fentanyl citrate / Generic mfg. 
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  • ||||||||||  Preclinical, Journal:  Effectiveness comparisons of G-protein biased and unbiased mu opioid receptor ligands in warm water tail-withdrawal and drug discrimination in male and female rats. (Pubmed Central) -  Jan 23, 2020   
    The present study compared the relative potency and effectiveness of two G-protein biased (GPB)-MOR ligands TRV130 and SR-14968 to five unbiased MOR ligands (NAQ, nalbuphine, buprenorphine, morphine, and methadone) on therapeutic-related (e.g. antinociception) and abuse-related (e.g. discriminative stimulus effects) endpoints...The efficacy-effect function generated from the fentanyl/naltrexone mixtures stratified the five unbiased ligands consistent with agonist-stimulated GTPγS binding (NAQ = nalbuphine < buprenorphine < morphine < methadone)...Furthermore, there was a significant positive correlation between rat and monkey antinociceptive effects. Overall, these results demonstrate GPB-MOR agonists produce undesirable abuse-related effects, albeit with slightly better potency and efficacy ratios compared to unbiased agonists.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Preclinical, Journal:  Oxycodone-Like Discriminative Stimulus Effects of Fentanyl-Related Emerging Drugs of Abuse in Mice. (Pubmed Central) -  Jan 23, 2020   
    These results indicate that the discriminative stimulus, and by extension, the interoceptive and subjective effects of the tested fentanyl analogs, overlap with those of oxycodone. These observations consequentially support the prediction that they would also engender the likelihood for abuse similar to oxycodone.
  • ||||||||||  fentanyl citrate / Generic mfg., loperamide hydrochloride / Generic mfg., methadone / Generic mfg.
    Journal:  Suppression of Human Natural Killer Cells by Different Classes of Opioids. (Pubmed Central) -  Jan 23, 2020   
    Suppression of natural killer cell cytotoxicity was observed with μ- and κ-receptor agonists but not δ-receptor agonists. These data suggest that the effect is mediated by μ- and κ-receptor agonism and that suppression is similar with many clinically used opioids.
  • ||||||||||  fentanyl citrate / Generic mfg., remifentanil / Generic mfg., ketamine / Generic mfg.
    Journal:  Predosing Chemical Stability of Admixtures of Propofol, Ketamine, Fentanyl, and Remifentanil. (Pubmed Central) -  Jan 21, 2020   
    Admixtures of propofol-ketamine, propofol-ketamine-fentanyl, and propofol-ketamine-remifentanil were subjected to various clinically relevant conditions to study their chemical stability. A novel high-performance liquid chromatography-mass spectrometry method revealed no degradation of any compound by incubation at 37°C, constant mixing, or table-top storage for 6- and 24-hour time periods, except variable recovery of both propofol and fentanyl in the admixtures of propofol-ketamine-fentanyl suggesting possible degradation.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Biomarker, Journal:  Proteomic and Metabolomic Profiling Identify Plasma Biomarkers for Exposure to Ultra-low Levels of Carfentanil. (Pubmed Central) -  Jan 21, 2020   
    Despite the recent epidemic of fentanyl abuse, there are few validated assays capable of rapidly detecting these compounds...This approach allows for the identification of > 800 small molecule features. By processing and analyzing datasets in parallel, we were able to identify a unique fingerprint of protein and metabolite perturbations that manifest following exposure to carfentanil.
  • ||||||||||  fentanyl citrate / Generic mfg., remifentanil / Generic mfg.
    Journal:  A 10-year update: national survey questionnaire of obstetric anesthesia units in Israel. (Pubmed Central) -  Jan 21, 2020   
    Use of intrathecal morphine for spinal anesthesia has become more widespread. Future efforts should focus on availability of emergency equipment, separate obstetric anesthesia staffing, and establishing emergency protocols.
  • ||||||||||  fentanyl citrate / Generic mfg., methadone / Generic mfg.
    Journal:  Medications for management of opioid use disorder. (Pubmed Central) -  Jan 21, 2020   
    Buprenorphine has become the medication of choice for many patients with OUD, but its use is limited by the low number of physicians certified to prescribe the agent. Other agents studied for treatment of OUD include methadone and naltrexone.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Carotid Artery Stent Placement via Radial Arterial Route () -  Jan 21, 2020 - Abstract #AAN2020AAN_1663;    
    The mean dose of intravenous fentanyl (82.4 mcg versus 89.7 mcg) and midazolam (1.35 mg versus 1.3 mg) was similar between the two arterial routes. Carotid artery stent placement via radial arterial route is feasible and comparable to procedures performed via femoral arterial route.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Opioid Overdose Awareness and Reversal Training () -  Jan 21, 2020 - Abstract #APA2020APA_374;    
    The Medical Examiner reports that 90% of the City’s fatal overdoses involve opioids, including heroin and fentanyl. This training will provide concrete actions one can take to help combat the overdose crisis and prevent fatal overdoses.
  • ||||||||||  fentanyl citrate / Generic mfg., Vivitrol (naltrexone extended-release injectable suspension) / Alkermes
    Buprenorphine Update and Evolving Standards of Care () -  Jan 21, 2020 - Abstract #APA2020APA_236;    
    We will review: 1) Recent regulatory changes and their effect on clinical practice and collaborative care models 2) The results of research studies comparing buprenorphine and extended-release naltrexone 3) The impact of new medication formulations, including injectable buprenorphine 4) Evolving standards of care for medication-assisted treatment including models for the management of opioid over-dose and the efforts to reduce or eliminate barriers to admission to long-term medication treatment. 5) Plans to expand access to evidence-based treatment within the justice system.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Clinical, Journal:  The health threat of drugs of abuse adulteration by new psychoactive substances. (Pubmed Central) -  Jan 18, 2020   
    In particular, the phenomenon of adulteration concerns fentanyl and its analogs, substances that can be toxic even if taken in very small quantities. The adulteration that involves NPS is creating a serious threat to the health of drug users, not only because of the pharmacological action but because of the increased toxicity of these new cutting agents.
  • ||||||||||  fentanyl citrate / Generic mfg., tramadol hydrochloride / Generic mfg., methadone / Generic mfg.
    Observational data, Retrospective data, Journal:  Trends in severe opioid-related poisonings and fatalities reported to the Paris poison control center - a 10-year retrospective observational study. (Pubmed Central) -  Jan 18, 2020   
    The secondary objectives were to assess the evolution of the number of these cases and their severity defined by the use of fentanyl and its derivatives, the use of the opioid-poisoning treatment naloxone, and the number of fatalities...During the 10-year study period, 130 opioid-related fatalities were recorded in the Paris area, mainly resulting from suicides (39%) in men and were attributed to morphine (27%), tramadol (24%), and methadone (21%)...The systematic analysis of data from the PCCs could be a good tool for health monitoring. To assess trends in France, a national study over a longer period would also be useful.
  • ||||||||||  fentanyl citrate / Generic mfg., Duragesic (fentanyl) / J&J
    Journal:  Allergic Contact Dermatitis To Fentanyl TTS With Good Tolerance To Systemic Fentanyl. (Pubmed Central) -  Jan 16, 2020   
    Positive PT in this patient suggests a type IV hypersensitivity mechanism. Allergic reactions to opioids are frequently immediate, but delayed reactions could appear, especially when the drug is administered topically.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Acute severe intoxication with cyclopropylfentanyl, a novel synthetic opioid. (Pubmed Central) -  Jan 15, 2020   
    The constantly growing diversity of NSO still poses a high risk for drug users and can be a challenging task for clinicians and forensic toxicologists. Clinicians treating opioid overdoses should be aware of the potentially long lasting respiratory depression induced by fentanyl analogs.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Application of the fentanyl analog screening kit toward the identification of emerging synthetic opioids in human plasma and urine by LC-QTOF. (Pubmed Central) -  Jan 15, 2020   
    For fentanyl, 8 fentanyl-related compounds and naloxone, lower reportable limits (LRL), defined as the lowest concentration with 100 % true positive rate (n = 12) within clinical samples, were evaluated and range from 0.5 ng/mL to 5.0 ng/mL for urine and 0.25 ng/mL to 2.5 ng/mL in plasma. The application of this high resolution mass spectrometry (HRMS) method enables the real-time detection of known and emerging synthetic opioids present in clinical samples.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Comparison of median effective concentration of ropivacaine in multiparas or primiparas during epidural labor analgesia: STROBE compliant. (Pubmed Central) -  Jan 15, 2020   
    Umbilical artery blood was drawn to analyze. The side effects, if any, were also recorded.The median effective concentration of ropivacaine was 0.057% (95% confidence interval [CI], 0.051-0.064%) in primiparas during epidural labor analgesia, and 0.068% (95% CI, 0.063-0.072%) in multiparas during epidural labor analgesia, there was significant difference between the groups (P = .02).This study indicated that the median effective concentration of ropivacaine with fentanyl for epidural labor analgesia was 0.068% (95% CI, 0.063-0.072%) and increased in multiparas compared with the primiparas (www.chictr.org.cn, registration number: ChiCTR-1800016486).
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Fentanyl can be mitochondrion -toxic depending on dosage and cell type. (Pubmed Central) -  Jan 12, 2020   
    The side effects, if any, were also recorded.The median effective concentration of ropivacaine was 0.057% (95% confidence interval [CI], 0.051-0.064%) in primiparas during epidural labor analgesia, and 0.068% (95% CI, 0.063-0.072%) in multiparas during epidural labor analgesia, there was significant difference between the groups (P = .02).This study indicated that the median effective concentration of ropivacaine with fentanyl for epidural labor analgesia was 0.068% (95% CI, 0.063-0.072%) and increased in multiparas compared with the primiparas (www.chictr.org.cn, registration number: ChiCTR-1800016486). No abstract available