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20 Diseases |  |
17 Trials |
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- |||| hydroxychloroquine / Generic mfg., ivermectin oral / Generic mfg., budesonide / Generic mfg.
Clinical: Here's 5 hour U.S. Senate panel discussion, January 24, 2022, w/ 12 medical doctors and researchers, etc, w/ many stating 500K out of 800K #Covid19 deaths could've been prevented w/ Early Treatment Protocols of #Ivermectin #Hydroxychloroquine #Budesonide https://t.co/llXKLH2CQP (Twitter) - Feb 1, 2022
- || dexamethasone / Generic mfg., famotidine / Generic mfg., budesonide / Generic mfg.
Ivermectin, Dexamethasone, Budesonide ( nebulizer 2X per day) …… along with Zinc, Vitamin D, C , Pepcid, Melatonin. I didn’t take Quercetin or NAC but should have. (Twitter) - Jan 31, 2022
- EP-201 / EpiThany, Aston Sci.
A case of PL-7 positive amyopathic dermatomyositis associated with autoimmune liver disease () - Jan 30, 2022 - Abstract #BSR2022BSR_489;
Other anti-ARS antibodies include Jo-1, PL-12, EJ, OJ, KS, ZO and YRS/HA. Antibodies to PL-7 have been reported to be associated with milder muscle involvement than antibodies to Jo-1.
- | budesonide / Generic mfg.
Journal: Transcriptomic profiling of collagenous colitis identifies hallmarks of non-destructive inflammatory bowel disease. (Pubmed Central) - Jan 28, 2022
Our study confirmed the implication of innate and adaptive immune responses in CC, governed by IECs and dendritic cells, respectively; and identified ongoing epithelial damage. Refractory CC could share pathomechanisms with UC.
- ||| budesonide / Generic mfg.
Clinical: Did I answer before? Budesonide 0.5 mg/2ml in nebulizer bid for 7 days like STOIC. I tried cutting duration to 4 days but even child patients came back not as resolved as I wanted to see at two or four week follow up treatment which went better enough. (Twitter) - Jan 28, 2022
- Entyvio (vedolizumab) / Takeda, Humira (adalimumab) / Eisai, AbbVie
VEDOLIZUMAB FOR REFRACTORY MICROSCOPIC COLITIS: A CASE SERIES () - Jan 28, 2022 - Abstract #CCCongress2022CCCongress_380;
Some patients suffer severe symptoms despite maximum dosage of budesonide, in these cases biologic therapies should be considered...The third patient was transitioned from vedolizumab to adalimumab and is now well controlled symptomatically and the final patient has not reached symptomatic remission of her disease...Due to low volume studies, the data supporting vedolizumab use in refractory microscopic colitis remains limited, and further studies are needed to elucidate the its potential as a first-line therapy. However, based on our experience, we recommend considering vedolizumab for patients suffering from refractory MC.
- | budesonide / Generic mfg.
New P2 trial: BESIDE: Pharmacokinetics, Efficacy, Tolerability and Safety of Different Budesonide Oral Gel Doses in Adults' Subjects of Both Genders With Eosinophilic Esophagitis (EoE) (clinicaltrials.gov) - Jan 27, 2022
P2, N=36, Not yet recruiting, Sponsor: Bazell Pharma AG
- | budesonide / Generic mfg.
Journal: New Strategies for Improving Budesonide Skin Retention. (Pubmed Central) - Jan 26, 2022
When the hydrogels were formulated with the inclusion complex, an increase in budesonide skin retention was observed with both hydrogels. Poloxamer hydrogel proved to be a suitable vehicle for cutaneous administration of budesonide.
- || budesonide / Generic mfg.
Review, Journal: Evidence-based treatments for eosinophilic esophagitis: insights for the clinician. (Pubmed Central) - Jan 26, 2022
Finally, endoscopic dilation should be considered in patients with reduced esophageal caliber or persistent dysphagia despite histological remission. This article provides a state-of-the-art review and updated discussion of current therapies and newly developed options for EoE.
- |||| fluvoxamine / Generic mfg., budesonide / Generic mfg.
Clinical, Clinical guideline: Fluvoxamine & Budesonide in the Clinical Practice Guideline Summary from @COVIDSciOntario https://t.co/cyjsDdV5Be (Twitter) - Jan 26, 2022
- || fluvoxamine / Generic mfg., budesonide / Generic mfg.
I’m on fluvoxamine + budesonide, both available in 🇧🇷. (Twitter) - Jan 22, 2022
- |||| budesonide / Generic mfg., mesalazine / Generic mfg., esomeprazole / Generic mfg.
Clinical: Hey #IBD folks on generic drugs - check out the GI meds at @costplusdrugs (A PBC) - Canasa, mesalamine, esomeprazole available at reasonable prices. Hoping that budesonide and biosimilars (adalimumab, infliximab) are next. Fewer patients driving to Canada? https://t.co/Xcrgjkctt1 (Twitter) - Jan 22, 2022
- ||| budesonide / Generic mfg.
Ceroid-laden macrophages on liver histo. No inflammation/steatosis/fibrosis. Enzymes fluctuate for months: 60-100s. No supplements. 30M. IgG 863. SMA: normal. What would you do? @AutoImmuneLiver @serperm @ebtapper @VinaySundaramMD was thinking of budesonide trial.. (Twitter) - Jan 22, 2022
- | budesonide / Generic mfg.
Journal: Reactive oxygen species-scavenging hollow MnO nanozymes as carriers to deliver budesonide for synergistic inflammatory bowel disease therapy. (Pubmed Central) - Jan 21, 2022
In addition, compared with free Bud, the drug delivery system can reduce side effects of Bud and improve its treatment outcome at the same dosage. Therefore, this study provides a new method for the design of highly effective synergistic anti-inflammatory nanomedicines.
- ||| budesonide / Generic mfg., paracetamol / Generic mfg.
Clinical: Crazy that a doctor in Texas was using budesonide back way early on in 2020. That’s when I first heard about it. The fact that we’ve had so many being untreated for so long is insane. I still hear of people being told to go home and take a Tylenol. (Twitter) - Jan 21, 2022
- ||| budesonide / Generic mfg.
Yes, very good question. I'd swap to ciclesonide ICS. It showed potent antiviral in vitro results against SARS-CoV-2 (budesonide did not). It also posted impressive results in the peer reviewed RCT published in JAMA. 82% reduction in ER and/or hospitalizations. (Twitter) - Jan 21, 2022
- || budesonide / Generic mfg.
I'd like to see more data on Budesonide, it looked so promising some months ago that i cant't explain results from others trials. (Twitter) - Jan 21, 2022
- || budesonide / Generic mfg.
I just wonder if budesonide is still as relevant with Omicron. (Twitter) - Jan 20, 2022
- | budesonide / Generic mfg.
Journal: Eosinophilic Gastroenteritis: Using Presenting Findings to Predict Disease Course. (Pubmed Central) - Jan 18, 2022
Patients with eosinophilic gastroenteritis may be characterized into 2 forms. Patients with weight loss at time of presentation, hypoalbuminemia at presentation, serosal disease involvement, or anemia at diagnosis were associated with a chronic disease course requiring chronic medications.
- || budesonide / Generic mfg.
Budesonide is also a corticosteroid, right? Is it required to be started on Day 1? (Twitter) - Jan 17, 2022
- || budesonide / Generic mfg.
Yes, budesonide is a corticosteroid, and there is some debate over whether it is fine to start on day 1 (if taken by inhaler), versus wait until after day 5 in case it causes some immune suppression that interferes with fighting the virus. (Twitter) - Jan 17, 2022
- |||| fluvoxamine / Generic mfg., budesonide / Generic mfg.
Paul it's OK to tell the @NIH to get step up to the plate and do what @ICMRDELHI did eight months ago in adding budesonide and what @COVIDSciOntario is doing with fluvoxamine! (Twitter) - Jan 16, 2022
- ||| budesonide / Generic mfg., fluticasone / Generic mfg.
I used inhaled fluticasone during my recent bout of acute COVID because budesonide was more expensive. I expect fluticasone might work since it is also a steroid, but I’d like to see a completed RCT to be sure (ACTIV-6 includes fluticasone). Seemed helpful for me but that’s n=1. (Twitter) - Jan 16, 2022
- || budesonide / Generic mfg.
Budesonide had been talked about in March/April 2020. Why so long to give it a shot? (Twitter) - Jan 16, 2022
- || budesonide / Generic mfg.
Do you find a difference between budesonide vs ciclesonide (Twitter) - Jan 16, 2022
- || budesonide / Generic mfg.
It thought a proxy was going to be used for Budesonide? (Twitter) - Jan 16, 2022
- || budesonide / Generic mfg.
Also good to see fluvox and inh budesonide included in protocols of some highly reputable institutions like Hopkins. (Twitter) - Jan 15, 2022
- |||| fluvoxamine / Generic mfg., budesonide / Generic mfg.
Clinical: Agree @PaulSaxMD - you & I both fans of the guideline committees; UCSF CFAR hosted Dr. Larry Corey last week for amazing talk on the vaccines & he pointed out the inevitability of endemicity so therapeutics become so important; "consider" fluvoxamine, ciclesonide, budesonide (Twitter) - Jan 15, 2022
- ||| hydroxychloroquine / Generic mfg., budesonide / Generic mfg., fluoxetine / Generic mfg.
Clinical: Can we finally admit that vaccines don’t work!! Trying the same crappy vaccine over and over again is insane. Time to look at alternatives like Fluoxetine, Budesonide, Ivermectin or Hydroxychloroquine as treatments (Twitter) - Jan 15, 2022
- ||| hydroxychloroquine / Generic mfg., budesonide / Generic mfg.
Clinical: Yeah, but did you give him an Early Treatment Protocol of #Hydroxychloroquine #Ivermectin #Budesonide #Quercetin #Zinc #Azithronycin #VitaminD #VitaminC Did you prescribe anything that would quickly BOOST HIS NATURAL IMMUNITY? As inquired by someone else, what was his severity? (Twitter) - Jan 15, 2022
- ||| budesonide / Generic mfg.
Video: Pharma finally got their greedy hands around the budesonide 'problem' before it became SoC in the 🇺🇸. A good nebulizer and a high quality colloidal silver are better alternatives anyway. @JackieS82674799 has a video up on bitchute https://t.co/0q2xIoKNxt (Twitter) - Jan 14, 2022
- |||| ivermectin oral / Generic mfg., budesonide / Generic mfg.
Clinical: Friend sent script pic from FLORIDA DR who does HOUSECALLS. Yes,Housecalls while 3 yr wait list of Family DR's in Quebekistan. Until swabs came back, placed on Covid Protocol & Bronchitis diagnosis. Ivermectin, Budesonide & Doxycyc Cleared up fast, had party for 30 in 2 days! (Twitter) - Jan 14, 2022
- ||||| fluvoxamine / Generic mfg., budesonide / Generic mfg.
Clinical: Am a fan of both the NIH and IDSA guidelines (and tx to the people serving on them), but would elevate both fluvoxamine and ciclesonide or budesonide to "consider use" status based on results from RCTs. Superb fluvoxamine guidance here: https://t.co/oWausm0jKR @COVIDSciOntario (Twitter) - Jan 14, 2022
- || budesonide / Generic mfg.
Also budesonide (Twitter) - Jan 14, 2022
- ||| budesonide / Generic mfg., fluticasone / Generic mfg.
Clinical: Todd, What's the difference between ciclesonide vs. fluticasone vs. budesonide? (Other than cicleosinde is on patent and more expensive). Any differnce in systemic absorption? Budesonide could not provide a matched placebo inhaler. Flovent could,thus fluticasone is in ACTIV-6. (Twitter) - Jan 14, 2022
- ||| budesonide / Generic mfg.
Retrospective data: Sample size for symptoms. If you pool the two ciclesonide trials in meta analysis you see a difference at 14 days with ciclesonide group. Not as big as open label budesonide but this is expected with placebo effect (Twitter) - Jan 13, 2022
- || budesonide / Generic mfg., fluticasone / Generic mfg.
Ciclesonide is felt to be less systemic. It was also the only steroid which seemed to have in vitro antiviral activity. Fluticasone is more potent than budesonide but I don't know if that matters at the dose given for budesonide trials. (Twitter) - Jan 13, 2022
- || budesonide / Generic mfg.
Review, Journal: Immunological drivers of IgA nephropathy: Exploring the mucosa-kidney link. (Pubmed Central) - Jan 13, 2022
Knowledge of antigen-mucosal interactions is now being successfully leveraged for therapeutic purposes; the gut-directed drug Nefecon (targeted release formulation-budesonide) is on track to become the first medication to be approved specifically for the treatment of IgAN. In this review, we examine established immunological paradigms in IgAN, explore how antigen-mucosal immune responses drive disease, and discuss how this knowledge is being used to develop new treatments.
- |||| budesonide / Generic mfg.
Clinical: Ciclesonide trials at the top (placebo) and budesonide at bottom (open label) (Twitter) - Jan 13, 2022
- ||| remdesivir / Generic mfg., budesonide / Generic mfg., Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Clinical: Nice of you Doc to recognize Fluvox on the list as an alternative. Remdesivir ($3k) & Molnupiravir ($700) are much ess useful to the patient than Fluvox & Budesonide. However, they are much more useful to the finances of the hospital, reinforced by gov't policy. Appalling. (Twitter) - Jan 13, 2022
- || budesonide / Generic mfg.
Aren't data on Budesonide too much confusive for putting in the list? (Twitter) - Jan 12, 2022
- || dexamethasone / Generic mfg., budesonide / Generic mfg.
Retrospective data, Review, Journal: Hypothalamic-pituitary-adrenal axis suppression and intranasal corticosteroid use: A systematic review and meta-analysis. (Pubmed Central) - Jan 11, 2022
Although modest, this risk may differ depending on the length of duration and type of INCS used. Informing patients of these risks is of importance for the treatment of chronic sinonasal conditions.
- || budesonide / Generic mfg.
Clinical, Journal: P032 Clinical Usefulness of Double Balloon Enteroscopy in Patients With Established or Suspected Small Bowel Crohn's Disease. (Pubmed Central) - Jan 11, 2022
Additionally, DBE in patients with established diagnosis of small bowel CD is an effective tool to assess disease activity and guide therapy. Serious complications are infrequent.
- | Entyvio (vedolizumab) / Takeda, Humira (adalimumab) / Eisai, AbbVie
Journal: P053 Interstitial Nephritis from IBD: Complicated Conclusions. (Pubmed Central) - Jan 11, 2022
TIN secondary to aminosalicylates is well-documented, but there are few reports of adalimumab-induced granulomatous TIN and only one report of vedolizumab-induced TIN. Each of our patients had well-controlled IBD and multiple confounding variables that could impact kidney function or cause TIN, including hypertension and multiple potential culprit medications, illustrating the dilemma of determining the etiology of renal injury in IBD patients.
- ||| budesonide / Generic mfg., fluticasone / Generic mfg.
Pricing: Thanks so much for this info. I was really freaked out about the cost of budesonide in my PDP – it's a tier 4 drug which is not only $$$ but has 😜 hoops to jump through. But fluticasone is a tier 2 on my plan which means I can afford it! 🙏 (Twitter) - Jan 10, 2022
- ||| hydroxychloroquine / Generic mfg., budesonide / Generic mfg.
Clinical: Let Drs treat patients using their best judgment. This has been the biggest mistake that we’ve made. Some will use Hydroxychloroquine. Others ivermectin. Most will use flovoxamine , budesonide and timed steroids. Let them do what they are trained to do. (Twitter) - Jan 10, 2022
- ||| fluvoxamine / Generic mfg., budesonide / Generic mfg.
Not what I'm saying..it's not just nasal irrigation. That's low hanging fruit that is accessible to many, including India. But so many other things that are already on the shelf, just Rx them offlabel - Fluvoxamine, budesonide, protease inhibitors, zinc Ionophores, even asprin. (Twitter) - Jan 10, 2022
- || budesonide / Generic mfg.
Thanks. Looks like Albuterol would help slightly (attenuated impulse function) but you'd practically need Lebesgue Integration to calculate its benefit; budesonide has a slow decay function because steroidal benefit persists as it's absorbed. So much larger integral of benefit. (Twitter) - Jan 10, 2022
- |||| budesonide / Generic mfg.
Clinical, Cytokine storm: When is it appropriate for Covid outpatients to get budesonide? The purpose is to reduce the hyperimmune reaction (cytokine storm), correct? My concern would be that giving steroids too early could suppress the immune system & prevent the body from fighting off viral replic. (Twitter) - Jan 10, 2022
- ||| hydroxychloroquine / Generic mfg., budesonide / Generic mfg., fluoxetine / Generic mfg.
Clinical: Time to look at alternatives like Fluoxetine, Budesonide, Ivermectin or Hydroxychloroquine as treatments since the vaccines are not very effective. This has become a pandemic of the vaccinated! Let’s do better in 2022 (Twitter) - Jan 10, 2022