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- || fentanyl citrate / Generic mfg.
Clinical, Journal: The effect of labor medications on normal newborn behavior in the first hour after birth: A prospective cohort study. (Pubmed Central) - Dec 23, 2019
Intrapartum exposure to the drugs fentanyl and synOT is associated with altered newborn infant behavior, including suckling, while in skin-to-skin contact with mother during the first hour after birth. Widström's 9 Stages offer an opportunity to analyze newborn behavior whilst in the optimal habitat of the infant.
- || fentanyl citrate / Generic mfg., ketamine / Generic mfg.
Clinical, Journal: Practice of anesthesia in african environment: experience of the hospitals of Conakry, Guinea. (Pubmed Central) - Dec 23, 2019
The mortality rate was 0.4 %. Better technical platforms and better training of young practitioners would improve the practice of anesthesia in Guinea.
- ||| Duragesic (fentanyl) / J&J
Clinical, Journal, Adverse events: Analyses of Respiratory Depression Associated with Opioids in Cancer Patients Based on the Japanese Adverse Drug Event Report Database. (Pubmed Central) - Dec 23, 2019
The median time-to-onset of oral morphine, oral oxycodone and transdermal fentanyl was 5.5, 11 and 12.5 d, respectively, and almost 50% of cases were reported within 30 d. Taken together, our results suggest that it is important to monitor patients carefully for at least the first one week to one month, even if opioids are administered at a relatively low dose, especially in elderly patients administered morphine.
- | fentanyl citrate / Generic mfg.
Journal: Quantitative Measurements of Codeine and Fentanyl on a Surface-Enhanced Raman-Active Pad Test. (Pubmed Central) - Dec 23, 2019
The calculated limit of detection for this measurement was 40 pg. This data strongly suggests that these pads, used with portable Raman analyzers, would be invaluable to airport security, drug raids, crime scenes, and forensic analysis.
- | Journal: Increasing heroin, cocaine, and buprenorphine arrests reported to the Maine Diversion Alert Program. (Pubmed Central) - Dec 23, 2019
Buprenorphine, fentanyl and crack/cocaine arrests increased appreciably suggesting that improved treatment is needed to prevent further nonmedical use and overdoses. The Diversion Alert Program provided a unique data source for research, a harm-reduction tool for health care providers, and an informational resource for law enforcement.
- || Decadron (dexamethasone) / Merck (MSD), ondansetron / Generic mfg.
Clinical, Journal: How Pediatric Anesthesiologists Manage Children with OSA Undergoing Tonsillectomy. (Pubmed Central) - Dec 22, 2019
68.2% used fentanyl intraoperatively, while 20.0% used morphine...98.2% used ondansetron, 62.7% used IV acetaminophen, and 8.2% used IV NSAIDs...Apart from using intraoperative dexamethasone and ondansetron, management varied. These children would likely benefit from best practices perioperative management guidelines.
- || fentanyl citrate / Generic mfg., methadone / Generic mfg.
Clinical, Journal: Analysis of 207,543 children with acute opioid poisonings from the United States National Poison Data System. (Pubmed Central) - Dec 22, 2019
Fentanyl (OR 12, CI 9.2-15.7), heroin (OR 11.1, CI 9.4-13.1), and methadone (OR 15, CI 13-17.3) were the opioids most associated with having a PICU procedure.Discussion and The severity of admissions for acute opioid ingestions, especially following attempted suicide, has increased over the studied time frame. Efforts focused on reducing access, especially to synthetic and illicit opioids, and addressing adolescent suicidality are needed to reduce these serious consequences of the opioid epidemic on children in the United States.
- ||| fentanyl citrate / Generic mfg.
Fentanyl works about as well as tylenol for me. Dilaudid breaks through the pain. (Twitter) - Dec 22, 2019
- || fentanyl citrate / Generic mfg.
My experience with Fentanyl was horrible. I never got good relief and spent a lot of $$. I was switched and it worked out. On the other hand, others do quite well on Fentanyl. Again amazing! (Twitter) - Dec 22, 2019
- |||| fentanyl citrate / Generic mfg.
My doctor prescribed me fentanyl as it was being marketed for people in chronic pain that were “opioid tolerant “ by Cephalon. It worked wonders. I also found out they paid my doctor over $100k. Is being paid by a pharmaceutical company a bad thing or business as usual? (Twitter) - Dec 22, 2019
- | fentanyl citrate / Generic mfg.
Hidden Fentanyl Prompts Call for Routine Screening in EDs https://t.co/YmmmIS2wgP via @medscape (Twitter) - Dec 22, 2019
- || fentanyl citrate / Generic mfg.
I ended out with dentures, that never fit right. I spent $13,000 on dental work and dentures. BUT...it worked. I could work and socialize. I now isolate myself because I can’t keep up. There are 4 others I know w/same issue. They would all take fentanyl again. (Twitter) - Dec 21, 2019
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Impact of Dexmedetomidine on Pediatric Agitation in the Postanesthesia Care Unit. (Pubmed Central) - Dec 21, 2019
Efforts focused on reducing access, especially to synthetic and illicit opioids, and addressing adolescent suicidality are needed to reduce these serious consequences of the opioid epidemic on children in the United States. Low-dose DEX could significantly reduce the delirium and agitation in the PACU stage of pediatric tonsillectomy, and there were no untoward hemodynamic events in this study of 80 patients.
- | fentanyl citrate / Generic mfg.
Journal: Fentanyl related overdose in Indianapolis: Estimating trends using multilevel Bayesian models. (Pubmed Central) - Dec 21, 2019
Policy and program responses must focus on education for those at highest risk of fentanyl exposure and death. These responses should also be tailored to meet the unique needs of high-risk demographics.
- | fentanyl citrate / Generic mfg.
Journal: Human Factors Results for Fentanyl Iontophoretic Transdermal System (ITS) With Enhanced Controller for Postoperative Pain Management. (Pubmed Central) - Dec 21, 2019
These responses should also be tailored to meet the unique needs of high-risk demographics. Patients, nurses, and pharmacists were able to use fentanyl ITS with ease.
- | fentanyl citrate / Generic mfg.
Journal: Gendered violence & overdose prevention sites: A rapid ethnographic study during an overdose epidemic in Vancouver, Canada. (Pubmed Central) - Dec 21, 2019
Patients, nurses, and pharmacists were able to use fentanyl ITS with ease. Although women who use drugs in Vancouver, Canada appear to feel that Overdose Prevention Sites (OPS) address forms of everyday violence made worse by the overdose epidemic, OPS remain 'masculine spaces' that can jeopardize women's access.
- | fentanyl citrate / Generic mfg., morphine/oxycodone (Q8011) / QRxPharma
Review, Journal: Respiratory depression and brain hypoxia induced by opioid drugs: morphine, oxycodone, heroin, and fentanyl. (Pubmed Central) - Dec 20, 2019
These data allowed us to compare the effects of these drugs on brain oxygen in terms of their potency, time-course, and their potential danger when used at high doses via rapid-onset administration routes. While most data discussed in this work were obtained in rats, we believe that these data have clear human relevance in addressing the alarming rise in lethality associated with the opioid abuse.
- || fentanyl citrate / Generic mfg.
Krantom and FENTANYL Combo? #cdcLIES (Twitter) - Dec 20, 2019
- |||| fentanyl citrate / Generic mfg.
Clinical: See Exhibit A on government using any means necessary to ban it: "... 65% of people with fatal overdoses in which kratom was involved had also taken the often deadly opioid fentanyl, the CDC team said, while heroin was in the mix in about 33% of cases." https://t.co/N2ilNy2u22 (Twitter) - Dec 20, 2019
- | fentanyl citrate / Generic mfg., nalbuphine / Endo, methadone / Generic mfg.
Preclinical, Journal: Role of Agonist Efficacy in Exposure-Induced Enhancement of Mu Opioid Reward in Rats. (Pubmed Central) - Dec 20, 2019
Repeated treatment with CP55940 and amphetamine produced different effects. Collectively, these results provide evidence to suggest that enhanced expression of opioid reward after initial regimens of opioid exposure has a low requirement for MOR agonist efficacy and is pharmacologically selective.
- | fentanyl citrate / Generic mfg.
Journal: Opioid-like antinociceptive and locomotor effects of emerging fentanyl-related substances. (Pubmed Central) - Dec 20, 2019
Naltrexone (1 mg/kg) increased antinociceptive ED values several fold in decreasing magnitudes of isobutyrylfentanyl (233x) > para-methoxybutyrylfentanyl (37.7x) > thiophenefentanyl (34.6x) > valerylfentanyl (11.9x) > para-fluorobutyrylfentanyl (10.9x) > benzodioxolefentanyl (8.42x) > crotonylfentanyl (6.27x) > fentanyl (3.95x) > morphine (1.48x). These findings establish that locomotor and antinociceptive effects of several fentanyl-related substances are similar to those of morphine and fentanyl and are mediated by opioid receptors.
- || fentanyl citrate / Generic mfg., remifentanil / Generic mfg.
Clinical, Journal: Total Intravenous Anesthesia in GLUT1 Deficiency Syndrome Patient: A Case Report. (Pubmed Central) - Dec 20, 2019
Our case highlights that TIVA, with the outlined medication used in this case, was safe when the patient's ketotic state and periprocedural blood glucose was monitored continuously. Nevertheless, we would suggest using remifentanil instead of fentanyl for future TIVAs due to a reduced increase in blood glucose level in our patient.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Application of a validated UHPLC-MS/MS method for 28 fentanyl-analogue and novel synthetic opioids in whole blood in authentic forensic cases. (Pubmed Central) - Dec 20, 2019
Moreover, the method was applied to the detection and quantification of fentanyl and its analogues in whole blood from real forensic cases. This methodology has great potential for use in the determination of fentanyl and its analogues in forensic cases.
- || fentanyl citrate / Generic mfg.
A couple of other legal efforts I want to be sure to highlight. First, more on the FOIA front, we supported investigators at Hopkins, including @drJoshS, to obtain information on FDA's program to regulate fentanyl, enabling this study 1/x https://t.co/mjwKn9mGKO (Twitter) - Dec 19, 2019
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Post-operative pain and morbidity in children who have tooth extractions under general anaesthesia: a service evaluation. (Pubmed Central) - Dec 19, 2019
Use of IV paracetamol and fentanyl reduced the immediate post-operative self-reported pain. After a week most families (99%) were satisfied with the treatment their child had received and morbidity was reported by 11% of families.
- | fentanyl citrate / Generic mfg.
Journal: Hyperpolarization of Pyridyl Fentalogues by Signal Amplification By Reversible Exchange (SABRE). (Pubmed Central) - Dec 19, 2019
Fentanyl, also known as 'jackpot', is a synthetic opiate that is 50-100 times more potent than morphine...The fentalogue possessing the ratio closest to unity produced the largest enhancement subsequent to performing SABRE at earth's magnetic field. It was possible to hyperpolarize a pyridyl fentalogue selectively from a matrix that consisted largely of heroin (97 : 3 heroin:fentalogue) to validate the use of SABRE as a forensic tool.
- ||| fentanyl citrate / Generic mfg.
Clinical: ... and don’t need narcs. Today’s OD problem has little to do with these patients, and the ‘studies’ are not rigorous enough to differentiate between all the subsets, but as a first step Fentanyl cases need to be studied separately. This is a complex subject and a simple grid ... (Twitter) - Dec 18, 2019
- || fentanyl citrate / Generic mfg.
... treatment program in 1967. Those addicts under treatment weren’t given a week of Percocet and became addicted. They were heroine addicts. When they OD they used street drugs and many died. The problem today is completely different. Fentanyl, Fentanyl, Fentanyl. The End. (Twitter) - Dec 18, 2019
- || fentanyl citrate / Generic mfg.
They know Rx opioids have little to do with ODs. But they have to look like they’re trying, and they won’t do the things that might actually work: harm rejection and legalization (we’re past the decrim point; dealers would still use fentanyl). It’s political theater. (Twitter) - Dec 18, 2019
- ||| fentanyl citrate / Generic mfg.
My personal opinion here is that the bureaucrats making the rules See OD rates that include heroin & fentanyl of unknown purity and strength. These tainted numbers are used to make the rules. 4-5 years ago, the fed declared ADD/ADHD as over diagnosed and limited the supply (1/2) (Twitter) - Dec 18, 2019
- || fentanyl citrate / Generic mfg.
... would help solve the problem when any decent evaluation would have shown that Fentanyl, and really a subset, illegal Fentanyl and analogues which are the problem. I’ve been retired for a long time, but ppl can’t have gotten so sloppy. It has to be intentional. (Twitter) - Dec 18, 2019
- || fentanyl citrate / Generic mfg.
Norwegian fentanyl anyone? (Twitter) - Dec 17, 2019
- | fentanyl citrate / Generic mfg.
Hidden Fentanyl Prompts Call for Routine Screening in EDs https://t.co/4cIEopGagq via @medscape (Twitter) - Dec 17, 2019
- ||| fentanyl citrate / Generic mfg.
Clinical: That’s old school.. years ago fear of disinhibition while seating needle. I let pts use. Or give them IV fentanyl if they are really distressed. No need for anyone to suffer. (Twitter) - Dec 16, 2019
- ||| fentanyl citrate / Generic mfg., gabapentin / Generic mfg.
I was on 375 ug fentanyl gabapentin /LA hydromorphone for many years with zero prob. Never sedated. Constipation handled with nutrition and restoralax. It was the only way I could do any ADL.I am only alive today because of help with pain control via opiates over those yrs. (Twitter) - Dec 16, 2019
- || Emestop (ramosetron hydrochloride) / Samyang Group
Clinical, Journal: Dose-Ranging Study of Ramosetron for the Prevention of Nausea and Vomiting after Laparoscopic Gynecological Surgery: A Prospective Randomized Study. (Pubmed Central) - Dec 15, 2019
Compared to the R0.3 group, the R0.45 and R0.6 groups had lower incidence of premature discontinuation of fentanyl-based patient-controlled analgesia primarily because of intractable PONV (9% and 5% vs. 24%; p = 0.038), and higher satisfaction scores (3.4 ± 0.8 and 3.3 ± 0.7 vs. 2.4 ± 0.9; p = 0.005). Compared to ramosetron 0.3 mg, ramosetron 0.45 and 0.6 mg did not reduce PONV, but reduced premature discontinuation of patient-controlled analgesia and increased patient satisfaction, without increasing adverse events.
- || fentanyl citrate / Generic mfg., Ultane (sevoflurane) / Generic mfg.
Clinical, Journal: Intraoperative Dexmedetomidine Maintains Hemodynamic Stability and Hastens Postoperative Recovery in Patients Undergoing Transsphenoidal Pituitary Surgery. (Pubmed Central) - Dec 15, 2019
Results In both the groups, an increase in heart rate and blood pressure occurred at the time of laryngoscopy and intubation, NS insertion, and extubation, but it was more in Group C ( p < 0.05). In Group D, intraoperative requirement of analgesic, neuromuscular relaxant, and inhalational anesthetic was lesser compared with Group C. Emergence time as well as visual analog scale at emergence was less in Group D. Conclusions Intraoperative Dex infusion is a reasonable choice in patients undergoing transsphenoidal pituitary surgery.
- || pregabalin / Generic mfg.
Clinical, Journal: Effect of Pregabalin on Postcraniotomy Pain in Patients Undergoing Supratentorial Tumor Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial. (Pubmed Central) - Dec 15, 2019
However, postoperative fentanyl requirement over 24 hours was least in the group that received 150 mg pregabalin (Group A-190 μg, Group B-240 μg, and Group C-100 μg; p = 0.03). Conclusions Even though pain scores were not significantly different, patients receiving 150 mg oral pregabalin required the least amount of postoperative opioids.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Sequence of same-day upper and lower gastrointestinal endoscopy does not affect total procedure' time or medication use: A randomized trial. (Pubmed Central) - Dec 15, 2019
Comparing U-L and L-U sequences, mean total procedure time was 41.9 (16.2) versus 43.0 (14.5) min (P = 0.73), diphenhydramine dose 5.5 (15.4) versus 4.5 (14.0) mg (P = 0.74), fentanyl dose 71.5 (119.3) versus 77.6 (164.02) μg (P = 0.83), midazolam dose 1.6 (2.5) versus 1.4 (2.7) mg (P = 0.69), and propofol dose 437.4 (351.4) versus 444.5 (256.0) mg (P = 0.91), respectively...The sequence of same-day double gastrointestinal endoscopy does not affect total procedure time or medication use. Longer total procedure and upper endoscopy times were associated with trainee presence and use of conscious sedation.
- |||| fentanyl citrate / Generic mfg.
Clinical: Not likely. Pharmaceutical pain meds are being denied to HOSPICE patients. Most heroin now is being cut with illicit fentanyl. (Twitter) - Dec 14, 2019
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Cough Suppression during Flexible Bronchoscopy Using Transcutaneous Electric Acupoint Stimulation: A Randomized Controlled Study. (Pubmed Central) - Dec 14, 2019
Compared with the controls, patients who received TEAS preconditioning had lower cough scores (P=0.0027) and requirement of lidocaine and fentanyl (P < 0.05) and significantly higher postprocedural plasma β-endorphin levels (P=0.0367)...The combination of midazolam and TEAS was superior to midazolam alone for cough suppression during FB, probably due to increased plasma β-endorphin levels. This trial is registered with ChiCTR1800016612 at chictr.org.cn/index.aspx.
- |||| fentanyl citrate / Generic mfg.
Clinical: So true....I see people describing some interesting mixtures of IV medications in an attempt to avoid 100mcg of fentanyl in their anesthetic plan. What are the unintended synergistic effects? What would I want If I were the patient? (Twitter) - Dec 13, 2019
- |||| fentanyl citrate / Generic mfg.
Clinical: It’s better for heroin addicts to use unregulated heroin and fentanyl, that way they’ll die sooner from aids, hepatitis or OD. And in keeping with his Scrooge theme “decrease the surplus population.” (Twitter) - Dec 13, 2019
- ||| fentanyl citrate / Generic mfg.
I thought harm reduction was of paramount concern to docs. Not taking opioids has consequences for #CPP. Prescription #opioids are safe with low addiction rates. Certainly actual prescription opioid pills are safer than street heroin and fentanyl. (Twitter) - Dec 13, 2019
- || fentanyl citrate / Generic mfg.
Heck the illicitly made pills on the street look exactly like pills from the manufacturers. Looking at them, I cannot tell the different. Even the coloring is spot on. The blue 30mg Roxy seems to be a favorite for fentanyl pressed pill makers. (Twitter) - Dec 13, 2019
- || fentanyl citrate / Generic mfg.
Recent studies and agency acknowledgements do not indicate that addicts, DEA, or CDC know what "pill" addicts are getting in the first place, so it is kind of a moot point. Most street pills are diverted, not prescribed, and often polydrug too (oxy+fentanyl combo pills, etc.) (Twitter) - Dec 13, 2019
- |||| fentanyl citrate / Generic mfg.
Clinical: "Opioid deficiency" is meant to ridicule us. They know we mean lack of effective pain treatment. Destabilizing a patient, because somewhere else in the country, someone is misusing fentanyl from China, while leaving the patient with few options for pain relief. (Twitter) - Dec 13, 2019
- || fentanyl citrate / Generic mfg.
Clinical, Observational data, Journal: The effect of colonoscopy on intraocular pressure: an observational prospective study. (Pubmed Central) - Dec 13, 2019
This trial is registered with ChiCTR1800016612 at chictr.org.cn/index.aspx. Routine colonoscopy performed under sedation using propofol, fentanyl, and midazolam does not increase the IOP in healthy adults.
- | fentanyl citrate / Generic mfg., morphine/oxycodone (Q8011) / QRxPharma, methadone / Generic mfg.
Journal: Dynamic changes in prescription opioids from 2006 to 2017 in Texas. (Pubmed Central) - Dec 12, 2019
Collectively, these findings indicate that continued vigilance is needed in Texas to appropriately treat pain and an OUD while minimizing the potential for prescription opioid diversion and misuse. Texas may lead the US in a return to pre-opioid epidemic prescription levels.
- || fentanyl citrate / Generic mfg.
Fentanyl will bring more problems than overdose. Shorter duration of effect means higher frequency of use. Every injection-use episode risks overdose and disease transmission. Could also encourage needle sharing because needles dull faster if used more frequently. (Twitter) - Dec 12, 2019