- |||||||||| Filspari (sparsentan) / Travere Therap
Review, Journal: State-of-Art Therapeutics in IgA Nephropathy. (Pubmed Central) - Oct 7, 2024
Other investigational therapies target the complement cascade by inhibiting proteins of the lectin or alternative pathways. As the therapeutic landscape evolves, it will be important to revise treatment guidelines and develop updated standards of care.
- |||||||||| budesonide / Generic mfg.
Journal: An Exploration of Dissolution Tests for Inhalation Aerosols. (Pubmed Central) - Oct 2, 2024
Budesonide was used as a model drug...The method employed in this study could offer a potential avenue for exploring the relationship between the orifice size of the actuator and the dissolution behavior of inhaled corticosteroids. This dissolution method was simple, reproducible, and suitable for determining the dissolution of inhalation aerosols.
- |||||||||| budesonide / Generic mfg.
Journal: Experimental measurement, thermodynamic analysis, and mathematical modeling for budesonide solubility in 1-propanol?+?water mixtures at T?=?(293.2 to 313.2) K. (Pubmed Central) - Sep 29, 2024
Thermodynamic studies demonstrated that BDS dissolution procedures were obtained as endothermic and entropy-driven in almost all cases. The overall MRDs% values for the back-computed BDS solubility in the aqueous mixture of 1-propanol based on van't Hoff model, Buchowski-Ksiazczak equation, CNIBS/R-K model, modified Wilson model, Jouyban-Acree model, Jouyban-Acree-van't Hoff model, MRS model, and Williams-Amidon excess Gibbs energy model were found 1.93%, 1.80%, 11.68%, 33.32%, 12.30%, 9.24%, 10.70%, and 6.57%, respectively.
- |||||||||| budesonide / Generic mfg.
Preclinical, Journal: A New Process for the Synthesis of Budesonide 21-Phosphate and Evaluation in a Murine Model of Inflammation. (Pubmed Central) - Sep 29, 2024
The new compounds are characterized by better water solubility compared to the parent compound. Moreover, they have been evaluated for their anti-inflammatory activity and the obtained results clearly evidence that Bud-21P and Bud-21P-Na2 retained anti-inflammatory activity like the parent compound budesonide (Bud) in mice with cutaneous induced edema.
- |||||||||| simvastatin / Generic mfg., budesonide / Generic mfg.
Journal, Gene therapy: Gene Therapy in the Light of Lifestyle Diseases: Budesonide, Acetaminophen and Simvastatin Modulates rAAV Transduction Efficiency. (Pubmed Central) - Sep 29, 2024
Attention should be paid to S100A8, which is a common drug-modified gene for drugs showing anti-inflammatory effects (budesonide and simvastatin), demonstrating an interaction with the gene encoding the receptor for AAV (HGFR). This study underscores the significance of assessing rAAV pharmacokinetics/pharmacodynamics (PKs/PDs) and drug-gene therapy interactions in optimizing gene therapy protocols.
- |||||||||| Fabhalta (iptacopan) / Novartis, Tai'ai (telitacicept) / Rongchang Pharma, atacicept (VT-001) / Vera Therap
Comparative Efficacy and Safety of New Therapies for IgA Nephropathy: A Systematic Review and Network Meta-Analysis (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3160;
The developed Nomogram model provides clinicians with a reliable tool to predict poor treatment outcomes in children with MP infection treated with BUD and NAC, supporting more personalized and effective treatment plans. This systematic review and network meta-analysis indicate Mycophenolate and Telitacicept are most effective in reducing UPCR and improving eGFR, suggesting these as preferable treatments for IgAN patients.
- |||||||||| Tarpeyo (budesonide) / Calliditas, Stada
Results from a Real-World Case Series of Patients with IgAN Who Received at Least 9 Months of Tarpeyo (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3132;
eGFR distribution in IgAN patients before and after Tarpeyo initiation Background: Tarpeyo, a targeted-release formulation of budesonide, is currently the only FDA-approved treatment for IgA nephropathy (IgAN) to significantly reduce the loss of kidney function. Results from this case series demonstrated that real-world use of Tarpeyo was well-tolerated and can reduce loss of kidney function in patients who receive ?9 months of treatment.
- |||||||||| Tarpeyo (budesonide) / Calliditas, Stada
Journal, Adverse events: Exploring Novel Adverse Events of Nefecon. (Pubmed Central) - Sep 20, 2024
Nefecon demonstrates a favorable safety profile, with no high-priority clinical events identified. The identification of novel AEs and subgroup-specific relative high-risk events fills a gap in existing studies and offers valuable insights for early clinical vigilance.
- |||||||||| budesonide / Generic mfg., loperamide / Generic mfg.
Review, Journal: Update on the epidemiology and management of microscopic colitis. (Pubmed Central) - Sep 14, 2024
There is an unmet need to further define the pathophysiology of microscopic colitis. Additionally, trials with novel therapies, particularly in patients with budesonide-refractory disease, are needed.
- |||||||||| Filspari (sparsentan) / Travere Therap, Tarpeyo (budesonide) / Calliditas, Stada
Review, Journal: Therapy of IgA nephropathy: time for a paradigm change. (Pubmed Central) - Sep 1, 2024
Following remission, treatments may be adjusted and stripped back as necessary in the maintenance phase with close monitoring. This review discusses the current status of IgAN treatment and explores future strategies to improve outcomes for patients with IgAN.
- |||||||||| Jorveza (budesonide orodispersible tablets) / Dr Falk
Journal: Budesonide Orodispersible Tablet for the Treatment of Refractory Esophageal Lichen Planus. (Pubmed Central) - Aug 23, 2024
We describe a severe case of esophageal lichen planus and recurrent esophageal stricture that was refractory to acid suppression, local and systemic steroid formulations, and dilatation. We present the first reported use of budesonide orodispersible tablet for this condition, including the excellent clinical, endoscopic, and histopathological response.
- |||||||||| budesonide / Generic mfg.
Enrollment change, Trial withdrawal, Trial primary completion date: BESIDE: Pharmacokinetics, Efficacy, Tolerability and Safety of Different Budesonide Oral Gel Doses in Adults' Subjects of Both Genders With Eosinophilic Esophagitis (EoE) (clinicaltrials.gov) - Aug 22, 2024
P2, N=0, Withdrawn,
We present the first reported use of budesonide orodispersible tablet for this condition, including the excellent clinical, endoscopic, and histopathological response. N=36 --> 0 | Not yet recruiting --> Withdrawn | Trial primary completion date: Apr 2025 --> Nov 2024
- |||||||||| Humira (adalimumab) / AbbVie
A Case of Autoimmune Enteropathy Associated With Lymphocytic Colitis (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_5529;
She was then treated with budesonide and started on a gluten-free diet without improvement of symptoms...The patient was treated with Adalimumab for AIE, and her symptoms improved...Gastroenterologists should be familiar with this rare disease and its diagnostic challenge to enhance earlier diagnosis and treatment. Figure: PATHOLOGY SLIDES
- |||||||||| Olmesartan-Induced Enteropathy Resulting in Hypokalemia-Induced Rhabdomyolysis (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_5525;
Home medications included allopurinol, gabapentin, olmesartan, and amlodipine...As o ur patient also improved after valsartan was substituted for olmesartan, OIE rose to the top of our differential diagnosis...Other characteristic findings include increase in intra-epithelial lymphocytes, noted on her outpatient endoscopy but not on repeat inpatient endoscopy (likely due to initiation of budesonide and mesalamine, lowering lymphocytic infiltrate biopsy yield). Clinical suspicion and a broad differential are key to diagnosing OIE; it often presents a diagnostic dilemma and improves if olmesartan is suspended.
- |||||||||| prednisone / Generic mfg., budesonide / Generic mfg., loperamide / Generic mfg.
Eosinophilic Gastroenteritis, An Underrecognized Source of Chronic Diarrhea (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_5461;
She was trialed on budesonide and loperamide without improvement...The patient was subsequently treated with an oral prednisone taper for 7 weeks until repeat endoscopy with biopsy was performed and demonstrated resolution of gastritis and eosinophilia...A high level of clinical suspicion for EGE in patients presenting with chronic diarrhea will aid in early diagnosis and treatment of the disease. Figure: CT A/P depicting bowel wall thickening.
- |||||||||| Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
A Rare Presentation of CMV Gastritis, Duodenitis, and Colitis in a Patient With Autoimmune Hepatitis on Immunosuppressive Therapy (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_5351;
Case Description/ A 62-year-old female with a history of autoimmune hepatitis (AIH) (Batts-Ludwig Grade 2, stage 0) on budesonide 6 mg q.d. and Mycophenolate (MMF) 1000 mg b.i.d...The patient received IV ganciclovir and transitioned to oral valganciclovir upon discharge with complete resolutions of her symptoms on follow-up...Figure: A- CT scan showing low grade gastroenteritis, nonspecific moderate grade pancolitis; B- Upper EGD showing erythema and edema in the duodenum; C- Gastric biopsy with CMV inclusion bodies (arrow), credit Dr. Seong Ra
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
A Case of Successful Treatment of High-Grade Immune-Mediated Hepatobiliary Toxicity With Oral Budesonide: Shifting the Paradigm Away From Systemic Steroids (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_5286;
Abbreviations: IMH, immune-mediated hepatobiliary toxicity; BUD, budesonide; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; GGT, gamma-glutamyl transferase; d, day; IV, intravenous; MP, methylprednisolone; pred., prednisone; UDCA, ursodeoxycholic acid. Note: The table for this abstract can be viewed in the ePoster Gallery section of the ACG 2024 ePoster Site or in The American Journal of Gastroenterology's abstract supplement issue, both of which will be available starting October 27, 2024.
- |||||||||| budesonide / Generic mfg., mycophenolate sodium / Generic mfg.
De Novo Ulcerative Colitis in a Kidney Transplant Recipient: Navigating Diagnostic Challenges and Management Strategies (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_4953;
Case Description/ 54-year-old male with PMHx of SLE and ADPKD s/p transplant 11 years prior to admission presented with subacute, non-bloody diarrhea with nocturnal symptoms while on chronic ISM regimen including tacrolimus and mycophenolate sodium (MFS)...He was discharged with close follow-up, at which time budesonide was tapered...A. Retroflexed Rectum: Edematous, erythematous, friable and hemorrhagic mucosa; B. Rectum: Edematous, erythematous, friable and hemorrhagic mucosa; C. Rectosigmoid: Edematous, erythematous, friable and hemorrhagic mucosa; D. Sigmoid Colon: Edematous, erythematous, friable and hemorrhagic mucosa.
- |||||||||| Stelara (ustekinumab) / J&J, Humira (adalimumab) / AbbVie
Use of Lumen Apposing Metal Stents (LAMS) in Refractory Ileocolonic Stricturing Crohn's Disease (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_4927;
He failed adalimumab previously and was not on a biologic...He was started on budesonide with improvement of his symptoms...Ustekinumab induction was offered but the patient declined due to apprehensiveness towards biologics...(C) Post-stent migration CT scan showing stent near ileocolonic anastomosis with diffuse small bowel dilation. Arrow indicates wall-thickening of terminal ileum at level of ileocecal valve consistent with ileitis.
- |||||||||| budesonide / Generic mfg.
A Multidisciplinary Approach to Fungemia During an Acute Crohn's Flare (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_4913;
With the resolution of the infections, budesonide taper was initiated with an improvement of GI symptoms...With continued Crohn's complications, this patient will likely require steroid treatment in the future that can potentiate fungemia on top of her risk at baseline with the use of TPN via central line. This demonstrates the importance of specialties broadening their tunnel vision to assess the greater clinical picture to prevent complications, injury, and clinical deterioration.
- |||||||||| prednisone / Generic mfg., budesonide / Generic mfg.
Impact of Social Distancing During the SARS-CoV-2 Pandemic on Flares of Inflammatory Bowel Disease (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_4772;
In UC, there was no difference in flares during 2020 isolation with increased flare activity in the 2021 isolation period compared to 2018 and 2019(74, 97, 67, 81; p=0.17). In Crohn's disease there was decreased flare activity during 2020 and 2021 isolation periods compared to 2018 and 2019(119,104,159,141; p=0.01).
- |||||||||| budesonide / Generic mfg.
Unravelling the Enigma: Cronkhite (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_4624;
The patient was treated with 9 mg of oral Budesonide, resulting in complete resolution of diarrhea, and was referred for nutritional evaluation...Further documentation and study are essential to advance understanding and treatment of this rare syndrome. Figure: Gastric antrum
- |||||||||| budesonide / Generic mfg., nitazoxanide / Generic mfg.
Cryptosporidium parvum Infection and Collagenous Colitis: A New Association (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_4259;
This underscores the need for comprehensive infectious evaluation in patients with chronic diarrhea. Figure: Fig A (Cecum with visible Ulceration on left side) and Fig B (Normal appearing cecum after 6 months of treatment on right side)
- |||||||||| ciprofloxacin oral / Generic mfg., budesonide / Generic mfg.
Multi-Disciplinary Approach to Ischemic Colitis Due to Arteriovenous Malformations in the Inferior Mesenteric Artery (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_4257;
Short course of budesonide and mesalamine were given but without any relief...This case emphasizes the importance of considering mesenteric arteriovenous malformations as part of the differential diagnosis for ischemic colitis. Figure: Image 1: Visceral angiogram of the inferior mesenteric artery with a large bundle of vasculature depicting the extensive arteriovascular malformations.
- |||||||||| colchicine / Generic mfg., budesonide / Generic mfg., loperamide / Generic mfg.
Mesalamine Induced Myopericarditis in Patient with Collagenous Colitis (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_4210;
Introduction : While loperamide and budesonide are first-line therapies for collagenous colitis, recurrent symptoms often require additional therapy for which mesalamine has been utilized...Given her collagenous colitis, she was not a candidate for colchicine and was discharged after symptom resolution...Although the offending agent was not initially confirmed, a subsequent workup uncovered that mesalamine was the common denominator in her presenting symptoms given that the patient improved with discontinuation of the medication. It is important to maintain a high level of suspicion for mesalamine-induced pericarditis in patients treated with mesalamine for IBD or collagenous colitis and demonstrating cardiac symptoms.
- |||||||||| Humira (adalimumab) / AbbVie
A Tale of Two Bleeds: A Case of Concomitant Crohn's Disease and Appendiceal Endometriosis (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_3193;
She was discharged on a steroid taper and budesonide due to concern for Crohn's...She was started on Humira with improvement in her anemia and pain with intermittent flares during her menstrual cycles...small, satellite ileal ulcer proximal to the large ulcer in prior images; 6. small ileal ulcer ~5cm distal to the large ulcer
- |||||||||| budesonide / Generic mfg., sertraline / Generic mfg.
A Rare Case of Melatonin Induced Microscopic Colitis (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_2524;
Lymphocytic colitis differs from other causes of diarrhea in that it requires initiation of budesonide along with cessation of any precipitating medications, environmental factors, and dietary restrictions. In this case, symptoms resolved with just cessation of melatonin.
- |||||||||| dasatinib / Generic mfg.
Drug-Induced Colitis Secondary to Dasatinib Therapy in a Patient With Established Ulcerative Colitis (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_2516;
Trials of omeprazole and famotidine provided minimal relief...Pathology showed patchy active colitis and ulcerations with features suggestive of drug toxicity (Image 2A/2B).Dasatinib was held, budesonide was stopped and the patient was started on Prednisone 40 mg daily...Rare crypt withering raises the possibility of superimposed drug toxicity. CMV immunostain was negative.
- |||||||||| budesonide / Generic mfg., loperamide / Generic mfg.
When Imaging Looks Like SCAD But Pathology Shows Collagenous Colitis (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_2493;
Case Description/ A n 88-year-old woman with a history of breast cancer and depression presented to the hospital due to one week of campy, non-bloody diarrhea for one week that did not improve with loperamide...Treatment with Budesonide was initiated, which quickly improved her diarrhea, and she returned to her nursing facility with close gastroenterology follow-up...Figure: CT findings (A and B, arrows) favor acute rectosigmoid colitis or segmental colitis associated with diverticulosis (SCAD) over diverticulitis. At the junction of the descending and sigmoid colon, there is an abrupt change in luminal caliber with upstream fluid-filled large bowel.
- |||||||||| Rectal Ulcer and Fistula Development in a Cancer Patient on Immune Checkpoint Inhibitor Immunotherapy: A Case Report (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_2483;
He was receiving treatment with nivolumab/ipilimumab and cabozantinib...Given the patient's persistent diarrhea secondary to presumed immune-mediated enteritis, he was started on budesonide and vedolizumab with significant symptom improvement...Contrast enhanced CT images (coronal) showing (C) thickened wall of the small bowel with peri-enteric stranding (yellow arrow), suggestive of immunotherapy related enteritis, and (D) thin perianal enhancing tracts (blue arrows). Contrast enhanced MRI images (coronal) showing (E) a perianal fistulous tract (blue arrow) associated with a 0.9 cm fluid collection (yellow arrow) and (F) a 1.4 cm fluid collection (yellow arrow).
- |||||||||| budesonide / Generic mfg., azathioprine / Generic mfg., ursodeoxycholic acid / Generic mfg.
Gallbladder, Liver, or Infection?: A Case of an Atypical Autoimmune Hepatitis Presentation (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_1928;
Azathioprine was started after her labs further improved...Our case highlights the importance of having a high clinical suspicion of AIH to avoid unnecessary interventions and facilitate initiation of proper treatment in a timely manner. Figure: LFT Trend
- |||||||||| Remicade (infliximab) / J&J
A Clinical Conundrum: Journey to a Diagnosis of Esophageal Crohn's (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_1518;
He had endoscopic improvement with a course of prednisone; however he still was requiring frequent dilation...The patient was started on Infliximab (IFX), Methotrexate (MTX) and Budesonide slurry...Figure: Figure A: Distal esophageal stenosis with friable, frond-like, and spongy appearance with heaped up edges and punched-out lesions Figure B: Aphthous Ulcer in the terminal ileum. Biopsies were normal
- |||||||||| budesonide / Generic mfg.
A Rare Case of Mesalamine-Induced Fever (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_1507;
Mesalamine was held upon admission, and supportive measures were added including antipyretics and a budesonide taper...However, a 2022 genome-wide study of Japanese patients suggests a potential genetic association and notes that this "allergy" is more common among ulcerative colitis patients. For these reasons, further study of this syndrome is warranted.
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