- |||||||||| fentanyl citrate / Generic mfg.
Journal: Xylazine Use among People Who Inject Drugs, Philadelphia 2022. (Pubmed Central) - Jan 30, 2024
Analgesia with morphine and fentanyl by specially trained ambulance personnel according to defined rules of use is a safe and necessary procedure for patients, especially in rural regions. Public health entities should prioritize studying the use and health effects of xylazine in their jurisdictions and consider supporting point-of-care and drug-checking surveillance in addition to raising awareness of xylazine in the drug supply.
- |||||||||| fentanyl citrate / Generic mfg., methadone / Generic mfg.
Review, Journal: Novel Therapeutic and Program-Based Approaches to Opioid Use Disorders. (Pubmed Central) - Jan 30, 2024
Expected final online publication date for the Annual Review of Medicine, Volume 75 is January 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
- |||||||||| methadone / Generic mfg.
Journal, Claims database: A Survey of the Status of Methadone Switching in Japan Using a Hospital-Based Administrative Claims Database. (Pubmed Central) - Jan 30, 2024
Younger age and outpatient status increased the risk of requiring high-dose methadone switching, whereas the concomitant use of nonsteroidal anti-inflammatory drugs and fentanyl as a pre-switching opioid decreased the risk. In conclusion, more than 30% of the patients underwent high-dose methadone switching and required long completion periods, suggesting that methadone switching remains challenging in Japan.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Emergency Department Access to Buprenorphine for Opioid Use Disorder. (Pubmed Central) - Jan 29, 2024
Self-reported fentanyl use (242 [52.2%]) and a comorbid mental health condition (328 [71.5%]) were common...The findings of this cohort study suggest that among patients with OUD presenting to EDs implementing low-threshold access to medications for OUD, buprenorphine treatment was associated with a substantially higher likelihood of follow-up treatment engagement 1 month later. Future research should investigate techniques to optimize both the uptake and effectiveness of buprenorphine initiation in low-threshold settings such as the ED.
- |||||||||| fentanyl citrate / Generic mfg.
Preclinical, Journal: Fentanyl overdose: Temporal effects and prognostic factors in SKH1 mice. (Pubmed Central) - Jan 29, 2024
F-FDG PET revealed decreased glucose uptake in the heart, lungs and brain for up to 24?h. These findings provide critical insights into fentanyl lethality in SKH1 mice, including non-invasive respiratory effects and organ-specific impacts that are invaluable for future translational studies investigating the temporal effects of fentanyl overdose.
- |||||||||| fentanyl citrate / Generic mfg., methadone / Generic mfg.
Journal: Developing and Evaluating the Greenness of a Reliable, All-in-One Thin-Film Microextraction Protocol for Determining Fentanyl, Methadone, and Zolpidem in Plasma, Urine, and Oral Fluid. (Pubmed Central) - Jan 27, 2024
An assessment of the protocol's environmental impact indicated that attention must be devoted to eliminating the use of toxic reagents and developing its capability for in situ sampling and in-field analysis using portable instruments. The proposed TFME-based protocol provides clinical laboratories with a versatile, one-step tool that enables the simultaneous monitoring of fentanyl, methadone, and zolpidem using the most popular biological matrices.
- |||||||||| NAVIGATING THE CHALLENGES OF TURNER SYNDROME WITH TYPE B AORTIC DISSECTION (Hall B4-5) - Jan 26, 2024 - Abstract #ACC2024ACC_5770;
Maintain a high index of suspicion for aortic dissection in Turner Syndrome patients with chest pain. Imaging is crucial for guiding management decisions and surveillance of Turner syndrome patients with Type B aortic dissection.
- |||||||||| fentanyl citrate / Generic mfg.
DEATH BY SLEEP: UNMASKING BRUGADA SYNDROME BY PROPOFOL INFUSION (Hall B4-5) - Jan 26, 2024 - Abstract #ACC2024ACC_3776;
It is important to be aware of the triggers of this syndrome, including medication induced in our common critical care practice. Understanding the key aspects of this syndrome is crucial for healthcare professionals to effectively identify and manage affected individuals, which reduces the associated risks and improving patient outcomes.
- |||||||||| fentanyl citrate / Generic mfg., epinephrine / Generic mfg., methadone / Generic mfg.
IVUS-GUIDED THROMBECTOMY OF CORONARY SEPTIC EMBOLISM (Hall B4-5) - Jan 26, 2024 - Abstract #ACC2024ACC_2164;
Background: Coronary artery septic embolization is a rare severe complication of endocarditis involving the left-sided valves.Case: 37 year old male with history of aortic valve endocarditis due to Staphylococcus constellatus s/p replacement with 23mm Edwards Inspiris, history of IV drug abuse, T2DM, HTN who presented to our institution with PEA cardiac arrest with ROSC obtained after 4 rounds of epinephrine...UDS was positive for cocaine, methadone, and fentanyl... ACS due to septic embolism is a serious complication of untreated aortic valve endocarditis that can be treated with IVUS-guided thrombectomy.
- |||||||||| remdesivir / Generic mfg.
REMDESIVIR-INDUCED BRADYCARDIA: A MULTICENTER RETROSPECTIVE ANALYSIS (Hall B4-5) - Jan 26, 2024 - Abstract #ACC2024ACC_1840;
A final sample of 1732 patients were obtained after application of exclusion criteria and concomitant use of remdesivir and IV dexmedetomidine/fentanyl. Our study provides evidence that remdesivir administration is a risk factor in the development of any degree of bradycardia in treatment of COVID-19 Disease.
- |||||||||| Vecuron (vecuronium) / Sun Pharma
Journal, Intubation: Effects of oral melatonin premedication on hemodynamic responses to intubation, anesthetic requirements and postoperative sedation: A randomized trial. (Pubmed Central) - Jan 25, 2024
Induction dose of propofol, isoflurane and fentanyl consumption were also compared...All patients were induced with intravenous propofol of 1.5-2.5mg/kg till loss of response to verbal commands, three minutes after vecuronium, laryngoscopy was done and trachea was intubated...Oral premedication with melatonin 6mg administered two hours before surgery significantly reduced MAP before and after induction of GA with a significant reduction in dose of propofol requirement. Titrating induction dose of propofol till loss of response to verbal commands did not effectively attenuate responses to laryngoscopy and intubation following melatonin oral premedication.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Presence of kratom in opioid overdose deaths: findings from coroner postmortem toxicological report. (Pubmed Central) - Jan 25, 2024
The combined use of kratom with opioids such as fentanyl appears most likely to increase the risk of a fatal overdose, but it may also occur with other medications such as benzodiazepines and psychiatric medications. It is a serious concern that in the midst of the opioid overdose epidemic there is a growing presence of kratom use in the U.S. population with a largely unregulated status.
- |||||||||| fentanyl citrate / Generic mfg., methadone / Generic mfg.
Observational data, Journal: The FASTER-BUP Study, Extended-Release Injectable Buprenorphine for the Treatment of Opioid Use Disorder Among Individuals at High Risk of Overdose: Protocol for an Observational Prospective Study. (Pubmed Central) - Jan 23, 2024
The mortality benefits of oral medication treatment for opioid use disorder (MOUD), such as methadone or buprenorphine, are well documented...FASTER-BUP is a 24-week observational prospective study evaluating the feasibility and clinical utility of extended-release injectable buprenorphine (XR-BUP) for the treatment of opioid use disorder (OUD) among 40 adults at high risk of overdose (ie, lifetime history of overdose or a positive urine drug test (UDT) for fentanyl within 30?days prior to screening) in Vancouver, BC...FASTER-BUP is the first study to explore XR-BUP among individuals at high risk of overdose in a real-world Canadian setting. This commentary provides a brief narrative about the study thus far and presents insights on key adaptations to the study protocol, including those adopted to mitigate recruitment challenges.
- |||||||||| methamphetamine / Generic mfg.
Review, Journal: Opioid, methamphetamine, and polysubstance use: perinatal outcomes for the mother and infant. (Pubmed Central) - Jan 22, 2024
These studies need to address the many confounders to perinatal outcomes and employ neurodevelopmental markers at birth that can help predict long-term neurodevelopmental outcomes. Two US initiatives that can provide critical research and treatment answers to this public health crisis are the US Environmental influences on Child Health Outcomes (ECHO) program and the Medication for Opioid Use Disorder During Pregnancy Network (MAT-LINK).
- |||||||||| Nucynta (tapentadol) / Collegium Pharma, Grunenthal
Journal: Declining but Pronounced State-Level Disparities in Prescription Opioid Distribution in the United States. (Pubmed Central) - Jan 22, 2024
Production quotas did not correspond with the distribution, particularly in the 2010-2016 period. Future research, focused on identifying factors contributing to the observed regional variability in opioid distribution, could prove valuable to understanding and potentially remediating the pronounced disparities in prescription opioid-related harms in the US.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Characterizing prescription opioid, heroin, and fentanyl initiation trajectories: A qualitative study. (Pubmed Central) - Jan 22, 2024
The increased risk of overdose with initiation into fentanyl use further emphasizes the need for an expansion of naloxone distribution and the implementation of more comprehensive measures, such as overdose prevention centers, drug testing, and a safer supply. Further research on the dynamics of the ongoing overdose death crisis in the era of fentanyl and the 4th wave of the overdose crisis is critical in developing responsive prevention and intervention strategies.
- |||||||||| tramadol hydrochloride / Generic mfg.
Review, Journal: Prevalence and health consequences of nonmedical use of tramadol in Africa: A systematic scoping review. (Pubmed Central) - Jan 18, 2024
However, the adverse health effects of tramadol use resulting from illicit trafficking, like those caused by fentanyl and methadone in North America, have not been well-documented in Africa...Future studies should focus on the social and economic costs of abuse on households to better understand the impact on well-being. Systematic review registration: Open Science Framework: https://osf.io/ykt25/.
- |||||||||| morphine sulphate / Generic mfg.
Journal: Morphine concentrations in fatalities after palliative treatment of acute burn injury. (Pubmed Central) - Jan 17, 2024
Besides morphine, propofol, fentanyl, sufentanil, midazolam, diazepam, lorazepam, cefazolin, and rocuronium were detected in femoral blood...Further evidence of therapeutic concentrations of quetiapine, duloxetine, and melperone could be matched to preexisting medication of the individuals...However, this prediction is not sufficient to explain the high morphine concentrations in femoral blood measured here. It can be assumed that burn shock in particular leads to altered pharmacokinetics, namely decreased distribution of morphine.
- |||||||||| fentanyl citrate / Generic mfg., remifentanil / Generic mfg., midazolam hydrochloride / Generic mfg.
Retrospective data, Review, Journal: Endovascular treatment of brain aneurysms under conscious sedation: a systematic review of procedural feasibility and safety. (Pubmed Central) - Jan 16, 2024
However, the limited nature of observational studies, methodological quality, the predominant absence of a comparative GA group, and clinical data during follow-up restrict a conclusive statement about the safety of EVT under CS. Accordingly, further research endeavors are warranted toward a higher level of evidence that can be translated into surgical practice.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Journal: British Columbia's Safer Opioid Supply Policy and Opioid Outcomes. (Pubmed Central) - Jan 16, 2024
Two years after its launch, the Safer Opioid Supply policy in British Columbia was associated with higher rates of safer supply opioid prescribing but also with a significant increase in opioid-related poisoning hospitalizations. These findings will help inform ongoing debates about this policy not only in British Columbia but also in other jurisdictions that are contemplating it.
- |||||||||| Lucemyra (lofexidine) / US WorldMeds, Stada
Preclinical, Journal: Impacts of xylazine on fentanyl demand, body weight, and acute withdrawal in rats: A comparison to lofexidine. (Pubmed Central) - Jan 15, 2024
Severity of weight loss during the first 24 h of withdrawal was also correlated with severity of somatic signs of fentanyl withdrawal. Together, these results suggest that body weight loss may be an important indicator of withdrawal severity during acute withdrawal from the xylazine/fentanyl combination, warranting further translational evaluation.
- |||||||||| fentanyl citrate / Generic mfg.
Review, Journal: IUPHAR review: Recent Progress in the Development of Mu Opioid Receptor Modulators to Treat Opioid Use Disorders. (Pubmed Central) - Jan 15, 2024
Because of the introduction of highly potent synthetic opioids (e.g. fentanyl) to the illicit drug market, there is an urgent need for therapeutics that successfully reduce the number of overdoses and can help OUD patients maintain sobriety...These medications are limited by their abuse potential, adverse effects, or pharmacological profiles which leaves ample room for research into designing new chemical entities with optimal physiological effects. These includes, orthosteric ligands that target the primary binding site of the MOR, allosteric ligands that positively, negatively, or "silently" modulate receptor function, and lastly, bitopic ligands target both the orthosteric and allosteric sites simultaneously.
- |||||||||| Palexia RP (tapentadol extended release) / Assertio, J&J, Grunenthal, Collegium Pharma
Journal: Comparison of the effects of OPRM1 A118G polymorphism using different opioids: A prospective study. (Pubmed Central) - Jan 15, 2024
These includes, orthosteric ligands that target the primary binding site of the MOR, allosteric ligands that positively, negatively, or "silently" modulate receptor function, and lastly, bitopic ligands target both the orthosteric and allosteric sites simultaneously. Tapentadol and methadone may be more suitable than hydromorphone, oxycodone, and fentanyl for G-allele carriers due to their dual mechanism of action and low susceptibility to OPRM1 A118G polymorphism.
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