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135 Diseases |  |
28 Trials |
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28 Trials |  |
1184 News |  |
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- ||| Tracleer (bosentan) / J&J, Roche
Trial completion, Enrollment change, Trial completion date, Trial primary completion date: CEASESTIFF: The Clinical And Subclinical Effects on Arterial Stiffness of Bosentan in Patients With Systemic Sclerosis (clinicaltrials.gov) - Dec 13, 2018
P4, N=20, Completed, Sponsor: University Medical Center Groningen
Not yet recruiting --> Completed | N=40 --> 20 | Trial completion date: Jun 2017 --> Jul 2018 | Trial primary completion date: Jun 2017 --> Jul 2018
- || Tracleer (bosentan) / J&J, Roche
Trial completion date, Trial primary completion date: GRegistry SCDU: Bosentan Treatment of Digital Ulcers Related to Systemic Sclerosis (clinicaltrials.gov) - Dec 5, 2018
P=N/A, N=100, Recruiting, Sponsor: Elpen Pharmaceutical Co. Inc.
Not yet recruiting --> Completed | N=40 --> 20 | Trial completion date: Jun 2017 --> Jul 2018 | Trial primary completion date: Jun 2017 --> Jul 2018 Trial completion date: Jun 2018 --> Jun 2019 | Trial primary completion date: Jun 2018 --> Jun 2019
- ||| Trial completion: PAH QuERI Ext: Pulmonary Arterial Hypertension Quality Enhancement Research Initiative Extension Program (clinicaltrials.gov) - Aug 15, 2018
P=N/A, N=797, Completed, Sponsor: Actelion
Trial completion date: Jun 2018 --> Jun 2019 | Trial primary completion date: Jun 2018 --> Jun 2019 Active, not recruiting --> Completed
- || Tracleer (bosentan) / J&J, Roche
Trial completion: Pharmacokinetic Effects of QTI571 on Sildenafil and Bosentan in Pulmonary Arterial Hypertension Participants (clinicaltrials.gov) - Jun 13, 2018
P3, N=21, Completed, Sponsor: Novartis Pharmaceuticals
Active, not recruiting --> Completed Terminated --> Completed
- ||| Tracleer (bosentan) / J&J, Roche
Trial completion, Combination therapy: First-line Bosentan and Sildenafil Combination Therapy for Pulmonary Arterial Hypertension (clinicaltrials.gov) - Jun 12, 2018
P=N/A, N=12, Completed, Sponsor: University of Calgary
Terminated --> Completed Recruiting --> Completed
- |||| Phase classification, Trial completion date, Trial primary completion date: PTN_POPS: Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care (clinicaltrials.gov) - Apr 4, 2018
P, N=10000, Recruiting, Sponsor: Daniel Benjamin
Recruiting --> Completed Phase classification: P=N/A --> P | Trial completion date: Feb 2018 --> Feb 2020 | Trial primary completion date: Feb 2018 --> Feb 2020
- || Trial completion date, Trial primary completion date: PAH QuERI Ext: Pulmonary Arterial Hypertension Quality Enhancement Research Initiative Extension Program (clinicaltrials.gov) - Mar 12, 2018
P=N/A, N=797, Active, not recruiting, Sponsor: Actelion
Phase classification: P=N/A --> P | Trial completion date: Feb 2018 --> Feb 2020 | Trial primary completion date: Feb 2018 --> Feb 2020 Trial completion date: Mar 2018 --> Jun 2018 | Trial primary completion date: Jan 2018 --> Jun 2018
- Tracleer (bosentan) / J&J, Roche
Enrollment change, Trial withdrawal: Pulmonary Arterial Hypertension Secondary to Idiopathic Pulmonary Fibrosis and Treatment With Bosentan (clinicaltrials.gov) - Mar 6, 2018
P4, N=0, Withdrawn, Sponsor: Rajan Saggar
Trial completion date: Mar 2018 --> Jun 2018 | Trial primary completion date: Jan 2018 --> Jun 2018 N=50 --> 0 | Recruiting --> Withdrawn
- | Tracleer (bosentan) / J&J, Roche
Trial completion: Treatment of Resistant Port-wine Stains With Bosentan and Pulsed Dye Laser: a Pilot Study (clinicaltrials.gov) - Feb 5, 2018
P2, N=4, Completed, Sponsor: Centre Hospitalier Universitaire de Nice
N=50 --> 0 | Recruiting --> Withdrawn Active, not recruiting --> Completed
- Tracleer (bosentan) / J&J, Roche
Enrollment change, Trial withdrawal: BOTA-PAH: Efficacy and Safety of Upfront Combination of ΒΟsentan and ΤΑdalafil in Pulmonary Arterial Hypertension (clinicaltrials.gov) - Jan 26, 2018
P=N/A, N=0, Withdrawn, Sponsor: Elpen Pharmaceutical Co. Inc.
Active, not recruiting --> Completed N=20 --> 0 | Not yet recruiting --> Withdrawn
- | Trial initiation date: Treatment of Supine Hypertension in Autonomic Failure (clinicaltrials.gov) - Oct 13, 2017
P1, N=152, Completed, Sponsor: Vanderbilt University
N=20 --> 0 | Not yet recruiting --> Withdrawn Initiation date: Jun 2001 --> Jan 2001
- | Tracleer (bosentan) / J&J, Roche
Enrollment open: ENDOTHELION Study Group: Effect of Bosentan in NAION Patients (clinicaltrials.gov) - Oct 6, 2017
P3, N=86, Recruiting, Sponsor: University Hospital, Grenoble
Initiation date: Jun 2001 --> Jan 2001 Not yet recruiting --> Recruiting
- ||| Tracleer (bosentan) / J&J, Roche
Enrollment open: GRegistry SCDU: Bosentan Treatment of Digital Ulcers Related to Systemic Sclerosis (clinicaltrials.gov) - Sep 29, 2017
P=N/A, N=100, Recruiting, Sponsor: Elpen Pharmaceutical Co. Inc.
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- ||||| Tracleer (bosentan) / J&J, Roche
Trial initiation date: FUTURE 3 Ext: FUTURE 3 Study Extension (clinicaltrials.gov) - Sep 20, 2017
P3, N=64, Completed, Sponsor: Actelion
Not yet recruiting --> Recruiting Initiation date: Jul 2011 --> Mar 2011
- Tracleer (bosentan) / J&J, Roche
Trial initiation date: BOTA-PAH: Efficacy and Safety of Upfront Combination of ΒΟsentan and ΤΑdalafil in Pulmonary Arterial Hypertension (clinicaltrials.gov) - Aug 22, 2017
P=N/A, N=20, Not yet recruiting, Sponsor: Elpen Pharmaceutical Co. Inc.
Initiation date: Jul 2011 --> Mar 2011 Initiation date: Jul 2017 --> Dec 2017
- | Tracleer (bosentan) / J&J, Roche
Trial primary completion date: Bosentan In Exercise Induced Pulmonary Arterial Hypertension in CongenitaL Heart diseasE (clinicaltrials.gov) - Aug 16, 2017
P2, N=12, Active, not recruiting, Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Initiation date: Jul 2017 --> Dec 2017 Trial primary completion date: Feb 2016 --> Feb 2018
- | Tracleer (bosentan) / J&J, Roche
New P4 trial: the Effect of Tracleer on Tourniquet-associated Hypertension (clinicaltrials.gov) - Jul 25, 2017
P4, N=80, Not yet recruiting, Sponsor: Xuzhou Medical University
- | Tracleer (bosentan) / J&J, Roche
Journal: Bosentan as Adjunctive Therapy for Persistent Pulmonary Hypertension of the Newborn: Results of the Randomized Multicenter Placebo-Controlled Exploratory Trial. (Pubmed Central) - May 11, 2017
P3
Adjunctive bosentan was well tolerated, but did not improve oxygenation or other outcomes in our patients with PPHN. This effect may be related to delayed absorption of bosentan on treatment initiation in critically ill neonates or to more severe illness of the neonates who received bosentan.
- Tracleer (bosentan) / J&J, Roche
New trial: BOTA-PAH: Efficacy and Safety of Upfront Combination of ΒΟsentan and ΤΑdalafil in Pulmonary Arterial Hypertension (clinicaltrials.gov) - May 3, 2017
P=N/A, N=20, Not yet recruiting, Sponsor: Elpen Pharmaceutical Co. Inc.
- || PK/PD data: PTN_POPS: Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care (clinicaltrials.gov) - Mar 22, 2017
P=N/A, N=10000, Recruiting, Sponsor: Daniel Benjamin
This effect may be related to delayed absorption of bosentan on treatment initiation in critically ill neonates or to more severe illness of the neonates who received bosentan. N=3000 --> 10000 | Trial primary completion date: Feb 2017 --> Feb 2018
- Tracleer (bosentan) / J&J, Roche
Trial termination, Trial primary completion date: Pharmacokinetic Effects of QTI571 on Sildenafil and Bosentan in Pulmonary Arterial Hypertension Participants (clinicaltrials.gov) - Feb 23, 2017
P3, N=21, Terminated, Sponsor: Novartis Pharmaceuticals
N=3000 --> 10000 | Trial primary completion date: Feb 2017 --> Feb 2018 Completed --> Terminated | Trial primary completion date: Jul 2012 --> Dec 2012
- Trial completion, Phase classification, Trial primary completion date: Treatment of Supine Hypertension in Autonomic Failure (clinicaltrials.gov) - Jan 18, 2017
P1, N=152, Completed, Sponsor: Vanderbilt University
Completed --> Terminated | Trial primary completion date: Jul 2012 --> Dec 2012 Recruiting --> Completed | Phase classification: P1/2 --> P1 | Trial primary completion date: Sep 2017 --> Jan 2017
- ||||||| Tracleer (bosentan) / J&J, Roche
Trial completion: RAPIDS-2: Efficacy and Safety of Oral Bosentan on Healing/Prevention of Digital (Finger) Ulcers in Patients With Scleroderma (clinicaltrials.gov) - Oct 26, 2016
P3, N=188, Completed, Sponsor: Actelion
Recruiting --> Completed | Phase classification: P1/2 --> P1 | Trial primary completion date: Sep 2017 --> Jan 2017 No longer recruiting --> Completed
- Tracleer (bosentan) / J&J, Roche
Enrollment change, Trial termination, Trial primary completion date: Bosentan for Treatment of Hepatopulmonary Syndrome in Patients With Liver Cirrhosis (clinicaltrials.gov) - Sep 28, 2016
P2, N=6, Terminated, Sponsor: Medical University of Vienna
No longer recruiting --> Completed N=18 --> 6 | Recruiting --> Terminated | Trial primary completion date: Oct 2013 --> Apr 2014; too slow patient recruitment
- || Tracleer (bosentan) / J&J, Roche
Trial initiation date: GRegistry SCDU: Bosentan Treatment of Digital Ulcers Related to Systemic Sclerosis (clinicaltrials.gov) - Aug 23, 2016
P=N/A, N=100, Not yet recruiting, Sponsor: Elpen Pharmaceutical Co. Inc.
N=18 --> 6 | Recruiting --> Terminated | Trial primary completion date: Oct 2013 --> Apr 2014; too slow patient recruitment Initiation date: Jun 2016 --> Sep 2016
- | Tracleer (bosentan) / J&J, Roche
Trial completion: ScS-REINBO: Effect of Bosentan in Scleroderma Renal Crisis (clinicaltrials.gov) - Jul 7, 2016
P2, N=16, Completed, Sponsor: Assistance Publique - Hôpitaux de Paris
Initiation date: Jun 2016 --> Sep 2016 Active, not recruiting --> Completed
- |||||||||| Tracleer (bosentan) / J&J, Roche
New P3 trial: RAPIDS-2: Efficacy and Safety of Oral Bosentan on Healing/Prevention of Digital (Finger) Ulcers in Patients With Scleroderma (clinicaltrials.gov) - Jun 16, 2016
P3, N=188, Completed, Sponsor: Actelion
- ||| Tracleer (bosentan) / J&J, Roche
New trial: GRegistry SCDU: Bosentan Treatment of Digital Ulcers Related to Systemic Sclerosis (clinicaltrials.gov) - Jun 15, 2016
P=N/A, N=100, Not yet recruiting, Sponsor: Elpen Pharmaceutical Co. Inc.
- |||| Tracleer (bosentan) / J&J, Roche
Trial primary completion date: FUTURE 3: Effects of Two Dosing Regimens of Bosentan in Children With Pulmonary Arterial Hypertension (clinicaltrials.gov) - Jun 10, 2016
P3, N=64, Completed, Sponsor: Actelion
Active, not recruiting --> Completed Trial primary completion date: Aug 2013 --> Apr 2013
- | Tracleer (bosentan) / J&J, Roche
Trial completion, Enrollment change: ET-blockade and Exercise-induced Vascular Adaptations in T2DM (clinicaltrials.gov) - May 5, 2016
P4, N=19, Completed, Sponsor: Radboud University
Trial primary completion date: Aug 2013 --> Apr 2013 Active, not recruiting --> Completed | N=36 --> 19
- Tracleer (bosentan) / J&J, Roche
Trial completion: ET-blockade and Exercise Induced Blood Flow in T2DM (clinicaltrials.gov) - May 4, 2016
P4, N=22, Completed, Sponsor: Radboud University
Active, not recruiting --> Completed | N=36 --> 19 Active, not recruiting --> Completed
- | Tracleer (bosentan) / J&J, Roche
Trial completion: Influence of Bosentan on the Pharmacokinetics of Nintedanib (clinicaltrials.gov) - Mar 21, 2016
P1, N=13, Completed, Sponsor: Boehringer Ingelheim
Active, not recruiting --> Completed Recruiting --> Completed
- Tracleer (bosentan) / J&J, Roche
Enrollment open: Influence of Bosentan on the Pharmacokinetics of Nintedanib (clinicaltrials.gov) - Feb 27, 2016
P1, N=14, Recruiting, Sponsor: Boehringer Ingelheim
Recruiting --> Completed Not yet recruiting --> Recruiting
- || Tyvaso (treprostinil) / United Therapeutics Corp
Trial primary completion date, Adverse events: Aspire: Study of Incidence of Respiratory Tract AEs in Patients Treated With Tyvaso (clinicaltrials.gov) - Feb 17, 2016
P=N/A, N=1333, Completed, Sponsor: United Therapeutics
Not yet recruiting --> Recruiting Trial primary completion date: Jul 2014 --> Dec 2014
- || Enrollment closed, Trial primary completion date: PAH QuERI Ext: Pulmonary Arterial Hypertension Quality Enhancement Research Initiative Extension Program (clinicaltrials.gov) - Feb 12, 2016
P=N/A, N=800, Active, not recruiting, Sponsor: Actelion
Trial primary completion date: Jul 2014 --> Dec 2014 Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2015 --> Jan 2018
- || PK/PD data: PTN_POPS: Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care (clinicaltrials.gov) - Feb 8, 2016
P=N/A, N=3000, Recruiting, Sponsor: Daniel Benjamin
Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2015 --> Jan 2018 N=2000 --> 3000 | Trial primary completion date: Aug 2016 --> Feb 2017
- | Tracleer (bosentan) / J&J, Roche
New P1 trial: Influence of Bosentan on the Pharmacokinetics of Nintedanib (clinicaltrials.gov) - Jan 29, 2016
P1, N=14, Not yet recruiting, Sponsor: Boehringer Ingelheim
- Trial primary completion date: Treatment of Supine Hypertension in Autonomic Failure (clinicaltrials.gov) - Jan 4, 2016
P1/2, N=160, Recruiting, Sponsor: Vanderbilt University
N=2000 --> 3000 | Trial primary completion date: Aug 2016 --> Feb 2017 Trial primary completion date: Sep 2016 --> Sep 2017
- Tracleer (bosentan) / J&J, Roche
Clinical data, Trial primary completion date, Surgery: BOCA: Bosentan Improves Clinical Outcome of Adults With Congenital Heart Disease or Mitral Valve Lesions Who Undergo CArdiac Surgery (clinicaltrials.gov) - Dec 23, 2015
P=N/A, N=100, Recruiting, Sponsor: Berto J Bouma
Trial primary completion date: Sep 2016 --> Sep 2017 Trial primary completion date: Dec 2015 --> Jul 2016
- Tracleer (bosentan) / J&J, Roche
Enrollment closed, Enrollment change: Bosentan In Exercise Induced Pulmonary Arterial Hypertension in CongenitaL Heart diseasE (clinicaltrials.gov) - Dec 23, 2015
P2, N=12, Active, not recruiting, Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Trial primary completion date: Dec 2015 --> Jul 2016 Recruiting --> Active, not recruiting | N=40 --> 12
- Tracleer (bosentan) / J&J, Roche
Trial primary completion date: ScS-REINBO: Effect of Bosentan in Scleroderma Renal Crisis (clinicaltrials.gov) - Oct 23, 2015
P2, N=16, Active, not recruiting, Sponsor: Assistance Publique - Hôpitaux de Paris
Recruiting --> Active, not recruiting | N=40 --> 12 Trial primary completion date: Jul 2015 --> Oct 2015
- ||||| Tracleer (bosentan) / J&J, Roche
Trial initiation date: BUILD 3: Bosentan Use in Interstitial Lung Disease (clinicaltrials.gov) - Sep 29, 2015
P3, N=616, Completed, Sponsor: Actelion
Trial primary completion date: Jul 2015 --> Oct 2015 Initiation date: Nov 2006 --> Feb 2007
- Thelin (oral sitaxsentan) / Pfizer, Tracleer (bosentan) / J&J, Roche
Trial completion, Trial primary completion date: Role of Endothelin-A (ETA) and Endothelin-B (ETB) Receptors in the Vasodilatory Response to Endothelin-3 (ET-3) (clinicaltrials.gov) - Jul 21, 2015
P0, N=10, Completed, Sponsor: University of Edinburgh
Initiation date: Nov 2006 --> Feb 2007 Active, not recruiting --> Completed | Trial primary completion date: Sep 2010 --> Sep 2009
- Tracleer (bosentan) / J&J, Roche
Enrollment open, Trial initiation date: End-Stress: Endothelin Receptor Function and Acute Stress (clinicaltrials.gov) - Jul 20, 2015
P=N/A, N=320, Recruiting, Sponsor: Georgia Regents University
Active, not recruiting --> Completed | Trial primary completion date: Sep 2010 --> Sep 2009 Not yet recruiting --> Recruiting | Initiation date: Jan 2015 --> Jun 2015
- | Tracleer (bosentan) / J&J, Roche
New P4 trial: CEASESTIFF: The Clinical And Subclinical Effects on Arterial Stiffness of Bosentan in Patients With Systemic Sclerosis (clinicaltrials.gov) - Jun 24, 2015
P4, N=40, Not yet recruiting, Sponsor: University Medical Centre Groningen
- ||||||| Tracleer (bosentan) / J&J, Roche
Trial completion: FUTURE 3 Ext: FUTURE 3 Study Extension (clinicaltrials.gov) - Jun 2, 2015
P3, N=64, Completed, Sponsor: Actelion
Not yet recruiting --> Recruiting | Initiation date: Jan 2015 --> Jun 2015 Active, not recruiting --> Completed
- | Tracleer (bosentan) / J&J, Roche
Enrollment closed: ScS-REINBO: Effect of Bosentan in Scleroderma Renal Crisis (clinicaltrials.gov) - Apr 30, 2015
P2, N=16, Active, not recruiting, Sponsor: Assistance Publique - Hôpitaux de Paris
Active, not recruiting --> Completed Recruiting --> Active, not recruiting
- | Tracleer (bosentan) / J&J, Roche
Trial completion: TRADOMS: Transcranial Doppler in Multiple Sclerosis (clinicaltrials.gov) - Apr 16, 2015
P=N/A, N=30, Completed, Sponsor: Universitair Ziekenhuis Brussel
Recruiting --> Active, not recruiting Active, not recruiting --> Completed
- Trial primary completion date: Treatment of Supine Hypertension in Autonomic Failure (clinicaltrials.gov) - Apr 14, 2015
P1/2, N=160, Recruiting, Sponsor: Vanderbilt University
Active, not recruiting --> Completed Trial primary completion date: Sep 2015 --> Sep 2016
- Tracleer (bosentan) / J&J, Roche
Clinical: TRADOMS: Transcranial Doppler in Multiple Sclerosis (clinicaltrials.gov) - Mar 17, 2015
P=N/A, N=30, Active, not recruiting, Sponsor: Universitair Ziekenhuis Brussel