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39 Diseases |  |
5 Trials |
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5 Trials |  |
18506 News |  |
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- || fentanyl citrate / Generic mfg.
What drugs are being laced with fentanyl & if so where R they made? @US_FDA @FDA @CDCgov @CDCDirector @FDArecalls @SteveFDA @cnnbrk @MSNBC_Breaking @VelshiMSNBC @60Minutes @CBSEveningNews @AP @HouseDemocrats @SenateDems @SenateGOP @HouseGOP @HHSGov @VeteransHealth @DNC @thehill (Twitter) - Jul 30, 2020
- ||| fentanyl citrate / Generic mfg.
Clinical: CDC/DEA wrong to demonize Rx opioids - they're safe for 99+% of pts. Illegal fentanyl heroin cocaine meth kill @POTUS @US_FDA @SecAzar @HHSGov @VanilaSingh @DonaldJTrumpJr @KimStrassel @MZHemingway @LisaMarieBoothe @MariaBartiromo @PressSec @RandPaul @MarkMeadows @CDCDirector @CR (Twitter) - Jul 29, 2020
- || ketamine / Generic mfg.
Clinical, Journal: Effect of different doses of ketamine with low-dose rocuronium on intubation conditions in children: prospective randomized double blind trial. (Pubmed Central) - Jul 29, 2020
Different intubation conditions were observed on the basis of ketamine dose used in conjunction with 0.3 mg/kg rocuronium and fentanyl 1 µg/kg. Ketamine dose ≥ 1.5 mg/kg with low-dose rocuronium should be used to improve intubation conditions in pediatrics.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Expert consensus on the management of breakthrough cancer pain in older patients. A Delphi study. (Pubmed Central) - Jul 29, 2020
Ketamine dose ≥ 1.5 mg/kg with low-dose rocuronium should be used to improve intubation conditions in pediatrics. The present Delphi has generated a set of recommendations that will help healthcare professionals in the management of BTcP in older patients.
- | fentanyl citrate / Generic mfg.
Journal: Suppression of neuropathic pain by selective silencing of DRG ectopia using non-blocking concentrations of lidocaine. (Pubmed Central) - Jul 29, 2020
Bolus injections of morphine or fentanyl were ineffective...Spike electrogenesis in the DRG is apparently the primary driver of tactile allodynia in the SNL model of neuropathic pain and it can be controlled selectively by superfusing the relevant DRG(s) with non-blocking concentrations of lidocaine. This approach has potential clinical application in conditions such as postherpetic neuralgia and phantom limb pain in which one or only a few identifiable ganglia are implicated as pain drivers.
- || fentanyl citrate / Generic mfg.
Clinical, Review, Journal: Naloxone interventions in opioid overdoses: a systematic review protocol. (Pubmed Central) - Jul 29, 2020
We anticipate limitations relating to study heterogeneity. We will disseminate study results widely to update overdose treatment guidelines and naloxone dosing in Take Home Naloxone programs.
- | fentanyl citrate / Generic mfg.
Preclinical, Journal: Effectiveness and selectivity of a heroin conjugate vaccine to attenuate heroin, 6-acetylmorphine, and morphine antinociception in rats: Comparison with naltrexone. (Pubmed Central) - Jul 29, 2020
The heroin-TT vaccine formulation examined is less effective, but more selective, than chronic naltrexone to attenuate heroin antinociception in rats. Furthermore, these results provide an empirical framework for future preclinical opioid vaccine research to benchmark effectiveness against naltrexone.
- | fentanyl citrate / Generic mfg.
Journal: Factors associated with help seeking by community responders trained in overdose prevention and naloxone administration in Massachusetts. (Pubmed Central) - Jul 29, 2020
Help seeking by OEND enrollees was significantly associated with several responder, victim, and event characteristics. Targeted interventions to promote help seeking are warranted, particularly as the lethality of opioid supplies rises.
- | fentanyl citrate / Generic mfg.
Journal: Preference for drugs containing fentanyl from a cross-sectional survey of people who use illicit opioids in three United States cities. (Pubmed Central) - Jul 29, 2020
Frequency of opioid use, not route of administration, was associated with preference. Our data demonstrate the need to consider preferences for fentanyl when targeting services and interventions for PWUD.
- || fentanyl citrate / Generic mfg.
It's nonsense, it has nothing to do with prohibition because cocaine, heroin, fentanyl etc. are all in schedule 2, it doesn't stop them being prohibited (Twitter) - Jul 29, 2020
- | fentanyl citrate / Generic mfg.
Journal: The nexus of opioids, pain, and addiction: Challenges and solutions. (Pubmed Central) - Jul 29, 2020
This, coupled with a shortfall in OUD treatment capacity and the unfettered flood of inexpensive heroin and fentanyl, behavioral economics and other factors facilitated the 21st century opioid epidemic...Many of these people are turning to illicit opioids, and no evidence shows that the reduction in opioid prescriptions is reducing OUD or overdose deaths. Comprehensive, science-based policies that increase access to addiction treatment for all in need and better serve people with pain are vital to addressing both pain and addiction.
- | fentanyl citrate / Generic mfg.
Journal: Risk of death associated with kratom use compared to opioids. (Pubmed Central) - Jul 29, 2020
Most such deaths have been ascribed to fentanyl, heroin, benzodiazepines, prescription opioids, cocaine and other causes (e.g., homicide, suicide and various preexisting diseases)...The limitations of the mortality risk estimate warrants caution in individuals with unknown factors such as use of other substances and medications, or other preexisting conditions. More research on kratom safety and risks is needed, as is regulation of commercial kratom products to ensure that consumers are informed by FDA labeling and that kratom products are not contaminated or adulterated with other substances.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Efficacy of ultrasound-guided erector spinae plane block for analgesia after laparoscopic cholecystectomy: a randomized controlled trial (Pubmed Central) - Jul 29, 2020
More research on kratom safety and risks is needed, as is regulation of commercial kratom products to ensure that consumers are informed by FDA labeling and that kratom products are not contaminated or adulterated with other substances. Bilateral US-ESP block provided significant reduction in postoperative opioid consumption, intraoperative fentanyl need and postoperative pain scores of patients undergoing laparoscopic cholecystectomy.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Pain management protocol implementation and opioid consumption in critical care: an interrupted time series analysis. (Pubmed Central) - Jul 29, 2020
A pain management protocol could reduce the intensive care unit consumption of fentanyl. This strategy was associated with a shorter mechanical ventilation duration.
- | fentanyl citrate / Generic mfg.
Preclinical, Journal: Characterization of a porcine model of atrial arrhythmogenicity in the context of ischaemic heart failure. (Pubmed Central) - Jul 29, 2020
Myocardial infarction (AMI) was induced in propofol/fentanyl/midazolam-anaesthetized pigs by occluding the left anterior descending artery for 90 minutes to model ischaemia with reperfusion...Histological analysis showed pronounced left atrial and left ventricular fibrosis demonstrating a structural substrate underlying the increased arrhythmogenicity. Consequently, selective ventricular infarction via LAD occlusion causes haemodynamic alterations inducing structural atrial remodeling which results in increased atrial fibrosis as the arrhythmogenic atrial substrate in pigs with IHF.
- | meloxicam / Generic mfg.
Journal: Postoperative Analgesic Effects of Laserpuncture and Meloxicam in Bitches Submitted to Ovariohysterectomy. (Pubmed Central) - Jul 28, 2020
Consequently, selective ventricular infarction via LAD occlusion causes haemodynamic alterations inducing structural atrial remodeling which results in increased atrial fibrosis as the arrhythmogenic atrial substrate in pigs with IHF. In this preliminary study, laserpuncture mitigated postoperative pain in dogs following ovariohysterectomy, and the technique is a promising adjunct to perioperative pain management in dogs undergoing soft tissue surgery.
- | fentanyl citrate / Generic mfg., vancomycin / Generic mfg.
Journal: Y-Site Physical Compatibility of Numeta G13E with Drugs Frequently Used at Neonatal Intensive Care. (Pubmed Central) - Jul 28, 2020
These results are reassuring. However, when contact time exceeds the established norm, caution in the form of filter utilisation and close inspection is advised.
- ||| fentanyl citrate / Generic mfg.
That's what happens when you mix fentanyl & meth... Notice she cannot stop moving and her heart is probably 160 beats per minute @CDCDirector @drsanjaygupta u ever have so much leverage but you don't know how to use it properly #Mentalhealth will come up with something creative😏 (Twitter) - Jul 27, 2020
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Comparison of Dexmedetomidine, Lidocaine, and Fentanyl in Attenuation Hemodynamic Response of Laryngoscopy and Intubation in Patients Undergoing Cardiac Surgery. (Pubmed Central) - Jul 24, 2020
As a result, dexmedetomidine was not suitable for hemodynamic control and led to hypotension and bradycardia; on the other hand, fentanyl was more effective than two other medications in patients undergoing cardiac surgery. This trial is registered with IRCT2017013132320N1.
- | methadone / Generic mfg.
Journal: A preoperative single dose of methadone for moderate-to-severely painful surgery reduces postoperative morphine consumption. (Pubmed Central) - Jul 22, 2020
This trial is registered with IRCT2017013132320N1. A single dose of methadone administered at anesthesia induction prior to moderate-to-severely painful surgery is a possible strategy to reduce postoperative morphine consumption.
- || fentanyl citrate / Generic mfg., Chirocaine (levobupivacaine) / Purdue
Clinical, Journal: Is breakthrough pain better managed by adding programmed intermittent epidural bolus to a background infusion during labor epidural analgesia? A randomized controlled trial. (Pubmed Central) - Jul 22, 2020
Adding PIEB to BEI+PCEA improved labor analgesia by significantly reducing the needs of rescue analgesia and prolonging the duration of effective analgesia. This combination provoked a higher consumption of local anesthetic with no detected clinical consequences.
- | fentanyl citrate / Generic mfg.
Preclinical, Journal: Evidence for nonlinear accumulation of the ultrapotent fentanyl analog, carfentanil, after systemic administration to male rats. (Pubmed Central) - Jul 21, 2020
Our findings reveal that carfentanil produces marked hypothermia and catalepsy, which is accompanied by nonlinear accumulation of the drug at high doses. We hypothesize that impaired clearance of carfentanil in humans could contribute to life-threatening effects of this ultrapotent opioid agonist.
- | fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
Review, Journal: Development of vaccines to treat opioid use disorders and reduce incidence of overdose. (Pubmed Central) - Jul 21, 2020
Despite clinical evaluation of vaccines targeting nicotine and cocaine showing proof of concept for this approach, no vaccine for SUD has yet reached the market. This review first discusses how vaccines for treatment of opioid use disorder (OUD) and reduction of opioid-induced fatal overdoses fit within the current medication assisted treatment (MAT) portfolio, and then summarizes ongoing efforts toward translation of vaccines targeting heroin, oxycodone, fentanyl, and other opioids.
- | fentanyl citrate / Generic mfg.
Journal: Vaccine blunts fentanyl potency in male rhesus monkeys. (Pubmed Central) - Jul 21, 2020
The fentanyl vaccine also increased fentanyl plasma levels approximately 6-fold consistent with the hypothesis that the vaccine sequesters fentanyl in the blood. Overall, these results support the continued development and evaluation of this fentanyl vaccine in humans to address the ongoing opioid crisis.
- | fentanyl citrate / Generic mfg.
Journal: Molecular mechanisms of fentanyl mediated β-arrestin biased signaling. (Pubmed Central) - Jul 21, 2020
We propose and validate an activation mechanism where the n-aniline ring of fentanyl mediates μOR β-arrestin through a novel M153 "microswitch" by synthesizing fentanyl-based derivatives that exhibit complete, clinically desirable, G protein biased coupling. Together, these results provide molecular insight into fentanyl mediated β-arrestin biased signaling and a rational framework for further optimization of fentanyl-based analgesics with improved safety profiles.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Current practice and perceptions regarding pain, agitation and delirium management in patients receiving venovenous extracorporeal membrane oxygenation. (Pubmed Central) - Jul 19, 2020
Most respondents use validated scales and protocols to assess and manage pain, agitation/sedation, and delirium. The majority of respondents reported targeting a deep level of sedation with propofol being used for both deep and light levels of sedation.
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Analgesia-first sedation in critically ill adults: A U.S. pilot, randomized controlled trial. (Pubmed Central) - Jul 19, 2020
The majority of respondents reported targeting a deep level of sedation with propofol being used for both deep and light levels of sedation. A multicenter RCT evaluating AFS is feasible to conduct in North America.
- | fentanyl citrate / Generic mfg.
Journal: "You can see those concentric rings going out": Emergency personnel's experiences treating overdose and perspectives on policy-level responses to the opioid crisis in New Hampshire. (Pubmed Central) - Jul 19, 2020
A multicenter RCT evaluating AFS is feasible to conduct in North America. Findings suggest that interventions addressing trauma and burnout are necessary to support emergency personnel, while expanded harm reduction and treatment access are critical to support those who experience opioid overdose in NH.
- ||| fentanyl citrate / Generic mfg.
Clinical, Observational data: Does administering boluses of Fentanyl affect cerebral oxygenation, tissue oxygen extraction or cardiac output in preemies? Find out here in this prospective observational study done by @souvik_neo et… https://t.co/dVJdF7xuvh (Twitter) - Jul 19, 2020
- |||| fentanyl citrate / Generic mfg.
Clinical, Observational data: Does administering boluses of Fentanyl affect cerebral oxygenation, tissue oxygen extraction or cardiac output in preemies? Find out here in this prospective observational study done by @souvik_neo et al. https://t.co/CHG3GFcw0l #EBNeoAlerts #NeoEBM (Twitter) - Jul 19, 2020
- Duragesic (fentanyl) / J&J
[VIRTUAL] IMPROVING QUALITY OF ENDOSCOPY REPORTING USING REPORTING TEMPLATES DRIVES UP THE DETECTION OF PATHOLOGY - A TERTIARY CENTRE EXPERIENCE AT VALIDATING THE TRUE PREVALENCE OF CERVICAL INLET PATCH (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_5209;
Improved detection rate may be related to numerous factors, including endoscopists level of experience at detecting pathology, sedation use and patient comfort, as well as a reporting template focusing the endoscopist to comment on presence/absence of inlet patch. Standardised reporting templates should be considered for routine use throughout upper GI endoscopy as a potential means of enhancing quality of endoscopy.
- fentanyl citrate / Generic mfg.
[VIRTUAL] ROLE OF β-ARRESTIN 2 IN OPIOID-INDUCED CONSTIPATION (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_4780;
Our data confirmed that β-arrestin 2 plays a critical role in regulating MOR mediated effects elicited by canonical opioids. Specifically, acute treatment with opioids exhibited greater analgesic effects in Arrb2-/- vs. Arrb2+/+ mice, with less OIC in equianalgesic conditions.
- fentanyl citrate / Generic mfg.
[VIRTUAL] A NOVEL APPROACH TO RADIOTHERAPY TARGETING FOR OESOPHAGEAL SQUAMOUS CELL CANCER USING LUGOL'S IODINE GUIDED ENDOCLIP MARKING (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_4181;
All procedures were undertaken with conscious sedation with a median dose of 2.5mg midazolam (2.5-3.0) and 50mcg fentanyl (0-75mcg)... Here we describe a novel technique using Lugols guided clip placement prior to radiotherapy, demonstrating it to be a quick and uncomplicated procedure which can be used in the management of patients with SCC.
- Duragesic (fentanyl) / J&J
[VIRTUAL] IMPROVING QUALITY OF ENDOSCOPY REPORTING USING REPORTING TEMPLATES DRIVES UP THE DETECTION OF PATHOLOGY - A TERTIARY CENTRE EXPERIENCE AT VALIDATING THE TRUE PREVALENCE OF CERVICAL INLET PATCH (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_3233;
Improved detection rate may be related to numerous factors, including endoscopists level of experience at detecting pathology, sedation use and patient comfort, as well as a reporting template focusing the endoscopist to comment on presence/absence of inlet patch. Standardised reporting templates should be considered for routine use throughout upper GI endoscopy as a potential means of enhancing quality of endoscopy.
- fentanyl citrate / Generic mfg.
[VIRTUAL] ROLE OF β-ARRESTIN 2 IN OPIOID-INDUCED CONSTIPATION (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_2804;
Our data confirmed that β-arrestin 2 plays a critical role in regulating MOR mediated effects elicited by canonical opioids. Specifically, acute treatment with opioids exhibited greater analgesic effects in Arrb2-/- vs. Arrb2+/+ mice, with less OIC in equianalgesic conditions.
- fentanyl citrate / Generic mfg.
[VIRTUAL] A NOVEL APPROACH TO RADIOTHERAPY TARGETING FOR OESOPHAGEAL SQUAMOUS CELL CANCER USING LUGOL'S IODINE GUIDED ENDOCLIP MARKING (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_2205;
All procedures were undertaken with conscious sedation with a median dose of 2.5mg midazolam (2.5-3.0) and 50mcg fentanyl (0-75mcg)... Here we describe a novel technique using Lugols guided clip placement prior to radiotherapy, demonstrating it to be a quick and uncomplicated procedure which can be used in the management of patients with SCC.
- Duragesic (fentanyl) / J&J
[VIRTUAL] IMPROVING QUALITY OF ENDOSCOPY REPORTING USING REPORTING TEMPLATES DRIVES UP THE DETECTION OF PATHOLOGY - A TERTIARY CENTRE EXPERIENCE AT VALIDATING THE TRUE PREVALENCE OF CERVICAL INLET PATCH (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_1249;
Improved detection rate may be related to numerous factors, including endoscopists level of experience at detecting pathology, sedation use and patient comfort, as well as a reporting template focusing the endoscopist to comment on presence/absence of inlet patch. Standardised reporting templates should be considered for routine use throughout upper GI endoscopy as a potential means of enhancing quality of endoscopy.
- fentanyl citrate / Generic mfg.
[VIRTUAL] ROLE OF β-ARRESTIN 2 IN OPIOID-INDUCED CONSTIPATION (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_820;
Our data confirmed that β-arrestin 2 plays a critical role in regulating MOR mediated effects elicited by canonical opioids. Specifically, acute treatment with opioids exhibited greater analgesic effects in Arrb2-/- vs. Arrb2+/+ mice, with less OIC in equianalgesic conditions.
- fentanyl citrate / Generic mfg.
[VIRTUAL] A NOVEL APPROACH TO RADIOTHERAPY TARGETING FOR OESOPHAGEAL SQUAMOUS CELL CANCER USING LUGOL'S IODINE GUIDED ENDOCLIP MARKING (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_221;
All procedures were undertaken with conscious sedation with a median dose of 2.5mg midazolam (2.5-3.0) and 50mcg fentanyl (0-75mcg)... Here we describe a novel technique using Lugols guided clip placement prior to radiotherapy, demonstrating it to be a quick and uncomplicated procedure which can be used in the management of patients with SCC.
- | fentanyl citrate / Generic mfg.
Journal: Impact of Fentanyl Use on Buprenorphine Treatment Retention and Opioid Abstinence. (Pubmed Central) - Jul 18, 2020
Both groups have lower abstinence rates at 6 months compared to individuals with negative toxicology at baseline. These findings suggest that people exposed to fentanyl still benefit from buprenorphine treatment.
- | fentanyl citrate / Generic mfg.
Journal: Pharmaceutical payments to physicians may increase prescribing for opioids. (Pubmed Central) - Jul 18, 2020
These findings suggest that people exposed to fentanyl still benefit from buprenorphine treatment. In the United States, physicians who receive direct payments from providers for opioid prescribing tend to prescribe substantially larger quantities, particularly for hydrocodone and oxycodone.
- | fentanyl citrate / Generic mfg.
Journal: Intraperitoneal nebulization versus intraperitoneal instillation of ropivacaine for postoperative pain management following laparoscopic donor nephrectomy. (Pubmed Central) - Jul 18, 2020
In ropivacaine nebulization group PONV was significantly reduce in PACU and at 6 hr. Intraperitoneal nebulization of ropivacaine reduced postoperative pain, fentanyl requirements, referred shoulder pain, PONV with earlier mobility but with no difference in duration of the hospital stay.
- || Neforex (nefopam) / Incepta
Clinical, Journal: Comparison Between Preoperative and Intraoperative Administration of Nefopam for Acute and Chronic Postoperative Pain in Colon Cancer Patients: A Prospective, Randomized, Double-Blind Study. (Pubmed Central) - Jul 18, 2020
It may be helpful to conduct early ambulation and deep breathing during the acute postoperative period in patients undergoing intestinal surgery. Trial registration No: KCT0001656.
- || ondansetron / Generic mfg.
Clinical, Journal: Risk factors for nausea and vomiting after adolescent idiopathic scoliosis surgery (Pubmed Central) - Jul 17, 2020
Trial registration No: KCT0001656. A high-dose intraoperative fentanyl consumption, a marked ΔHb, and postoperative analgesia with fentanyl are risk factors for PONV while intraoperative administration of dexmedetomidine and dexamethasone combined with ondansetron are protective factors against PONV following surgeries for AIS.
- | fentanyl citrate / Generic mfg.
Acetaminophen Beats Fentanyl in STEMI https://t.co/1ytAKgq4X8 via @medscape (Twitter) - Jul 17, 2020
- || fentanyl citrate / Generic mfg.
#WarOnDrugs costs $47B/yr. We’ve somehow managed to make life-saving treatment inaccessible yet we can’t stop increasingly potent fentanyl analogues from saturating our illicit supply. The absence of logic is as profound as it is pervasive. (Twitter) - Jul 16, 2020
- ||| fentanyl citrate / Generic mfg.
This is bad— and I used to work on opioid overdose research. Nearly 71,000 Americans died of drug overdoses last year, a new record. Trend is driven by fentanyl & synthetic opioid overdoses, accounting for half. Deaths from cocaine & meth also are rising. https://t.co/ciui9EhQBZ (Twitter) - Jul 16, 2020
- || fentanyl citrate / Generic mfg., ketamine / Generic mfg.
PK/PD data, Journal: Sampling site has a critical impact on PBPK modeling. (Pubmed Central) - Jul 16, 2020
This can lead to clinically significant error in predictions of plasma concentration-time profiles in unstudied scenarios. To address this error, we developed and verified a novel peripheral sampling site model to simulate arm vein drug concentrations that can be applied to different drug dosing scenarios.
- || fentanyl citrate / Generic mfg., Bridion (sugammadex) / Merck (MSD)
Clinical, Journal: Changes in laryngeal airway patency in response to complete reversal of rocuronium-induced paralysis with sugammadex in small children with a supraglottic airway: protective effect of fentanyl? (Pubmed Central) - Jul 16, 2020
To address this error, we developed and verified a novel peripheral sampling site model to simulate arm vein drug concentrations that can be applied to different drug dosing scenarios. No abstract available
- | fentanyl citrate / Generic mfg.
Preclinical, Journal: Severe Hypoxemia Prevents Spontaneous and Naloxone-induced Breathing Recovery after Fentanyl Overdose in Awake and Sedated Rats. (Pubmed Central) - Jul 16, 2020
No abstract available Hypoxia-induced ventilatory depression during fentanyl induced apnea (1) opposes the spontaneous emergence of a respiratory rhythm, which would have rescued the animals otherwise, and (2) prevents the effects of high dose naloxone.