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- | fentanyl citrate / generics
Synthetic opioid #Isotonitazene - alert for US. This new opioid has potency similar to fentanyl. https://t.co/UX1lpl3nCM @IsaiahHouse @ONDCP @FEDUpRally @jcnjmama @FDA_Drug_Info @kyodcp (Twitter) - Nov 26, 2019
- || Desoxyn (methamphetamine) / Lundbeck
You all must be sitting around trying to figure out a way to get rid of Fentanyl & heroin on the streets. By the way methamphetamines are booming again. Every time you open your mouth you create a black market. Hope you're proud of all the people you're killing. #opioidhysteria (Twitter) - Nov 26, 2019
- | fentanyl citrate / generics
Are they combatting fentanyl by putting embargo’s on your in laws shipping containers? #cocainemitch (Twitter) - Nov 25, 2019
- | fentanyl citrate / generics, methadone / generics
Journal: The role of managed care professionals and pharmacists in combating opioid abuse. (Pubmed Central) - Nov 24, 2019
In addition, the expenses associated with drug use disorders are comparable to the costs of other chronic diseases, such as diabetes. Policymakers, criminal justice officials, and healthcare providers consider illicit drug and opioid misuse a national epidemic that must be addressed more strongly to improve pain management in the United States, optimize patient outcomes, and decrease unlawful drug use for pain relief.
- | Duragesic (fentanyl) / J&J
Journal: Evaluation of soluble fentanyl microneedles for loco-regional Anti-Nociceptive activity. (Pubmed Central) - Nov 24, 2019
Policymakers, criminal justice officials, and healthcare providers consider illicit drug and opioid misuse a national epidemic that must be addressed more strongly to improve pain management in the United States, optimize patient outcomes, and decrease unlawful drug use for pain relief. No abstract available
- fentanyl citrate / generics
Use of ENTONOX (50%N2O + 50%O2) for analgesia in colonoscopy: Randomized controlled study (P2) - Nov 24, 2019 - Abstract #APDW2019APDW_166;
As compared to conscious sedation the incidence of adverse events is significantly lower. To our knowledge this is the first report from India of the use of Entonox for colonoscopy.
- fentanyl citrate / generics
Bronchoscopic intervention before the bronchial tree: Is therapeutic vocal cord polyp excision a possibility in selected patients? () - Nov 24, 2019 - Abstract #NAPCON2019NAPCON_173;
Complete excision of polyps was done with flexible bronchocopic electro -surgery, with local anesthesia and deep sedation (fentanyl and midazolam, propofol as needed). Conclusion/Clinical Implications: 1.
- || fentanyl citrate / generics
Clinical, Journal: The Effect of Nitroglycerine Infusion on Postoperative Pain in Lower Limb Surgery: A Clinical Double-Blind Study. (Pubmed Central) - Nov 24, 2019
Patients were randomly assigned to receive three regimens for postoperative pain control via intravenous analgesia pump, including group A (fentanyl 10mc/kg + 10 mL distilled water), B (fentanyl 10 mc/kg + nitroglycerin 500 mc), and C (fentanyl 10 mc/kg + nitroglycerin 1000 mc)...The HR, MAP, and VAS mean scores showed a significant difference for intragroup and intergroup differences in the three groups at many times. Low dose nitroglycerine, as an adjuvant drug, can be added to intravenous patient-controlled analgesia pump in patients undergoing surgery for better analgesic purposes in patients without underlining disease.
- || fentanyl citrate / generics
Clinical, Journal: Characteristics of false-positive alerts on transcranial motor evoked potential monitoring during pediatric scoliosis and adult spinal deformity surgery: an "anesthetic fade" phenomenon. (Pubmed Central) - Nov 23, 2019
In particular, anesthetic doses were associated with false-positive TcMEP alerts during pediatric scoliosis surgery. The authors believe that false-positive alerts during pediatric scoliosis surgery, in particular, are caused by "anesthetic fade.".
- | fentanyl citrate / generics
Review, Journal: The Fentanyl Epidemic and Evolution of Fentanyl Analogs in the United States and the European Union. (Pubmed Central) - Nov 23, 2019
Fentanyl and FAs have evolved into a global public health threat. It is important to understand the analytical, clinical, and regulatory efforts underway to assist communities affected by the current fentanyl epidemic.
- || Instanyl (fentanyl) / Takeda
Clinical, Journal: Effect of Intranasal Ketamine vs Fentanyl on Pain Reduction for Extremity Injuries in Children: The PRIME Randomized Clinical Trial. (Pubmed Central) - Nov 23, 2019
P3
Ketamine should be considered for pediatric pain management in the emergency setting, especially when opioids are associated with increased risk. ClinicalTrials.gov Identifier: NCT02778880.
- | fentanyl citrate / generics
Journal: Synthesis and μ-Opioid Activity of the Primary Metabolites of Carfentanil. (Pubmed Central) - Nov 23, 2019
Carfentanil is a synthetic opioid significantly more potent than clinically prescribed fentanyl...Three other metabolites showed significant MOR functional activity. The availability of the metabolites could aid improvements in the analysis of biomedical samples obtained from suspected human exposures to carfentanil and development of treatment protocols.
- || fentanyl citrate / generics, ketamine / generics
Clinical, Journal: Variation in Pediatric Procedural Sedations Across Children's Hospital Emergency Departments. (Pubmed Central) - Nov 22, 2019
The availability of the metabolites could aid improvements in the analysis of biomedical samples obtained from suspected human exposures to carfentanil and development of treatment protocols. There is significant variability across pediatric EDs in the use of procedural sedation, suggesting sedations may be performed too often or too little in some hospitals.
- | fentanyl citrate / generics
Journal: Opioid Prescribing Behavior in Long-Term Geriatric Care in the Netherlands. (Pubmed Central) - Nov 22, 2019
Prescribers base their choices almost exclusively on personal experience and are barely influenced by guidelines. Further research should therefore focus on clinical relevance for, and implementation in, daily practice.
- | Duragesic (fentanyl) / J&J
Journal: Trends in Opioid Prescribing and Dispensing by Veterinarians in Pennsylvania. (Pubmed Central) - Nov 22, 2019
The extent to which these data may represent similar volumes of prescriptions from the general veterinary practices and hospitals across the United States is suggested by the accompanying Pennsylvania state data. These findings highlight an opportunity to assess the risk of veterinarian opioid prescriptions to safeguard public health.
- || Subsys (fentanyl sublingual spray) / Insys Therapeutics
Clinical, Review, Journal: The role of rapid onset fentanyl products in the management of breakthrough pain in cancer patients. (Pubmed Central) - Nov 22, 2019
However, the treatment of breakthrough pain should be adjusted to suit specific patient requirements. Nevertheless, particularly in predictable bursts of pain and also in spontaneous episodes of breakthrough pain with slowly intensifying pain, immediate-release formulations of opioids may play an important role.
- | fentanyl citrate / generics
Journal: Changes in serum cortisol and blood glucose concentrations in anesthetized, pain-free dogs administered fentanyl. (Pubmed Central) - Nov 22, 2019
Nevertheless, particularly in predictable bursts of pain and also in spontaneous episodes of breakthrough pain with slowly intensifying pain, immediate-release formulations of opioids may play an important role. Fentanyl, administered at analgesic doses to healthy, pain-free, anesthetized dogs, was not associated with significant changes in serum cortisol or glucose concentrations in the studied population.
- | fentanyl citrate / generics
Journal: Designing Traceable Opioid Material Kits to Improve Laboratory Testing During the U.S. Opioid Overdose Crisis. (Pubmed Central) - Nov 22, 2019
Since 2013, there have been significant increases in overdose deaths involving synthetic opioids - particularly those involving illicitly-manufactured fentanyl...These kits were designed to dramatically increase laboratory capability to confirm which opioids are on the streets and causing deaths. The kits are free to U.S based laboratories in the public, private, clinical, law enforcement, research, and public health domains.
- || dexamethasone / generics
Journal, Adverse drug reaction: Improving Recognition and Reporting of Adverse Drug Reactions in the NICU: A Quality Improvement Project. (Pubmed Central) - Nov 22, 2019
We experienced challenges with consistently identifying patients on target drugs and getting the tool to the bedside. Application of the Du score for ADR classification in neonates appears to be more appropriate than the use of the Naranjo.
- || fentanyl citrate / generics
Clinical, Journal: Ultrasonographic Assessment of Bladder Volumes in Children Undergoing Penile Surgery: Does the Type of Anesthesia Matter? (Pubmed Central) - Nov 21, 2019
None of the anesthetic techniques provoked postoperative urinary retention after minor penile surgery in children. The penile block appears superior to caudal block or to IV fentanyl-based anesthesia with regard to postoperative recovery of normal micturition.
- || gabapentin / Generic Mfg.
Clinical, Journal: Role of Preemptive Gabapentin on Postoperative Analgesia After Infraumbilical Surgeries Under Subarachnoid Block-A Randomized, Placebo-Controlled, Double-Blind Study. (Pubmed Central) - Nov 21, 2019
We found the optimal dose to be 400 mg for gabapentin. However, increasing dose from 400 to 1200 mg does not increase its efficacy as analgesic but with higher adverse effects.
- || fentanyl citrate / generics, remifentanil / generics, methadone / generics
Review, Journal: Opioid-Induced Hyperalgesia in the Nonsurgical Setting: A Systematic Review. (Pubmed Central) - Nov 21, 2019
However, due to conflicting conclusions and various limitations, the clinical impact of OIH could not be assessed. Clinicians should monitor for effects of OIH in the nonoperative setting because there is insufficient evidence from the available literature to conclude that OIH is consistently observed in this setting.
- | fentanyl citrate / generics, lansoprazole / generics
Journal: Oral Feeding Outcome after Analgesic and Sedative Exposure in VLBW Preterm Infant. (Pubmed Central) - Nov 21, 2019
Clinicians should monitor for effects of OIH in the nonoperative setting because there is insufficient evidence from the available literature to conclude that OIH is consistently observed in this setting. Analgesic and sedative exposure in VLBW infants is highly associated with poor oral feeding and need for tube feedings at discharge.
- | fentanyl citrate / generics
Journal: DARK Classics in Chemical Neuroscience: Fentanyl. (Pubmed Central) - Nov 21, 2019
Despite this controversial history, derivatization of fentanyl has resulted in numerous synthetic analogues that provide valuable insights into opioid receptor binding and signaling events. In this review, the impact of fentanyl on chemical neuroscience is shown through its synthesis and properties, manufacturing, metabolism, pharmacology, approved and off-label indications, adverse effects, and the responsibility it has in the opioid epidemic.
- | fentanyl citrate / generics
CDC/DEA use phony combined stats to promote anti-opiod agenda when killer drugs are illicit Fentanyl (& analogs) cocaine meth heroin. @realDonaldTrump @RealCandaceO @VDHanson @US_FDA @HHSGov @cmoHHS @DrNickels @SecAzar @JohnRLottJr @EpochTimes @marklevinshow @benshapiro @FDRLST (Twitter) - Nov 21, 2019
- || fentanyl citrate / generics
Clinical, Review, Journal: A Systematic Review of Caudal Anesthesia and Postoperative Outcomes in Pediatric Cardiac Surgery Patients. (Pubmed Central) - Nov 21, 2019
There are many other anesthetic alternatives to facilitate early extubation. Our review is limited by heterogeneous populations, variable pain measurement scales, and absent definitions of extubation indicators.
- || ondansetron / generics
Clinical, Journal: Parent controled analgesia system in postoperative pain management in patients undergoing lip and cleft palate surgery (Pubmed Central) - Nov 21, 2019
Our review is limited by heterogeneous populations, variable pain measurement scales, and absent definitions of extubation indicators. The PCA system is a safe and risk-free insurance for analgesia of fissured patients with benefits such as: decrease in pain, stay in PICU, the need for analgesia and initiation of early tolerance.
- || pregabalin / generics, ibuprofen / generics
Clinical, Journal: Low-dose preoperative pregabalin improves postoperative pain management in septorhinoplasty surgery: a double-blind randomized clinical trial. (Pubmed Central) - Nov 21, 2019
A single dose of 75 mg pregabalin is very effective for pain control after septorhinoplasty procedure when administered one hour before anesthesia induction. Side effects are rare and opioid sparing was noted.
- || fentanyl citrate / generics
Just fentanyl or do you add Duramorph? (Twitter) - Nov 20, 2019
- || fentanyl citrate / generics
Clinical, Journal: Evaluation of Pain Assessment and Management in Critically Ill Intubated Patients in a Referral University Hospital in Iran. (Pubmed Central) - Nov 20, 2019
The most prescribed analgesic was morphine sulfate (48.3%) followed by fentanyl (23.3%)...Quality of pain assessment and management in our setting is inappropriate and inadequate, which leads to over- or under-use of analgesics. The lack of an established pain protocol may contribute to this situation.
- ||| fentanyl citrate / generics
.@LizSamuels four key harm reduction approaches for the #OpioidCrisis. 1. Naloxone 2. Needle exchange 3. Fentanyl test strips 4. Supervised consumption facilities. No one solution. (Twitter) - Nov 20, 2019
- | fentanyl citrate / generics
Retrospective data, Journal: Prophylactic Intravenous Lidocaine at Different Doses for Fentanyl-Induced Cough (FIC): A Meta-Analysis. (Pubmed Central) - Nov 19, 2019
Fentanyl doses added no significant heterogeneity as shown by meta-regression. The findings of this meta-analysis indicate that prophylactic intravenous lidocaine is effective at preventing FIC in both adults and children.
- | Desoxyn (methamphetamine) / Lundbeck
Journal: Estimating the Number of People Who Inject Drugs in A Rural County in Appalachia. (Pubmed Central) - Nov 19, 2019
Published online ahead of print January 24, 2019: e1-e6. doi:10.2105/AJPH.2018.304873).
- || fentanyl citrate / generics
Clinical, Journal: Breaktrough cancer pain in metastatic prostate adenocarcinoma: a case report. (Pubmed Central) - Nov 19, 2019
Its proper diagnostic framework is important to optimize the treatment. We describe the case of a patient suffering from breaktrough cancer pain treated with sublingual fentanyl.
- | nalbuphine / Endo
Journal: Nalbuphine suppresses breast cancer stem-like properties and epithelial-mesenchymal transition via the AKT-NFκB signaling pathway. (Pubmed Central) - Nov 19, 2019
We describe the case of a patient suffering from breaktrough cancer pain treated with sublingual fentanyl. Our results demonstrate a new role of nalbuphine in inhibiting cancer stem-like properties and EMT in addition to relieving pain, which suggests that nalbuphine may be effective in breast cancer treatment.
- ||| fentanyl citrate / generics, methadone / generics
Clinical: James, this was an initial prospective study where we had better than anticipated results, as such I did not want to change our parameters. Patients were on the entire spectrum of opioids (fentanyl, oxycodone, hydrocodone, methadone, oxymorohone, hydromorphone and others). (Twitter) - Nov 19, 2019
- | fentanyl citrate / generics
Clinical, Review, Journal: Intranasal therapy with opioids for children and adolescents with cancer: results from clinical studies. (Pubmed Central) - Nov 19, 2019
Fentanyl is a lipophilic opioid commonly proposed for intranasal use among pediatric patients, but no studies have been conducted yet about intranasal use of other available opioids for management of pediatric cancer pain. In this review, we analyze several elements which may influence absorption of intranasal opioids in children and adolescents, with a focus on pharmacokinetics and therapeutic aspects of each opioid currently available for intranasal use.
- || fentanyl citrate / generics
Clinical, Journal: Long-term tracking of opioid consumption in two United States cities using wastewater-based epidemiology approach. (Pubmed Central) - Nov 19, 2019
Anticipated overdoses and overdose-deaths calculated from analyte concentrations in wastewater forecasted 200 opioid-related overdoses/year and 39 opioid related overdose-deaths/year across the two cities during the year 2016, which aligned well with observed coroner-reported opioid deaths. This long-term U.S. screening study of opioids in wastewater was the first to utilize wastewater epidemiological data to estimate the number of expected overdose and overdose-deaths, and to identify detectable levels of the powerful synthetic opioid fentanyl in community wastewater consistently over the course of one whole year.
- | fentanyl citrate / generics
Journal: Comparison between the Effects of Dexmedetomidine and Midazolam on Postoperative Cognitive Impairment after Coronary Artery Bypasses Graft Surgery: A Randomized Clinical Trial. (Pubmed Central) - Nov 18, 2019
Both groups were given fentanyl and propofol for the induction of anesthesia and muscle relaxants...Additionally, the MMSE results were not statistically different between the 2 groups postoperatively (24.80±3.18 vs. 23.55±4.18, respectively; P=0.394). Our results showed that dexmedetomidine might have a lower impact on cognitive function than might midazolam among patients undergoing CABG.
- | methadone / generics
Journal: Postoperative Pain and Analgesic Requirements in the First Year after Intraoperative Methadone for Complex Spine and Cardiac Surgery. (Pubmed Central) - Nov 18, 2019
Our results showed that dexmedetomidine might have a lower impact on cognitive function than might midazolam among patients undergoing CABG. Analgesic benefits of a single dose of intraoperative methadone were observed during the first 3 months after spinal surgery (but not at 6 and 12 months), and during the first month after cardiac surgery, when the intensity and frequency of pain were the greatest.
- ||| fentanyl citrate / generics
Clinical: The DEA is using PM docs and patients as scapegoats to blame the opioid crisis on despite the growing amount of evidence to the contrary. Need to distract from the fact that they created the crisis and are failing to deal with heroin and fentanyl/analogues. (Twitter) - Nov 16, 2019
- | fentanyl citrate / generics
Fentanyl? 😂 (Twitter) - Nov 15, 2019
- || fentanyl citrate / generics
#TIME So far, the Fentanyl/Oxygen arm is leading to better improvements in Borg Dyspnea scale scores while the bronchodilator lead to better improvement in Tidal volume and ventilation (Twitter) - Nov 15, 2019
- ||| nebulized fentanyl citrate / Boehringer Ingelheim
#TIME Nebulized Fentanyl and Oxygen being given experimentally to see if it can decrease the ventilatory drive while a combination long acting beta-agonist/antimuscarinic age will increase ventilatory output. Study being done in an RCT of 17 participants with COPD (Twitter) - Nov 15, 2019
- fentanyl citrate / generics
Long-term follow-up of people who use drugs (PWUD) following HCV infection therapy: drug use patterns among HIV co-infected versus mono-infected patients (Exhibition hall) - Nov 15, 2019 - Abstract #EACS2019EACS_1916;
In our analysis, co-infected patients used significantly more illicit drugs, but within the context of engagement in our care program, this did not affect long-term health outcomes. HIV co-infection should not be a factor to limit access to HCV treatment.
- fentanyl citrate / generics
Long-term follow-up of people who use drugs (PWUD) following HCV infection therapy: drug use patterns among HIV co-infected versus mono-infected patients (Exhibition hall) - Nov 15, 2019 - Abstract #EACS2019EACS_1106;
In our analysis, co-infected patients used significantly more illicit drugs, but within the context of engagement in our care program, this did not affect long-term health outcomes. HIV co-infection should not be a factor to limit access to HCV treatment.
- fentanyl citrate / generics
Long-term follow-up of people who use drugs (PWUD) following HCV infection therapy: drug use patterns among HIV co-infected versus mono-infected patients (Exhibition hall) - Nov 15, 2019 - Abstract #EACS2019EACS_641;
In our analysis, co-infected patients used significantly more illicit drugs, but within the context of engagement in our care program, this did not affect long-term health outcomes. HIV co-infection should not be a factor to limit access to HCV treatment.
- | Preclinical, Journal: A Kappa Opioid Receptor Agonist Blocks Bone Cancer Pain Without Altering Bone Loss, Tumor Size, or Cancer Cell Proliferation in a Mouse Model of Cancer-Induced Bone Pain. (Pubmed Central) - Nov 15, 2019
Cancer-induced bone pain (CIBP) is characterized as moderate to severe ongoing pain, primarily managed by mu opioid agonists such as fentanyl...Follow-up studies in human cancer cell lines confirmed that KOR agonists do not affect cancer cell proliferation. These studies suggest that KOR agonists could be a new target for cancer pain management that does not induce cancer cell proliferation or alter bone loss.
- || dexamethasone / generics
Clinical, Journal: Additional benefit of local infiltration of analgesia to femoral nerve block in total knee arthroplasty: double-blind randomized control study. (Pubmed Central) - Nov 14, 2019
The addition of local infiltration of analgesia to femoral nerve block promoted post-operative pain relief and the recovery of knee ROM in the early post-operative period. This combination is an effective method for post-operative pain management after TKA.
- | fentanyl citrate / generics
Retrospective data, Journal: The Outbreak of Fentanyl-Related Deaths in Cook County, Illinois, Between October 2015 and December 2017: A Retrospective Study and a Comparison with Previous Data. (Pubmed Central) - Nov 14, 2019
Within our population, some drug combinations were more common in specific demographic subgroups (male/females; Caucasian/African American; and certain age groups). The epidemiology and the most significant drug associations found at the toxicology are discussed, highlighting the usefulness of the knowledge about this outbreak for public health.