budesonide / Generic mfg. 
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  • ||||||||||  budesonide / Generic mfg.
    Allergic contact dermatitis to topically applied glucocorticosteroids. (Poster Area) -  Aug 5, 2024 - Abstract #EADV2024EADV_2769;    
    The collected data has significant implications from a public health perspective. Continuous upading of data regarding the prevalence of drug sensitizations, including glucocorticorteroids, is justified due to their impact on the selection of futher diagnostics and treatment of patients, especially in the era of an aging society.
  • ||||||||||  Tarpeyo (budesonide) / Calliditas, Stada
    Review, Journal, Immunomodulating:  Insights on Nefecon (Pubmed Central) -  Aug 5, 2024   
    These studies demonstrated that Nefecon has a distinct pharmacokinetic profile from other budesonide products, allowing for targeted, localized action in the distal ileum. When considered alongside existing clinical trial data showing the effect of Nefecon on gut-associated biomarkers, available evidence indicates that Nefecon has a selective immunomodulatory mechanism of action and a direct disease-modifying effect in patients with IgAN, while having low systemic exposure and adverse effects.
  • ||||||||||  prednisone / Generic mfg., budesonide / Generic mfg., loperamide / Generic mfg.
    OVERCOMING THE ANCHORING BIAS: A CASE OF MICROSCOPIC COLITIS INITIALLY PERCEIVED AS MESENTERIC ISCHEMIA (Convention Center Exhibit Hall: Poster Area 2) -  Jul 31, 2024 - Abstract #CHEST2024CHEST_5278;    
    Antidiarrheal agents including loperamide can be utilized for symptom management... Given the significant overlap of symptoms, any patient with diarrhea should be approached with a broad differential and appropriate diagnostics should be performed in a timely manner to provide patient-centered and evidence-based care.
  • ||||||||||  Dificid (fidaxomicin) / Merck (MSD), Astellas
    USE OF INTRAVENOUS IMMUNOGLOBULIN FOR SEVERE RELAPSING CLOSTRIDIUM DIFFICILE PSEUDOMEMBRANOUS COLITIS (Convention Center Exhibit Hall: Poster Area 2) -  Jul 31, 2024 - Abstract #CHEST2024CHEST_1286;    
    While conventional treatments often suffice, some cases may necessitate unconventional approaches like IVIG, as demonstrated here. Further research is warranted to elucidate the role of IVIG in such cases and to refine treatment strategies for challenging C. difficile infections.
  • ||||||||||  Flarex (fluorometholone acetate ophthalmic suspension) / Novartis
    Journal:  Exposure to synthetic steroid hormones and precocious puberty in girls: A case-control study. (Pubmed Central) -  Jul 31, 2024   
    In conclusion, precocious puberty was associated with halcinonide and budesonide exposure, but not steroid hormone mixture among girls. It highlighted the management of the residual synthetic steroid hormones in the environment and provided a direction for the prevention of precocious puberty.
  • ||||||||||  Stelara (ustekinumab) / J&J, Entyvio (vedolizumab) / Takeda
    A PROSPECTIVE, PILOT, REAL-WORLD STUDY TO ASSESS THE PRESENCE AND SEVERITY OF URGENCY IN PATIENTS WITH CROHN (Science Lounge) -  Jul 18, 2024 - Abstract #UEGW2024UEGW_1530;    
    Validation of the terminology in different ethnic languages may also pose additional barriers in patient understanding and reporting the symptom in the presence of additional IBS-type symptoms. Large studies are needed to assess if urgency is present in patients with iCD and how reliably is reported especially in multinational RCTs.
  • ||||||||||  Jorveza (budesonide orodispersible tablets) / Dr Falk
    RISK FACTORS FOR ORAL AND ESOPHAGEAL CANDIDIASIS DURING BUDESONIDE TREATMENT IN EOSINOPHILIC ESOPHAGITIS PATIENTS (Science Lounge) -  Jul 18, 2024 - Abstract #UEGW2024UEGW_1093;    
    Our results suggest that consistent eosinophilic count (> 35/HPF) and concomitant PPI therapy could represent risk factors in developing mycosis in EoE patients. According to literature, major esophageal inflammation, PPI-induced elimination of the gastric acid barrier and corticosteroid immunosuppression are the main mechanisms leading to oral and esophageal candida colonization.
  • ||||||||||  Entyvio (vedolizumab) / Takeda
    VISCERAL LEISHMANIASIS MIMICKING ULCERATIVE COLITIS  (Science Lounge) -  Jul 18, 2024 - Abstract #UEGW2024UEGW_917;    
    The patient was started on budesonide and mesalazine and was escalated to vedolizumab due to insufficient symptom control...The patient was then treated with liposomal amphotericin B for 14 days...This however made the diagnosis of the underlying systemic parasitic infection possible as the immune system was able to suppress the parasites without elimination. This highlights the difficulties of diagnosing latent visceral leishmaniasis when presenting with atypical symptoms like mimicking autoimmune bowel diseases like ulcerative colitis.
  • ||||||||||  budesonide / Generic mfg.
    NET SUCH AN EASY DIAGNOSIS (Science Lounge) -  Jul 18, 2024 - Abstract #UEGW2024UEGW_869;    
    Symptom resolution was noted on an initial course of oral budesonide...Small bowel tumours present a very specific diagnostic challenge given their location. This case demonstrates the importance of capsule endoscopy in the diagnosis of small bowel tumours.
  • ||||||||||  budesonide / Generic mfg.
    GASTRIC MYELOID SARCOMA: A RARE CAUSE OF ACUTE UPPER GASTROINTESTINAL HEMORRHAGE  (Science Lounge) -  Jul 18, 2024 - Abstract #UEGW2024UEGW_851;    
    During the second post-HSCT period, she developed grade I gastrointestinal graft-versus-host disease (GI GVHD), confirmed by biopsy and managed with budesonide.Five months post-HSCT, the patient was admitted due to upper gastrointestinal bleeding (melena) and worsening anemia (Hb: 5,6 g/dL)...Six months post-HSCT, the patient succumbed to AML progression.- Myeloid Sarcoma (MS) typically affects the skin, lymph nodes, and brain, making its occurrence in the gastrointestinal tract uncommon.- Endoscopic imaging may mimic other conditions therefore biopsies are required to confirm the diagnosis.- In hematologic patients post-HSCT, endoscopic evaluations are essential for diagnosing gastrointestinal complications such as opportunistic infections, GI graft-versus-host disease (GI GVHD), and progression of their underlying disease. Our case highlights the rarity of gastric MS.
  • ||||||||||  Ocaliva (obeticholic acid) / Intercept
    Review, Journal:  Progress in the Management of Patients with Cholestatic Liver Disease: Where Are We and Where Are We Going? (Pubmed Central) -  Jul 8, 2024   
    Considerable progress has been made in the management of cholestatic liver disease but there are still many opportunities and challenges. In this review, we summarized the recommended guidelines for the management of cholestatic disease and the progress of new drug research and development, in order to provide an important reference for the clinical practice of cholestatic liver disease.
  • ||||||||||  budesonide / Generic mfg.
    Journal:  Lymphocytic Colitis With Enterocolic Lymphocytic Phlebitis. (Pubmed Central) -  Jun 28, 2024   
    Colonoscopic examination revealed normal-appearing mucosa, but biopsy findings revealed lymphocytic colitis with coexisting enterocolic lymphocytic phlebitis. The patient was started on oral budesonide and responded to the treatment with symptomatic and histopathological resolution.
  • ||||||||||  Dipentum (olsalazine sodium) / Viatris, UCB, Humira (adalimumab) / AbbVie
    Journal:  Refractory Crohn's Disease Responsive to Dietary Therapy: A Case Report. (Pubmed Central) -  Jun 28, 2024   
    In conclusion, for patients whose disease is refractory to different treatments, or who develop antibodies to the medication, AIDs may offer a solution to reduce disease symptoms and progression. Education of healthcare professionals and patients alike is vital in order for Crohn's patients to gain the benefits from dietary therapy.
  • ||||||||||  Filspari (sparsentan) / Travere Therap
    Review, Journal, IO biomarker:  Drugs in Development to Treat IgA Nephropathy. (Pubmed Central) -  Jun 20, 2024   
    Other new possible strategies include spleen tyrosine kinase inhibitors, anti-CD40 ligands and anti-CD38 antibodies. In an era increasingly characterised by 'personalised medicine' and 'precision therapy' approaches and considering that the potential therapeutic armamentarium for IgA nephropathy will be very broad in the near future, the identification of biomarkers capable of helping the nephrologist to select the right drug for the right patient should be the focus of future studies.
  • ||||||||||  budesonide / Generic mfg.
    Clinical data, Retrospective data, Journal:  Factors associated with long-term clinical outcome in microscopic colitis. (Pubmed Central) -  Jun 20, 2024   
    In the present cohort of patients with microscopic colitis, a favourable response to budesonide was significantly associated with long-term clinical remission, and all patients achieving histological remission were able to maintain clinical remission without further medical therapy. Larger studies are required to confirm these findings.
  • ||||||||||  budesonide / Generic mfg.
    Journal:  Anti-inflammatory activity of plant sterols in a co-culture model of intestinal inflammation: focus on food-matrix effect. (Pubmed Central) -  Jun 17, 2024   
    The pharmacological interaction between samples and budesonide (1 ?M, 90 min) was evaluated...This study demonstrates the potent intestinal anti-inflammatory activity of a PS-FS, positioning it as a promising nutraceutical product for the management of inflammatory bowel diseases. However, the food matrix of the milk-based fruit beverage and rye bread appear to interfere with the anti-inflammatory activity of PS.
  • ||||||||||  budesonide / Generic mfg.
    Journal:  Three-dimensional environment sensitizes pancreatic cancer cells to the anti-proliferative effect of budesonide by reprogramming energy metabolism. (Pubmed Central) -  Jun 15, 2024   
    Collectively, our study reveals that the microenvironment influences the susceptibility of PDAC cells to GCs and provides unprecedented evidence for the anti-proliferative activity of budesonide on PDAC cells in 3D conditions, in vitro and in vivo. Our findings may explain, at least in part, the reason for the lower occurrence of pancreatic cancer in asthmatic patients and suggest a potential suitability of budesonide for clinical trials as a therapeutic approach to fight pancreatic cancer.
  • ||||||||||  prednisone / Generic mfg., budesonide / Generic mfg., azathioprine / Generic mfg.
    Journal:  Autoimmune hepatitis after COVID-19 infection. (Pubmed Central) -  Jun 4, 2024   
    Initial treatment with budesonide was ineffective, leading to a switch to prednisone, with maintenance therapy comprising prednisone and azathioprine. COVID-19 infection may act as a trigger for the development of autoimmune hepatitis.
  • ||||||||||  budesonide / Generic mfg.
    Journal:  Effect of drug load on the aerosolisation propensity of binary adhesive mixtures for inhalation. (Pubmed Central) -  May 26, 2024   
    Thus, the drug dispersion process could be linked to different configurations of the lactose carrier and budesonide in the blends, i.e. blend states. In conclusion, the study suggests that the concept of blend states can provide an explanation for the complex dispersion process observed in adhesive blends.
  • ||||||||||  budesonide / Generic mfg.
    Enrollment open:  ReDUCE: Combination of Diet and Oral Budesonide for Ulcerative Colitis (clinicaltrials.gov) -  May 23, 2024   
    P=N/A,  N=90, Recruiting, 
    Larger prospective studies are necessary to determine the role of budesonide as well as its safety profile. Not yet recruiting --> Recruiting