fentanyl citrate / Generic mfg. 
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  • ||||||||||  Ultane (sevoflurane) / Generic Mfg.
    Preclinical, Journal:  Effects of anesthesia on renal function and metabolism in rats assessed by hyperpolarized MRI. (Pubmed Central) -  Sep 20, 2019   
    Inactin and sevoflurane were found to affect the renal hemodynamic and metabolic status to a lesser degree than FFM. Sevoflurane anesthesia is particularly easy to induce and maintain during the whole anesthesia procedure, and as such, represents a good alternative to inaction, although it alters the blood glucose level.
  • ||||||||||  fentanyl citrate / generics, methadone / generics
    Journal:  Utilizing resources of neuropsychopharmacology to address the opioid overdose crisis. (Pubmed Central) -  Sep 20, 2019   
    Although more research on the genetic factors that influence opioid sensitivity is needed, analgesic requirements may be predicted by analyzing ATF2SNPs, together with other polymorphisms of genes that are reportedly associated with opioid sensitivity, such as CREB1, OPRM1, and GIRK2. Hopefully, this crisis will reinvigorate both basic and clinical neuropsychopharmacological research leading to the develop new and more effective options for dealing with the many and varied elements of the current opioid crisis as described in the present commentary.
  • ||||||||||  fentanyl citrate / generics
    Clinical, Journal:  Comparison of Fentanyl and Dexmedetomidine as Intrathecal Adjuvants to Spinal Anaesthesia for Abdominal Hysterectomy. (Pubmed Central) -  Sep 20, 2019   
    Hopefully, this crisis will reinvigorate both basic and clinical neuropsychopharmacological research leading to the develop new and more effective options for dealing with the many and varied elements of the current opioid crisis as described in the present commentary. Dexmedetomidine is better than Fentanyl as an intrathecal adjuvant to spinal anaesthesia in minimizing visceral pain during abdominal hysterectomy and in prolonging post-operative analgesia.
  • ||||||||||  fentanyl citrate / generics
    Journal:  It is time for an ethical, evidence-based approach to youth presenting to the ED with an opioid overdose. (Pubmed Central) -  Sep 19, 2019   
    Currently, there is a dangerous inconsistency between our current understanding of adolescent development and the effects of drugs on cognition when compared to our collective approach to youth who present in the emergency department with an opioid overdose. We call upon practitioners to embrace a new paradigm and we ask the Canadian Pediatric Society (CPS) to spearhead the development of guidelines to advise on best practices to manage youth who present to the emergency department with an illicit drug overdose.
  • ||||||||||  Journal:  β-Fluorofentanyls Are pH-Sensitive Mu Opioid Receptor Agonists. (Pubmed Central) -  Sep 19, 2019   
    We synthesized and tested analogs of fentanyl possessing one or two fluorine atoms at the beta position of the phenethylamine side chain, with additional fluorines optionally added to the benzene ring of the side chain...The novel bis-fluorinated analog RR-49 showed superior pH sensitivity, with full efficacy relative to DAMGO, but with 19-fold higher potency (IC) in a MOR cAMP assay at pH 6.5 versus 7.4. Such compounds hold significant promise as analgesics for inflammatory pain with reduced abuse potential.
  • ||||||||||  Journal:  To what extent do data from pharmaceutical claims under-estimate opioid analgesic utilisation in Australia? (Pubmed Central) -  Sep 18, 2019   
    Despite increased capture of less expensive (under co-payment) opioid items since 2012, PBS/RPBS claims still under-estimate opioid use in Australia, with varying degrees across opioids. The estimates generated in this study allow us to better understand the degree of under-estimation and account for these in research using Australia's national pharmaceutical claims data.
  • ||||||||||  fentanyl citrate / generics
    Review, Journal:  Opioids and the immune system - friend or foe. (Pubmed Central) -  Sep 14, 2019   
    However, the results are inconsistent: Exogenous opioids such as morphine and fentanyl have been found to impair the function of macrophages, natural killer cells and T-cells and to weaken the gut barrier in vitro and in animal studies...In summary, there is a reciprocal interaction between the immune system and endogenous as well as exogenous opioids. In addition to the existing epidemiological studies, controlled clinical studies are necessary in the future to delineate the role of the opioid-immune system interaction in patients and estimate the clinical relevance of it.
  • ||||||||||  fentanyl citrate / generics
    Clinical, Review, Journal:  Influence of opioids on immune function in patients with cancer pain: from bench to bedside. (Pubmed Central) -  Sep 14, 2019   
    Animal models have shown that this is not a class effect, in that morphine and fentanyl suppress NK cell cytotoxicity; buprenorphine does not affect NK cell cytotoxicity, whereas tramadol increases NK cell cytotoxicity, reducing metastasis...Pain is immunosuppressive, so analgesia is important. Opioids for cancer-related pain will continue to be recommended until definitive data on the effects of opioids on clinical outcomes in specific patient groups becomes available.
  • ||||||||||  fentanyl citrate / generics, ketamine / generics, furosemide / generics
    Journal:  Physico-chemical stability of Plasma-Lyte 148 and Plasma-Lyte 148 + 5% Glucose with eight common intravenous medications. (Pubmed Central) -  Sep 14, 2019   
    Morphine, fentanyl, ketamine, salbutamol, aminophylline, and clonidine are stable for 24 hours when mixed with Plasma-Lyte 148® and Plasma-Lyte 148®+5% Glucose for administration at concentrations equivalent to those found at a typical Y-site with maintenance fluid. Furosemide is stable at lower concentrations than those seen at a Y-site, but midazolam displayed instability.
  • ||||||||||  fentanyl citrate / generics
    Clinical, Journal:  Incidence of Long-term Opioid Use Among Opioid-Naive Patients With Hidradenitis Suppurativa in the United States. (Pubmed Central) -  Sep 13, 2019   
    The most frequent schedule II opioid prescriptions included oxycodone hydrochloride (55 of 74 patients [74.3%]), hydrocodone bitartrate (44 [59.5%]), hydromorphone hydrochloride (16 [21.6%]), morphine sulfate (13 [17.6%]), and fentanyl citrate (6 [8.1%])...In this study, patients with HS were at higher risk for long-term opioid use. These results suggest that periodic assessment of pain and screening for long-term opioid use may be warranted, particularly among patients who are older, who smoke tobacco, or who have depression and other medical comorbidities.
  • ||||||||||  fentanyl citrate / generics
    Journal:  Editorial: Advances in Analytical Methods for Drugs of Abuse Testing. (Pubmed Central) -  Sep 10, 2019   
    Propofol TIVA regimen was the more peaceful recovery approach with less perioperative respiratory complications than sevoflurane-based anesthesia in infants undergoing cleft palate repair surgery. No abstract available
  • ||||||||||  naloxone nasal spray / generics
    Journal:  Covalent Poly(lactic acid) Nanoparticles for the Sustained Delivery of Naloxone. (Pubmed Central) -  Sep 10, 2019   
    This protocol afforded well-defined nanoparticles possessing a drug loading of approximately 7% w/w. The resulting Nal-cNPs demonstrated excellent biocompatibility, while exhibiting sustained linear release kinetics in vitro and blocking the effects of high dose (10 mg/kg) acute morphine for up to 98 h in an in vivo rodent model of neuropathic pain.