- |||||||||| budesonide / Generic mfg.
[VIRTUAL] Nonasthmatic wheeze in an atopic 27-year old woman: Case report () - May 19, 2020 - Abstract #EAACI2020EAACI_2106;
With this case, we aim to highlight the importance of careful interpretation of wheezing. Bronchial carcinoid like other obstructive endobronchial lesions may cause wheezing and should be recognized as early as possible so that patients can be optimally treated.
- |||||||||| budesonide / Generic mfg.
[VIRTUAL] Budesonide/formoterol efficacy in obese asthma () - May 19, 2020 - Abstract #EAACI2020EAACI_1359;
Changes in HR and BP were not statistically significant. Patients with obese asthma had worse asthma control, FEV1 values and higher number of exacerbations.
- |||||||||| Decadron (dexamethasone) / Merck (MSD), budesonide / Generic mfg.
[VIRTUAL] Late addition of budesonide inhibits virus-induced cytokine production () - May 19, 2020 - Abstract #EAACI2020EAACI_1310;
Post addition of BUD inhibited the virus-induced TSLP and CCL26 from the airway epithelial cells. These results suggest that an inhalation of BUD after viral infection has beneficial effects for asthma.
- |||||||||| Remicade (infliximab) / Mitsubishi Tanabe, J&J, Enbrel (etanercept) / Pfizer, Amgen
[VIRTUAL] STAGE IV INTESTINAL ACUTE GRAFT VERSUS HOST DISEASE: EXPERIENCE AFTER 1428 ALLOGENIC HEMATOPOIETIC STEM CELL TRANSPLANTATIONS () - May 16, 2020 - Abstract #EHA2020EHA_1876;
All received methylprednisolone 2mg/kg /24h +/- Budesonide +/- Beclomethasone as first line treatment...Other rescue treatments used were infliximab or etanercept (27,6%), extracorporeal photopheresis (27,6%) and mycophenolate mofetil (18%)...Although most of the patients respond to salvage GvHD strategies, including Mesenchymal cells or photopheresis, finally most of our patients died due to direct aGvHD or to associated complications. Our analysis shows that most of the patients (98%) do not respond to steroids, so efforts should be made to find which agents need to be associated to steroids in the first line to improve the dismal prognosis of stage IV iaGvHD.
- |||||||||| Veramyst (fluticasone furoate nasal spray) / GSK
Review, Journal: Treatment with inhaled corticosteroids in chronic obstructive pulmonary disease. (Pubmed Central) - May 14, 2020
Studies comparing the effect and safety of other ICSs such as fluticasone furoate and beclomethasone are too few to draw firm conclusions from...The indication of using ICS in COPD is stronger if the patient has increased blood eosinophils levels. There are data indicating that the choice of ICS matters, with studies showing a better effect-safety profile with budesonide compared to fluticasone propionate whereas it is not possible to make benefit-risk comparisons between the other licensed ICSs.
- |||||||||| Nucala (mepolizumab) / GSK, Xolair (omalizumab) / Roche, Novartis
Clinical, Journal: Case study: A Combination of Mepolizumab and Omaluzimab injections for severe asthma. (Pubmed Central) - May 9, 2020
There are data indicating that the choice of ICS matters, with studies showing a better effect-safety profile with budesonide compared to fluticasone propionate whereas it is not possible to make benefit-risk comparisons between the other licensed ICSs. Combination of omalizumab and mepolizumab could become the gold standard for severe asthma patients that have elevated IgE levels and an eosinophilic phenotype.
- |||||||||| budesonide / Generic mfg.
Journal: Surfactant plus budesonide decreases lung and systemic responses to injurious ventilation in preterm sheep. (Pubmed Central) - May 7, 2020
Combination of omalizumab and mepolizumab could become the gold standard for severe asthma patients that have elevated IgE levels and an eosinophilic phenotype. In lambs receiving Injury V, the addition of budesonide to surfactant improved lung physiology, and decreased pro-inflammatory cytokine responses in the lung, liver, and brain to levels similar to lambs receiving Normal V.
- |||||||||| budesonide / Generic mfg.
Journal: Thiolated hydroxypropyl-β-cyclodextrin as mucoadhesive excipient for oral delivery of budesonide in liquid paediatric formulation. (Pubmed Central) - May 7, 2020
Phase-solubility studies demonstrated the capability of HP- β CD-SH (100 mM) to form a reversible water soluble inclusion complex with BUD (S β = 10.9·10 M; K = 2013.52 M), which increases its permanence on the target site as proved by mucoadhesive studies on porcine oesophagus mucosa. HP- β CD-SH might be a useful MDDS for the pharmacist to prepare BUD oral liquid formulations at the recommended doses, with pH values below 5, which guarantee the chemical stability of the new mucoadhesive excipient.
- |||||||||| budesonide / Generic mfg.
A COMPARISON OF LYMPHOCYTIC COLITIS AND COLLAGENOUS COLITIS () - May 4, 2020 - Abstract #DDW2020DDW_5914;
Among the medications which could potentially be responsible for their etiology, use of statins and BB seems to be more commonly associated with LC than CC. There is a higher chance for individuals living in urban areas to develop LC than CC.
- |||||||||| prednisone / Generic mfg., budesonide / Generic mfg.
ESOPHAGEAL STRICTURES IN PEDIATRIC PATIENTS WITH EOSINOPHILIC ESOPHAGITIS ; SHORT SEGMENT STRICTURE VS. NARROW CALIBER ESOPHAGUS. () - May 4, 2020 - Abstract #DDW2020DDW_5851;
There is a higher chance for individuals living in urban areas to develop LC than CC. Incidence of esophageal stricture:6.5% within the entire EoE patients and 17.7% within the EoE–D.NCE group required more dilations than the SS group,but was not significant.SS group had significant improvement in dysphagia,and composite score.Both groups; EGD scores and PEC had minimal improvement with dilation and treatment,but was not significant.
- |||||||||| budesonide / Generic mfg., lansoprazole / Generic mfg.
EOSINOPHILIC ESOPHAGITIS IN NON-CAUCASIANS: A UNIQUE PEDIATRIC DATABASE AT CHILDREN'S NATIONAL (CN) () - May 4, 2020 - Abstract #DDW2020DDW_5772;
Average PPI dose was 1.2 mg/kg/d and lansoprazole the most commonly prescribed PPI...TCS induced REM in 25/40 (62.5%), budesonide=14 & fluticasone=11...Due to the non-protocolized nature of the review, we acknowledge limitations of missing data, variable reporting of endoscopy, pathology, treatment regimens and unknown adherence. Expansion of the database will perhaps elucidate the role of epigenetics, atopy and outcomes of this uniquely diverse cohort
- |||||||||| CHARACTERIZATION OF STEROID THERAPY FOR DRUG-INDUCED LIVER INJURY () - May 4, 2020 - Abstract #DDW2020DDW_4227;
Systemic steroid therapy was administered in 14% of patients with DILI and more common in women with hepatocellular injury exhibiting histologic features of autoimmune-like injury. Patients receiving steroids had worse liver injury at presentation and yet their mortality was not significantly higher, suggesting a potential therapeutic benefit.
- |||||||||| budesonide / Generic mfg., Breo Ellipta (fluticasone furoate / vilanterol) / GSK, Innoviva
Clinical, Journal: Assessment of COPD-related outcomes in patients initiating a once daily or twice daily ICS/LABA. (Pubmed Central) - May 2, 2020
Patients initiating once-daily FF/VI were more adherent, and were associated with a lower risk of subsequent COPD-related exacerbations compared with twice-daily BUD/F, however this was not associated with a significant difference in costs. (GSK Study HO1617333/206702).
- |||||||||| budesonide / Generic mfg.
Review, Journal: Alternatives to systemic postnatal corticosteroids: Inhaled, nebulized and intratracheal. (Pubmed Central) - Apr 30, 2020
An alternative to inhalation is the intratracheal administration of corticosteroids using surfactant as a vehicle, but this approach has only been studied in a limited number of infants. We review the evidence for the short-term clinical efficacy and safety of inhaled, nebulized and intratracheal PCS for the prevention and treatment of BPD.
- |||||||||| budesonide / Generic mfg.
Review, Journal: The impact of asthma and its treatment on growth: an evidence-based review. (Pubmed Central) - Apr 29, 2020
Regular use of inhaled corticosteroids may cause a small reduction in linear growth in children with asthma, but the well-established benefits of inhaled corticosteroids in controlling asthma outweigh the potential adverse effects on growth. Use of the minimally effective dose of inhaled corticosteroids and regular monitoring of child's height during inhaled corticosteroids therapy are recommended.
- |||||||||| budesonide / Generic mfg.
Clinical, Journal: The use of platelet-rich plasma in treatment of olfactory dysfunction: A pilot study. (Pubmed Central) - Apr 28, 2020
Seven patients who had olfactory loss greater than 6 months in duration, no evidence of sinonasal inflammatory disease, and no improvement with olfactory training and budesonide topical rinses were enrolled in this preliminary study...PRP appears safe for use in the treatment of olfactory loss, and preliminary data suggest possible efficacy, especially for those with moderate yet persistent loss. Further studies will help determine optimal frequency and duration of use.
- |||||||||| Journal: Treatment-resistant severe capecitabine-induced diarrhoea resolved with oral budesonide. (Pubmed Central) - Apr 26, 2020
Small case reports have shown benefit with budesonide in CID secondary to 5-FU and irinotecan, but there is no literature base addressing budesonide use in CID secondary to capecitabine. We describe a case of a patient with severe capecitabine-induced diarrhoea that was refractory to guideline based therapy but resolved with the use of budesonide.
- |||||||||| budesonide / Generic mfg.
Review, Journal, Benefit-risk assessment: Benefit:Risk Profile of Budesonide in Obstructive Airways Disease. (Pubmed Central) - Apr 23, 2020
Budesonide remains one of the most well-established and versatile of the inhaled anti-inflammatory drugs. This narrative review provides a clinical reappraisal of the benefit:risk profile of budesonide in the management of asthma and COPD.
- |||||||||| Symbicort (budesonide/formoterol) / AstraZeneca, budesonide / Generic mfg.
Journal: As-needed ICS-LABA in Mild Asthma: What Does the Evidence Say? (Pubmed Central) - Apr 23, 2020
Finally, the SIENA study showed that 73% of patients with mild asthma do not have an eosinophilic phenotype and that these patients have a similar clinical response to ICS (mometasone) and antimuscarinic drugs (tiotropium), results that challenge the indication of a drug combination that incorporates ICS as a first option. Overall, we believe there is insufficient evidence for the systematic recommendation of as-needed ICS-LABA instead of SABA on request for GINA step 1 or as a replacement for chronic ICS in GINA step 2.
- |||||||||| budesonide / Generic mfg., Uceris (budesonide rectal foam) / Bausch Health, Dr Falk
Journal: Budesonide foam for prevention of rectal stricture following endoscopic submucosal dissection. (Pubmed Central) - Apr 16, 2020
Endoscopic submucosal dissection (ESD) for removal of gastrointestinal tumors is a conventional technique; however, ESD has been reported to result in complications such as stricture and delayed bleeding. In the case of colorectal ESD, resection of >90% of the circumference is a significant factor related to stricture, and the median duration until the diagnosis of stricture after ESD is 1 month (range, 0.5-2.0 months).
- |||||||||| budesonide / Generic mfg.
Journal: Chemoprevention of lung carcinogenesis by dietary nicotinamide and inhaled budesonide. (Pubmed Central) - Apr 16, 2020
We conclude nicotinamide is an effective and safe agent for lung cancer dietary prevention at both early and late stage carcinogenesis and that efficacy is increased with aerosol budesonide. Combination chemoprevention with these agents is a well-tolerated and effective strategy which could be clinically advanced to human studies.
- |||||||||| Journal: Medications and the larynx. (Pubmed Central) - Apr 12, 2020
This case demonstrates that the use of a topical steroid, combined with an endoscopic approach, may easily resolve an unusual endoscopic complication in patients suffering from complicated diverticular disease. Further study is warranted to explore the effects that these and other classes of agents, such as antibiotics, have on the structure and function of the larynx.
- |||||||||| Breztri Aerosphere (budesonide/formoterol fumarate/glycopyrronium) / AstraZeneca
Clinical, P1 data, PK/PD data, Journal: Pharmacokinetics of Co-Suspension Delivery Technology Budesonide/Glycopyrronium/Formoterol Fumarate Dihydrate (BGF MDI) and Budesonide/Formoterol Fumarate Dihydrate (BFF MDI) Fixed-Dose Combinations Compared With an Active Control: A Phase 1, Randomized, Single-Dose, Crossover Study in Healthy Adults. (Pubmed Central) - Apr 10, 2020
P1
While systemic exposure to budesonide and formoterol was higher for BGF MDI and BFF MDI than for BUD/FORM DPI, there were no appreciable differences in the incidence of pharmacologically predictable adverse events. This, coupled with the absence of PK interactions, suggests the BGF MDI safety profile will be comparable to BUD/FORM DPI.
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