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39 Diseases |  |
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18506 News |  |
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- || fentanyl citrate / Generic mfg.
Clinical, Retrospective data, Journal: Trends in hospital consumption of analgesics after the implementation of a pain performance improvement plan (Pubmed Central) - Jan 11, 2020
Opioid consumption showed an increasing trend during the 5 year period, with fentanyl replacing morphine as the most used opioid. In general, analgesics diminished use was due to the decreasing trend of consumption of non-steroidal anti-inflammatory and antirheumatic products.
- || fentanyl citrate / Generic mfg., dexketoprofen/trometamol tablet / Menarini
Clinical, Journal: Ultrasound guided erector spinae plane block for postoperative analgesia after augmentation mammoplasty: case series (Pubmed Central) - Jan 11, 2020
At the postoperative 24th hour, the mean Numerical Rating Scale score was 1. The mean intravenous tramadol consumption was 70.8±15.3mg in the first 24 h. None of the patients had any complications related to erector spinae plane block.
- | fentanyl citrate / Generic mfg., morphine/oxycodone (Q8011) / QRxPharma
Journal: Possible biased analgesic of hydromorphone through the G protein-over β-arrestin-mediated pathway: cAMP, CellKey™, and receptor internalization analyses. (Pubmed Central) - Jan 11, 2020
Hydromorphone had the strongest potency next to fentanyl; however, contribution of the β-arrestin-mediated pathway was small, suggesting that its effect could be biased toward the G protein-mediated pathway. Based on these properties, hydromorphone could be chosen as an effective analgesic.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Analysis of Acetyl Fentanyl in Postmortem Specimens by Gas Chromatography-Mass Spectrometry (GC-MS): Method Validation and Case Report. (Pubmed Central) - Jan 10, 2020
This suggests acetyl fentanyl is less potent than its prototype drug, fentanyl and requires an increased dose to achieve its desired effects. The demographic analysis indicated white males aged 21-40 years and individuals with a previous history of drug use have the highest risk for acetyl fentanyl abuse.
- || Duragesic (fentanyl) / J&J
Clinical, Journal: Opioid-induced constipation in mixed chronic pain patients: Prevalence and predictors analysis. (Pubmed Central) - Jan 10, 2020
In our experience, macrogol relieved constipation in those on the combination of oxycodone and naloxone and in those on fentanyl patches. Lactulose and glycerol suppositories were associated with severe constipation.
- | fentanyl citrate / Generic mfg.
Journal: Fentanyl analogue overdose: Key lessons in management in the synthetic opioid age. (Pubmed Central) - Jan 10, 2020
This includes protecting against occupational exposure, administering adequate doses of naloxone, and working with public health departments to respond to fentanyl outbreaks. Additionally, fentanyl overdoses represent a critical opportunity to move beyond acute stabilization, start buprenorphine or methadone for opioid use disorder during hospitalization, link patients to ongoing addiction treatment, and distribute naloxone into the community to help curb the overdose epidemic.
- | fentanyl citrate / Generic mfg., methadone / Generic mfg.
Journal: Patterns in opioid prescription in the United States by region and prescribers over a 4-year period. (Pubmed Central) - Jan 10, 2020
Patterns of prescription per opioid vary considerably per physician specialty and per US region. Although an overall decrease in prescriptions was seen, certain opioids were more frequently prescribed in 2015 than in 2012.
- || Duragesic (fentanyl) / J&J
Clinical, Journal: Effect of enterostomy on analgesic pattern in patients with advanced digestive tract cancer (Pubmed Central) - Jan 10, 2020
Enterostomy may affect the analgesic pattern in advanced digestive tract cancer. Patients with stoma are more likely to use fentanyl transdermal patches and younger patients with stoma do not need prophylactic use of laxatives.
- ||| fentanyl citrate / Generic mfg., Lazanda (fentanyl) / Assertio, Kyowa Hakko Kirin
1. Emergency ESWL if access (and nil contraindications) + IV / nasal fentanyl on table (as per @NICEComms) OR 2. Primary URS + stent Depends on #access to #surgery! #urology (Twitter) - Jan 9, 2020
- | fentanyl citrate / Generic mfg., Duragesic (fentanyl) / J&J
Journal: Can't take the heat: sauna and Fentanyl patch intoxication. (Pubmed Central) - Jan 9, 2020
Patients with stoma are more likely to use fentanyl transdermal patches and younger patients with stoma do not need prophylactic use of laxatives. No abstract available
- | fentanyl citrate / Generic mfg.
Ur-Fentanyl (Twitter) - Jan 8, 2020
- || fentanyl citrate / Generic mfg.
@Pfizer Release Fentanyl 2 cowards (Twitter) - Jan 8, 2020
- || fentanyl citrate / Generic mfg.
Clinical, Journal, Head-to-Head: Comparison of bupivacaine plus intrathecal fentanyl and bupivacaine alone for spinal anesthesia with intravenous dexmedetomidine sedation: a randomized, double-blind, noninferiority trial. (Pubmed Central) - Jan 8, 2020
P=N/A
The duration of spinal anesthesia with bupivacaine alone is noninferior to that of bupivacaine plus fentanyl in patients receiving intravenous dexmedetomidine intraoperatively. Our results suggest that intrathecal fentanyl may not be required when intravenous dexmedetomidine is administered.
- | fentanyl citrate / Generic mfg.
Journal: Current management of breakthrough cancer pain according to physicians from pain units in Spain. (Pubmed Central) - Jan 8, 2020
There was broad agreement among pain experts on many important areas of BTcP management, except for the diagnostic method. Pain-unit physicians suggest that rapid-onset opioids may be underused by BTcP patients in Spain, an important issue that need to be evaluated in future studies.
- | fentanyl citrate / Generic mfg.
Journal: Financial impact of ultrasound-guided lumbar plexus and sciatic nerve blocks with electrostimulation for tibial plateau leveling osteotomy surgery in dogs. (Pubmed Central) - Jan 8, 2020
Ultrasound-guided lumbar plexus and sciatic nerve blocks with electrostimulation confirmation can increase the anesthesia cost through use of specific equipment. However, in most cases, the anesthesia cost decreased as a result of decreased costs for pain management and treatment of complications.
- || fentanyl citrate / Generic mfg.
No reason for fentanyl in the first place (Twitter) - Jan 8, 2020
- | fentanyl citrate / Generic mfg.
Journal: Comparison of ultrasound-guided lumbar plexus and sciatic nerve blocks with ropivacaine and sham blocks with saline on perianesthetic analgesia and recovery in dogs undergoing tibial plateau leveling osteotomy surgery. (Pubmed Central) - Jan 8, 2020
However, in most cases, the anesthesia cost decreased as a result of decreased costs for pain management and treatment of complications. As part of a multimodal analgesia regimen, ultrasound-guided lumbar plexus and sciatic nerve blocks provided greater analgesia and improved recovery quality in dogs during TPLO surgery.
- || fentanyl citrate / Generic mfg., methadone / Generic mfg.
Clinical, Review, Journal: The anaesthetist, opioid analgesic drugs, and serotonin toxicity: a mechanistic and clinical review. (Pubmed Central) - Jan 8, 2020
The intraoperative recognition of serotonin toxicity is challenging as it can mimic other serious syndromes, such as malignant hyperthermia, sepsis, thyroid storm, and neuroleptic malignant syndrome. Anaesthetists must maintain a heightened awareness of its possible occurrence and a readiness to engage in early treatment to avoid poor outcomes.
- | fentanyl citrate / Generic mfg.
Journal: Occurrence of Tramadol and Fentanyl Use in Domestic Wastewater in Beijing (Pubmed Central) - Jan 8, 2020
Seasonal variation in TRA loads was significant, with greater use in the summer than in winter. The method presented in this study can be used as an important reference for monitoring TRA and FEN use via wastewater-based epidemiology and for assessing the risk of the abuse of these compounds in China.
- | fentanyl citrate / Generic mfg.
Journal: Surge in Fentanyl Toxicity Deaths in Jefferson Parish, LA, 2013-2018. (Pubmed Central) - Jan 8, 2020
The percentage of fentanyl-related overdose deaths increased from 4% of all drug deaths in 2013 to 45% in 2018. The data validate the hypothesis that the fentanyl epidemic has affected Jefferson Parish in southeast Louisiana.
- | fentanyl citrate / Generic mfg.
Journal: A High Dose of Fentanyl May Accelerate the Onset of Acute Postoperative Pain. (Pubmed Central) - Jan 8, 2020
The current retrospective study was conducted on 56 patients undergoing laparoscopic sleeve gastrectomy. In patients receiving relatively large doses of fentanyl intraoperatively (over 3 µg/kg body weight), the onset of acute postoperative pain accelerated significantly, in comparison with the ones receiving lower doses.
- |||| fentanyl citrate / Generic mfg., sumatriptan succinate / Generic mfg.
Clinical: Very nice report on #Serotonin Syndrome with #BlackSeed oil, #Fentanyl #oxycodone #Sumatriptan. 👏👏 This is specially relevant in #headache patients. #HeadacheTipOfTheDay @aihsHeadache @HeadacheBoard (Twitter) - Jan 6, 2020
- || fentanyl citrate / Generic mfg.
A prediction that @ProfDavidNutt made in 2017 is sadly becoming more likely by the day. https://t.co/ciOPOTtszY A recent report from the ACMD highlights the rise in Fentanyl-related deaths. #Fentanyl poses a significant ongoing risk to UK public health. https://t.co/WOCW0QNFyr (Twitter) - Jan 6, 2020
- || fentanyl citrate / Generic mfg.
Mostly sedation with Midazolam and Fentanyl. Around 10% are assisted by anesthesiologist with deep sedation with propofol. (Twitter) - Jan 5, 2020
- |||| fentanyl citrate / Generic mfg.
Clinical: 1 of the most painfully tone deaf & useless articles that I have seen in a while. At min @TonyaMosley & @CikuTheuri could have sought out a Black doc like @MdKanika or @DrChinazo =actually providing care 2 Black pts w/ SUD & FFS @andrewkolodny heroin & fentanyl r #opioids right? (Twitter) - Jan 4, 2020
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Opioid maintenance, weaning and detoxification techniques; where we have been, where we are now & what the future holds: an update. (Pubmed Central) - Jan 4, 2020
In 2010, there was a shift in causes primarily due to the use of heroin, and currently the latest shift in opioid-related deaths involves a variety of synthetic opioids, particularly illicitly manufactured fentanyl. As the medical, sociological and political environments have drastically changed, especially in the USA, over the last 6 years with regard to opioid use and misuse, an updated review of the literature was necessary.
- | fentanyl citrate / Generic mfg.
Journal: Physician's role in prescribing opioids in developing countries. (Pubmed Central) - Jan 4, 2020
A debate remains as to whether tramadol induces addictive effects like those of stronger analogues such as oxycodone or fentanyl. Here we present a case of tramadol dependence in an Ecuadorian patient and find that substance abuse can occur in normal individuals affected by chronic pain, otherwise treatable with standard methods.
- || fentanyl citrate / Generic mfg., Duragesic (fentanyl) / J&J
Clinical, Review, Journal: Consensus Perioperative Management Best Practices for Patients on Transdermal Fentanyl Patches Undergoing Surgery. (Pubmed Central) - Jan 4, 2020
The current manuscript discusses the history of fentanyl and the fentanyl patch, as well as perioperative considerations, contraindications, current clinical efficacy, and clinical adversities related to the transdermal fentanyl patch. Regarding the heating of a transdermal fentanyl patch, which significantly increases blood levels of fentanyl, it is of the utmost importance that the patch be removed prior to surgery.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Does ultrasound-guided transversus abdominis plane blockade decrease perioperative opioids in morbid obese patients undergoing laparoscopic surgery? (Pubmed Central) - Jan 3, 2020
Regarding the heating of a transdermal fentanyl patch, which significantly increases blood levels of fentanyl, it is of the utmost importance that the patch be removed prior to surgery. The USG- TAP-blockade has analgetic and opioid-sparing advantages in MO patients undergoing laparoscopic surgery in the lower abdomen and in the pelvis and may be a part of the efficient multimodal analgesia within ERAS in that patient's group.
- ||||| fentanyl citrate / Generic mfg.
Clinical: Menthol and tobacco e-cigs remain available to children. Is the logical equivalent of having oxycodone and fentanyl as OTC meds while banning all other opioids and declaring “war on opioid abuse” @OncoAlert @IASLC (Twitter) - Jan 3, 2020
- |||| fentanyl citrate / Generic mfg.
Clinical: @prince suffered severe @HipPainManage prescribed deadliest chemical fentanyl; PLACEBOS for #ChronicPain #chronicillness has no ability to help heal cure reverse normal muscle pain! Fraud, criminal, felony act of omission & commission leading to his death! https://t.co/lxFxW1YRne (Twitter) - Jan 1, 2020
- || methadone / Generic mfg.
Clinical, Journal: Intraoperative Methadone in Same-Day Ambulatory Surgery: A Randomized, Double-Blinded, Dose-Finding Pilot Study. (Pubmed Central) - Jan 1, 2020
The USG- TAP-blockade has analgetic and opioid-sparing advantages in MO patients undergoing laparoscopic surgery in the lower abdomen and in the pelvis and may be a part of the efficient multimodal analgesia within ERAS in that patient's group. In same-day discharge surgery, this pilot study identified a single intraoperative dose of methadone (0.15 mg/kg ideal body weight), which decreased intraoperative and postoperative opioid requirements and postoperative pain, compared with conventional intermittent short-duration opioids, with similar side effects.
- | fentanyl citrate / Generic mfg.
Journal: Discovering Pain in Newborn Infants. (Pubmed Central) - Jan 1, 2020
Compared with the fentanyl group, the nonfentanyl group had circulatory and metabolic complications postoperatively. The findings indicate that preterm babies mount a substantial stress response to surgery under anesthesia with nitrous oxide and curare and that prevention of this response by fentanyl anesthesia may be associated with an improved postoperative outcome.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: A case report on potential postmortem redistribution of furanyl fentanyl and 4-ANPP. (Pubmed Central) - Jan 1, 2020
The outcomes from the presented case report suggest that the two substances have been not only injected intravenously, but probably also ingested by the man. Fentanyl derivative and its precursor seemed to undergo an extensive postmortem redistribution.
- | fentanyl citrate / Generic mfg.
Journal: Contact Transfer Risk from Fentanyl-Contaminated RSDL® Kit. (Pubmed Central) - Jan 1, 2020
The present study determined that a contaminated RSDL Kit, used for removal of fentanyl, should be handled with proper care. Use of protective gloves in operational use and washing skin afterwards is advised to prevent undesired contamination.
- | Duragesic (fentanyl) / J&J
Review, Journal: Opioids for Cancer Pain and its Use under Particular Conditions: A Narrative Review (Pubmed Central) - Dec 29, 2019
In this case, as when considering pharmacological interactions, an individualized therapeutic plan is the best solution and the patient should be assessed regularly. Unadjusted doses may relate to bad pain control and a higher prevalence of adverse events.
- || Simdax (levosimendan IV) / AbbVie
Clinical, Journal: Levosimendan for patients with heart failure undergoing major oncological surgery: A randomised blinded pilot study. (Pubmed Central) - Dec 29, 2019
Duration of postoperative ventilation and hospital stay were significantly shorter in the levosimendan group (P < 0.001) while the frequency of dysrhythmia, deterioration of renal function and sepsis was comparable. In patients with low EF <35% and CHF, administration of levosimendan for 24 hours before major abdominal oncologic surgeries may reduce the risk of hypotension and decompensated heart failure and may improve cardiac function.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Role of erector spinae plane block versus paravertebral block in pain control after modified radical mastectomy. A prospective randomised trial. (Pubmed Central) - Dec 29, 2019
Post-operative 24 h morphine consumption, intra-operative fentanyl consumption, time of the first request for analgesia and post-operative visual analogue scale (VAS), heart rate (HR), mean blood pressure (MBP) and complications were recorded...All patients displayed a stable haemodynamic profile. Both TPVB and ESPB can be effectively used in controlling post-mastectomy pain and reduce intra-operative and post-operative opioid consumption.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Functional magnetic resonance imaging under anaesthesia of a patient with severe chronic disorders of consciousness. (Pubmed Central) - Dec 28, 2019
Considering the other three extremities no significant responses were found. Nevertheless, we conclude that a functional Magnetic Resonance Imaging under anaesthesia is possible for patients with severe chronic disorders of consciousness and brain areas responding to stimuli can be detected.
- | fentanyl citrate / Generic mfg.
Journal: Effectiveness of fentanyl pectin nasal citrate in controlling episodes of breakthrough cancer pain triggered by routine radiotherapy procedures. (Pubmed Central) - Dec 28, 2019
In our knowledge, our study is the one of highest recruitment, and with the fastest response of BTCP treated with FPNS reported in advanced cancer patients undergoing radiotherapy. FPNS has proven to be highly effective in reducing the intensity of procedural BTCP in a very short period of time.
- || fentanyl citrate / Generic mfg.
Ironically it’s the DEA’s war on opioids and semi legalized Weed that has pushed people onto street fentanyl, the cartels’ new cash cow. But we can blame it on the health system if you want, it still sucks. (Twitter) - Dec 27, 2019
- | fentanyl citrate / Generic mfg., Duragesic (fentanyl) / J&J
Journal: Fatal misuse of transdermal fentanyl patches. (Pubmed Central) - Dec 26, 2019
Co-administered drugs and signs of opioid intoxication, especially pulmonary edema, were frequently found. Lastly, it is advised to include norfentanyl and hair analysis in the interpretation of post-mortem fentanyl concentrations.
- | fentanyl citrate / Generic mfg.
Journal: Post-mortem analysis of prescription opioids-A follow-up examination by LC-MS/MS with focus on fentanyl. (Pubmed Central) - Dec 26, 2019
Despite the global problem of opioid abuse, there are significant regional differences in the nature and extent of opioid abuse. It is necessary to collect data at the national level to develop appropriate prevention strategies.
- | fentanyl citrate / Generic mfg.
Journal: Distribution of synthetic opioids in postmortem blood, vitreous humor and brain. (Pubmed Central) - Dec 26, 2019
In the US, the use of synthetic opioids (e.g. fentanyl and derivatives) has become an increasing health issue with thousands of overdose deaths being observed since 2013...Through the case analyses, vitreous humor and brain demonstrated to be viable alternatives to blood when performing postmortem analyses of synthetic opioids. Brain exhibited a higher detectability for most analytes when compared to blood and vitreous humor.
- || fentanyl citrate / Generic mfg., ketamine / Generic mfg.
Clinical, Review, Journal: Pre-hospital pain management; a systematic review of proposed guidelines. (Pubmed Central) - Dec 26, 2019
Based on the obtained evidence, no guideline is yet presented concerning opioid-free management of moderate and severe pain. The evidence is insufficient for using non opioid medications such as ketamine.
- | fentanyl citrate / Generic mfg.
Journal: Aminoguanidine hydrazone derivatives as non-peptide NPFF1 receptor antagonists reverse opioid induced hyperalgesia. (Pubmed Central) - Dec 25, 2019
As earlier shown with the prototypical dipeptide antagonist RF9, both 1n and 22e reduced significantly the long lasting fentanyl-induced hyperalgesia in rodents. Altogether these data indicate that AGH rigidification maintains nanomolar affinities for both NPFF receptors, while improving antagonist character towards NPFF1R.
- || fentanyl citrate / Generic mfg.
Good point about the naltrexone being in a CPPs system if they need emergency surgery..that can be a scary thought.I doubt many doctors would know what doses of what opioids would override the naltrexone. We have found that fentanyl overrides the naltrexone n of course bupe does (Twitter) - Dec 25, 2019
- | fentanyl citrate / Generic mfg., Duragesic (fentanyl) / J&J
Journal: Opioid-associated amnestic syndrome observed with fentanyl patch use. (Pubmed Central) - Dec 25, 2019
Altogether these data indicate that AGH rigidification maintains nanomolar affinities for both NPFF receptors, while improving antagonist character towards NPFF1R. No abstract available
- | fentanyl citrate / Generic mfg., ketamine / Generic mfg.
Journal: The circadian PER2 enhancer Nobiletin reverses the deleterious effects of midazolam in myocardial ischemia and reperfusion injury. (Pubmed Central) - Dec 23, 2019
We identified midazolam mediated downregulation of cardiac PER2 as an underlying mechanism for a deleterious effect of midazolam pretreatment in myocardial IR-injury. These findings highlight PER2 as a cardioprotective mechanism and suggest the PER2 enhancers nobiletin or tangeritin as preventative therapy for myocardial IR-injury in the perioperative setting where midazolam pretreatment occurs frequently.
- | fentanyl citrate / Generic mfg.
Review, Journal: Non-nociceptive roles of opioids in the CNS: opioids' effects on neurogenesis, learning, memory and affect. (Pubmed Central) - Dec 23, 2019
Less known is the impact of opioids on hippocampal neurogenesis, the functional manipulation of which may improve the deleterious effects of opioid use. We provide new insights into how the dysregulation of neurogenesis by opioids can modify learning and affect, mood and emotions, processes that have been well accepted to motivate addictive behaviours.