating higher versus lower dosage regimens showed that higher-dosage regimens may reduce the incidence of death or neurodevelopmental impairment, we cannot conclude what the optimal type, dosage, or timing of initiation is for the prevention of BPD in preterm infants, based on current level of evidence. Further high quality trials would be needed to establish the optimal systemic postnatal corticosteroid dosage regimen.
  • ||||||||||  indomethacin / Generic mfg., hydrocortisone / Generic mfg., paracetamol / Generic mfg.
    Journal:  Evaluation of Health-Related Values and Preferences of Adults Who Were Preterm Infants and Parents of Preterm Infants Concerning Use of Prophylactic Cyclooxygenase Inhibitor Drugs. (Pubmed Central) -  Mar 14, 2023   
    To explore the health-related values and preferences of adults who were preterm infants and families of preterm infants concerning the prophylactic use of indomethacin, ibuprofen, and acetaminophen initiated within the first 24 hours after birth...Relative importance of clinical outcomes, willingness to use each of the COX-Is when presented as the only option, preference for using prophylactic hydrocortisone vs indomethacin, willingness to use any of the COX-Is when all 3 options are available, and relative importance of having family values and preferences included in decision-making...The findings of this cross-sectional study of former preterm infants and parents of preterm infants suggest that there was minimal variability in how participants valued the main outcomes, with death and severe IVH being rated as the 2 most important undesirable outcomes. While indomethacin was the most preferred form of prophylaxis, variability was noted in the choice of COX-I interventions when participants were presented with the benefits and harms of each drug.
  • ||||||||||  hydrocortisone / Generic mfg., milrinone / Generic mfg.
    Variability in Hemodynamic Support Practices for Infants with Congenital Diaphragmatic Hernia (CDH) across the Children () -  Mar 14, 2023 - Abstract #PAS2023PAS_4799;    
    Most survey respondents 1) had guidelines for hemodynamic support (90%) and 2) targeted BP values based on adequate signs of tissue perfusion (68%). Forty two percent of responding sites use echo-guided (EG) vasoactive support decision-making, 42% have pre-determined algorithms (non-echo guided (NEG)) while 16% have no vasoactive medication algorithm (Fig.
  • ||||||||||  sildenafil / Generic mfg., hydrocortisone / Generic mfg.
    Clinical variables associated with ECMO use and non-survival in infants with CDH () -  Mar 14, 2023 - Abstract #PAS2023PAS_3744;    
    Pooled survival for ECMO patients was 42% (vs 88% for non-ECMO patients), but improved over time after implementation of a standardized guideline in 2012. Most ECMO patients and non-survivors had an antenatal diagnosis with lower 1- and 5-minute APGAR scores (Table 1).
  • ||||||||||  dexamethasone / Generic mfg., hydrocortisone / Generic mfg., furosemide / Generic mfg.
    Hearing Loss Prevalence and Clinical Factors in Neonates Admitted to the Neonatal Intensive Care Unit () -  Mar 14, 2023 - Abstract #PAS2023PAS_2900;    
    41/189 (21.6%) of those who failed hearing screen had persistent hearing loss on Auditory Brainstem Response (ABR) testing 6 to 12 months after NICU discharge. Neonates who failed their hearing screen had significantly lower GA (p< 0.001) and birth weight (p< 0.01), had lower APGAR scores at 1 minute (p< 0.01) and 5 minutes (p< 0.01).
  • ||||||||||  hydrocortisone / Generic mfg.
    PDA Treatments and Hydrocortisone exposure in extremely preterm infants: A secondary analysis of the Hydrocortisone Trial. () -  Mar 14, 2023 - Abstract #PAS2023PAS_2747;    
    The interaction between PDA treatment and HC was not statistically significant for moderate to severe BPD or death (p=0.93). PDA treatment alone was associated with a significant increase in moderate to severe BPD or death at 36 weeks, moderate to severe CP or death, home oxygen, duration of ventilatory support, oxygen supplementation at 36 weeks, and BPD severity, and with decreased weight-for-age z-score at 36 weeks.
  • ||||||||||  fluconazole oral / Generic mfg.
    Comparative Safety of Fluconazole Loading Dose Regimens in Infants () -  Mar 14, 2023 - Abstract #PAS2023PAS_2406;    
    We found no difference in safety outcomes, except for a higher rate of AI in the 25 mg/kg group when defined as new or increased hydrocortisone [26 (31%) vs. 288 (22%), p=0.04] compared to the ? 12 mg/kg group (Table 2) .
  • ||||||||||  dobutamine / Generic mfg., hydrocortisone / Generic mfg.
    Journal:  Fluid and vasopressor therapy in sepsis (Pubmed Central) -  Mar 9, 2023   
    With increasing norepinephrine dose, addition of hydrocortisone or vasopressin may contribute to maintaining the hemodynamic state, although the prognostic advantage of these drugs has not been demonstrated. While dobutamine may be considered in patients with septic cardiomyopathy, the evidence for inotropic therapy in sepsis is limited.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Abrupt Discontinuation Versus Taper of Hydrocortisone in Patients With Septic Shock. (Pubmed Central) -  Mar 9, 2023   
    All other secondary outcomes were similar between groups. The abrupt discontinuation of hydrocortisone in the treatment of septic shock was associated with a nonstatistically significant 50% absolute reduction in the need for vasopressor reinitiation.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Encapsulation and release of hydrocortisone from proliposomes govern vaginal delivery. (Pubmed Central) -  Mar 6, 2023   
    However, under non-sink conditions, the drug release plateaued at levels corresponding to the encapsulation efficiency. After redispersion, all liposomal formulations performed better than the commercial drug product indicating that the encapsulation into the lipid phase is the main driver sustaining the release.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Adrenal crisis in infants and young children with adrenal insufficiency: Management and prevention. (Pubmed Central) -  Mar 3, 2023   
    Both children on therapy with a micronized weighted formulation reported no episode of suspected adrenal crisis during the 6-month observation period. Parental education on oral stress dosing and switching to parenteral hydrocortisone when necessary are the essential approaches to prevent adrenal crisis in children.
  • ||||||||||  Monofer (iron isomaltoside 1000) / Pharmacosmos
    Retrospective data, Journal:  Evaluation of MONOFER-induced hypersensitive reactions: A retrospective cohort study. (Pubmed Central) -  Mar 2, 2023   
    A total of 43 (68.25%) participants who experienced hypersensitivity reactions showed clinical symptoms within one hour, 11(17.46%) showed reaction in 1-3 hours and 9 (14.29%) showed in > 3 Hours. The majority of the studied population showed significant improvement only after the administration of Pheniramine maleate, while only a few of them received Hydrocortisone.
  • ||||||||||  Trial completion date, Trial primary completion date:  A Study in Adults With Untreated Acute Lymphoblastic Leukemia (clinicaltrials.gov) -  Feb 28, 2023   
    P2,  N=100, Active, not recruiting, 
    Trial completion date: Sep 2029 --> Dec 2029 | Trial primary completion date: Sep 2029 --> Dec 2029 Trial completion date: Jul 2023 --> Jul 2024 | Trial primary completion date: Jan 2023 --> Jan 2024
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Addition of nebulised lidocaine to prevent refractory bronchospasms in a patient receiving serial bronchoscopies. (Pubmed Central) -  Feb 27, 2023   
    During his 8th to 15th bronchoscopies, nebulised lidocaine was added to the pretreatment regimen, which eliminated perioperative bronchospasms and allowed for the elimination of all other adjunctive preventative treatments. This case highlights the novel perioperative use of nebulised lidocaine, in combination with nebulised albuterol and intravenous hydrocortisone, to successfully prevent previously refractory bronchospasms in a patient undergoing a general anaesthetic.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  The effect of vasopressin and hydrocortisone on cytokine trajectories. (Pubmed Central) -  Feb 27, 2023   
    This case highlights the novel perioperative use of nebulised lidocaine, in combination with nebulised albuterol and intravenous hydrocortisone, to successfully prevent previously refractory bronchospasms in a patient undergoing a general anaesthetic. No abstract available
  • ||||||||||  dexamethasone / Generic mfg., hydrocortisone / Generic mfg., fluticasone / Generic mfg.
    Journal:  Glucocorticoids increase tissue cell protection against pore-forming toxins from pathogenic bacteria. (Pubmed Central) -  Feb 27, 2023   
    Dexamethasone protected several cell types against the cholesterol-dependent cytolysin, pyolysin, from Trueperella pyogenes...Hydrocortisone and fluticasone also protected against pyolysin-induced cell damage...However, cytoprotection was dependent on the glucocorticoid receptor and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR). Collectively, our findings imply that glucocorticoids could be exploited to limit tissue damage caused by pathogens secreting pore-forming toxins.