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- | Ultane (sevoflurane) / Generic Mfg.
Clinical, Journal: Anesthesia and perioperative challenges for surgical separation of thoraco-omphalopagus twins: case report (Pubmed Central) - Aug 30, 2019
Conjoined twin separation surgery is a challenge, which requires planning and coordination of a multidisciplinary team during all stages.
- | Retrospective data, Review, Journal: The use of intra-articular analgesics to improve outcomes after temporomandibular joint arthrocentesis: a review. (Pubmed Central) - Aug 30, 2019
There is inconclusive evidence in literature on the benefits of using intra-articular analgesics after TMJ arthrocentesis. Well-designed high-quality RCTs with standard protocol studying the effects of intra-articular opioids and NSAIDS after TMJ arthrocentesis would provide stronger evidence on its use.
- || fentanyl citrate / generics
Fentanyl>meperidine>>>morphine (Twitter) - Aug 30, 2019
- ||| fentanyl citrate / generics
Depends. Provided reasonable renal/hepatic function Oral (not obstetrics) tapentadol Oral (obs) tramadol if no other serotonergic agents, oxycodone if SS risk IV PACU: often oxycodone, sometimes fentanyl, sometimes morphine IV ward for loading up (APS): fentanyl IV PCA: morphine (Twitter) - Aug 30, 2019
- | fentanyl citrate / generics
Journal: Effect of intravenous acetaminophen versus fentanyl on postoperative pain after transurethral lithotripsy (Pubmed Central) - Aug 30, 2019
Well-designed high-quality RCTs with standard protocol studying the effects of intra-articular opioids and NSAIDS after TMJ arthrocentesis would provide stronger evidence on its use. This trial indicated that intravenous acetaminophen is as effective as intravenous fentanyl in pain relief after urologic surgeries (transurethral lithotripsy).
- | Chirocaine (levobupivacaine) / Purdue
Clinical, Journal: Effect of posterior quadratus lumborum blockade on the quality of recovery after major gynaecological laparoscopic surgery: A randomized controlled trial. (Pubmed Central) - Aug 30, 2019
...Both groups were administered fentanyl-based intravenous patient-controlled analgesia postoperatively...The intraoperative remifentanil dosage was significantly less in the QLB group...There were no statistically significant differences in secondary outcome variables. Single-shot QLB did not improve the QoR or postoperative pain in patients managed by multimodal analgesia after gynaecological LS.
- | fentanyl citrate / generics
Clinical, Journal: Evaluation of the Intraoperative Perfusion Index for Correlation with Acute Postoperative Pain in Patients Undergoing Laparoscopic Colorectal Cancer Surgery. (Pubmed Central) - Aug 29, 2019
The perfusion index change ratios did not significantly differ between the groups. The intraoperative perfusion index change ratios do not correlate with acute postoperative pain following laparoscopic colorectal cancer surgery.
- |||| fentanyl citrate / generics
Clinical: Anesthesia. Fentanyl up front, hydromorphone at least 15 mi prior to end of case and ideally PO on floor. Morphine for those in recovery and wishing to stay that way bc less euphoric. Never, ever tramadol bc it’s flaming garbage @DavidJuurlink (Twitter) - Aug 29, 2019
- || fentanyl citrate / generics
But IV in pacu...I use fentanyl 😱 (Twitter) - Aug 29, 2019
- | fentanyl citrate / generics
Fentanyl is extremely dangerous. It can kill you in the smallest amount. (Twitter) - Aug 29, 2019
- | fentanyl citrate / generics
Journal: Effect of Local Ropivacaine on Hemodynamic Responses in Craniotomy Patients. (Pubmed Central) - Aug 28, 2019
The intraoperative perfusion index change ratios do not correlate with acute postoperative pain following laparoscopic colorectal cancer surgery. Local anesthetic of 0.05% ropivacaine scalp infiltration is effective in clinical usage of regional anesthesia for producing good quality anesthesia, it seems to be a significant choice for management of optimal hemodynamic profile, providing a better hemodynamic stability during craniotomy.
- ||| fentanyl citrate / generics
I never said that, Im talking about the government manipulating our pain doctors and making them fear arrest if they don’t decrease prescriptions. This has all occurred in America due to the overdose epidemic of heroin and illicit fentanyl users, then blaming Pain pills. (Twitter) - Aug 28, 2019
- |||| fentanyl citrate / generics
Clinical: That’s what I thought. No clue about chronic pain and how we are suffering due to illegal heroin and illicit fentanyl!! #opioidhysteria, #painpatientsaredying (Twitter) - Aug 28, 2019
- | fentanyl citrate / generics
Journal: A 52-year-old man with fentanyl-induced muscle rigidity. (Pubmed Central) - Aug 28, 2019
Local anesthetic of 0.05% ropivacaine scalp infiltration is effective in clinical usage of regional anesthesia for producing good quality anesthesia, it seems to be a significant choice for management of optimal hemodynamic profile, providing a better hemodynamic stability during craniotomy. No abstract available
- fentanyl citrate / generics
019 - What You Need to Know About Treating Patients with PTSD and Substance Use Disorder (Location: 20A) - Aug 28, 2019 - Abstract #USPSYCH2019PSYCH_32;
This session will discuss the epidemiological aspects of opioid overdose epidemic and outline effective pharmacologic and behavioral treatments for opioid use disorder and opioid overdoses. Expert faculty will also discuss improving access to treatment and recovery services and strengthening public health surveillance.
- | fentanyl citrate / generics
Journal: Effect of fentanyl on thermal and mechanical nociceptive thresholds in horses and estimation of anti-nociceptive plasma concentration. (Pubmed Central) - Aug 27, 2019
Fentanyl IV at 10μg/kg produced anti-nociception for 10-30min and fentanyl plasma concentrations of ≥6.1-6.8ng/mL appear necessary to induce thermal anti-nociception. Dose-dependent increased locomotion was the main side effect observed.
- || fentanyl citrate / generics
I’m just wondering if the Bupe train got knocked off course in terms of its oft quoted “cuts death rates by 50% or more” stemming from pre-Fentanyl era data. I mean, does it really cut deaths rates that much when OD deaths rise even in areas with ample MAT access? (Twitter) - Aug 27, 2019
- ||| fentanyl citrate / generics
Maybe what we can say is that fentanyl in the mix makes for a higher overdose risk. I have no other explanation for the overdose crisis that makes sense. It wasn’t doctors overprescribing opioids 10 years ago 🙄. Correct me if you feel this os inaccurate. (Twitter) - Aug 27, 2019
- || Suboxone (buprenorphine/naloxone sublingual film) / Indivior
Ppl using on top of suboxone. Methadone tends to be preferred by those who want to continue to use as it's easier to dose and feel the effect of fentanyl on top. With suboxone, a little harder to do that (but not impossible). We ask what OAT/dosage on entrance. (Twitter) - Aug 27, 2019
- || fentanyl citrate / generics
Administrative diagnosis, right? I have not seen so far a surge of fentanyl alone deaths. One other way to see things maybe that presence of polydrug use and comorbidities reduces the threshold for fentanyl cardio respiratory adverse efffect. (Twitter) - Aug 27, 2019
- ||| fentanyl citrate / generics
Meaning, it’s mostly people who have been using opioids for sometime. I’m not saying fentanyl does not have an additive effect, but it has to be seen within the larger perspective of overdose as a complicated medical event and not simply a dose event. (Twitter) - Aug 27, 2019
- || fentanyl citrate / generics
Even in fentanyl era, most OD appears to be poly substance induced. Fentanyl seems to be adding a monster punch to the polydrug cocktail, meaning it doesn’t take much fentanyl to cause death in a polydrug situation (Twitter) - Aug 27, 2019
- || fentanyl citrate / generics
Also benzo contamination into the heroin/fentanyl supply. https://t.co/URw0Z82Pad (Twitter) - Aug 27, 2019
- ||| fentanyl citrate / generics
Clinical: yeah, that used to be true pre-fentanyl, but it no longer seems to be the case. Also, hard to avoid polydrug use if your heroin is cut w/fentanyl bc that's poly right there! & fent so sleepy people also seek stimulants... so... (Twitter) - Aug 27, 2019
- | fentanyl citrate / generics
Review, Journal: Evidence of Modeling Impact in Development of Policies for Controlling the Opioid Epidemic and Improving Public Health: A Scoping Review. (Pubmed Central) - Aug 27, 2019
While most studies examined the role of prescription opioids and trafficking on this epidemic, the transition of patients from prescription opioid use to nonprescription use including heroin and synthetic opioids such as fentanyl impacts the system significantly and results in an epidemic with quite different characteristics than what it had a decade ago. We recommend including the impact of age and geographic location on the opioid epidemic using modeling methods.
- || fentanyl citrate / generics
WTF! No one knows @AmerMedicalAssn is a REAL @FTC CONVICTED worldwide criminal conglomerate of opium cocaine Fentanyl of drug cartels + Can prescribe REAL CHEMICAL WEAPONS of mass destruction. @US_FDA @DEAHQ @USAGov @USSupremeCourt YOUR & OUR obedience Tacit Complicit Agreements! (Twitter) - Aug 27, 2019
- | fentanyl citrate / generics
Legalize fentanyl (Twitter) - Aug 26, 2019
- Duragesic (fentanyl) / J&J
Continuous measurement of combined oximetry and transcutaneous carbon dioxide in patients with opioid-treated chronic pain in a palliative care setting. (TP-03) - Aug 26, 2019 - Abstract #ERS2019ERS_4202;
It is feasible to continuously monitor ventilation noninvasively using combined SpO2 and TcCO2 to detect hypoventilation in the palliative care setting. Patients with advanced cancer administered opioids in palliative care are at risk of manifesting hypercapnia and hypoxemia.
- fentanyl citrate / generics
Effects of lumbar transcutaneous electrical nerve stimulation (TENS) on endurance capacity in patients with COPD: A randomized double-blind cross-over study (6F) - Aug 26, 2019 - Abstract #ERS2019ERS_3787;
Introduction: Intrathecal administration of fentanyl improves endurance capacity in patients with COPD (Gagnon P. et al, Am J Respir Crit Care Med 2012), through a plausible inhibition of muscle group III/IV sensory afferents... Lumbar TENS does not improve endurance capacity during exercise in patients with COPD but may modulate the quadriceps muscle activity.
- fentanyl citrate / generics
Early Prediction of Extubation Failure in Severe Pneumonia: A Retrospective Cohort Study (TP-02) - Aug 26, 2019 - Abstract #ERS2019ERS_2424;
APACHE II score of 17.5, blood glucose of 9.87mmol/L, and fentanyl average usage of 1.135mg/d resulted in a sensitivity of 62.79%, 41.86% and 37.21%, and a specificity of 69.51%, 71.95% and 85.37%, respectively, in identifying severe pneumonia patients with high risk of extubation failure. Conclusions In patients with severe pneumonia, APACHE II score > 17.5, blood glucose > 9.87mmol/L, fentanyl usage > 1.135mg/d, and the need for RBC transfusion might potentially discriminate the patients with high risk of extubation failure.
- nebulized fentanyl citrate / Boehringer Ingelheim
Impact of nebulized fentanyl on exertional dyspnea in interstitial lung disease (6A) - Aug 26, 2019 - Abstract #ERS2019ERS_1823;
Conclusions : In ILD exertional dyspnea increases in tandem with IND as IRV decreases. Nebulized fentanyl had no effect on dyspnea, IND, dynamic respiratory mechanics or their inter-relationships during exercise.
- fentanyl citrate / generics
Effects of a neuromuscular blocking agent on chest wall mechanics in rats (TP-09) - Aug 26, 2019 - Abstract #ERS2019ERS_839;
Data were collected during iv infusion of fentanyl (3 μg/kg/min) and after iv bolus of pipecuronium (0.2 mg/kg)...Further experiments using this suitable experimental model are needed to assess distinct changes in chest-wall mechanics following administrations of opioids and NMBAs. Grants: OTKA K115253, GINOP-2.3.2-15-2016-00006
- ||| fentanyl citrate / generics
Blaming vaping instead of the street drugs that caused this death is like blaming the syringe instead of fentanyl for an opioid overdose. (Twitter) - Aug 24, 2019
- | Duragesic (fentanyl) / J&J
Journal: Opioid Prescription Use in Nursing Home Residents with Advanced Dementia. (Pubmed Central) - Aug 23, 2019
However, in this population, despite the relatively prevalent use of strong prescription opioids, pain was still prevalent. This emphasizes the challenge of proper pain treatment and need for regular evaluation of pain and pain management.
- || fentanyl citrate / generics
Trump’s drug supply UPS FEDEx shipping strategy does not address China’s unregulated Pharm and Chemical Fentanyl Industry and their Financial backers. Trump’s Trade War, and Tweet Orders undermines the US economy and chances of international drug control policy. #MAGAMadness (Twitter) - Aug 23, 2019
- ||| fentanyl citrate / generics
https://t.co/Q9xDG5GrMI Trump cites "100,000 death from Fentanyl each year" Facts Check CDC: among the 47,600 opioid-related overdose deaths in 2017; 28,400 involved fentanyl analogs. Trade war with China #MAGAMadness (Twitter) - Aug 23, 2019
- | fentanyl citrate / generics
Are you saying prior to today Federal policy was just counting on China to stop the flow of Fentanyl into U.S.? @US_FDA @CBP ??? (Twitter) - Aug 23, 2019
- | fentanyl citrate / generics
Journal: An Unusual Amnestic Syndrome Associated With Combined Fentanyl and Cocaine Use. (Pubmed Central) - Aug 23, 2019
This emphasizes the challenge of proper pain treatment and need for regular evaluation of pain and pain management. No abstract available
- | fentanyl citrate / generics
Journal: An Unusual Amnestic Syndrome Associated With Combined Fentanyl and Cocaine Use. (Pubmed Central) - Aug 23, 2019
No abstract available No abstract available
- | nalbuphine / Endo
Retrospective data, Journal: Postsurgery analgesic and sedative drug use in a French neonatal intensive care unit: A single-center retrospective cohort study. (Pubmed Central) - Aug 22, 2019
Pain assessment should be conducted for all neonates in order to optimize their treatment. Research on analgesic and sedative medicine in vulnerable neonates seems necessary to standardize practices and reduce adverse drug reactions.
- ||| fentanyl citrate / generics
Clinical: it means that theyre taking a clean and safe dosage in a clinical setting, instead of going out on the streets and buying heroin laced with fentanyl and overdosing. its not a matter of saying "toughen up" or being weak. its a physical dependency and should be treated as such (Twitter) - Aug 22, 2019
- | fentanyl citrate / generics
Journal: Molecular dynamics of fentanyl bound to μ-opioid receptor. (Pubmed Central) - Aug 22, 2019
Principal component analysis reveals differences in the trajectories dependent on the ligand bound. The differences found could be linked to ligand-dependent efficacy with respect to receptor intracellular signaling events.
- | Nimotop (nimodipine) / Bayer
Clinical, Journal: The Nimodipine-Sparing Effect of Perioperative Dexmedetomidine Infusion During Aneurysmal Subarachnoid Hemorrhage: A Prospective, Randomized, Controlled Trial. (Pubmed Central) - Aug 22, 2019
The incidence of symptomatic cerebral vasospasm during 7 days after surgery, GOS of 3 months, and cerebral infarction after 30 days were also comparable among the three groups. Dexmedetomidine (infusion at 0.5 µg·kg for 10 min, then adjusted to 0.4 µg·kg·h during the surgery) significantly reduced the total consumption of nimodipine during the first 48 h after surgery and promoted early rehabilitation of patients although the incidences of symptomatic cerebral vasospasm, GOS, and cerebral infarction were not reduced.
- | Journal: Consumption trend and prescription pattern of opioid analgesics in China from 2006 to 2015. (Pubmed Central) - Aug 22, 2019
Consumption of oxycodone had a tendency to increase, whereas pethidine tended to decrease. Consumption of opioids has shown an increasing tendency and in the meantime the prescription pattern has changed, indicating the progress of pain relief in China, though it remained far lower than the average global level.
- Duragesic (fentanyl) / J&J
Trends in the Prehospital Care of ST-Elevation Myocardial Infarction in the United States: Lessons From STEMI EMS Activations in the NEMSIS Database (Zone 4, Science and Technology Hall) - Aug 21, 2019 - Abstract #AHA2019AHA_7345;
This large dataset of prehospital STEMI care shows that STEMI recognition, the low rate of field EKG acquisition, medication use, and overall EMS efficiency all have room for improvement. In particular, better triage by dispatchers, more expeditious recording of EKGs, and wider use of aspirin can optimize STEMI outcomes.
- Desoxyn (methamphetamine) / Lundbeck, Ergamisol (levamisole) / J&J
Impact of Polysubstance Use on Markers of Cardiovascular Disease in Homeless and Unstably Housed Women (Zone 3, Science and Technology Hall) - Aug 21, 2019 - Abstract #AHA2019AHA_5873;
Polysubstance use was associated with elevated markers of cardiac injury, dysfunction, and fibrosis in homeless and unstably housed women, suggesting that the use of these substances may act as a chronic cardiac insult. Consideration of polysubstance use as an additional risk factor for CVD, and the role of drug use in risk stratification merit additional investigation.
- Vycavert (10 mg hydrocodone bitartrate/325 mg acetaminophen) / Acura
Association Between Intravenous Acetaminophen and Opioid Use in Postoperative Management of Patients Following Congenital Heart Defect Repair (Zone 4, Science and Technology Hall) - Aug 21, 2019 - Abstract #AHA2019AHA_5356;
Time to extubation, sedation scores, liver enzymes, and serum total bilirubin levels were similar in both groups. Conclusion Patients with ASD, VSD, or TOF who received IV APAP after heart surgery required statistically significant less morphine in the first 48hrs after surgery than those patients who did not receive IV APAP.
- fentanyl citrate / generics
Influence of Metabolic Demand on Locomotor Group III/IV Afferents Contribution to Ventilatory Control During Exercise in Heart Failure (Zone 2, Science and Technology Hall) - Aug 21, 2019 - Abstract #AHA2019AHA_3324;
Locomotor muscle afferent feedback inhibition reduced the ventilatory response in HFrEF and controls during matched metabolic load exercise. These data suggest locomotor muscle afferent feedback remains a significant contributor to augmented exercise ventilation in HFrEF even when metabolism is controlled.
- | fentanyl citrate / generics
I recommend Fentanyl & Midazolam for colonoscopy #AskGastro (Twitter) - Aug 21, 2019
- ||| fentanyl citrate / generics
Clinical: Clinicians know pts take "diverted" buprenorphine to access a safer option than heroin/fentanyl and pts otherwise can't get treatment or very high threshold. Pt recently told me "I was buying it in my building, I'm so happy that I can take it regularly now and I feel so normal." (Twitter) - Aug 21, 2019