Cetrotide (cetrorelix) / EMD Serono 
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 39 Diseases   32 Trials   32 Trials   385 News 


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  • ||||||||||  valsartan / Generic mfg.
    Journal:  Angiotensin blockade attenuates diabetic nephropathy in hypogonadal adult male rats. (Pubmed Central) -  Dec 23, 2019   
    In HG-D rats, valsartan reduced renal collagen IV and TGF-β1, especially when the testosterone level was corrected by letrozole. Thus, normalizing testosterone and inhibiting renal angiotensin II have a renoprotective effect against DN in HG male rats.
  • ||||||||||  Cetrotide (cetrorelix) / EMD Serono
    Journal:  The effect of GnRH antagonist cetrorelix on Wnt signaling members in pubertal and adult mouse ovaries. (Pubmed Central) -  Dec 19, 2019   
    CTNNB1 intensity in granulosa cells was the lowest in pubertal and the highest in adult ovaries and its expression was decreased by cetrorelix in adult ovaries. Cetrorelix affected the expression of specific members of the Wnt signaling depending on the developmental stage of mice, pointing out its possible interaction with gonadotropins during pubertal and adult stages.
  • ||||||||||  Firmagon (degarelix) / Astellas, Ferring, Cetrotide (cetrorelix) / EMD Serono
    Trial completion date:  Dysregulation of FSH in Obesity: Functional and Statistical Analysis (clinicaltrials.gov) -  Nov 27, 2019   
    P=N/A,  N=68, Recruiting, 
    Cetrorelix affected the expression of specific members of the Wnt signaling depending on the developmental stage of mice, pointing out its possible interaction with gonadotropins during pubertal and adult stages. Trial completion date: May 2020 --> Feb 2020
  • ||||||||||  Cetrotide (cetrorelix) / EMD Serono
    Trial completion, Trial completion date, Trial primary completion date:  Coasting Versus Antagonist Protocol in Patients at High Risk of OHSS (clinicaltrials.gov) -  Nov 21, 2019   
    P4,  N=300, Completed, 
    Trial completion date: May 2020 --> Feb 2020 Recruiting --> Completed | Trial completion date: Aug 2019 --> Nov 2019 | Trial primary completion date: Aug 2019 --> Nov 2019
  • ||||||||||  Cetrotide (cetrorelix) / EMD Serono
    Preclinical, Journal:  Evaluation of ovarian and metabolic effects of GnRH modulators in two rat models of PCOS. (Pubmed Central) -  Sep 26, 2019   
    Only testosterone level, total cholesterol level and follicular development were improved. Therefore, it was concluded that both leuprolide and cetrorelix showed improvement in follicular development which could be helpful for improving fertility in PCOS.
  • ||||||||||  Menopur (menotropin) / Ferring, Orgalutran (ganirelix acetate) / Organon, Cetrotide (cetrorelix) / EMD Serono
    Trial completion date, Trial primary completion date:  DuoStim in Cases of PGT: Comparison of Embryo Quantity and Embryonic Quality Using MitoScore (clinicaltrials.gov) -  Aug 20, 2019   
    P=N/A,  N=136, Recruiting, 
    Therefore, it was concluded that both leuprolide and cetrorelix showed improvement in follicular development which could be helpful for improving fertility in PCOS. Trial primary completion date: Oct 2018 --> Dec 2019 | Trial completion date: Dec 2018 --> Jun 2020
  • ||||||||||  Cetrotide (cetrorelix) / EMD Serono
    Enrollment open:  Coasting Versus Antagonist Protocol in Patients at High Risk of OHSS (clinicaltrials.gov) -  Jul 24, 2019   
    P4,  N=300, Recruiting, 
    Trial primary completion date: Oct 2018 --> Dec 2019 | Trial completion date: Dec 2018 --> Jun 2020 Not yet recruiting --> Recruiting
  • ||||||||||  Firmagon (degarelix) / Astellas, Ferring, Cetrotide (cetrorelix) / EMD Serono
    Trial completion date, Trial primary completion date:  Dysregulation of FSH in Obesity: Functional and Statistical Analysis (clinicaltrials.gov) -  May 14, 2019   
    P=N/A,  N=68, Recruiting, 
    A focus will be set on delivery of pharmaceutical proteins and peptides. Trial completion date: Jun 2019 --> May 2020 | Trial primary completion date: Feb 2019 --> Feb 2020
  • ||||||||||  Cetrotide (cetrorelix) / EMD Serono
    Enrollment open:  Frozen Embryo Transfer With GnRH-antagonist Trial (clinicaltrials.gov) -  Apr 25, 2019   
    P4,  N=300, Enrolling by invitation, 
    However, owing to some benefits, antagonist therapy could be considered as a reasonable alternative to IVF in order to reduce PCOS patients'emotional distress. Not yet recruiting --> Enrolling by invitation
  • ||||||||||  letrozole / Generic mfg.
    Trial completion date, Trial primary completion date:  Letrozole in Stimulated IVF Cycles (clinicaltrials.gov) -  Apr 17, 2019   
    P3,  N=900, Recruiting, 
    Not yet recruiting --> Enrolling by invitation Trial completion date: Dec 2019 --> Dec 2020 | Trial primary completion date: Dec 2018 --> Dec 2019
  • ||||||||||  Menopur (menotropin) / Ferring, Orgalutran (ganirelix acetate) / Organon, Cetrotide (cetrorelix) / EMD Serono
    Trial completion date, Trial primary completion date:  DuoStim in Cases of PGT: Comparison of Embryo Quantity and Embryonic Quality Using MitoScore (clinicaltrials.gov) -  Sep 4, 2018   
    P=N/A,  N=136, Recruiting, 
    Not yet recruiting --> Recruiting Trial completion date: Aug 2018 --> Dec 2018 | Trial primary completion date: Jun 2018 --> Oct 2018
  • ||||||||||  Cetrotide (cetrorelix) / EMD Serono
    Enrollment closed, Preclinical, Enrollment change:  NATOS: NATural Ovarian Stimulation (clinicaltrials.gov) -  May 1, 2018   
    P4,  N=129, Active, not recruiting, 
    Trial completion date: Aug 2018 --> Dec 2018 | Trial primary completion date: Jun 2018 --> Oct 2018 Recruiting --> Active, not recruiting | N=320 --> 129
  • ||||||||||  Orgalutran (ganirelix acetate) / Organon, Cetrotide (cetrorelix) / EMD Serono
    New P4 trial, Preclinical:  Cetrorelix and Ganirelix Flexible Protocol for (IVF) (clinicaltrials.gov) -  Mar 27, 2018   
    P4,  N=100, Recruiting, 
  • ||||||||||  Cetrotide (cetrorelix) / EMD Serono
    Preclinical, Trial completion date, Trial primary completion date:  NATOS: NATural Ovarian Stimulation (clinicaltrials.gov) -  Mar 19, 2018   
    P4,  N=320, Recruiting, 
    Recruiting --> Active, not recruiting | N=320 --> 129 Trial completion date: Dec 2018 --> Jun 2019 | Trial primary completion date: Nov 2018 --> Jun 2019
  • ||||||||||  Menopur (menotropin) / Ferring, Orgalutran (ganirelix acetate) / Organon, Cetrotide (cetrorelix) / EMD Serono
    Enrollment open, Trial initiation date:  DuoStim in Cases of PGT: Comparison of Embryo Quantity and Embryonic Quality Using MitoScore (clinicaltrials.gov) -  Feb 28, 2018   
    P=N/A,  N=136, Recruiting, 
    Trial completion date: Dec 2018 --> Jun 2019 | Trial primary completion date: Nov 2018 --> Jun 2019 Not yet recruiting --> Recruiting | Initiation date: Sep 2017 --> Dec 2017
  • ||||||||||  letrozole / Generic mfg.
    Enrollment open, Trial primary completion date:  Letrozole in Stimulated IVF Cycles (clinicaltrials.gov) -  Oct 31, 2017   
    P3,  N=900, Recruiting, 
    Recruiting --> Completed | N=100 --> 204 Not yet recruiting --> Recruiting | Trial primary completion date: Dec 2017 --> Dec 2018
  • ||||||||||  Firmagon (degarelix) / Astellas, Ferring, Cetrotide (cetrorelix) / EMD Serono
    Trial primary completion date:  Dysregulation of FSH in Obesity: Functional and Statistical Analysis (clinicaltrials.gov) -  Oct 19, 2017   
    P=N/A,  N=68, Recruiting, 
    Not yet recruiting --> Recruiting | Trial primary completion date: Dec 2017 --> Dec 2018 Trial primary completion date: Aug 2017 --> Feb 2018
  • ||||||||||  Cetrotide (cetrorelix) / EMD Serono
    Enrollment open, Preclinical, Trial initiation date, Trial primary completion date:  NATOS: NATural Ovarian Stimulation (clinicaltrials.gov) -  Jul 26, 2017   
    P4,  N=320, Recruiting, 
    Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting | Initiation date: Sep 2016 --> Jan 2017 | Trial primary completion date: Jul 2018 --> Nov 2018