- |||||||||| Erbitux (cetuximab) / Eli Lilly, EMD Serono
Trial initiation date, Trial primary completion date, Metastases: Cetuximab and Dasatinib in Recurrent Squamous Cell Carcinoma (clinicaltrials.gov) - Jan 5, 2018 P2, N=21, Terminated, Initiation date: Oct 2013 --> Sep 2011 | Trial primary completion date: Oct 2016 --> Jan 2016
- |||||||||| utomilumab (PF-05082566) / Pfizer, Erbitux (cetuximab) / Eli Lilly, EMD Serono
Enrollment open, IO biomarker, Metastases: Utomilumab, Cetuximab, and Irinotecan Hydrochloride in Treating Patients With Metastatic Colorectal Cancer (clinicaltrials.gov) - Dec 29, 2017 P1, N=32, Recruiting, N=120 --> 17 Not yet recruiting --> Recruiting
- |||||||||| Erbitux (cetuximab) / Eli Lilly, EMD Serono, Opdivo (nivolumab) / BMS, Yervoy (ipilimumab) / BMS
New P3 trial, Combination therapy, PD(L)-1 Biomarker, IO biomarker, Metastases: CheckMate 651: Study of Nivolumab in Combination With Ipilimumab Compared to the Standard of Care (Extreme Regimen) as First Line Treatment in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (clinicaltrials.gov) - Dec 29, 2017 P3, N=460, Not yet recruiting,
- |||||||||| Avastin (bevacizumab) / Roche, Erbitux (cetuximab) / Eli Lilly, EMD Serono
Trial initiation date, Trial termination, Trial primary completion date, Combination therapy, Metastases: REGAIN: Rechallenge of Cetuximab Combined With Irinotecan as Third-line Chemotherapy in Patients With Metastatic Colorectal Cancer - Phase II Study (clinicaltrials.gov) - Dec 29, 2017 P2, N=2, Terminated, Not yet recruiting --> Recruiting Initiation date: Jan 2015 --> Sep 2015 | Active, not recruiting --> Terminated | Trial primary completion date: Sep 2016 --> Jan 2016
- |||||||||| Avastin (bevacizumab) / Roche, Erbitux (cetuximab) / Eli Lilly, EMD Serono, pemetrexed / Generic mfg.
Clinical, P2 data, Journal: Phase II randomized trial of radiation therapy, cetuximab and pemetrexed with or without bevacizumab in patients with locoregionally-advanced head and neck cancer. (Pubmed Central) - Dec 27, 2017 Adding bevacizumab increased toxicity without apparent improvement in efficacy, countering the hypothesis that dual EGFR-VEGF targeting would overcome radiation resistance, and enhance clinical benefit. Further development of cetuximab, pemetrexed, and RT will require additional prospective study in defined, high-risk populations where treatment intensification is justified.
- |||||||||| Braftovi (encorafenib) / Ono Pharma, Pierre Fabre, Pfizer, Mektovi (binimetinib) / Ono Pharma, Pierre Fabre, Pfizer
New P3 trial, Metastases: BEACON CRC: Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuximab or Infusional 5-Fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab With a Safety Lead-in of Encorafenib + Binimetinib + Cetuximab in Patients With BRAF V600E-mutant Metastatic Colorectal Cancer (clinicaltrials.gov) - Dec 20, 2017 P3, N=645, Recruiting,
- |||||||||| Erbitux (cetuximab) / Eli Lilly, EMD Serono
P1/2 data, Trial termination, Combination therapy, Surgery, Metastases: A Phase 1-2 Trial of Cetuximab in Combination With Oxaliplatin, Capecitabine, and Radiation Therapy Followed by Surgery for Locally-advanced Rectal Cancer (clinicaltrials.gov) - Dec 20, 2017 P1/2, N=23, Terminated, N=720 --> 940 Completed --> Terminated; The response rate observed in the phase 1 portion of the study did not merit further evaluation in phase 2 portion of the study.
- |||||||||| 5-fluorouracil / Generic mfg., cisplatin / Generic mfg., docetaxel / Generic mfg.
Trial initiation date, Trial termination, Metastases: Docetaxel/Cisplatin/5-Fluorouracil (TPF) Human Papillomavirus (HPV) Squamous Cell Carcinoma Study (clinicaltrials.gov) - Dec 19, 2017 P2, N=7, Terminated, Completed --> Terminated; The response rate observed in the phase 1 portion of the study did not merit further evaluation in phase 2 portion of the study. Initiation date: Sep 2010 --> Jul 2011 | Withdrawn --> Terminated; Due to slow accrual
- |||||||||| Erbitux (cetuximab) / Eli Lilly, EMD Serono, Vectibix (panitumumab) / Amgen, Takeda
Trial primary completion date: S1013: Validation of Cancer Questionnaire for Skin Toxicities in Patients With Colorectal Cancer or Lung Cancer Receiving Cetuximab, Panitumumab, or Erlotinib Hydrochloride (clinicaltrials.gov) - Dec 15, 2017 P=N/A, N=140, Active, not recruiting, There was limited efficacy of the combination therapy. Trial primary completion date: Oct 2017 --> Apr 2018
- |||||||||| Cyramza (ramucirumab) / Eli Lilly, Avastin (bevacizumab) / Roche, Erbitux (cetuximab) / Eli Lilly, EMD Serono
Enrollment closed, Trial primary completion date, Metastases: Irinotecan Hydrochloride and Cetuximab With or Without Ramucirumab in Treating Patients With Advanced Colorectal Cancer With Progressive Disease After Treatment With Bevacizumab-Containing Chemotherapy (clinicaltrials.gov) - Dec 14, 2017 P2, N=135, Active, not recruiting, Active, not recruiting --> Completed Recruiting --> Active, not recruiting | Trial primary completion date: Jun 2017 --> Jul 2018
- |||||||||| Erbitux (cetuximab) / Eli Lilly, EMD Serono, Lynparza (olaparib) / Merck (MSD), AstraZeneca
Trial primary completion date, Combination therapy, Metastases: Study of Olaparib With Radiation Therapy and Cetuximab in Advanced Head and Neck Cancer With Heavy Smoking History (clinicaltrials.gov) - Dec 13, 2017 P1, N=16, Active, not recruiting, Recruiting --> Active, not recruiting | Trial primary completion date: Jun 2017 --> Jul 2018 Trial primary completion date: Nov 2017 --> Dec 2016
- |||||||||| Erbitux (cetuximab) / Eli Lilly, EMD Serono, Neucardin (recombinant human neuregulin-1β) / Zensun
Journal: The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor. (Pubmed Central) - Nov 30, 2017 Previous studies identified two mechanisms of resistance to the EGFR monoclonal antibody cetuximab...Overexpression of LYN and NRG1 in cells depleted of AXL resulted in accumulation of nEGFR, rescuing the deficit induced by lack of AXL. Collectively, these data uncover a previously unrecognized role for AXL in regulating the nuclear translocation of EGFR and suggest that AXL-mediated SFK and NRG1 expression promote this process.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
Trial primary completion date, Metastases: Pembrolizumab and Monoclonal Antibody Therapy in Advanced Cancer (clinicaltrials.gov) - Nov 28, 2017 P1/2, N=90, Active, not recruiting, clinicaltrials.gov Identifier: NCT00566852. Trial primary completion date: Oct 2017 --> Jun 2018
- |||||||||| Erbitux (cetuximab) / Eli Lilly, EMD Serono
Biomarker, Trial primary completion date, Metastases: Biomarker Directed Treatment in Metastatic Colorectal Cancer (clinicaltrials.gov) - Nov 27, 2017 P2, N=30, Recruiting, Trial primary completion date: Oct 2017 --> Jun 2018 Trial primary completion date: Aug 2016 --> Aug 2018
- |||||||||| Erbitux (cetuximab) / Eli Lilly, EMD Serono, Imfinzi (durvalumab) / AstraZeneca
Phase classification, Trial initiation date, Trial primary completion date, PD(L)-1 Biomarker, Metastases: DUCRO-HN: Durvalumab, Cetuximab and Radiotherapy in Head Neck Cancer (clinicaltrials.gov) - Nov 22, 2017 P1/2, N=69, Not yet recruiting, Trial primary completion date: Aug 2016 --> Aug 2018 Phase classification: P2 --> P1/2 | Initiation date: Jun 2017 --> Jan 2018 | Trial primary completion date: Jun 2021 --> Jan 2022
- |||||||||| Erbitux (cetuximab) / Eli Lilly, EMD Serono
Enrollment closed, Metastases: Weekly Carboplatin, Paclitaxel and Cetuximab Treatment for Patients With Recurrent or Metastatic SCCHN (clinicaltrials.gov) - Nov 14, 2017 P2, N=38, Active, not recruiting, Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting
- |||||||||| Erbitux (cetuximab) / Eli Lilly, EMD Serono
Trial completion, Trial primary completion date, Metastases: Nab-Paclitaxel, Cisplatin, and Cetuximab With Concurrent Radiation Therapy for Locally Advanced Head and Neck Cancer (clinicaltrials.gov) - Nov 6, 2017 P1/2, N=80, Completed, Active, not recruiting --> Completed Active, not recruiting --> Completed | Trial primary completion date: Dec 2015 --> Oct 2013
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