fentanyl citrate / Generic mfg. 
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  • ||||||||||  fentanyl citrate / generics
    Journal:  Fentanyl Induces Rapid Onset Hyperalgesic Priming: Type I at Peripheral and Type II at Central Nociceptor Terminals. (Pubmed Central) -  Jul 7, 2019   
    Thus, acting at MOR in the nociceptor, fentanyl rapidly induces hyperalgesia and priming at both the central (Type II) and peripheral (Type I) terminal, mediated by Casignaling.Fentanyl, acting at the mu-opioid receptor, induced hyperalgesia and hyperalgesic priming, at both the central and peripheral terminal of nociceptors, mediated by endoplasmic reticulum Casignaling. Priming in the central terminal is Type II while that in the peripheral terminal is Type I. Our findings may provide useful information for the design of drugs with improved therapeutic profiles, selectively disrupting individual mu-opioid receptor signaling pathways, to maintain an adequate long-lasting control of pain.
  • ||||||||||  fentanyl citrate / generics
    Journal:  Microfluidic analysis of fentanyl-laced heroin samples by surface-enhanced Raman spectroscopy in a hydrophobic medium. (Pubmed Central) -  Jul 6, 2019   
    Using this method, we were able to reliably detect fentanyl from samples with as low as 1 : 10 000 (mol/mol) fentanyl-to-heroin ratio, improving the limits of detection of fentanyl-laced heroin samples by two orders of magnitude over current techniques. The described system could also be useful in chemical detection where rapid and robust preconcentration of trace hydrophobic analytes, and rapid SERS detection in non-aqueous solvents is indicated.
  • ||||||||||  fentanyl citrate / generics
    Review, Journal:  Methodological Complexities in Quantifying Rates of Fatal Opioid-Related Overdose. (Pubmed Central) -  Jul 3, 2019   
    Epidemiologists can stimulate positive changes in MDI data quality by demonstrating the critical role of data in guiding public health and safety decisions and addressing the challenges of accurate and timely overdose mortality measures with stakeholders. Education, training, and resources specific to drug overdose surveillance and analysis will be essential as the nation's overdose crisis continues to evolve.
  • ||||||||||  sevoflurane / generics
    Clinical, Journal:  Sevoflurane anaesthesia for nasal surgery in a patient with multiple chemical sensitivity. (Pubmed Central) -  Jun 28, 2019   
    Therefore, sevoflurane in these circumstances might be "the ideal anaesthetic". Performing general anaesthesia with sevoflurane as the sole anaesthetic agent, together with a series of environmental measures formed the basis for successful anaesthesia and surgery in our patient with a multiple chemical sensitivity syndrome.
  • ||||||||||  Review, Journal:  Choosing the anesthetic and sedative drugs for supraventricular tachycardia ablations: A focused review. (Pubmed Central) -  Jun 28, 2019   
    Low-dose ketamine has potential use as an adjunctive medication in the EP lab and additional studies would be beneficial. The effects of dexmedetomidine on conduction and arrhythmia inducibility during SVT ablation is not as clear as studies have yielded conflicting results, and may not be the best choice for sedation in this patient population.
  • ||||||||||  fentanyl citrate / generics
    Journal:  Fentanyl and fentanyl-analog involvement in drug-related deaths. (Pubmed Central) -  Jun 28, 2019   
    A serum fentanyl concentration of 0.4-0.6 ng/mL produces adequate analgesia and sedation in neonates. Fentanyl, rapidly emerging FAs, and other illicit drugs in recent years pose a serious health threat even though prescription opioid-related deaths decreased over the same time period.
  • ||||||||||  morphine/oxycodone (Q8011) / QRxPharma, Desoxyn (methamphetamine) / Lundbeck
    Journal:  Drugs Most Frequently Involved in Drug Overdose Deaths: United States, 2011-2016. (Pubmed Central) -  Jun 28, 2019   
    The drugs most frequently mentioned varied by the intent of the drug overdose death. In 2016, the drugs most frequently mentioned in unintentional drug overdose deaths were fentanyl, heroin, and cocaine, while the drugs most frequently mentioned in suicides by drug overdose were oxycodone, diphenhydramine, hydrocodone, and alprazolam.
  • ||||||||||  fentanyl citrate / generics
    Journal:  Drug Overdose Deaths Involving Fentanyl, 2011-2016. (Pubmed Central) -  Jun 28, 2019   
    Numbers and rates increased for all sex, age, and racial and ethnic subgroups, and most public health regions. Adjustment for improved drug reporting over the study period did not change the trend patterns observed.
  • ||||||||||  Desoxyn (methamphetamine) / Lundbeck
    Journal:  The Elephant in the Room: Outbreak of Carfentanil Deaths in Minnesota and the Importance of Multiagency Collaboration. (Pubmed Central) -  Jun 27, 2019   
    ...Several cases were presumptively positive for fentanyl by immunoassay, yet failed to confirm positive for fentanyl...Cointoxicants included ethanol (n=2), methamphetamine (n=3), benzodiazepines (n=3), and cocaine (n=1)...All deaths were certified as accidental acute or mixed carfentanil toxicity. These cases present additional information about carfentanil-related deaths and highlight the importance of collaboration between forensic pathologists and toxicologists.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Identifying the role of group III/IV muscle afferents in the carotid baroreflex control of mean arterial pressure and heart rate during exercise. (Pubmed Central) -  Jun 24, 2019   
    Lumbar intrathecal fentanyl was used to attenuate the central projection of μ-opioid receptor-sensitive group III/IV leg muscle afferent feedback...In contrast, FENT administration reduced the exercise-induced resetting of the operating point for MAP and HR during both EVO (116 ± 10 mmHg to 100 ± 15 mmHg and 93 ± 14 bpm to 82 ± 10 bpm) and VOL (107 ± 13 mmHg to 100 ± 17 mmHg and 89 ± 10 bpm to 72 ± 10 bpm) exercise bouts. Together, these findings document that group III/IV muscle afferent feedback is critical for the resetting of the carotid baroreflex MAP and HR operating points, independent of exercise-induced changes in central command, but not for spontaneous carotid baroreflex responsiveness.
  • ||||||||||  fentanyl citrate / generics, lidocaine topical / generics
    Clinical, Journal:  Survey of flexible bronchoscopy practice in adults in Saudi Arabia. (Pubmed Central) -  Jun 23, 2019   
    Midazolam was used by 62%, fentanyl by 50%, and propofol by 12% of respondents...Safety procedures for bronchoscopists, for example, wearing masks and eye protection, and for patients, for example, availability of anesthetic reversal agents, were not universally applied.  Bronchoscopy is not standardized in Saudi Arabia. National guidelines for the indications and practice of bronchoscopy are required.