- |||||||||| isoflurane / Generic mfg.
Journal: Phenylpiperidine opioid effects on isoflurane minimum alveolar concentration in cats. (Pubmed Central) - Jun 20, 2020
Next, naltrexone 0.6 mg/kg was administered to cats hourly during the opioid infusion, and isoflurane MAC was measured in duplicate...Alfentanil and sufentanil modestly reduce isoflurane MAC via agonist effects on opioid receptors. However, these effects are too small to justify clinical use of phenylpiperidine opioids as single agents to reduce MAC in cats.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Analgesic Effectiveness of Ultrasound-Guided Pecs II Block in Central Venous Port Catheter Implantation. (Pubmed Central) - Jun 19, 2020
While the number of fentanyl rescue doses administered in PACU was similar, the total NSAID consumption in the first 24 hours was higher in the LA group than in the Pecs group. In CVPC placement, ultrasound-guided Pecs II block is a more reliable, easily applicable and longer-acting approach than LA infiltration for postoperative analgesia.
- |||||||||| fentanyl citrate / Generic mfg., methadone / Generic mfg.
Clinical, Journal: The Association between Patient Characteristics and Opioid Treatment Response in Neuropathic and Nociceptive Pain Due to Cancer. (Pubmed Central) - Jun 18, 2020
In CVPC placement, ultrasound-guided Pecs II block is a more reliable, easily applicable and longer-acting approach than LA infiltration for postoperative analgesia. Careful analyses of patient attributes, treatment, and pain type of patients with head and neck cancer resulted in a prediction model that allowed to predict short-term pain relief and the opioid treatment response in neuropathic and nociceptive pain owing to cancer.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Illicit fentanyls in the opioid street market: desired or imposed? (Pubmed Central) - Jun 18, 2020
Market condition data indicate heroin supply shocks and shortages prior to the introduction of fentanyl in the United States and parts of Europe, but the much lower production cost of fentanyl compared with heroin may be a more significant factor Current evidence points to a supply-led addition of fentanyl to the drug market in response to heroin supply shocks and shortages, changing prescription opioid availability and/or reduced costs and risks to suppliers. Current drug users in affected regions of the United States, Canada and Europe appear largely to lack both concrete knowledge of fentanyl's presence in the drugs they buy and access to fentanyl-free alternatives.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Annotated Guidance and Recommendations for the Role and Actions of Emergency Medical Services Systems in the Current Opioid and Drug-Related Epidemics. (Pubmed Central) - Jun 18, 2020
Current drug users in affected regions of the United States, Canada and Europe appear largely to lack both concrete knowledge of fentanyl's presence in the drugs they buy and access to fentanyl-free alternatives. Beyond a need to update acute medical rescue practices and improved assessment techniques, EMS providers should also learn to optimally communicate, encourage, and even participate in facilitating management continuity for the affected individuals by identifying and using the appropriate resources that will provide viable, evidence-based pathways toward sustained recovery.
- |||||||||| fentanyl citrate / Generic mfg.
Review, Journal: Opioids Preconditioning Upon Renal Function and Ischemia-Reperfusion Injury: A Narrative Review. (Pubmed Central) - Jun 18, 2020
According to the available evidence, opioid preconditioning appears to reduce inflammation and reactive oxygen species generation after ischemia reperfusion. Therefore, opioid preconditioning represents a promising strategy to reduce renal ischemia reperfusion injury and, its application on current clinical practice could be beneficial in events such as acute renal injury and kidney transplantation.
- |||||||||| fentanyl citrate / Generic mfg., Carafate (sucralfate) / AbbVie
Clinical, Clinical guideline, Review, Journal: Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients and clinical practice guidelines. (Pubmed Central) - Jun 18, 2020
Professionals were able to classify the painful and stressful procedures; however, low use of measures for analgesia was evidenced. Of the agents studied for the management of OM in this paper, the evidence supports a Suggestion in favor of topical morphine 0.2% in H&N cancer patients treated with RT-CT for the treatment of OM-associated pain.
- |||||||||| fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
[VIRTUAL] Naloxone is Less Effective at Reversing the Cardiovascular Effects of Fentanyl-Methamphetamine Mixtures Than Fentanyl Alone () - Jun 13, 2020 - Abstract #CPDD2020CPDD_924;
Together, these studies suggest that concurrent use of opioids (fentanyl) and stimulants (methamphetamine) can result in an enhanced cardiovascular response. In addition, although naloxone produced a rapid and full reversal of fentanyl’s cardiovascular effects, the fact that it was unable to reverse the effects of a mixture of fentanyl + methamphetamine suggests that alternate strategies are needed to address the growing number of overdoses related to co-use of opioids and methamphetamine.
- |||||||||| fentanyl citrate / Generic mfg.
[VIRTUAL] Discriminative Stimulus Effects of Fentanyl Analogs () - Jun 13, 2020 - Abstract #CPDD2020CPDD_916;
Most of the fentanyl analogs produced morphine-like interoceptive effects and have the potential to be used as substitutes for legal and illegal opioids. Because most of these substances share similar mechanism of action with fentanyl and morphine, and because 10 of the 13 were more potent than morphine, they have the potential for inadvertent overdose.
- |||||||||| fentanyl citrate / Generic mfg., methamphetamine / Generic mfg., methadone / Generic mfg.
[VIRTUAL] Characteristics of High-Risk Injectors Opioid Use Disorder Individuals in Philadelphia, PA: Highlights for Interventions () - Jun 13, 2020 - Abstract #CPDD2020CPDD_878;
They are mostly polysubstance users with urine drug screens were positive for cocaine (62.7%), cannabis (29.6%), benzodiazepines (21.9%), methamphetamines (9.9%) and amphetamines (2.9%), almost all reported smoking tobacco (94.4%) and 28.7% reported drinking alcohol regularly (more than 10 days per month)... The prevalence of HIV infection, risk-behavior and depression were high and highlight the needs to develop strategies to enhance the engagement, adherence and retention in integrated mental health-addiction-HIV care.
- |||||||||| fentanyl citrate / Generic mfg.
[VIRTUAL] Death Discounting: A Behavioral Economic Analysis of Heroin and Fentanyl Overdose Risk () - Jun 13, 2020 - Abstract #CPDD2020CPDD_804;
Fentanyl was on average less preferred than heroin but the majority of participants were still willing to consume fentanyl and hypothetical fentanyl purchasing was equal or greater than that observed for heroin for many participants. These data suggest willingness to use opioids despite overdose risk corresponds to heroin dependence severity, and that a behavioral-economic framework can be used to assess attitudes toward synthetic opioid use and opioid overdose risk.
- |||||||||| fentanyl citrate / Generic mfg.
[VIRTUAL] Understanding Fentanyl Overdose Risk Among People who use Cocaine () - Jun 13, 2020 - Abstract #CPDD2020CPDD_794;
Findings suggest that people who primarily use cocaine/crack and have no history of opioid use may be at greatest risk for a fatal overdose as they have less awareness of fentanyl in the drug supply and are less prepared to respond to an overdose than other groups. Public health campaigns are needed to increase fentanyl awareness and overdose prevention preparedness among people primarily using cocaine/crack.
- |||||||||| fentanyl citrate / Generic mfg.
[VIRTUAL] A New Surge in Opioid-Related Overdoses in the Emergency Department During COVID-19 () - Jun 13, 2020 - Abstract #CPDD2020CPDD_793;
We have observed an increasing trend of opioid-related OD visits in our local ED during COVID-19 via real-time monitoring. Given this, efforts are needed to examine the effects of the pandemic on the opioid crisis and to improve ED-initiated treatment and public health interventions to reduce the potential downstream effects of COVID-19 on exacerbating the opioid epidemic.
- |||||||||| fentanyl citrate / Generic mfg.
[VIRTUAL] Evaluating the Treatment Preferences of Adults who Use Non-Prescribed Opioids Using Web-Based Sampling Strategies () - Jun 13, 2020 - Abstract #CPDD2020CPDD_718;
In the past year, 824 (96.8%) participants reported non-prescribed use of opioid pain relievers (mean TAPS score=2.72, SD=0.46) and 552 (64.9%) reported concurrent heroin or fentanyl use (mean TAPS score=2.73, SD=0.51)... Though the majority of participants preferred receiving short-acting MOUD formulations and treatment in non-integrated settings, the substantial variation in responses suggests that expanding access to all forms of OUD treatment would be beneficial.
- |||||||||| fentanyl citrate / Generic mfg.
[VIRTUAL] Physicians' Attitudes Regarding Patients with Opioid Use Disorder () - Jun 13, 2020 - Abstract #CPDD2020CPDD_669;
Given the increase in fentanyl-related overdose deaths the identification and treatment of this subset of opioid-using patients is highly important. Preliminary results indicates a lack of interest in prescribing buprenorphine.
- |||||||||| fentanyl citrate / Generic mfg., oxycodone controlled release / Generic mfg., methamphetamine / Generic mfg.
[VIRTUAL] Trends in Internet Search Behavior for Substance Use Treatment: A Measure of Health Seeking Behavior () - Jun 13, 2020 - Abstract #CPDD2020CPDD_635;
Our study identified temporal patterns in substance use treatment searches in the U.S., including a dramatic spike in opioid use treatment searches, consistent with the increased morbidity burden associated with the opioid crisis. Next steps will focus on assessing the geographic heterogeneity of these searches and their potential use to improve the targeting of substance use treatment information.
- |||||||||| fentanyl citrate / Generic mfg.
[VIRTUAL] Fentanyl-Induced Changes in Brain Activity in Awake Nonhuman Primates () - Jun 13, 2020 - Abstract #CPDD2020CPDD_599;
Results should inform prevention and harm reduction efforts. Results suggest that this fMRI approach, using awake nonhuman primates, can be utilized to investigate changes in neural circuitry following opioid administration and, perhaps, to investigate medication-related changes in opioid-induced neural activity.
- |||||||||| fentanyl citrate / Generic mfg.
[VIRTUAL] Overdose Risk Among Opioid Users in New Jersey: The Role of Fentanyl and Naloxone () - Jun 13, 2020 - Abstract #CPDD2020CPDD_505;
Fentanyl-seeking attitudes and behaviors were significantly associated with overdose risk and mediated the relationship between overdose and naloxone-related risk-taking. As long as demand for fentanyl remains high, harm reduction strategies to increase OU’s awareness and identification of fentanyl-contaminated products may be less effective than opioid treatment.
- |||||||||| Imperan (metoclopramide) / Generic mfg.
Journal: Fragmentation studies of selected drugs utilized in palliative care. (Pubmed Central) - Jun 12, 2020
On their basis, transitions for quantitative analysis are selected and chromatographic conditions for the determination of the palliative care drugs are proposed as well. These results enable future studies on palliative care drugs in elderly patients including both their quantitation in body fluids and easier identification of their metabolites.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Highly potent fentanyl analogs: apnea from exposure to small quantities of ß-hydroxyfentanyl and furanylfentanyl. (Pubmed Central) - Jun 10, 2020
Fentanyl analogs were detected in the product at 109-120mg per gram of powder, which suggests that a 500mcg dose of fentanyl analog is the equivalent to 4.17-4.59mg of powder, or about the mass in 1/500th of a packet of sugar. Unique aspects of these cases are the rarely reported use of furanylfentanyl and ß-hydroxyfentanyl, intentional insufflation of "fentanyl" for therapeutic and recreational use, the small quantities of powder ingested, and the use of non-targeted analysis to identify the fentanyl analogs.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Dual Pharmacophores Explored via Structure-Activity Relationship (SAR) Matrix: Insights into Potent, Bifunctional Opioid Ligand Design. (Pubmed Central) - Jun 10, 2020
However, selective MOR agonists including fentanyl and morphine derivatives are limited clinically due to high risks of dependence, tolerance, and respiratory depression...In this study, we utilized a 2D structure-activity relationship (SAR) matrix to identify pharmacological trends attributable to combinations of two key pharmacophore elements within the chemotype. This work enhances our ability to modulate efficacy at MOR and DOR, accessing a variety of bifunctional profiles while maintaining high affinity and potency at both receptors.
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