- |||||||||| fentanyl citrate / Generic mfg.
Journal: Low-dose Induction of Buprenorphine in Pregnancy: A Case Series. (Pubmed Central) - Oct 20, 2023
The low-dose buprenorphine induction regimen described was successful in 5 of 6 pregnant individuals. Further research, particularly regarding continuation rates, is needed.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: 48-hour Induction of Transdermal Buprenorphine to Extended-release Buprenorphine. (Pubmed Central) - Oct 17, 2023
We report a case of a hospitalized patient with unregulated fentanyl use who underwent a successful transdermal buprenorphine induction for 48 hours to initiate BUP-XR with minimal levels of withdrawal and without precipitating opioid withdrawal. The approach described could provide a practical, patient-centered, accelerated induction strategy that, once independently validated, could considerably facilitate the use of BUP-XR.
- |||||||||| fentanyl citrate / Generic mfg., tramadol hydrochloride / Generic mfg.
Journal, Real-world evidence, Real-world: Electrophysiological appropriateness technique based on TCM meridian theory for postoperative pain after urethral reconstruction: A real-world study (Pubmed Central) - Oct 17, 2023
The approach described could provide a practical, patient-centered, accelerated induction strategy that, once independently validated, could considerably facilitate the use of BUP-XR. Electrophysiological therapy based on the TCM meridian theory can safely and effectively alleviate postoperative pain after urethral reconstruction, reduce opioid consumption, and decrease adverse events.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal: Perioperative Analgesia and Patients' Satisfaction in Spinal Anesthesia for Cesarean Section: Fentanyl Versus Morphine. (Pubmed Central) - Oct 14, 2023
On the other hand, fentanyl had significantly fewer non-life-threatening side effects, such as high-intensity pruritus (Mann-Whitney U test, p < 0.001), nausea (OR = 0.324; p = 0.019), vomiting and dizziness upon first mobilization (OR = 0.256; p < 0.001). It remains for future clinical trials to help establish doses that will tilt the scale to one side or the other.
- |||||||||| fentanyl citrate / Generic mfg., tramadol hydrochloride / Generic mfg.
Journal, Adverse events, Adverse drug reaction: Adverse Drug Reactions to Opioids: A Study in a National Pharmacovigilance Database. (Pubmed Central) - Oct 12, 2023
In general, ADRs related to opioids presented higher RORs when uncorrected and corrected for sexes and expenditure than other drugs. There was more disproportionate reporting for ADRs concerning abuse, misuse, and medication errors for opioids than other drugs in the Dutch SRS.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Development of Photoswitchable Tethered Ligands that Target the (Pubmed Central) - Oct 11, 2023
Methadone or buprenorphine use was associated with reductions in mortality. This work describes chemical, photophysical and biochemical characterizations of a variety of PTLs designed to target the
- |||||||||| fentanyl citrate / Generic mfg., midazolam hydrochloride / Generic mfg.
Journal: A comparison of balloon-assisted versus dilator in percutaneous gastrostomy tube placement. (Pubmed Central) - Oct 9, 2023
BAG is a safe and efficient technique for percutaneous gastrostomy tube placement. BAG patients required significantly lesser radiation, OR time, post-operative pain management, and recorded lower postoperative complications compared to their counterparts in gastrostomies utilizing dilators.
- |||||||||| fentanyl citrate / Generic mfg., midazolam hydrochloride / Generic mfg.
Journal: Vocal Cord Monitoring by Flexible Fiberoptic Laryngoscopy During Thyroid Radiofrequency Ablation. (Pubmed Central) - Oct 9, 2023
BAG patients required significantly lesser radiation, OR time, post-operative pain management, and recorded lower postoperative complications compared to their counterparts in gastrostomies utilizing dilators. The procedure was assisted by an anesthetist administering fentanyl 50?mcg, midazolam 1.5 to 5.0?mg, and propofol infusion 2?mg/(kg
- |||||||||| ropivacaine / Generic mfg.
Clinical, Journal, Surgery: Efficacy of lumbosacral and sacrococcygeal epidural ropivacaine in dogs undergoing surgery for perineal hernia. (Pubmed Central) - Oct 9, 2023
After premedication with IM acepromazine 0.02?mg/kg and butorphanol 0.3?mg/kg, general anesthesia was induced with propofol and maintained with sevoflurane in oxygen...Clinical failure was defined as the need of more than two boluses of fentanyl/h each dog received meloxicam 0.2?mg/kg IV at the end of the surgery...No significant differences between groups were detected in the GCPS-SF score, tactile sensitivity, pressure pain thresholds, need of post-operative methadone, or motor blockade. Both epidural techniques are valuable analgesic options for perineal hernia repair in dogs.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Educational Attainment and US Drug Overdose Deaths. (Pubmed Central) - Oct 6, 2023
In this cross-sectional study, lower educational attainment was found to be associated with higher growth in overdose deaths. As the opioid crisis has transitioned to fentanyl and polysubstance use, overdose deaths have become more prevalent in groups with lower socioeconomic status, potentially exacerbating existing life-expectancy disparities.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: 'Safer drug supply' measures in Canada to reduce the drug overdose fatality toll: Clarifying concepts, practices and evidence within a public health intervention framework. (Pubmed Central) - Oct 5, 2023
North America has been home to an unprecedented crisis of drug overdose deaths, driven largely by drug users' exposure to highly potent and toxic, illicit opioid drugs (e.g., fentanyl)...In this Perspective paper, we briefly address some of these issues, and clarify selected issues of elementary concepts, practices, and evidence related to 'safer supply' measures. These measures are also discussed in reference to other, comparable types of public health-oriented emergency health or survival care standards, while considering the extreme contexts of an ongoing, acute drug-death-crisis in Canada.
- |||||||||| fentanyl citrate / Generic mfg., ketamine / Generic mfg., sevoflurane / Generic mfg.
Preclinical, Journal: Comparison of the respiratory effects of commonly utilized general anaesthesia regimes in male Sprague-Dawley rats. (Pubmed Central) - Oct 4, 2023
Bronchial hyperresponsiveness in response to ketamine-xylazine anaesthesia should be considered when designing experiments using this regime. The findings of the present study indicate commonly used anaesthetic regimes allow fair comparison of respiratory mechanics in experimental animals undergoing any of the examined anaesthesia protocols.
- |||||||||| Zepatier (grazoprevir/elbasvir) / Merck (MSD), Vosevi (sofosbuvir/velpatasvir/voxilaprevir) / Gilead, Mavyret (glecaprevir/pibrentasvir) / AbbVie, Enanta Pharma
Journal, Adverse events: Reported adverse events related to use of hepatitis C virus direct-acting antivirals with opioids: 2017-2021. (Pubmed Central) - Oct 1, 2023
Low numbers of DAA AE reports with opioids may provide reassurance to prioritize HCV treatment in this population. These data contribute to evidence supporting the continued scale-up of DAA treatment among people who use drugs to achieve HCV elimination goals.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Hippocampal volume loss in individuals with a history of non-fatal opioid overdose. (Pubmed Central) - Oct 1, 2023
Voxel-based morphometry showed lower hippocampal volume in the OD group than in the NOD group, which on post hoc analysis was evident in the left but not the right hippocampus. These findings strengthen the evidence that hippocampal injury is associated with non-fatal opioid overdose, which is hypothesized to underlie overdose-related amnestic syndrome.
- |||||||||| fentanyl citrate / Generic mfg., methadone / Generic mfg.
A Child and Adolescent Psychiatry Guide to Medications for Opioid Use Disorder (Mercury Ballroom (New York Hilton Midtown); In-person) - Sep 30, 2023 - Abstract #AACAP2023AACAP_1394;
A working knowledge and plan to intervene with patients who have OUD reduces personal, structural, and institutional discrimination. Clinicians who treat adolescents and TAY should understand the risks that fentanyl poses to their patients and have a plan for initiating or referring those with primary or co-occurring OUD for MOUD treatment.
- |||||||||| fentanyl citrate / Generic mfg.
Fentanyl and Fatal Opioid Overdoses Among Youth: Overdose Risk, Treatment, and Prevention Planning (Mercury Ballroom (New York Hilton Midtown); In-person) - Sep 30, 2023 - Abstract #AACAP2023AACAP_1393;
Naloxone kits are a powerful tool to reduce the risk of death from an overdose, but a simple prescription or provision of a kit does not insure proper utilization. Treatment planning and medications to reduce opioid overdose are increasingly needed as tools in the fight against fentanyl overdose among adolescents in the United States.
- |||||||||| fentanyl citrate / Generic mfg.
How Fentanyl Is Fueling the Opioid Epidemic Among Youth (Mercury Ballroom (New York Hilton Midtown); In-person) - Sep 30, 2023 - Abstract #AACAP2023AACAP_1392;
As a result, many youth are exposed to fentanyl unintentionally and are at risk of fatal opioid overdose, even among youth with minimal fentanyl exposure. Conclusions Fentanyl, a highly lipophilic synthetic opioid, exhibits high potency, rapid onset, and short duration of action, which increase the misuse potential and risk of fatal overdose among youth, including among youth with minimal or unintentional fentanyl exposure.
- |||||||||| fentanyl citrate / Generic mfg.
Clinical Perspectives 72 : Fentanyl and the Opioid Epidemic: Practical Guidance for Child and Adolescent Psychiatry Clinicians (Mercury Ballroom (New York Hilton Midtown); In-person) - Sep 30, 2023 - Abstract #AACAP2023AACAP_1391;
Conclusions It is vital to screen all youth for fentanyl exposure and intentional use, to engage youth in education and overdose prevention, and to provide naloxone to youth at risk of opioid overdose. Evidence-based treatments include medications for OUD combined with psychotherapy, which may be initiated in primary mental health settings while facilitating a referral to treatment.
- |||||||||| fentanyl citrate / Generic mfg., naltrexone / Generic mfg.
Opioid, Stimulant, and Hallucinogen Use Disorders in Consultation-Liaison Psychiatry (Empire Ballroom East (Sheraton New York Times Square Hotel); In-person) - Sep 30, 2023 - Abstract #AACAP2023AACAP_305;
There has also been a rise in overdose-related deaths among adolescents aged 14 to 18 years old, particularly due to fentanyl contamination of drug supply...This will include indications for and an approach to the use of naltrexone and buprenorphine in opioid use disorder treatment...A biopsychosocial clinical approach to maintenance treatment including pharmacotherapy, psychosocial interventions, and an outline of harm-reduction counseling points for each substance is key to improving outcomes. Conclusions The rising rates of stimulant, hallucinogen, and opioid use in the pediatric population highlight the need for the child and adolescent psychiatrist CL to update our knowledge base and skills on initiating evidence-based interventions in pediatric hospital settings.
- |||||||||| fentanyl citrate / Generic mfg., midazolam hydrochloride / Generic mfg., diazepam / Generic mfg.
Observational data, Journal: Electroencephalographic findings in preterm neonates (Pubmed Central) - Sep 28, 2023
Early postnatal screening is helpful, but additional records are usually needed to detect high-risk newborns. It would be important to continue studying this line of research in pediatrics.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Benzylfentanyl as a Surrogate Template for Fentanyl-Selective Imprinted Polymers. (Pubmed Central) - Sep 28, 2023
Important studies herein determined the optimum ratio of the template/functional monomer, with subsequent evaluations of selectivity of the MIP for the template and fentanyl versus the commonly encountered narcotics such as methamphetamine, cocaine, and heroin. The data obtained from the HPLC analysis showed that the Bfen-MIP was successful in selectively binding the template and actual fentanyl, better than other common narcotics.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Opioid-related deaths in Ontario correctional facilities and penitentiaries (2009-2019). (Pubmed Central) - Sep 26, 2023
Data also indicates the recent emergence of fentanyl-related analogues in this population. The results from this study provide valuable information about drug-related deaths in the Ontario prison system and provide insight into how the opioid crisis and the increased use of fentanyl and its analogues have affected this vulnerable population.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Review, Journal: Endogenous Opiates and Behavior: 2022. (Pubmed Central) - Sep 25, 2023
This paper is the forty-fifth consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2022 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides and receptors as well as effects of opioid/opiate agonists and antagonists. The review is subdivided into the following specific topics: molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors (1), the roles of these opioid peptides and receptors in pain and analgesia in animals (2) and humans (3), opioid-sensitive and opioid-insensitive effects of nonopioid analgesics (4), opioid peptide and receptor involvement in tolerance and dependence (5), stress and social status (6), learning and memory (7), eating and drinking (8), drug abuse and alcohol (9), sexual activity and hormones, pregnancy, development and endocrinology (10), mental illness and mood (11), seizures and neurologic disorders (12), electrical-related activity and neurophysiology (13), general activity and locomotion (14), gastrointestinal, renal and hepatic functions (15), cardiovascular responses (16), respiration and thermoregulation (17), and immunological responses (18).
- |||||||||| Journal: Prescription of off-label and unlicensed medication for newborns hospitalized in the Intensive Care Unit. (Pubmed Central) - Sep 24, 2023
This study showed a large percentage of prescriptions made in the off-label (50.7%) and unlicensed (37.2%) form in the Neonatal Intensive Care Unit, corroborating the worrying world scenario. The most exposed neonates were precisely the most vulnerable ones and, among the most commonly prescribed medications, ampicillin and gentamicin stood out in off-label form and caffeine in unlicensed form.
- |||||||||| Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca
Opioid Withdrawal Causing a Broken Heart! (Zone 2, Science and Technology Hall, Level 2) - Sep 21, 2023 - Abstract #AHA2023AHA_8123;
Although it was previously thought of as a benign self-limiting condition, it is now known to be associated with significant morbidity and mortality.Case: A 26-year-old male patient with past medical history of Fentanyl abuse now on methadone, presented with features of opioid withdrawal...Due to excessive agitation and vomiting, he was given IV haloperidol and ondansetron...He was diagnosed with takotsubo cardiomyopathy and was initiated on dapagliflozin, metoprolol succinate and losartan...Approximately 4.5% of these patients can die during their hospitalization and 4% can die within 30 days of discharge. So, clinicians must keep a high index of suspicion for this syndrome in patients with history of substance use disorder, especially in the setting of troponin elevation.
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