fentanyl citrate / Generic mfg. 
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  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Functionalized Gold Nanoparticles and Halogen Bonding Interactions Involving Fentanyl and Fentanyl Derivatives. (Pubmed Central) -  Jun 13, 2024   
    Ultimately, spectroscopy and TEM analysis were combined to study whole-molecule FTN interactions with the functionalized MPCs in solution. The results suggested that the strongest XB interaction site on FTN, while common to most of the drug's derivatives, is not strong enough to induce NP-aggregation detection but may be better exploited in sensing schemes involving films.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Fentanyl-Type Antagonist of the ?-Opioid Receptor: Important Role of Axial Chirality in the Active Conformation. (Pubmed Central) -  Jun 13, 2024   
    The aS- and aR-enantiomers exerted antagonistic and agonistic effects on the MOR, respectively, and each atropisomer interacted with the MOR by assuming a distinct binding mode through molecular docking. These findings suggest that introducing atropisomerism into fentanyl may serve as a key feature in the molecular design of future MOR antagonists to help mitigate the opioid crisis.
  • ||||||||||  Clinical, Journal, Surgery:  Opioid-free versus opioid-based anesthesia in major spine surgery: a prospective, randomized, controlled clinical trial. (Pubmed Central) -  Jun 13, 2024   
    All patients received intraoperative sevoflurane, propofol, rocuronium, ketamine, dexamethasone, ondansetron and postoperative paracetamol and patient-controlled analgesia device set to deliver intravenous morphine for 48 hours after surgery...OFA can be an alternative to OBA in patients undergoing multilevel spine fusion surgery. OFA reduces opioids consumption in the first 24 hours and PONV.
  • ||||||||||  fentanyl citrate / Generic mfg., methadone / Generic mfg.
    Journal:  Clinician Ordering and Management Patterns of Urine Toxicology Results at a Cancer Center. (Pubmed Central) -  Jun 12, 2024   
    Overall UDT ordering was infrequent for patients with cancer on opioid therapy, especially by oncologists, and clinicians rarely made prescribing changes when definitive UDT results were aberrant. More definitive guidance related to UDT ordering and opioid management are needed for patients with cancer and aberrant UDT results.
  • ||||||||||  fentanyl citrate / Generic mfg.
    PK/PD data, Journal:  Fentanyl Pharmacokinetic Paradoxical in Cancer Cachexia. (Pubmed Central) -  Jun 12, 2024   
    More definitive guidance related to UDT ordering and opioid management are needed for patients with cancer and aberrant UDT results. No abstract available
  • ||||||||||  fentanyl citrate / Generic mfg., methadone / Generic mfg.
    Retrospective data, Journal:  Overdose deaths before and during the COVID-19 pandemic in a US county. (Pubmed Central) -  Jun 11, 2024   
    Overdose deaths remained 27% higher (CI 4-55%, p = 0.015) than before the pandemic through 2021.Abrupt service reductions occurred when the pandemic began: in-clinic methadone treatment dropped by two-thirds, counseling by 38%, opioid seizures by 29%, and drug arrests by 56%...County level data dashboards comprised of overdose toxicology, and interdiction and service data, can help explain changes in overdose deaths. As a next step in predicting which policies and practices will best reduce local overdoses, we propose using simulation modeling with agent-based models to examine complex interacting systems.
  • ||||||||||  fentanyl citrate / Generic mfg., verapamil / Generic mfg., moxifloxacin intravenous / Generic mfg.
    Journal:  In silico modelling of stroke volume, cardiac output and systemic vascular resistance in cardiovascular safety pharmacology studies by telemetry. (Pubmed Central) -  Jun 9, 2024   
    Furthermore, the examples of verapamil, quinidine and moxifloxacin show that iSV, iCO and iSVR are earlier biomarkers than blood pressure itself for predicting drug effect on blood pressure. This in silico modelling approach included in vivo telemetry safety pharmacology studies can be considered as a New Approach Methodology (NAM) that provides valuable additional information and contribute to improving non-clinical translational research to the clinic.
  • ||||||||||  Seizalam (midazolam intramuscular) / Pfizer
    Review, Journal:  What is the evidence for using intranasal medicine in the prehospital setting? A systematic review. (Pubmed Central) -  Jun 7, 2024   
    There are likely to be certain populations, for example pediatrics, that will benefit the most, although conclusions are limited by the quality of evidence currently available. We encourage additional research in this area, particularly with robust prospective double-blind RCTs.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Black Americans' Drug Mortality Increases and Local Employment Opportunities, 2010?2021. (Pubmed Central) -  Jun 5, 2024   
    To test the associations between local employment opportunities for the Black workforce and drug mortality among Black Americans, while examining the potential moderating effects of fentanyl seizure rates...Published online ahead of print April 25, 2024:e1-e4. https://doi.org/10.2105/AJPH.2024.307646).
  • ||||||||||  Review, Journal:  Beyond Traditional Pain Relief: A Review of Alternative Analgesics in Myocardial Infarction Patient Management. (Pubmed Central) -  Jun 5, 2024   
    Acetaminophen, a centrally acting analgesic, emerges as a safer alternative with comparable pain relief efficacy and minimal side effects. The results of multiple clinical trials emphasize the significance of customizing pain management approaches to match individual patient profiles and achieving the optimal balance between pain relief and potential adverse outcomes.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Testing for protonitazene in human hair using LC-MS/MS. (Pubmed Central) -  Jun 5, 2024   
    The results of multiple clinical trials emphasize the significance of customizing pain management approaches to match individual patient profiles and achieving the optimal balance between pain relief and potential adverse outcomes. Drugs were incubated overnight at 40
  • ||||||||||  fentanyl citrate / Generic mfg.
    Review, Journal:  Fentanyl Deaths in Infants and Children: A Case Series and Literature Review. (Pubmed Central) -  Jun 4, 2024   
    The legal ramifications of a positive fentanyl level in a child increase the need for caution on the part of the forensic pathologist. Understanding what can and cannot be proven by autopsy as well as what resources are available to strengthen one's justification for fentanyl being the primary cause of death is critical.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Public Perceptions of Opioid Use for Chronic Non-Cancer Pain. (Pubmed Central) -  Jun 3, 2024   
    These findings inform strategies to correct public misperceptions, emphasizing the importance of personal experience, perceived risks, and stigmatization of chronic pain patients. This insight can guide effective pain management for those with chronic non-cancer pain.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  "Coke in the Dope": The Underrecognized Complications of a Cocaine-Adulterated Fentanyl Supply. (Pubmed Central) -  Jun 3, 2024   
    Specifically, further research is needed evaluating complications of low-level cocaine exposure with chronic/persistent opioid use. The hazards associated with cocaine-adulterated fentanyl emphasize the significance of understanding not only fentanyl's presence in cocaine but also cocaine's role in the fentanyl supply.
  • ||||||||||  Journal:  Triazole antifungal drug interactions-practical considerations for excellent prescribing. (Pubmed Central) -  Jun 2, 2024   
    We highlight interactions with drugs used in children and new agents introduced for the treatment of haematological malignancies or graft versus host disease (midostaurin, ibrutinib, ruxolitinib and venetoclax). We also summarize the multiple interactions between oral and inhaled corticosteroids and triazole antifungals, and the strategies needed to optimize the therapeutic benefits of triazole antifungal therapy while minimizing potential harm to patients.
  • ||||||||||  fentanyl citrate / Generic mfg., ketamine / Generic mfg.
    Clinical, Journal:  Comparison of Fentanyl, Ketamine, and Lidocaine Combined with Propofol Anesthesia in Patients with Crohn Disease Undergoing Colonoscopy. (Pubmed Central) -  Jun 1, 2024   
    Dizziness occurred less frequently with lidocaine than fentanyl (17.2%, P=0.018) and ketamine (15.1%, P=0.019), while metallic taste incidents were more prevalent in the lidocaine group (13.5%, P=0.04) than fentanyl group. CONCLUSIONS Using ketamine or lidocaine instead of fentanyl in anesthesia for colonoscopy in patients with CD significantly lowers propofol use, reduces desaturation events, maintains blood pressure more effectively, without increasing hypotension risk, and accelerates recovery, without negatively impacting adverse events or patient satisfaction.
  • ||||||||||  fentanyl citrate / Generic mfg., midazolam hydrochloride / Generic mfg.
    Preclinical, Journal:  Effects of vatinoxan in rats sedated with a combination of medetomidine, midazolam and fentanyl. (Pubmed Central) -  Jun 1, 2024   
    CONCLUSIONS Using ketamine or lidocaine instead of fentanyl in anesthesia for colonoscopy in patients with CD significantly lowers propofol use, reduces desaturation events, maintains blood pressure more effectively, without increasing hypotension risk, and accelerates recovery, without negatively impacting adverse events or patient satisfaction. Acceleration of induction of sedation, alleviation of hyperglycaemia and prevention of profuse diuresis by vatinoxan may be beneficial when sedating rats for clinical and experimental purposes with subcutaneous medetomidine, midazolam and fentanyl.