Cetrotide (cetrorelix) / EMD Serono 
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 39 Diseases   32 Trials   32 Trials   385 News 


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  • ||||||||||  Firmagon (degarelix) / Astellas, Ferring, Cetrotide (cetrorelix) / EMD Serono
    Trial completion, Enrollment change:  Dysregulation of FSH in Obesity: Functional and Statistical Analysis (clinicaltrials.gov) -  Mar 8, 2021   
    P=N/A,  N=99, Completed, 
    Recruiting --> Completed | N=68 --> 99
  • ||||||||||  Cetrotide (cetrorelix) / EMD Serono
    [VIRTUAL] Are all osmoles created equal? - A case of post obstructive diuresis (POD) () -  Mar 2, 2021 - Abstract #NKFSCM2021NKF-SCM_482;    
    Caution is advised with high initial BUN, since a rapid drop could create an osmotic gradient (drop in S.osm of 1 mOsm/kg per 2.8 mg/dL of BUN). The hypernatremia correction recommendation of ≤20 mOsm/day was targeted, as is also recommended for urea reduction in at-risk patients for DDS. CONCLUSION Calculated S.osm could be a more reliable guide to choice/rate of replacement fluid, as we eventually adopted.
  • ||||||||||  Ovidrel (choriogonadotropin alfa) / EMD Serono, Menopur (menotropin) / Ferring, Cetrotide (cetrorelix) / EMD Serono
    Enrollment closed, Trial completion date:  CS-EOSP-ICSI: Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility (clinicaltrials.gov) -  Feb 23, 2021   
    P=N/A,  N=200, Active, not recruiting, 
    Many research efforts have provided the basis for the development of new therapeutic modalities for the management of lower urinary tract dysfunctions, some of which might be offered to the patients in the near future. Recruiting --> Active, not recruiting | Trial completion date: Dec 2019 --> Dec 2021
  • ||||||||||  Menopur (menotropin) / Ferring, Orgalutran (ganirelix acetate) / Organon, Cetrotide (cetrorelix) / EMD Serono
    Trial completion:  DuoStim in Cases of PGT: Comparison of Embryo Quantity and Embryonic Quality Using MitoScore (clinicaltrials.gov) -  Dec 29, 2020   
    P=N/A,  N=136, Completed, 
    Finally, the proposed method was compared with and shown to have higher recoveries than, the conventional electromembrane extraction method for the peptides under study. Recruiting --> Completed
  • ||||||||||  Eligard (leuprolide acetate) / TOLMAR, Astellas, Sanofi, Cetrotide (cetrorelix) / EMD Serono
    Journal:  NAV3, a Tumor Suppressor Gene, Is Decreased in Uterine Leiomyoma Tissue and Cells. (Pubmed Central) -  Dec 18, 2020   
    Similarly, Western blot analysis on leuprolide-treated leiomyoma cells showed a non-significant increase in NAV 3 protein expression (1.26 ± 0.09, p = 0.063). NAV 3, a tumor suppressor in numerous cancers, is decreased in leiomyoma cells and tissue compared with myometrium, and increased by GnRH analog treatment, suggesting that NAV3 may mediate steroid hormone-independent leiomyoma regulation by GnRH analogs.
  • ||||||||||  Cetrotide (cetrorelix) / EMD Serono
    Clinical, Journal:  Short-Term Effects of Single-Session Split-Belt Treadmill Training on Dual-Task Performance in Parkinson's Disease and Healthy Elderly. (Pubmed Central) -  Oct 28, 2020   
    They were randomized into one of four training groups: (A) SB75-steady belt speed ratio 0.75:1; (B) SB50-steady belt speed ratio 0.5:1; (C) SBCR-changing belt speed ratios between 0.75:1 and 0.5:1; and (D) Tied-Belt (TBT)...Cognitive DT performance was also improved in SBT, likely due to reduced cortical control of gait. These results illustrate the potential for SBT to improve DT during complex gait and possibly reduce fall risk in clinical and healthy populations.
  • ||||||||||  Rekovelle (follitropin delta) / Ferring
    Trial completion date, Trial primary completion date:  Follitropin Delta in Long GnRH Agonist and GnRH Antagonist Protocols (BEYOND) (clinicaltrials.gov) -  Oct 19, 2020   
    P3,  N=415, Recruiting, 
    These results illustrate the potential for SBT to improve DT during complex gait and possibly reduce fall risk in clinical and healthy populations. Trial completion date: Dec 2021 --> Sep 2022 | Trial primary completion date: Nov 2020 --> Dec 2021
  • ||||||||||  Cetrotide (cetrorelix) / EMD Serono
    Enrollment open:  The LUTEAL Trial: Luteal Stimulation vs. Estrogen Priming Protocol (clinicaltrials.gov) -  Sep 23, 2020   
    P=N/A,  N=142, Recruiting, 
    Trial completion date: Dec 2021 --> Sep 2022 | Trial primary completion date: Nov 2020 --> Dec 2021 Not yet recruiting --> Recruiting
  • ||||||||||  Cetrotide (cetrorelix) / EMD Serono
    Journal:  Laser-induced fluorescence of the trans-CHBrCHO radical. (Pubmed Central) -  Sep 18, 2020   
    From an analysis of the laser-induced single vibronic level fluorescence aided by ab initio calculations, some of the vibrational frequencies were assigned to the ground electronic state ν (C-O str.) = 1581 cm, ν (C-C str.) = 1130 cm, and ν (C-C-O bend.) = 409 cm. The fluorescence lifetimes of the excited B̃ state were 35 ns-75 ns, depending on the excited vibrational modes, implying that predissociation had accelerated as the energy level (v') increased.
  • ||||||||||  Cetrotide (cetrorelix) / EMD Serono
    Preclinical, Journal:  Evaluation of testis hormonal and histopathological alterations in type I and type II diabetic rats. (Pubmed Central) -  Sep 17, 2020   
    The fluorescence lifetimes of the excited B̃ state were 35 ns-75 ns, depending on the excited vibrational modes, implying that predissociation had accelerated as the energy level (v') increased. Overall, diabetes can induce hypothalamus-pituitary-gonad axis dysfunction, affects hormonal secretion, and causes histological damage to testes, collectively leading to deleterious effects on male fertility.
  • ||||||||||  Firmagon (degarelix) / Astellas, Ferring, Cetrotide (cetrorelix) / EMD Serono
    Trial completion date, Trial primary completion date:  Dysregulation of FSH in Obesity: Functional and Statistical Analysis (clinicaltrials.gov) -  Aug 20, 2020   
    P=N/A,  N=68, Recruiting, 
    Overall, diabetes can induce hypothalamus-pituitary-gonad axis dysfunction, affects hormonal secretion, and causes histological damage to testes, collectively leading to deleterious effects on male fertility. Trial completion date: Feb 2020 --> Feb 2021 | Trial primary completion date: Feb 2020 --> Feb 2021
  • ||||||||||  letrozole / Generic mfg.
    Trial completion date, Trial primary completion date:  Letrozole in Stimulated IVF Cycles (clinicaltrials.gov) -  Aug 20, 2020   
    P3,  N=900, Recruiting, 
    Trial completion date: Feb 2020 --> Feb 2021 | Trial primary completion date: Feb 2020 --> Feb 2021 Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2019 --> Dec 2020
  • ||||||||||  Cetrotide (cetrorelix) / EMD Serono
    Journal:  The Role of GnRH Receptor Autoantibodies in Polycystic Ovary Syndrome. (Pubmed Central) -  Aug 18, 2020   
    The GnRHR antagonist cetrorelix significantly suppressed (P < .01) the elevated GnRHR activity induced by IgG from 7 PCOS patients while the IgG activity level from 7 OIC subjects was unchanged...GnRHR-ECL2-AAb are significantly elevated in patients with PCOS compared with NCs. Their presence raises important etiological, diagnostic, and therapeutic implications.
  • ||||||||||  Cetrotide (cetrorelix) / EMD Serono
    Journal:  The Direct Effects of Gonadotropin-releasing Hormone on Proliferation of Granulosa Cells and Development of Follicles in Goose. (Pubmed Central) -  Jul 9, 2020   
    The study objectives were to determine the direct effects of gonadotropin-releasing hormone (GnRH) on the proliferation of ovarian granulosa cells (GCs) and the development of follicles in geese (Anser cygnoides) by colorimetry and ethynyl-2'-deoxyuridine (EdU) cell proliferation assays, in which primary GCs were treated with different concentrations of GnRH agonist (alarelin acetate) and an antagonist (cetrorelix acetate)...The pathways that regulate the development of follicles were identified, including the biological progress of cAMP accumulation, ovulation cycle and vasculature that are essential to follicular selection.The results suggested that GnRH might directly regulate GC proliferation via autocrine or paracrine pathways related to cell junctions. In particular, it was confirmed that the mRNA and protein expression levels of the oestrogen receptor 2 (ESR2) gene, a negative transcription factor involved in follicular maturation and ovulation, were affected by GnRH agonist or antagonist in GCs.In conclusion, GnRH might play an important role in follicular development by changing the expression of genes that participate in cAMP accumulation, ovulation cycle and cell junctions in ovarian GCs.
  • ||||||||||  Cetrotide (cetrorelix) / EMD Serono
    Enrollment open:  Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Patients Undergoing PGT-A (clinicaltrials.gov) -  Jul 7, 2020   
    P3,  N=400, Recruiting, 
    In particular, it was confirmed that the mRNA and protein expression levels of the oestrogen receptor 2 (ESR2) gene, a negative transcription factor involved in follicular maturation and ovulation, were affected by GnRH agonist or antagonist in GCs.In conclusion, GnRH might play an important role in follicular development by changing the expression of genes that participate in cAMP accumulation, ovulation cycle and cell junctions in ovarian GCs. Not yet recruiting --> Recruiting
  • ||||||||||  Climara (estradiol) / Bausch Health, Bayer, Cetrotide (cetrorelix) / EMD Serono
    New trial:  EDEN: Estrogen, Diabetes, and Endothelial Function (clinicaltrials.gov) -  Jun 4, 2020   
    P=N/A,  N=40, Completed, 
  • ||||||||||  teverelix LA (EP 24332) / Ardana Biosci, Orgalutran (ganirelix acetate) / Merck (MSD), Cetrotide (cetrorelix) / EMD Serono
    Journal:  GnRH Antagonists Produce Differential Modulation of the Signaling Pathways Mediated by GnRH Receptors. (Pubmed Central) -  Mar 26, 2020   
    Although immunostainings suggested that Teverelix could be less effective than Cetrorelix and Ganirelix in inhibiting 1 µM GnRH-induced β-catenin activation, Lhb gene expression increase occurring upon LβT2 cell treatment by 1 µM GnRH was similarly inhibited by all antagonists. To conclude, this study has demonstrated Cetrorelix-, Ganirelix- and Teverelix-specific biased effects at the intracellular level, not affecting the efficacy of antagonists in inhibiting Lhb gene transcription.
  • ||||||||||  Cetrotide (cetrorelix) / EMD Serono
    Journal:  GnRH antagonist treatment of malignant adrenocortical tumors. (Pubmed Central) -  Mar 4, 2020   
    We further studied the effects of the GnRH antagonist cetrorelix acetate (CTX) on cultured adrenocortical tumor (ACT) cells (mouse Cα1 and Y-1, and human H295R), and in vivo in transgenic mice (SV40 T-antigen expression under inhibin α promoter) bearing Lhcgr and Gnrhr in ACT...Upregulated genes included Grb10, Rerg, Nfatc and Gnas, all recently found to be abundantly expressed in healthy adrenal vs ACT. Our data suggest that CTX treatment may improve the therapy of human adrenocortical carcinomas by direct action on GNRHR-positive cancer cells inducing apoptosis and/or reducing gonadotropin release, directing tumor cells towards a healthy adrenal gene expression profile.
  • ||||||||||  Cetrotide (cetrorelix) / EMD Serono
    Journal:  Hormonal regulation and function of an RNA helicase, Ddx5 in corpus luteum of adult Wistar rats. (Pubmed Central) -  Jan 23, 2020   
    Under in vivo conditions, the administration of PGF or gonadotropin-releasing hormone antagonist; cetrorelix (CET) caused luteolysis as well as an increase in the protein level of Ddx5 (foldchange:1.9 ± 0.27 and 1.4 ± 0.09 viz.; p < 0.05) in CL of adult rats...Further, the data significantly correlates ddx5 expression to CL regression suggesting involvement of ddx5 in luteolysis. These results suggest a significant role of Ddx5 in female reproduction biology and warrant in depth examination of the function of Ddx5 in CL.
  • ||||||||||  metformin / Generic mfg.
    Case report: Oocyte cryopreservation in Turner syndrome mosaic with polycystic ovaries () -  Jan 16, 2020 - Abstract #Fertility2020FERTILITY_318;    
    Stimulation was with 100 i.u. of follitropin alfa and ganirelix acetate (0.25mg on day 5)...At 21, she underwent a second OR with 100 i.u. of follitropin alfa and cetrorelix (0.25mg on day 5)...To date none of the oocytes have been fertilised nor resulting embryos implanted. This suggests, that performing an ultrasound and checking AMH levels should be considered in patients with TS who have undergone spontaneous puberty to allow for appropriate fertility preservation counselling
  • ||||||||||  bleomycin / Generic mfg., BMS
    Preclinical, Journal:  Kisspeptin‑13 inhibits bleomycin‑induced pulmonary fibrosis through GPR54 in mice. (Pubmed Central) -  Jan 1, 2020   
    Furthermore, apoptosis‑related proteins, such as Bax and caspase‑3, were decreased, whereas Bcl‑2 was markedly increased as determined by western blotting. Collectively, these data suggested that the KP/GPR54 signaling pathway may be a promising target for the treatment of idiopathic pulmonary fibrosis.