fentanyl citrate / Generic mfg. 
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  • ||||||||||  fentanyl citrate / Generic mfg.
    Clinical, PK/PD data, Journal:  Dosing of Continuous Fentanyl Infusions in Obese Children: A Population Pharmacokinetic Analysis. (Pubmed Central) -  Dec 11, 2019   
    Use of an allometric relationship between weight and clearance was appropriate for describing the PK of intravenous fentanyl in our cohort of predominately obese children. Our proposed model-derived continuous infusion strategy maximized the probability of achieving target C in children of varying weights.
  • ||||||||||  Acular (ketorolac ophthalmic) / Allergan, Grunenthal, Omidria (phenylephrine and ketorolac injection) / Omeros
    Journal:  Effect Of Intracameral Phenylephrine And Ketorolac 1.0%/0.3% On Intraoperative Pain And Opioid Use During Cataract Surgery. (Pubmed Central) -  Dec 8, 2019   
    Sixty patients at a single center underwent femtosecond laser (FLACS) or conventional phacoemulsification under topical lidocaine gel anesthesia and intracameral preservative-free lidocaine 1%...For the composite endpoint, patients receiving phenylephrine and ketorolac 1.0%/0.3% were 94% less likely to require fentanyl or to have moderate-to-severe pain (pain VAS ≥ 4; OR, 0.06; 95% CI 0.02-0.24) than patients receiving epinephrine. Our results suggest that the routine use of intracameral phenylephrine and ketorolac 1.0%/0.3% during cataract surgery can significantly reduce patient pain as well as the need for opioids.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Clinical, Journal:  Perioperative management of adult cadaveric and live donor renal transplantation in the UK: a survey of national practice. (Pubmed Central) -  Dec 8, 2019   
    In all, 12 (54.5%) centres perform transversus abdominis plane blocks with fentanyl-based patient-controlled analgesia as the most common mode of postoperative analgesia...This questionnaire highlighted a high degree of heterogeneity in current UK practice as regards the perioperative management of renal transplant recipients. Development of evidence-based national consensus guidelines to standardize the perioperative care of these patients is recommended in order to improve patient outcomes and focus areas of future research.
  • ||||||||||  fentanyl citrate / generics
    Journal:  Factors Associated with Nonfatal Overdose During a Public Health Emergency. (Pubmed Central) -  Dec 6, 2019   
    Fentanyl injection and public injection were associated with an increased likelihood of non-fatal overdose. These findings underscore the need for drug checking, safer sources of opioids and safer injecting interventions as part of overdose prevention strategies.
  • ||||||||||  fentanyl citrate / generics
    Journal:  Neuraxial anesthesia for postpartum tubal ligation at an academic medical center. (Pubmed Central) -  Nov 29, 2019   
    Patient height, epidural volume of local anesthetic and administered fentanyl dose were lower in the group that failed reactivation...Our success rates for both spinal anesthesia and epidural reactivation for PPTL were lower than the generally accepted rates of successful epidural and spinal anesthesia for cesarean delivery. This gap may reflect a lower level of motivation on behalf of both the patients and anesthesia providers to tolerate "imperfect" neuraxial anesthesia once fetal considerations are removed.
  • ||||||||||  fentanyl citrate / generics
    Clinical, Review, Journal:  A Brief Overview of Identification and Management of Opiate Use Disorder in the Primary Care Setting. (Pubmed Central) -  Nov 29, 2019   
    Our results strongly indicate that postmortem blood concentrations of fentanyl after transdermal application should be interpreted carefully. This article offers a brief review geared toward primary care providers of the most critical aspects of the management of opiate use disorder, including screening, brief intervention, and referral to treatment as well as medication-assisted treatment and the alarming trends and dangers of illicitly produced fentanyl.
  • ||||||||||  pregabalin / generics
    Clinical, Journal:  Pre-emptive multimodal analgesic regimen reduces post-operative epidural demand boluses in traumatic shaft of femur fracture - A randomised controlled trial. (Pubmed Central) -  Nov 29, 2019   
    Patients received either (Preemptive multimodal group) intravenous acetaminophen 1 gm, diclofenac 75 mg, morphine 3 mg, 75 mg Pregabalin (per oral) or a placebo 30 minutes pre-operatively...Post-operatively, patients received patient-controlled epidural analgesia (PCEA) programmed to deliver a bolus of 5 ml of 0.2% Ropivacaine with 2 μg/ml of Fentanyl with lockout interval time of 15 min...Time to first rescue epidural bolus was significantly greater in preemptive multimodal group than placebo group. The use of preemptive MMA regimen reduced the requirement of demand epidural bolus doses.
  • ||||||||||  fentanyl citrate / generics
    Journal:  Fatigue-related group III/IV muscle afferent feedback facilitates intracortical inhibition during locomotor exercise. (Pubmed Central) -  Nov 28, 2019   
    Both under control conditions (CTRL) and with lumbar intrathecal fentanyl (FENT) impairing feedback from group III/IV leg muscle afferents, subjects (n = 11) cycled at a comparable vastus-lateralis EMG signal (∼0.26 mV) before (PRE; 100 W) and immediately after (POST; 90 ± 2 W) fatiguing constant-load cycling exercise (80% Wpeak; 221 ± 10 W; ∼8 min)...These findings reveal that feedback from group III/IV muscle afferents innervating locomotor muscle decreases the excitability of the motor cortex during fatiguing cycling exercise. This impairment is, at least in part, determined by the facilitating effect of these sensory neurons on inhibitory GABAB intracortical interneurons.
  • ||||||||||  Journal:  Long noncoding RNA MALAT1 downregulates cardiac transient outward potassium current by regulating miR-200c/HMGB1 pathway. (Pubmed Central) -  Nov 28, 2019   
    The lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is reported to be highly expressed in myocardial ischemia-reperfusion injury and offsets cardioprotective effects of fentanyl...In addition, cardiac Ito, peak current density, and the levels of Kv4.2 and Kv4.3 in arrhythmic model rats were detected to be negatively correlated with the expression of HMGB1, and to be positively with miR-200c expression. Taken together, these results suggested that MALAT1 may act as a competing endogenous RNA for miR-200c to upregulate the expression of HMGB1 and downregulate cardiac Ito.
  • ||||||||||  Duragesic (fentanyl) / J&J
    Journal:  Sex-by-formulation interaction in bioequivalence trials with transdermal patches. (Pubmed Central) -  Nov 27, 2019   
    The sex-by-formulation interaction detected in some pharmacokinetic parameters of some studies is excluded when the study is repeated, which shows that these results are not reproducible. There is no evidence to require bioequivalence demonstration for transdermal patches in males and females separately.
  • ||||||||||  Subsys (fentanyl sublingual spray) / Insys Therapeutics
    Journal:  Association of a Risk Evaluation and Mitigation Strategy Program With Transmucosal Fentanyl Prescribing. (Pubmed Central) -  Nov 27, 2019   
    Implementation of the TIRF-REMS Access Program, a restrictive drug distribution program, was associated with a temporary reduction in the rate of TIRF prescribing to Medicare Part D beneficiaries, and with a sustained decrease in the percentage of TIRF prescriptions for patients without known opioid tolerance. Implementation may have also been associated with a temporary decrease in the percentage of TIRF prescriptions for patients without cancer.