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- || fentanyl citrate / Generic mfg.
Biomarker, Clinical, Journal: Testing hair for fentanyl exposure: a method to inform harm reduction behavior among individuals who use heroin. (Pubmed Central) - Mar 29, 2020
Hair testing is useful in detecting past exposure to fentanyl, its analogs, and other novel synthetic opioids. Further research is needed to determine whether individuals who use heroin learning about exposure affects drug-taking and treatment-seeking behavior.
- || fentanyl citrate / Generic mfg., gabapentin / Generic mfg.
Thanks for sharing @drrobbietee. We cannot use SROM here, but gabapentin is used often — tho less frequently during induction. Look forward to reading more about that. Also appreciate comment on lipophilicity of fentanyl, and benefit of a wash out. We have fewer options there. (Twitter) - Mar 29, 2020
- || fentanyl citrate / Generic mfg.
One would think the fentanyl half life being short, it would not be a problem. But due to its lipophilic properties it is believed the cause for precipitated withdrawal even 12-18-24 hours of detox. (Twitter) - Mar 29, 2020
- || fentanyl citrate / Generic mfg., gabapentin / Generic mfg.
Yes for gabapentin. As for morphine it is used to help wash out illicit fentanyl. It is commonly a cause of precipitated withdrawal. The morphine gives the fentanyl 3 days to get out of the system and reduce risk of precipitated withdrawal. (Twitter) - Mar 29, 2020
- || fentanyl citrate / Generic mfg.
Clinical, Journal, HEOR: Clinical and Economic Analysis of Morphine Versus Fentanyl in Managing Ventilated Neonates With Respiratory Distress Syndrome in the Intensive Care Setting. (Pubmed Central) - Mar 29, 2020
It had 98% probability of dominance over fentanyl. Results in this study support the use of morphine over fentanyl as first-line monotherapy with MV in NICU settings.
- | fentanyl citrate / Generic mfg.
Journal: Adolescent exposures to traditional and novel psychoactive drugs, reported to National Poison Data System (NPDS), 2007-2017. (Pubmed Central) - Mar 29, 2020
Opioids and 2C drugs contributed to the highest mortality rates, moderate/major symptoms and healthcare utilization, and LSD had the most significant increase in calls. Multi-source surveillance methodology is critical in understanding the public health impact on drug abuse in the adolescent population.
- || Ultane (sevoflurane) / Generic mfg.
Clinical, Journal: Lidocaine Reduces Sevoflurane Consumption and Improves Recovery Profile in Children Undergoing Major Spine Surgery. (Pubmed Central) - Mar 28, 2020
After 9 h, more patients in the control group were still sleepy (P=0.032), and there were fewer perioperative complications in the lidocaine group. CONCLUSIONS Lidocaine treatment decreases sevoflurane consumption and improves recovery profiles in children undergoing major spine surgery.
- | fentanyl citrate / Generic mfg., Instanyl (fentanyl) / Takeda
Journal: Intranasal Fentanyl Use in Neonates. (Pubmed Central) - Mar 28, 2020
Intranasal adjuncts are increasingly used in the NICU. Starting dose of INF is 1.5 µg/kg/dose, and typically, one dose is given.
- || fentanyl citrate / Generic mfg.
This is a positive sign we are being heard, so we must not stop our work even if it’s just calling out an article with the wording of “fentanyl related deaths” It’s is in fact ILLICIT I look at it as the tide is actually beginning to turn because the truth will ALWAYS triumph (Twitter) - Mar 28, 2020
- || fentanyl citrate / Generic mfg.
After yrs of combining all drug overdose deaths, CDC starting to separate illegal Fentanyl @POTUS @US_FDA @CDCDirector @HHSGov @SecAzar @RandPaul @SenJohnKennedy @KennedyNation @KatiePavlich @kayleighmcenany @SenatorCollins @MarshaBlackburn @PattyMurray @SenBobCasey @SenatorBurr (Twitter) - Mar 28, 2020
- |||| fentanyl citrate / Generic mfg.
A message from your (e-)neighborhood ER pharmer. Besides critical shortage of PPE, medication shortages includes fentanyl...post-intubation analgesia without fentanyl kinda sucks (lower affect on BP than morphine) @uche_blackstock @DrOniBee @eddyjoemd (Twitter) - Mar 26, 2020
- | fentanyl citrate / Generic mfg.
Journal: Determination of Selected Opiates in Hair Samples Using Microextraction by Packed Sorbent: A New Approach for Sample Clean-up. (Pubmed Central) - Mar 26, 2020
In this article the development and validation of an analytical method using microextraction by packed sorbent (MEPS) to determine tramadol (TRM), codeine (COD), morphine (MOR), 6-acetylcodeine (6-AC), 6-monoacetylmorphine (6-MAM) and fentanyl (FNT) in hair samples by gas chromatography coupled to tandem mass spectrometry (GC-MS-MS) is presented...Precision and accuracy revealed coefficients of variation typically below 15% and relative errors within a ±15% interval, respectively. This new approach has proven to be an excellent alternative to classic procedures, reducing the volumes of organic solvents required.
- | fentanyl citrate / Generic mfg.
Journal: Unique Structural/Stereo-Isomer and Isobar Analysis of Novel Fentanyl Analogues in Postmortem and DUID Whole Blood by UHPLC-MS-MS. (Pubmed Central) - Mar 26, 2020
To the authors' knowledge, FG2 is the first published method that achieved baseline resolution of the nine structural/stereo isomers and one isobar by ultra-high performance liquid chromatography-MS-MS and provided quantitative validation data for nine compounds. FG2 may be used as the new baseline for future isomers that need to be chromatographically separated.
- |||| fentanyl citrate / Generic mfg.
Clinical, Video: You have every right to be scared. I work in an ICU as a RN in a hospital in the Detroit area. The nurse in the video isn’t exaggerating AT ALL. We have no more propofol, are almost out of (likely are, by now) of fentanyl… It’s fucking terrifying + folks need to STAY HOME. (Twitter) - Mar 26, 2020
- |||| fentanyl citrate / Generic mfg., olanzapine / Generic mfg.
Clinical: Olanzapine controlled rapid fentanyl craving in a cancer patient with non medical opioid use. https://t.co/qSKkOjxukn (Twitter) - Mar 25, 2020
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Post-operative Single-shot Epidural Fentanyl and Bupivacaine for Post-operative Analgesia after Lumbar Decompression: A Prospective, Double-Blind Randomized Study. (Pubmed Central) - Mar 25, 2020
FG2 may be used as the new baseline for future isomers that need to be chromatographically separated. A postoperative bolus of Fentanyl and Bupivacaine is effective in reducing early postoperative pain without the related complications of opiod administration.
- || fentanyl citrate / Generic mfg.
Clinical, Review, Journal: Systematic review of the clinical consequences of butyrfentanyl and corresponding analogues. (Pubmed Central) - Mar 25, 2020
The toxidrome was consistent with other opioid overdoses, and naloxone was successfully used in nine of 10 patients. We encourage toxicology screenings of novel fentanyl analogs such as butyrfentanyl or 4-fluorobutyrfentanyl when an opioid overdose of unknown nature presents.
- || fentanyl citrate / Generic mfg.
Clinical, PK/PD data, Journal: Identification of Cytochrome P450 Polymorphisms in Burn Patients and Impact on Fentanyl Pharmacokinetics: A Pilot Study. (Pubmed Central) - Mar 24, 2020
All three patients with variant polymorphisms had increased serum fentanyl concentrations due to impaired clearance. This pilot study supportsthe need for further research in this topic and CYP genotyping of individual patients prior to receiving opiate analgesics to inform precision-guided decisions, improve therapeutic efficacy, and, most importantly, increase patient well-being and safety.
- || fentanyl citrate / Generic mfg., remifentanil / Generic mfg., lidocaine topical / Generic mfg.
Retrospective data, Review, Journal: Pharmacological methods for reducing coughing on emergence from elective surgery after general anesthesia with endotracheal intubation: protocol for a systematic review of common medications and network meta-analysis. (Pubmed Central) - Mar 24, 2020
This pilot study supportsthe need for further research in this topic and CYP genotyping of individual patients prior to receiving opiate analgesics to inform precision-guided decisions, improve therapeutic efficacy, and, most importantly, increase patient well-being and safety. The proposed systematic review and network meta-analysis will not only provide a more thorough review of common medications used to decrease emergence coughing, but also inform clinicians which of these pharmacological strategies is the best approach.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Opioid overdose deaths and potentially inappropriate opioid prescribing practices (PIP): A spatial epidemiological study. (Pubmed Central) - Mar 24, 2020
Results indicate that PIP clustering alone does not explain overdose clustering patterns. Our findings can inform public health policy decisions at the local level, which include a focus on PIP and misuse of heroin and fentanyl that aim to curb opioid overdoses.
- | fentanyl citrate / Generic mfg.
Journal: Acceptability of implementing community-based drug checking services for people who use drugs in three United States cities: Baltimore, Boston and Providence. (Pubmed Central) - Mar 24, 2020
The majority of PWUD endorsed drug checking for overdose prevention, with intent amplified by having witnessed a fatal overdose and recent fentanyl exposure. Drug checking should be part of a comprehensive approach to address the risks associated with the proliferation of fentanyl.
- || fentanyl citrate / Generic mfg., ondansetron / Generic mfg.
Clinical, Journal: Comparison of the Analgesic Effect of Sufentanil versus Fentanyl in Intravenous Patient-Controlled Analgesia after Total Laparoscopic Hysterectomy: A Randomized, Double-blind, Prospective Study. (Pubmed Central) - Mar 24, 2020
In comparison with fentanyl, sufentanil showed comparable analgesic efficacy and safety with less analgesic consumption (under a potency ratio of 1:5) in IV-PCA after total laparoscopic hysterectomy. Therefore, we suggest that sufentanil can be a useful alternative to fentanyl for IV-PCA.
- | fentanyl citrate / Generic mfg.
Biomarker, Journal: Effect of fentanyl and its three novel analogues on biochemical, oxidative, histological, and neuroadaptive markers after sub-acute exposure in mice. (Pubmed Central) - Mar 24, 2020
Three novel analogues of fentanyl were envisaged to have alternative therapeutic potentials. However, their comparative sub-acute toxicity revealed undesirable side effects, thereby masking their therapeutic ability.
- | fentanyl citrate / Generic mfg.
Journal: Continuous Opioid Monitoring along with Nerve Agents on a Wearable Microneedle Sensor Array. (Pubmed Central) - Mar 24, 2020
The new multimodal microneedle sensor array relies on unmodified and organophosphorus hydrolase (OPH) enzyme-modified carbon paste (CP) microneedle electrodes for square wave voltammetric (SWV) detection of the fentanyl and nerve agent targets, respectively...Successful OPi-OP detection con-ducted in a skin-mimicking phantom gel demonstrates the suitability of the device for rapid on-body sensing. Such progress towards continuous minimally-invasive transdermal analysis of drugs of abuse and nerve agents holds promise for rapid countermeasures for protecting soldiers, civil-ians, and healthcare personnel.
- | fentanyl citrate / Generic mfg.
Retrospective data, Journal: Conversion of Intrathecal Opioids to Fentanyl in Chronic Pain Patients With Implantable Pain Pumps: A Retrospective Study. (Pubmed Central) - Mar 22, 2020
Such progress towards continuous minimally-invasive transdermal analysis of drugs of abuse and nerve agents holds promise for rapid countermeasures for protecting soldiers, civil-ians, and healthcare personnel. Given the pharmacokinetics of lipophilic fentanyl compared to hydrophilic morphine/hydromorphone, the current conversion ratio of IV fentanyl to IT fentanyl and IV morphine to IT fentanyl appears to be conservative.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Prevalence and characterization of breakthrough pain in cancer patients with proctalgia treated with 3D pelvic radiotherapy. (Pubmed Central) - Mar 22, 2020
This study demonstrated a high prevalence of BTcP prevalence in cancer patients undergoing pelvic 3D radiotherapy and with proctalgia. Although the variables determining the onset of BTcP are still unclear, our results could help in the design of future clinical studies addressing the treatment of BTcP in these patients.
- || Duragesic (fentanyl) / J&J
Clinical, Review, Journal: Opioid Management in Older Adults with Chronic Kidney Disease: A Review. (Pubmed Central) - Mar 22, 2020
Since older adults with non-dialysis chronic kidney disease are at increased risk for adverse events, vigilant monitoring of opioid prescription is critical. Lastly, collaboration among an interprofessional clinical team can ensure safe prescription of opioids in older adults with non-dialysis chronic kidney disease.
- ||| fentanyl citrate / Generic mfg., lorazepam / Generic mfg.
Clinical: I use fentanyl/ativan for T&Os without smit sleeve. I like the idea of switching to 4 fx. I have several cervix patients recently start EBRT and plan to get their brachy in once weekly ASAP - not all of our nurses/physicists are brachy-trained and I worry about staff availability (Twitter) - Mar 22, 2020
- || fentanyl citrate / Generic mfg.
Fentanyl cisatracurium train of 4 meters (Twitter) - Mar 22, 2020
- | fentanyl citrate / Generic mfg.
Journal: Neu: Fentanyl Aristo® Buccal-tabletten zur Behandlung von Durchbruchschmerzen. (Pubmed Central) - Mar 21, 2020
Lastly, collaboration among an interprofessional clinical team can ensure safe prescription of opioids in older adults with non-dialysis chronic kidney disease. No abstract available
- | fentanyl citrate / Generic mfg., methadone / Generic mfg.
Journal: Drug and Opioid-Involved Overdose Deaths - United States, 2017-2018. (Pubmed Central) - Mar 21, 2020
Efforts related to all opioids, particularly deaths involving synthetic opioids, should be strengthened to sustain and accelerate declines in opioid-involved deaths. Comprehensive surveillance and prevention measures are critical to reducing opioid-involved deaths, including continued surveillance of evolving drug use and overdose, polysubstance use, and the changing illicit drug market; naloxone distribution and outreach to groups at risk for IMF exposure; linkage to evidence-based treatment for persons with substance use disorders; and continued partnerships with public safety.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Etomidate plus fentanyl for anesthesia in pediatric strabotomy. (Pubmed Central) - Mar 21, 2020
The mean emergence agitation score in group B was significantly lower than that in group A when the maximum emergence in group B was at 20 min after entering into PACU (p < 0.05). In conclusion, etomidate combined with fentanyl plays a good efficacy in anesthesia of pediatric strabotomy compared with etomidate plus ketamine.
- | fentanyl citrate / Generic mfg.
Preclinical, Journal: Sedative and Analgesic Drug Sequestration After a Single Bolus Injection in an Ex Vivo Extracorporeal Membrane Oxygenation Infant Circuit. (Pubmed Central) - Mar 20, 2020
Sequestration of fentanyl, midazolam, and dexmedetomidine in an ECMO circuit with Phisio-coated PVC tubing and PMP MO may limit drug delivery to infants. Future in vivo studies are needed to determine the clinical impact of sequestration.
- || fentanyl citrate / Generic mfg.
Clinical, Journal, Endobronchial Ultrasound: Utility and safety of endobronchial ultrasound-guided transbronchial needle aspiration and endoscopic ultrasound with an echobronchoscope-guided fine needle aspiration in children with mediastinal pathology. (Pubmed Central) - Mar 20, 2020
Future in vivo studies are needed to determine the clinical impact of sequestration. EBUS-TBNA and EUS-B-FNA are helpful in children with undiagnosed mediastinal pathology with fair diagnostic yield and excellent patient safety profile.
- || fentanyl citrate / Generic mfg., remifentanil / Generic mfg.
Clinical, Retrospective data, Journal: Fentanyl versus remifentanil-based TIVA for pediatric scoliosis repair: does it matter? (Pubmed Central) - Mar 20, 2020
Substitution of fentanyl for remifentanil during surgical correction of AIS does not appear to solve the problem of OIH or acute tolerance. Prospective studies are needed to confirm this unexpected result.
- || fentanyl citrate / Generic mfg., Chirocaine (levobupivacaine) / Purdue
Clinical, Journal: Greater analgesic effect with intermittent compared with continuous mode of lumbar plexus block for total hip arthroplasty: a randomized controlled trial. (Pubmed Central) - Mar 20, 2020
Prospective studies are needed to confirm this unexpected result. Greater analgesic effect was achieved using the intermittent mode than the continuous mode of LPB administration.
- | fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
Journal: Rate of Fentanyl Positivity Among Urine Drug Test Results Positive for Cocaine or Methamphetamine. (Pubmed Central) - Mar 20, 2020
Stimulant users who may be opioid naive are at a heightened risk of overdose when exposed to fentanyl. Clinicians need to be aware that patients presenting for treatment of suspected drug overdose or substance use disorder may have been exposed, knowingly or unknowingly, to multiple substances, including the combination of stimulants and opioids.
- | fentanyl citrate / Generic mfg., Fentora (fentanyl buccal) / Teva
Journal: Effectiveness of Risk Minimization Measures for Fentanyl Buccal Tablet (FENTORA) in Canada: A Mixed-Methods Evaluation Using Surveys, Medical Chart Records and Web Surveillance. (Pubmed Central) - Mar 19, 2020
Clinicians need to be aware that patients presenting for treatment of suspected drug overdose or substance use disorder may have been exposed, knowingly or unknowingly, to multiple substances, including the combination of stimulants and opioids. The aRMMs as measured by the prescriber KAU were effective for most key safety messages; however, not all key messages of the aRMMs were stringently followed in routine practice.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Knowledge, attitudes and practices of Canadian pediatric emergency physicians regarding short-term opioid use: a descriptive, cross-sectional survey. (Pubmed Central) - Mar 19, 2020
Emergency department physicians appeared minimally concerned about physical dependence, addiction risk and the current opioid crisis when prescribing opioids to children. Evidence-based development of guidelines and protocols for use of opioids in children may improve physicians' ability to manage pain in children responsibly and adequately.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Impact of Oral Clonidine on Duration of Opioid and Benzodiazepine Use in Mechanically Ventilated Children: A Randomized, Double-Blind, Placebo-Controlled Study. (Pubmed Central) - Mar 19, 2020
This trial showed a reduction in total doses of midazolam and fentanyl given in ventilated children who were administered clonidine as add-on therapy. Clonidine addition had no effect on duration of mechanical ventilation.
- | fentanyl citrate / Generic mfg., Penthrox (methoxyflurane) / Medical Developments International
Retrospective data, Journal: Palliative care in paramedic practice: A retrospective cohort study. (Pubmed Central) - Mar 18, 2020
Paramedics have a significant role in caring for patients receiving palliative care. These results should inform the design of integrated systems of care that involve ambulance services in the planning and delivery of community-based palliative care.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Effect of intrathecal morphine and epidural analgesia on postoperative recovery after abdominal surgery for gynecologic malignancy: an open-label randomised trial. (Pubmed Central) - Mar 18, 2020
P4
Compared with EDA, ITM is simpler to administer and manage, is associated with shorter hospital stay and reduces opioid consumption postoperatively with an equally good QoL. ITM is effective as postoperative analgesia in gynaecological cancer surgery.
- |||| fentanyl citrate / Generic mfg.
Clinical: A bit concerned about patients on #opioid during #COVID2019 outbreak. After reviewing quickly some abstracts it is confirmed that fentanyl has a potent lymphocytes suppression effect. Would appreciate most an opinion from @SISPhysicians @AEMPSGOB and other peers. @NarouzeMD (Twitter) - Mar 18, 2020
- | fentanyl citrate / Generic mfg.
Journal: Conjugate vaccine produces long-lasting attenuation of fentanyl vs. food choice and blocks expression of opioid withdrawal-induced increases in fentanyl choice in rats. (Pubmed Central) - Mar 18, 2020
Lastly, fentanyl vaccine administration prevented the expression of withdrawal-associated increases in fentanyl-vs.-food choice following introduction of extended 12 h fentanyl access sessions. Overall, these results support the potential and further consideration of immunopharmacotherapies as candidate treatments to address the current opioid crisis.
- | fentanyl citrate / Generic mfg.
Journal: The role of orexin-1 receptor signaling in demand for the opioid fentanyl. (Pubmed Central) - Mar 18, 2020
Baseline α values predicted the amount of cued reinstatement of fentanyl seeking; this reinstatement behavior was attenuated by SB administration. These results highlight the promise of the orexin system as a treatment target for opioid addiction and emphasize the usefulness of BE procedures in the study of opioid abuse.
- || fentanyl citrate / Generic mfg.
Review, Journal: Is pain part of a systemic syndrome in head and neck cancer? (Pubmed Central) - Mar 17, 2020
Fentanyl, easily absorbed and generally well tolerated, appears to be a possible choice due to its versatility. Non-pharmacological interventions, such as tailored yoga, physical exercise, and acupuncture, may have a role in pain management in patients with HNC.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Determination of dose and efficacy of atracurium for rapid sequence induction of anesthesia: A randomised prospective study. (Pubmed Central) - Mar 17, 2020
All patients were given 2-3 mg/kg propofol and 1 μg/kg fentanyl intravenously for the induction of anesthesia followed by different doses of atracurium (0.6 mg/kg, 0.75 mg/kg or 1 mg/kg) without a priming dose...An atracurium dose of 1 mg/kg facilitated significant differences in vocal cord and diaphragm paralysis compared with the dose of 0.6 mg/kg (P = 0.03). The administration of a relatively high dose of atracurium without priming can be used as an alternative neuromuscular blocking agent for rapid sequence induction of anesthesia in some circumstances.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Comparison of Continuous Epidural Infusion of Bupivacaine and Fentanyl Versus Patient Controlled Analgesia Techniques for Labor Analgesia: A Randomized Controlled Trial (RCT). (Pubmed Central) - Mar 17, 2020
However, there was no significant difference between patients' satisfaction and VAS in study groups. Epidural analgesia using PCEA combined with continuous infusion did not provide higher analgesia or patients' satisfaction compared to PCEA alone; however, it led to a decreased rate of drug injection and total administered dosage.
- | fentanyl citrate / Generic mfg.
Journal: Fentanyl inhibits the progression of gastric cancer through the suppression of MMP-9 via the PI3K/Akt signaling pathway. (Pubmed Central) - Mar 17, 2020
Furthermore, the inhibition of PI3K/Akt/MMP-9 by LY294002 and SB-3CT enhanced the anticancer effects of fentanyl. Fentanyl inhibits the proliferation, invasion and migration of gastric cancer cells by inhibiting the PI3K/Akt/MMP-9 pathway, which could be very useful for gastric cancer treatment.
- |||| fentanyl citrate / Generic mfg.
#Opioid overdose death data from 10 states suggest a shift away from illicit fentanyl analog distribution to distribution of illicitly manufactured fentanyl. https://t.co/D7NgEK3CtD @CDCMMWR (Twitter) - Mar 16, 2020