fentanyl citrate / Generic mfg. 
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  • ||||||||||  Duragesic (fentanyl) / J&J
    Clinical, Journal:  A population-based study of transdermal fentanyl initiation in Australian clinical practice. (Pubmed Central) -  Jun 7, 2019   
    Three in ten Australians initiating TD fentanyl are opioid naïve. Our findings suggest that specific patient sub-populations already at increased risk of opioid-related adverse events are not receiving prior opioid treatment before initiation, highlighting the need for greater adherence to current treatment guidelines.
  • ||||||||||  fentanyl citrate / generics
    Clinical, Journal:  Proximal RUMM block in dogs: preliminary results of cadaveric and clinical studies. (Pubmed Central) -  Jun 7, 2019   
    Fentanyl at the studied doses did not result in chest wall rigidity in dogs anesthetized with equipotent doses of isoflurane (1.3 MAC). The US-guided proximal RUMM block performed at the axillary level with a single, in-plane needling approach using 0.15 mL kg of ropivacaine 0.5% minimized fentanyl requirement during thoracic limb surgery, contributing to postoperative analgesia up to 8 hours after execution of the peripheral nerve block.
  • ||||||||||  fentanyl citrate / generics
    Clinical, Journal:  Anesthetic Considerations for Ivor-Lewis Esophagectomy in a Patient With Hereditary Spastic Paraplegia: A Case Report. (Pubmed Central) -  Jun 7, 2019   
    This is the first report in the literature describing the anesthetic management of a patient with HSP successfully undergoing complex thoracoabdominal surgery. Key to the provision of postoperative analgesia was the intraoperative placement of catheters in the right thoracic paravertebral space and retro-rectus plane for continuous infusion of ropivacaine 0.2% for 3 days, as well as a fentanyl patient-controlled analgesia for 7 days.
  • ||||||||||  fentanyl citrate / generics, methadone / generics
    Journal:  Targeted Opioid Screening Assay for Pain Management Using High-Resolution Mass Spectrometry. (Pubmed Central) -  Jun 7, 2019   
    Superior testing strategies are required to specifically identify low concentrations of opioids found in adherent pain management patients. Therefore we present a method for the qualitative identification of 33 opioids and metabolites (codeine, codeine-6-β-glucuronide, morphine, morphine-6-β-glucuronide, 6-acetylmorphine, hydrocodone, norhydrocodone, dihydrocodeine, hydromorphone, hydromorphone-3-β-glucuronide, oxycodone, noroxycodone, oxymorphone, oxymorphone-3-β-glucuronide, noroxymorphone, meperidine, normeperidine, methadone, EDDP, propoxyphene, norpropoxyphene, tramadol, O-desmethyltramadol, tapentadol, tapentadol-β-glucuronide, N-desmethyltapentadol, buprenorphine, norbuprenorphine, norbuprenorphine glucuronide, naloxone, naloxone glucuronide, fentanyl, and norfentanyl) in unhydrolyzed urine using a liquid chromatography tandem mass spectrometry (LC-MS/MS) with high-resolution, accurate-mass Orbitrap detection.
  • ||||||||||  fentanyl citrate / generics
    Journal:  Quantification of Designer Opioids by Liquid Chromatography-Tandem Mass Spectrometry. (Pubmed Central) -  Jun 7, 2019   
    Opioids including heroin and commonly prescribed drugs such as oxycodone and fentanyl are among the most commonly abused drugs...The assay described is for the quantitative determination of 19 designer opioids in serum, plasma, and whole blood. Also included is a discussion on the challenges of keeping an analytical method current as new analytes appear on the illicit drug market.
  • ||||||||||  Soma (carisoprodol) / Mylan
    Journal:  Analysis of Drugs in Oral Fluid Using LC-MS/MS. (Pubmed Central) -  Jun 7, 2019   
    Because of the low volume of specimen available for analysis and the drug concentrations present (generally much lower than those in urine), efficient extraction methods and sensitive confirmation procedures are necessary for routine analysis of drugs in oral fluid. In this chapter, solid-phase extraction methods are described for a variety of drugs with liquid chromatography-tandem mass spectrometry detection.
  • ||||||||||  fentanyl citrate / generics
    Journal:  A chemically contiguous hapten approach for a heroin-fentanyl vaccine. (Pubmed Central) -  Jun 6, 2019   
    After thorough investigation of this strategy, we have identified key considerations for the development of a chemically contiguous heroin-fentanyl vaccine. Importantly, this is the first report of such a strategy in the opioid-drug-vaccine field.
  • ||||||||||  oliceridine (TRV130) / Trevena, cebranopadol (GRT6005) / Assertio, Grunenthal, Targin (oxycodone/naloxone ER) / Shionogi, Purdue, Mundipharma
    Review, Journal:  Hot topics in opioid pharmacology: mixed and biased opioids. (Pubmed Central) -  Jun 5, 2019   
    Moreover, the observation that β-arrestin coupling underlies the side-effect profile for MOP ligands (from knockout animal studies) led to the discovery of biased (to G-protein and away from β-arrestin intracellular signalling) MOP ligands, such as oliceridine. There is sufficient excitement in the opioid field to suggest that opioid analgesics without significant side-effects may be on the horizon, and the 'opioid Holy Grail' might be in reach.
  • ||||||||||  metoclopramide / generics
    Journal, Adverse events:  Adverse Events and Concurrent Medications Associated with Parenteral Nutrition Use. (Pubmed Central) -  May 30, 2019   
    The frequent adverse events remained consistent after accounting for concurrent medications. Our findings from a nationwide reporting system database found that gastrointestinal (nausea and vomiting) were the leading adverse events, requiring further studies on their prevalence, mechanisms and therapeutic options.
  • ||||||||||  fentanyl citrate / generics
    Review, Journal:  Non-Medical Use of Novel Synthetic Opioids: A New Challenge to Public Health. (Pubmed Central) -  May 30, 2019   
    The severity of the opioid crisis has intensified with the introduction of highly potent NSOs on the drug market. As long as addicts are dying from overdose or similar causes, there is something more constructive to do than waiting for addicts to overdose on heroin at a place located near a remedy, as if to say, within reach of naloxone.
  • ||||||||||  fentanyl citrate / generics
    Journal:  Collision-Induced Dissociation Studies of Synthetic Opioids for Non-targeted Analysis. (Pubmed Central) -  May 30, 2019   
    The spectra obtained from these studies included a number of diagnostic fragments common to the different opioid classes that, when used in combination, show potential for use as class predictors. By using simple data processing techniques, such as extracted ion chromatograms, these diagnostic product ions identified can be applied to a non-targeted screening workflow.
  • ||||||||||  fentanyl citrate / generics
    Journal:  Comparison of Fentanyl Oral and Nasal Formulations #331. (Pubmed Central) -  May 30, 2019   
    By using simple data processing techniques, such as extracted ion chromatograms, these diagnostic product ions identified can be applied to a non-targeted screening workflow. No abstract available
  • ||||||||||  morphine/oxycodone (Q8011) / QRxPharma, nalbuphine / Endo
    Journal:  Application of receptor theory to the design and use of fixed-proportion mu-opioid agonist and antagonist mixtures in rhesus monkeys. (Pubmed Central) -  May 30, 2019   
    The maximum effects of fentanyl, naltrexone, and each mixture were also used to generate an efficacy-effect scale for antinociception at each temperature, and this scale was evaluated for its utility in quantifying (a) efficacy requirements for antinociception at 50 and 54°C and (b) relative efficacy of six MOR agonists that vary in their efficacies to produce agonist-stimuated GTPγS binding in vitro (from lowest to highest efficacy: NAQ, nalbuphine, buprenorphine, oxycodone, morphine, and methadone). These results suggest that fixed-proportion agonist/antagonist mixtures may offer a useful strategy to manipulate apparent drug efficacy for basic research or therapeutic purposes.
  • ||||||||||  fentanyl citrate / generics
    Journal:  Effect of class III and class IV obesity on oocyte retrieval complications and outcomes. (Pubmed Central) -  May 29, 2019   
    These patients were also more likely to require higher doses of propofol and fentanyl, have longer oocyte retrievals, and require a transabdominal retrieval. Overall, oocyte retrieval can be safely performed as an outpatient procedure in women with class III and class IV obesity.
  • ||||||||||  fentanyl citrate / generics
    Clinical, Journal:  Opioid-induced constipation in chronic pain: Experience with 180 patients. (Pubmed Central) -  May 29, 2019   
    Most patients receiving long-term treatment with opioids present symptoms of constipation. The bowel function profile was more favorable for tapentadol and oxycodone, with no differences between them, even though morphine equivalent doses were on average higher in the tapentadol group.
  • ||||||||||  Duragesic (fentanyl) / J&J
    Journal:  Driving under the influence of opioids: What prescribers should know. (Pubmed Central) -  May 29, 2019   
    The present narrative review attempts to highlight the existing problem, the different legal thresholds for arrest and prosecution for DUID, and the challenge of trying to have zero-tolerance for driving under the influence of a drug used illegally, while at the same time not arresting legitimate patients who are taking pain medication as prescribed. There is a clear and present need for an integrated assessment and addressing of the current confounding situation.