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20 Diseases |  |
17 Trials |
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17 Trials |  |
3666 News |  |
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- ||| budesonide / Generic mfg.
If compliance to 5 ASA is good, starting Budesonide is a good option. I will use this opportunity to talk about further Rx options down the line to avoid steroid dependence #MondayNightIBD #ulcerativecolitis (Twitter) - Jun 30, 2020
- || budesonide / Generic mfg.
🔸We should never assume meds are being taken 🔸Assuming he is, would assess disease burden - FCP + symptoms 🔸Offer alternatives - curcumin, watch and monitor in 4 weeks 🔸If worse, would offer budesonide course and plan to escalate Not sure if I would push the enemas though (Twitter) - Jun 30, 2020
- |||| budesonide / Generic mfg.
Clinical: Good case, tough question - too sick for 5-ASA, too well for biologics. Assuming bx consistent with inflam, assess adherence, cont mesal, short course of budesonide or pred, check calpro for future monitoring. If still symptomatic/inflamed, immunomodulator next. (Twitter) - Jun 30, 2020
- || budesonide / Generic mfg.
other causes (celiac? etc), agree w/ discussing compliance and checking infl markers trend , shared decision, if symptoms seem to stem up from UC activity I would give 3 months chance for mesalamine +- budesonide rpt colonoscopy and or crp if still active dis or worse, escalate (Twitter) - Jun 29, 2020
- ||| budesonide / Generic mfg., budesonide ER / Generic mfg.
Clinical: I agree with @VictorChedidMD. If despite optimizing both oral AND rectal 5-ASA patient continues to have symptoms, I would favor trial of budesonide MMX as next step. (Twitter) - Jun 29, 2020
- ||| budesonide / Generic mfg.
Clinical: Biologics seem to be a big jump for patients and they would want to delay/avoid them if possible. A short course of budesonide and then reassess ? (Twitter) - Jun 29, 2020
- || budesonide / Generic mfg., azathioprine orodispersible / Generic mfg.
Start planning how to bridge to azathioprine (budesonide or short course prednisolon) soon enough. (Twitter) - Jun 29, 2020
- || budesonide / Generic mfg.
Charlie @charlie_lees @PlevrisN what FCP cutoff would you use to determine if budesonide is warranted in UC? #MondayNightIBD (Twitter) - Jun 29, 2020
- ||| budesonide / Generic mfg.
Clinical: One more point. I wouldn’t have scoped this patient at this time point given mild symptoms. I’d have checked CRP and calpro. If either up then mmx budesonide. If this doesn’t work then scope and vedo if active disease. (Twitter) - Jun 29, 2020
- ||| budesonide / Generic mfg.
Clinical: Patient preference also key. This seemingly subtle increase in symptoms may be much more significant in some than others. A course of oral mmx budesonide or beclamethasone may do the job. If things worsen after or inspite of this I may escalate to vedo. (Twitter) - Jun 29, 2020
- || budesonide / Generic mfg.
Clinical, Journal: Duration of treatment with inhaled corticosteroids in nonasthmatic eosinophilic bronchitis: a randomized open label trial. (Pubmed Central) - Jun 28, 2020
P4
Patients were randomized to receive 1-month, 2-month, or 4-month treatment with inhaled budesonide (200 μg, twice daily)...The study was registered on ClinicalTrials.gov (NCT02002715). The reviews of this paper are available via the supplemental material section.
- || Clinical, Journal: Budesonide Foam for Ulcerative Colitis Patients Experiencing Inadequate Response to Biological Therapy. (Pubmed Central) - Jun 28, 2020
CONCLUSIONS Although the number of patients was small, budesonide foam had significant efficacy when added to the treatment of patients having an inadequate response to Bio or to tacrolimus. These results suggest that in cases responding poorly to Bio, adding budesonide foam as combination therapy can achieve a clinical remission.
- | Decadron (dexamethasone) / Merck (MSD)
Journal: Pharmacotherapy of oral mucosal manifestations of chronic graft-versus-host disease: When? What? and How? (Pubmed Central) - Jun 27, 2020
These results suggest that in cases responding poorly to Bio, adding budesonide foam as combination therapy can achieve a clinical remission. No abstract available
- || budesonide / Generic mfg.
Clinical, Review, Journal: Eosinophilic esophagitis in children: doubts and future perspectives. (Pubmed Central) - Jun 26, 2020
We speculate that combined biological therapies targeting more than one molecule or cell may provide better results, with conventional therapies potentially enhancing the effects of antibodies. However, further studies should aim to find the best therapeutic approach to target the cells involved in the remodelling process and to reverse the histological changes in this complex clinical condition.
- | Preclinical, Journal: An Exploration of Factors Affecting In Vitro Deposition of Pharmaceutical Aerosols in the Alberta Idealized Throat. (Pubmed Central) - Jun 26, 2020
Three pressurized metered-dose inhalers (pMDIs; QVAR, Ventolin Evohaler, and Flovent HFA) were examined considering the joint effects of insertion angle (as above) and relative humidity at low (15%-25%) and high (>95%) conditions...When oriented toward the back of the oral cavity, the filter dose decreased from 46.5% to 36.9% for Ventolin Evohaler (p = 0.005) and from 56.7% to 44.2% for Flovent HFA (p < 0.001) at high humidity relative to low. High humidity may cause a reduction in total in vitro lung doses for some pMDI aerosols.
- || budesonide / Generic mfg., Flutiform (fluticasone/formoterol) / Kyorin, Mundipharma, Vectura, Sanofi
Clinical, Journal: Comparative Safety Profile of the Fixed-Dose Combination Corticosteroid and Long-acting β-Agonist Fluticasone Propionate/Formoterol Fumarate: A 36-Month Longitudinal Cohort Study in UK Primary Care. (Pubmed Central) - Jun 25, 2020
High humidity may cause a reduction in total in vitro lung doses for some pMDI aerosols. The results suggest that FP/FORM was associated with an overall lower adverse outcome rate than the licensed comparators.
- || Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA, budesonide / Generic mfg., budesonide ER / Generic mfg.
Clinical, Journal: Budesonide MMX Is Effective in Patients Having Persistent Symptoms and Raised Fecal Calprotectin Following Treatments for Diverticular Disease. (Pubmed Central) - Jun 25, 2020
The results suggest that FP/FORM was associated with an overall lower adverse outcome rate than the licensed comparators. Treatment with budesonide MMXTM seems to be effective in obtaining symptoms' control and dropping of FC in patients with DD and not responding to standard treatments.
- || budesonide / Generic mfg.
Just out of curiosity, what is the name of the budesonide product available in Panama? (Twitter) - Jun 23, 2020
- ||| budesonide / Generic mfg.
Don't have direct experience with this but chewing would ruin protective coating and increase drug exposure, so budesonide absorption could be more systemic and not as targeted. See excerpt from article below! https://t.co/iQlTG4Zf3E (Twitter) - Jun 23, 2020
- || budesonide / Generic mfg., Budenofalk granules (budesonide gastro-resistant granules) / Dr Falk
Thanks for the tag Alison! Yep the budesonide capsules can be opened and granules can be mixed into applesauce if unable to swallow capsule whole. MMX technology is intended to extend drug's release to distal part of colonic mucosa so essential to swallow these tabs whole. (Twitter) - Jun 23, 2020
- || budesonide / Generic mfg., Budenofalk (budesonide effervescent tablet) / Dr Falk
Review, Journal: Orodispersible budesonide tablets for the treatment of eosinophilic esophagitis: a review of the latest evidence. (Pubmed Central) - Jun 23, 2020
The new orodispersible budesonide tablet with effervescent properties is the first approved esophageal-targeted formulation specifically developed for the treatment of EoE, which has become available in many European countries. This article gives an overview of the evolution of topical corticosteroids in EoE and provides an update on recent data from large-scale multicenter trials exploring the efficacy and safety of the orodispersible budesonide tablet with effervescent properties in adult EoE patients.
- || methylprednisolone oral / Generic mfg., budesonide / Generic mfg.
Clinical, Journal: Effect of short-course glucocorticoid application on patients with chronic rhinosinusitis with nasal polyps. (Pubmed Central) - Jun 23, 2020
Budesonide suspension nasal drop can significantly improve the quality of life and reduce the endoscopic score following short-course treatment, and the treatment effect of nasal drop was better than that of regular nasal spray. Budesonide nasal suspension can be used as a regular treatment for eosinophilic CRSwNP and can be an alternative choice for patients with a high percentage of tissue eosinophil infiltration who cannot use oral glucocorticoids.
- | budesonide / Generic mfg., Duaklir (aclidinium bromide/formoterol fumarate) / AstraZeneca
Journal: Budesonide, Aclidinium and Formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke. (Pubmed Central) - Jun 19, 2020
Combined therapy with BUD, ACL and FO counteracted the effects of CSE on LPS binding, FoxO3 nuclear expression, ERK 1/2 activation, survivin and IL-8 release and mRNA levels. These findings suggest a new role of combination therapy with BUD, ACL and FO in counteracting inflammaging processes induced by cigarette smoke exposure.
- | Formoterol Clickhaler (formoterol dry-powder inhaler) / Vectura, Foradil Aerolizer (formoterol dry powder inhaler) / Novartis, budesonide / Generic mfg.
Journal: Variability in airway inflammation, symptoms, lung function and reliever use in asthma: anti-inflammatory reliever hypothesis and STIFLE study design. (Pubmed Central) - Jun 19, 2020
Daily data will be captured for fractional exhaled nitric oxide, spirometry, asthma symptoms and medication use using devices connected to a smartphone via the STIFLE application. STIFLE will thereby enable not only characterisation of the variability of airway inflammation and clinical outcomes in relation to asthma worsening, but also elucidate the effect of as-needed budesonide/formoterol on airway inflammation against a background of daily maintenance therapy.
- | budesonide / Generic mfg.
Journal: Latest developments on topical therapies in chronic rhinosinusitis. (Pubmed Central) - Jun 18, 2020
Wide surgical access and aggressive surgical debridement of polyposis facilitates the delivery of steroid irrigations to sinonasal mucosa and is associated with improved long-term outcomes following endoscopic sinus surgery. The use of novel treatments remains within the research setting alone.
- | budesonide / Generic mfg.
Journal: Lymphocytic Esophagitis Successfully Treated by Esophageal Balloon Dilation and Topical Budesonide. (Pubmed Central) - Jun 18, 2020
The use of novel treatments remains within the research setting alone. No abstract available
- ||||||| budesonide / Generic mfg.
Trial completion: To Evaluate the Efficacy and Safety of FE 999315 in Japanese Subjects With Mild to Moderate Active Ulcerative Colitis (clinicaltrials.gov) - Jun 17, 2020
P3, N=274, Completed, Sponsor: Ferring Pharmaceuticals
No abstract available Active, not recruiting --> Completed
- budesonide / Generic mfg.
[VIRTUAL] THE NEFIGARD TRIAL: THE EFFECT OF NEFECON® (BUDESONIDE) IN PATIENTS WITH PRIMARY IGA NEPHROPATHY AT RISK OF DEVELOPING END-STAGE RENAL DISEASE () - Jun 13, 2020 - Abstract #ERAEDTA2020ERA-EDTA_732;
- | budesonide / Generic mfg.
New P2 trial: Co-STAR: Coronavirus Smell Therapy for Anosmia Recovery (clinicaltrials.gov) - Jun 8, 2020
P2, N=200, Not yet recruiting, Sponsor: Washington University School of Medicine
- || budesonide / Generic mfg.
Biomarker, Clinical, Journal: Pharmacogenomics and Placebo Response in a Randomized Clinical Trial in Asthma. (Pubmed Central) - Jun 8, 2020
The rs12930749 effect was attenuated with budesonide (P =1.32E-02) and nedocromil (P =1.09E-02). Pharmacogenomic analysis revealed differential effects with placebo and drug treatment that could potentially guide precision drug development in asthma.
- | budesonide / Generic mfg.
Preclinical, Journal: Inula helenium and Grindelia squarrosa as a source of compounds with anti-inflammatory activity in human neutrophils and cultured human respiratory epithelium. (Pubmed Central) - Jun 8, 2020
The present study demonstrated that Inula helenium and Grindelia squarrosa, which have been traditionally used in Europe as medicinal plants, are a valuable source of active compounds with anti-inflammatory activity. Our observations justify the traditional use of I. helenium and G. squarrosa for a treatment of inflammation-based diseases in respiratory tract.
- || budesonide / Generic mfg.
Review, Journal: Proline Metabolism in Tumor Growth and Metastatic Progression. (Pubmed Central) - Jun 6, 2020
Specifically, we propose a model whereby proline availability generates a cycle based on collagen synthesis and degradation, which, in turn, influences the epigenetic landscape and tumor heterogeneity. Therapeutic strategies targeting this metabolic-epigenetic axis hold great promise for the treatment of metastatic cancers.
- || prednisone / Generic mfg., budesonide / Generic mfg.
Clinical, Journal: Predictors of efficacy for combination oral and topical corticosteroids to treat patients with chronic rhinosinusitis with nasal polyps. (Pubmed Central) - Jun 4, 2020
In treatment of CRSwNP with prednisone and budesonide irrigations, pretreatment endoscopy was not informative of treatment response. Pretreatment SNOT-22 and comorbid asthma may be more predictive.
- || budesonide / Generic mfg.
Clinical, Journal: Asthma and treatment with inhaled corticosteroids: associations with hospitalisations with pneumonia. (Pubmed Central) - Jun 4, 2020
Having asthma is associated with a three times higher risk of being hospitalised for pneumonia. This analysis also indicates that there are intraclass differences between ICS compounds with respect to pneumonia risk, with an increased risk of pneumonia related to fluticasone propionate.
- ||| budesonide / Generic mfg.
Clinical, Adverse events: As GIs we like to avoid steroids as much as possible because of their associated side effects. But if the patient does need them, they need them.... As @DCharabaty and @SophieBalzoraMD mentioned Budesonide maybe a better option in the current scenario. (Twitter) - Jun 2, 2020
- |||| budesonide / Generic mfg.
Clinical: 1/ •When possible, use budesonide •For sévère #IBD flare that need oral or IV CS, minimize duration of dose >20mg & start effective therapy/change in therapy •✅ #COVID19 in hospitalized/severe IBD flare or if unusual GI symptoms/fever/URI (Twitter) - Jun 2, 2020
- ||| budesonide / Generic mfg.
Clinical: Agree w Dr. Charabaty - If/when applicable, optimize use of PO/PR 5ASA in combo, make budesonide ur friend (tho Uceris can b pricey!), & avoid a prolonged CS taper. Can’t avoid CS altogether, but need to be mindful of its use, & be frank w pts when initiating this short-term tx. (Twitter) - Jun 2, 2020
- || budesonide / Generic mfg.
Wondering if any studies have been done to see if corticosteroid like budesonide/formoterol could reduce the destruction providing a margin of survivability. https://t.co/7dI8BDk0Oz (Twitter) - May 30, 2020
- | sildenafil / Generic mfg., budesonide / Generic mfg.
Journal: Protein-Losing Enteropathy Following Fontan Palliation. (Pubmed Central) - May 29, 2020
PLE mortality is high-approximately 50%-but may be mitigated by aggressive investigation and management. The evolving understanding of the role of lymphatics in the pathophysiology of PLE and the emerging role of interventional lymphatic procedures may further improve outcomes in this patient population.
- || Xeljanz (tofacitinib) / Pfizer, Marche Polytechnic University, Humira (adalimumab) / Eisai, AbbVie
Clinical, Journal: Comparison of the effects of tofacitinib and adalimumab on transcolonoscopic ph and calprotectin levels in patients with ulcerative colitis. (Pubmed Central) - May 29, 2020
The evolving understanding of the role of lymphatics in the pathophysiology of PLE and the emerging role of interventional lymphatic procedures may further improve outcomes in this patient population. Tofacitinib, compared to adalimumab and budesonide, has better influence on clinical, endoscopic and laboratory parameters of UC.
- | Veramyst (fluticasone furoate nasal spray) / GSK
Preclinical, Journal: Pulmonary dissolution of poorly soluble compounds studied in an ex vivo rat lung model. (Pubmed Central) - May 28, 2020
A wetting factor was introduced to the in silico model to explain the difference in absorption profiles between the suspensions and dry powders, where AZD5423 had the poorest wettability, followed by FP and FF. The IPL model in combination with an in silico model is a useful tool for investigating pulmonary dissolution and improving understanding of dissolution-related parameters for poorly soluble inhaled compounds.
- ||| budesonide / Generic mfg.
Journal, Adverse events: Adverse events related to low dose corticosteroids in autoimmune hepatitis. (Pubmed Central) - May 26, 2020
The IPL model in combination with an in silico model is a useful tool for investigating pulmonary dissolution and improving understanding of dissolution-related parameters for poorly soluble inhaled compounds. Even low doses of corticosteroids frequently lead to substantial adverse events refuting the assumption that adverse events are prevented by administering low doses.
- || budesonide / Generic mfg.
Clinical, Observational data, Journal: A Multicenter, Observational, Prospective Study of the Effectiveness of Switching from Budesonide/Formoterol Turbuhaler to Budesonide/Formoterol Easyhaler. (Pubmed Central) - May 25, 2020
This real-life, non-interventional, non-inferiority study in adults with persist asthma demonstrates equivalent or better disease control when patients switch from B/F Turbuhaler to B/F Easyhaler. A further study with direct comparison between treatments could add to the understanding of inhaler switch.
- | budesonide / Generic mfg., Flutiform (fluticasone/formoterol) / Kyorin, Mundipharma, Vectura, Sanofi
Journal: An innovative corticosteroid/long-acting β2-agonist breath-triggered inhaler: facilitating lung delivery of fluticasone propionate/formoterol fumarate for the treatment of asthma. (Pubmed Central) - May 23, 2020
Finally, we review patient experiences using the BTI, device characteristics, and health economic aspects.Expert opinion: Despite the availability of therapies, asthma control levels remain low, and there is a clear need for easy-to-use inhalers. Research to increase our understanding of critical errors with each inhaler and how to overcome them is important for improving care.
- || prednisone / Generic mfg., budesonide / Generic mfg.
I did not read the paper, is it the same for Budesonide and prednisone? @ryanungaro (Twitter) - May 20, 2020
- ||| budesonide / Generic mfg.
I was tested 3 times after staring IFX. The good IFX levels helped my GI to discuss possible dual therapy options after an MRE detected continued inflammation. Short term Budesonide + IFX eventually worked great without MTX or AZA. Those levels were big data points for decisions. (Twitter) - May 20, 2020
- budesonide / Generic mfg.
[VIRTUAL] Tracheal leiomyoma in a 14-year-old teenager with initially misdiagnosed asthma () - May 19, 2020 - Abstract #EAACI2020EAACI_2174;
The case presented demonstrates a cause of obstruction of the airways tracheal leiomyoma in a 14-year-old teenager with initially misdiagnosed asthma. The reported study was funded by RFBR and MOST according to the research project № 19-515-06001
- Fasenra (benralizumab) / AstraZeneca
[VIRTUAL] Benralizumab therapy in eosinophilic esophagitis () - May 19, 2020 - Abstract #EAACI2020EAACI_2158;
More than 100 eosinophils per high-power fieldin the esophageal biopsies, that did not decrease with esomeprazole 80mg daily for 8 weeks. -Skin prick tests with aeroallergens, plant panallergens and foods: positives to lipid transfer protein, hazelnut, rice, corn, wheat, soy, egg and milk.
- Decadron (dexamethasone) / Merck (MSD)
[VIRTUAL] Evaluation and management of a clinic case: Corticosteroids hypersensitivity () - May 19, 2020 - Abstract #EAACI2020EAACI_2139;
The immediate and delayed reading prick test, intradermal test and patch tests do not appear useful to confirm or exclude hypersensitivity to corticosteroids. The test of tolerance/exposure is essential for diagnosis of hypersensitivity to corticosteroids.In this case the latency between exposure and showing of acute reaction symptoms do not appear IgE- and T-cell-mediated.Finally it seems to be possible to confirm a high possibility of cross reactivity between different molecules of corticosteroids.
- Emerade (epinephrine) / Bausch Health, budesonide / Generic mfg.
[VIRTUAL] Cold urticaria – case report () - May 19, 2020 - Abstract #EAACI2020EAACI_2107;
She had asthma controlled with inhaled budesonide/formoterol; no family history of allergic, immunologic diseases and/or chronic urticaria...Patients need to be counseled to avoid a prolonged skin contact with cold. The first-line symptomatic treatment is a nonsedating H1 antihistamine and an epinephrine autoinjector should be prescribed for severe reactions.