- |||||||||| Erbitux (cetuximab) / Eli Lilly, EMD Serono, Gilotrif (afatinib) / Boehringer Ingelheim
Enrollment closed, Combination therapy, EGFR exon 20: AFACET: Afatinib and Cetuximab in Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Positive Non-small-cell Lung Cancer (clinicaltrials.gov) - Dec 11, 2018 P2, N=37, Active, not recruiting, Not yet recruiting --> Active, not recruiting
- |||||||||| Erbitux (cetuximab) / Eli Lilly, EMD Serono, Lynparza (olaparib) / Merck (MSD), AstraZeneca
Trial completion, Combination therapy, Metastases: Study of Olaparib With Radiation Therapy and Cetuximab in Advanced Head and Neck Cancer With Heavy Smoking History (clinicaltrials.gov) - Dec 3, 2018 P1, N=16, Completed, Not yet recruiting --> Recruiting Active, not recruiting --> Completed
- |||||||||| Bavencio (avelumab) / EMD Serono, Pfizer, Erbitux (cetuximab) / Eli Lilly, EMD Serono, Lynparza (olaparib) / Merck (MSD), AstraZeneca
Journal, BRCA Biomarker, PARP Biomarker, PD(L)-1 Biomarker, IO biomarker: Immunotherapy utilizing the combination of natural killer- and antibody dependent cellular cytotoxicity (ADCC)-mediating agents with poly (ADP-ribose) polymerase (PARP) inhibition. (Pubmed Central) - Dec 1, 2018 Active, not recruiting --> Completed These studies support the combined use of NK- and ADCC-mediating agents with correctly timed PARP inhibition.
- |||||||||| Avastin (bevacizumab) / Roche, Erbitux (cetuximab) / Eli Lilly, EMD Serono, Vectibix (panitumumab) / Amgen
Enrollment open, Surgery: SULTAN: Improving SUrgery of Liver Metastases: a Trial of the Arterial Chemotherapy Network (clinicaltrials.gov) - Nov 27, 2018 P2, N=140, Recruiting, Although this study did not meet its primary endpoints, prespecified subgroup analyses of patients with EGFR FISH-positive squamous-cell carcinoma cancers are encouraging and support continued evaluation of anti-EGFR antibodies in this subpopulation. Active, not recruiting --> Recruiting
- |||||||||| Erbitux (cetuximab) / Eli Lilly, EMD Serono
Enrollment closed, Trial completion date, Trial primary completion date, Metastases: Post-operative Radiation With Cetuximab for Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck (clinicaltrials.gov) - Nov 15, 2018 P2, N=40, Active, not recruiting, This finding provides a strong argument to consider panitumumab in lieu of cetuximab in these patients. Recruiting --> Active, not recruiting | Trial completion date: Oct 2021 --> Oct 2022 | Trial primary completion date: Apr 2017 --> Jan 2019
- |||||||||| monalizumab (IPH2201) / AstraZeneca, Innate, Imfinzi (durvalumab) / AstraZeneca
Phase classification, Enrollment change, Trial primary completion date, IO biomarker, Metastases: A Study of Durvalumab (MEDI4736) and Monalizumab in Solid Tumors (clinicaltrials.gov) - Nov 13, 2018 P1/2, N=501, Recruiting, Recruiting --> Active, not recruiting | Trial completion date: Oct 2021 --> Oct 2022 | Trial primary completion date: Apr 2017 --> Jan 2019 Phase classification: P1 --> P1/2 | N=262 --> 501 | Trial primary completion date: Feb 2020 --> Oct 2021
- |||||||||| Avastin (bevacizumab) / Roche, Erbitux (cetuximab) / Eli Lilly, EMD Serono
Trial completion, Metastases: ITACa: Sequential Treatment Strategy for Metastatic Colorectal Cancer (clinicaltrials.gov) - Nov 9, 2018 P3, N=350, Completed, Crizotinib has the potential to improve outcomes in locally advanced rectal cancer patients undergoing chemoradiation. Active, not recruiting --> Completed
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
Enrollment change, Trial completion date, Trial termination, Metastases: Pembrolizumab and Monoclonal Antibody Therapy in Advanced Cancer (clinicaltrials.gov) - Nov 2, 2018 P1/2, N=16, Terminated, N=90 --> 16 | Trial completion date: Dec 2018 --> Aug 2018 | Active, not recruiting --> Terminated; PI no longer at sight. Results not collected
- |||||||||| Erbitux (cetuximab) / Eli Lilly, EMD Serono
Trial completion date, Metastases: CA225200: PhII ICb With/Without Erbitux in MBC Pts (clinicaltrials.gov) - Oct 25, 2018 P2, N=154, Active, not recruiting, Results not collected Trial completion date: Dec 2014 --> Dec 2019
- |||||||||| Erbitux (cetuximab) / Eli Lilly, EMD Serono
Enrollment closed, Trial completion date, Metastases: Phase II Trial of Carboplatin, 5-FU and Cetuximab in Elderly Fit (no Frailty) Patients With Recurrent/Metastatic HNSCC (clinicaltrials.gov) - Oct 25, 2018 P2, N=82, Active, not recruiting, Trial completion date: Dec 2014 --> Dec 2019 Recruiting --> Active, not recruiting | Trial completion date: Dec 2019 --> Aug 2021
- |||||||||| Bavencio (avelumab) / EMD Serono, Erbitux (cetuximab) / Eli Lilly, EMD Serono
Enrollment closed, Combination therapy, Metastases: Avelumab and Cetuximab in Combination With FOLFOX in Patients With Previously Untreated Metastatic Colorectal Cancer - The Phase II AVETUX-CRC Trial. (clinicaltrials.gov) - Oct 25, 2018 P2, N=43, Active, not recruiting, Recruiting --> Active, not recruiting | Trial completion date: Dec 2019 --> Aug 2021 Recruiting --> Active, not recruiting
- |||||||||| Opdivo (nivolumab) / BMS
Enrollment closed, Combination therapy, Metastases: CheckMate 9TM: Nivolumab or Nivolumab Plus Cisplatin, in Combination With Radiotherapy in Patients With Cisplatin-ineligible or Eligible Locally Advanced Squamous Cell Head and Neck Cancer (clinicaltrials.gov) - Oct 22, 2018 P3, N=1046, Active, not recruiting, Recruiting --> Active, not recruiting Recruiting --> Active, not recruiting
- |||||||||| Avastin (bevacizumab) / Roche, Erbitux (cetuximab) / Eli Lilly
Trial completion date, Metastases: SWOG S0819: S0819: Carboplatin and Paclitaxel With or Without Bevacizumab and/or Cetuximab in Treating Patients With Stage IV or Recurrent Non-Small Cell Lung Cancer (clinicaltrials.gov) - Oct 12, 2018 P3, N=1546, Active, not recruiting, In Europe, SB3, a trastuzumab biosimilar, is approved for use as well as two rituzimab biosimilars, truxima and rixathon. Trial completion date: Aug 2018 --> Aug 2019
- |||||||||| Trial completion date, Trial primary completion date, Metastases: QUILT-3.072: NANT Hepatocellular Carcinoma (HCC) Vaccine (clinicaltrials.gov) - Oct 5, 2018
P1/2, N=382, Recruiting, Trial completion date: Dec 2017 --> Mar 2019 | Trial primary completion date: Dec 2017 --> Mar 2019 Trial completion date: Dec 2020 --> Dec 2022 | Trial primary completion date: Dec 2019 --> Jul 2020
- |||||||||| Avastin (bevacizumab) / Roche, Erbitux (cetuximab) / Eli Lilly, EMD Serono, Vectibix (panitumumab) / Amgen
Enrollment closed, Surgery: SULTAN: Improving SUrgery of Liver Metastases: a Trial of the Arterial Chemotherapy Network (clinicaltrials.gov) - Oct 2, 2018 P2, N=140, Active, not recruiting, Trial completion date: Nov 2018 --> Nov 2019 | Trial primary completion date: Nov 2018 --> Nov 2019 Not yet recruiting --> Active, not recruiting
- |||||||||| Erbitux (cetuximab) / Eli Lilly, EMD Serono
Trial completion date, Trial primary completion date, Metastases: Cetuximab Rechallenge Study (clinicaltrials.gov) - Sep 20, 2018 P2, N=17, Active, not recruiting, Trial primary completion date: Apr 2018 --> Dec 2018 Trial completion date: Jun 2018 --> Dec 2019 | Trial primary completion date: Jun 2018 --> Dec 2018
- |||||||||| Ibrance (palbociclib) / Pfizer, Bavencio (avelumab) / EMD Serono, Erbitux (cetuximab) / Eli Lilly, EMD Serono
Enrollment open, Metastases: Avelumab, Cetuximab, and Palbociclib in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (clinicaltrials.gov) - Sep 20, 2018 P1, N=24, Recruiting, Trial completion date: Jun 2018 --> Dec 2019 | Trial primary completion date: Jun 2018 --> Dec 2018 Not yet recruiting --> Recruiting
- |||||||||| Erbitux (cetuximab) / Eli Lilly, EMD Serono
Enrollment change, Trial termination, Surgery, Metastases: COMBATAC: Combined Anticancer Treatment of Advanced Colon Cancer (clinicaltrials.gov) - Sep 5, 2018 P2, N=26, Terminated, N=70 --> 100 | Trial completion date: Jun 2019 --> Sep 2020 | Trial primary completion date: Jun 2019 --> Sep 2020 N=60 --> 26 | Active, not recruiting --> Terminated; Slow recruitment.
- |||||||||| Braftovi (encorafenib) / Ono Pharma, Pierre Fabre, Pfizer
Trial completion date, Metastases: Study of LGX818 and Cetuximab or LGX818, BYL719, and Cetuximab in BRAF Mutant Metastatic Colorectal Cancer (clinicaltrials.gov) - Sep 5, 2018 P1/2, N=150, Active, not recruiting, N=60 --> 26 | Active, not recruiting --> Terminated; Slow recruitment. Trial completion date: Jul 2018 --> Jul 2019
- |||||||||| Erbitux (cetuximab) / Eli Lilly, EMD Serono, Vectibix (panitumumab) / Amgen, Takeda
Trial completion: S1013: Validation of Cancer Questionnaire for Skin Toxicities in Patients With Colorectal Cancer or Lung Cancer Receiving Cetuximab, Panitumumab, or Erlotinib Hydrochloride (clinicaltrials.gov) - Sep 1, 2018 P=N/A, N=146, Completed, Trial completion date: Jul 2018 --> Jul 2019 Active, not recruiting --> Completed
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